메뉴 건너뛰기




Volumn 5, Issue , 2015, Pages

Bilirubin increases insulin sensitivity by regulating cholesterol metabolism, adipokines and PPAR 3 Levels

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; BILIRUBIN; CHOLESTEROL; GLUCOSE BLOOD LEVEL; INSULIN RECEPTOR; LEPTIN; LIPID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; SREBF1 PROTEIN, MOUSE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1;

EID: 84930628457     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep09886     Document Type: Article
Times cited : (75)

References (50)
  • 1
    • 33845493476 scopus 로고    scopus 로고
    • Prevalence and determinants of insulin resistance among U.S. Adolescents: A population-based study
    • Lee, J. M., Okumura, M. J., Davis, M. M., Herman, W. H. & Gurney, J. G. Prevalence and determinants of insulin resistance among U.S. adolescents: A population-based study. Diