Characterization of the hypothetical protein Cpn1027, a newly identified inclusion membrane protein unique to Chlamydia pneumoniae

Microbiology

Volumn 153, Issue 3, 2007, Pages 777-786

  Flores, Rhonda ^a   Luo, Jianhua ^a   Chen, Ding ^a   Sturgeon, Gracie ^a   Shivshankar, Pooja ^a   Zhong, Youmin ^a   Zhong, Guangming ^a  

^a Mays Cancer Center at UT Health San Antonio   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; MEMBRANE PROTEIN; PROTEIN CPN 1027; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANTIBODY PRODUCTION; ARTICLE; CHLAMYDOPHILA PNEUMONIAE; HUMAN; IMMUNOFLUORESCENCE TEST; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN SECONDARY STRUCTURE; SEQUENCE ANALYSIS; WESTERN BLOTTING;

BACTERIAL PROTEINS; CHLAMYDOPHILA PNEUMONIAE; INCLUSION BODIES; MEMBRANE PROTEINS; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE; PROTEIN STRUCTURE, SECONDARY;

CHLAMYDOPHILA PNEUMONIAE;

EID: 33947407229     PISSN: 13500872     EISSN: None     Source Type: Journal    
DOI: 10.1099/mic.0.2006/002956-0     Document Type: Article

References (46)

1. Alzhanov, D., Barnes, J., Hruby, D. E. & Rockey, D. D. (2004). Chlamydial development is blocked in host cells transfected with Chlamydophila caviae incA. BMC Microbiol 4, 24.
2. Bannantine, J. P., Rockey, D. D. & Hackstadt, T. (1998). Tandem genes of Chlamydia psittaci that encode proteins localized to the inclusion membrane. Mol Microbiol 28, 1017-1026.
3. Bannantine, J. P., Griffiths, R. S., Viratyosin, W., Brown, W. J. & Rockey, D. D. (2000). A secondary structure motif predictive of protein localization to the chlamydial inclusion membrane. Cell Microbiol 2, 35-47.
4. Campbell, L. A. & Kuo, C. C. (2004). Chlamydia pneumoniae - an infectious risk factor for atherosclerosis? Nat Rev Microbiol 2, 23-32.
5. Campbell, L. A., Nosaka, T., Rosenfeld, M. E, Yaraei, K. & Kuo, C. C. (2005). Tumor necrosis factor alpha plays a role in the acceleration of atherosclerosis by Chlamydia pneumoniae in mice. Infect Immun 73, 3164-3165.
6. Carabeo, R. A., Mead, D. J. & Hackstadt, T. (2003). Golgi-dependent transport of cholesterol to the Chlamydia trachomatis inclusion. Proc Natl Acad Sci U S A 100, 6771-6776.
7. Chen, C., Chen, D., Sharma, J., Cheng, W., Zhong, Y., Liu, K., Jensen, J., Shain, R., Arulanandam, B. & Zhong, G. (2006). The hypothetical protein CT813 is localized in the Chlamydia trachomatis inclusion membrane and is immunogenic in women urogenitally infected with C. trachomatis. Infect Immun 74, 4826-4840.
8. Delevoye, C., Nilges, M., Dautry-Varsat, A. & Subtil, A. (2004). Conservation of the biochemical properties of IncA from Chlamydia trachomatis and Chlamydia caviae: oligomerization of IncA mediates interaction between facing membranes. J Biol Chem 279, 46896-46906.
9. Dong, F., Pirbhai, M., Xiao, Y., Zhong, Y., Wu, Y. & Zhong, G. (2005). Degradation of the proapoptotic proteins Bik, Puma, and Bim with Bcl-2 domain 3 homology in Chlamydia trachomatis-infected cells. Infect Immun 73, 1861-1864.
10. Dong, F., Zhong, Y., Arulanandam, B. & Zhong, G. (2005). Production of a proteolytically active protein, chlamydial protease/proteasome-like activity factor, by five different Chlamydia species. Infect Immun 73, 1868-1872.
11. Fan, P., Dong, F., Huang, Y. & Zhong, G. (2002). Chlamydia pneumoniae secretion of a protease-like activity factor for degrading host cell transcription factors required for [correction of factors is required for] major histocompatibility complex antigen expression. Infect Immun 70, 345-349.
12. Fan, T., Lu, H., Hu, H., Shi, L., McClarty, G. A., Nance, D. M., Greenberg, A. H. & Zhong, G. (1998). Inhibition of apoptosis in chlamydia-infected cells: blockade of mitochondrial cytochrome c release and caspase activation. J Exp Med 187, 487-496.
13. + T cells recognize an inclusion membrane-associated protein from the vacuolar pathogen Chlamydia trachomatis. Proc Natl Acad Sci U S A 98, 1160-1165.
14. Grayston, J. T. (1992). Chlamydia pneumoniae, strain TWAR pneumonia. Annu Rev Med 43, 317-323.
15. Greene, W., Xiao, Y., Huang, Y., McClarty, G. & Zhong, G. (2004). Chlamydia-infected cells continue to undergo mitosis and resist induction of apoptosis. Infect Immun 72, 451-460.
16. Hackstadt, T. (1998). The diverse habitats of obligate intracellular parasites. Curr Opin Microbiol 1, 82-87.
17. Hackstadt, T., Scidmore, M. A. & Rockey, D. D. (1995). Lipid metabolism in Chlamydia trachomatis-infected cells: directed trafficking of Golgi-derived sphingolipids to the chlamydial inclusion. Proc Natl Acad Sci U S A 92, 4877-4881.
18. Hackstadt, T., Rockey, D. D., Heinzen, R. A. & Scidmore, M. A. (1996). Chlamydia trachomatis interrupts an exocytic pathway to acquire endogenously synthesized sphingomyelin in transit from the Golgi apparatus to the plasma membrane. EMBO J 15, 964-977.
19. Hackstadt, T., Fischer, E. R., Scidmore, M. A., Rockey, D. D. & Heinzen, R. A. (1997). Origins and functions of the chlamydial inclusion. Trends Microbiol 5, 288-293.
20. Hackstadt, T., Scidmore-Carlson, M. A., Shaw, E. I. & Fischer, E. R. (1999). The Chlamydia trachomatis IncA protein is required for homotypic vesicle fusion. Cell Microbiol 1, 119-130.
21. Hu, H., Pierce, G. N. & Zhong, G. (1999). The atherogenic effects of chlamydia are dependent on serum cholesterol and specific to Chlamydia pneumoniae. J Clin Invest 103, 747-753.
22. Kalman, S., Mitchell, W., Marathe, R., Lammel, C., Fan, J., Hyman, R. W., Olinger, L., Grimwood, J., Davis, R. W. & Stephens, R. S. (1999). Comparative genomes of Chlamydia pneumoniae and C. trachomatis. Nat Genet 21, 385-389.
23. Kuo, C. C., Grayston, J. T., Campbell, L. A., Goo, Y. A., Wissler, R. W. & Benditt, E. P. (1995a). Chlamydia pneumoniae (TWAR) in coronary arteries of young adults (15-34 years old). Proc Natl Acad Sci U S A 92, 6911-6914.
24. Kuo, C. C., Jackson, L. A., Campbell, L. A. & Grayston, J. T. (1995b). Chlamydia pneumoniae (TWAR). Clin Microbiol Rev 8, 451-461.
25. Kuo, C. C., Campbell, L. A. & Rosenfeld, M. E. (2002). Chlamydia pneumoniae infection and atherosclerosis: methodological considerations. Circulation 105, E34.
26. Kyte, J. & Doolittle, R. F. (1982). A simple method for displaying the hydropathic character of a protein. J Mol Biol 157, 105-132.
27. Liu, L., Hu, H., Ji, H., Murdin, A. D., Pierce, G. N. & Zhong, G. (2000). Chlamydia pneumoniae infection significantly exacerbates aortic atherosclerosis in an LDLR-/- mouse model within six months. Mol Cell Biochem 215, 123-128.
28. Read, T. D., Brunham, R. C., Shen, C., Gill, S. R., Heidelberg, J. F., White, O., Hickey, E. K., Peterson, J., Utterback, T. & other authors (2000). Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39. Nucleic Acids Res 28, 1397-1406.
29. Rockey, D. D., Heinzen, R. A. & Hackstadt, T. (1995). Cloning and characterization of a Chlamydia psittaci gene coding for a protein localized in the inclusion membrane of infected cells. Mol Microbiol 15, 617-626.
30. Rockey, D. D., Scidmore, M. A., Bannantine, J. P. & Brown, W. J. (2002). Proteins in the chlamydial inclusion membrane. Microbes Infect 4, 333-340.
31. Scidmore, M. A., Fischer, E. R. & Hackstadt, T. (1996). Sphingolipids and glycoproteins are differentially trafficked to the Chlamydia trachomatis inclusion. J Cell Biol 134, 363-374.
32. Sharma, J., Niu, Y., Ge, J., Pierce, G. N. & Zhong, G. (2004). Heat-inactivated C. pneumoniae organisms are not atherogenic. Mol Cell Biochem 260, 147-152.
33. Sharma, J., Dong, F., Pirbhai, M. & Zhong, G. (2005). Inhibition of proteolytic activity of a chlamydial proteasome/protease-like activity factor by antibodies from humans infected with Chlamydia trachomatis. Infect Immun 73, 4414-4419.
34. Sharma, J., Zhong, Y., Dong, F., Piper, J. M., Wang, G. & Zhong, G. (2006). Profiling of human antibody responses to Chlamydia trachomatis urogenital tract infection using microplates arrayed with 156 chlamydial fusion proteins. Infect Immun 74, 1490-1499.
35. Shaw, A. C., Vandahl, B. B., Larsen, M. R., Roepstorff, P., Gevaert, K., Vandekerckhove, J., Christiansen, G. & Birkelund, S. (2002). Characterization of a secreted Chlamydia protease. Cell Microbiol 4, 411-424.
36. Su, H., McClarty, G., Dong, F., Hatch, G. M., Pan, Z. K. & Zhong, G. (2004). Activation of Raf/MEK/ERK/cPLA2 signaling pathway is essential for chlamydial acquisition of host glycerophospholipids. J Biol Chem 279, 9409-9416.
37. Subtil, A., Parsot, C. & Dautry-Varsat, A. (2001). Secretion of predicted Inc proteins of Chlamydia pneumoniae by a heterologous type III machinery. Mol Microbiol 39, 792-800.
38. Subtil, A., Delevoye, C., Balana, M. E., Tastevin, L., Perrinet, S. & Dautry-Varsat, A. (2005). A directed screen for chlamydial proteins secreted by a type III mechanism identifies a translocated protein and numerous other new candidates. Mol Microbiol 56, 1636-1647.
39. Toh, H., Miura, K., Shirai, M. & Hattori, M. (2003). In silico inference of inclusion membrane protein family in obligate intracellular parasites chlamydiae. DNA Res 10, 9-17.
40. Vandahl, B. B., Stensballe, A., Roepstorff, P., Christiansen, G. & Birkelund, S. (2005). Secretion of Cpn0796 from Chlamydia pneumoniae into the host cell cytoplasm by an autotransporter mechanism. Cell Microbiol 7, 825-836.
41. Xiao, Y., Zhong, Y., Greene, W., Dong, F. & Zhong, G. (2004). Chlamydia trachomatis infection inhibits both Bax and Bak activation induced by staurosporine. Infect Immun 72, 5470-5474.
42. Xiao, Y., Zhong, Y., Su, H., Zhou, Z., Chiao, P. & Zhong, G. (2005). NF-kappa B activation is not required for Chlamydia trachomatis inhibition of host epithelial cell apoptosis. J Immunol 174, 1701-1708.
43. Zhong, G., Toth, I., Reid, R. & Brunham, R. C. (1993). Immunogenicity evaluation of a lipidic amino acid-based synthetic peptide vaccine for Chlamydia trachomatis. J Immunol 151, 3728-3736.
44. Zhong, G., Berry, J. & Brunham, R. C. (1994). Antibody recognition of a neutralization epitope on the major outer membrane protein of Chlamydia trachomatis. Infect Immun 62, 1576-1583.
45. Zhong, G., Reis e Sousa, C. & Germain, R. N. (1997). Production, specificity, and functionality of monoclonal antibodies to specific peptide-major histocompatibility complex class II complexes formed by processing of exogenous protein. Proc Natl Acad Sci U S A 94, 13856-13861.
46. Zhong, G., Fan, P., Ji, H., Dong, F. & Huang, Y. (2001). Identification of a chlamydial protease-like activity factor responsible for the degradation of host transcription factors. J Exp Med 193, 935-942.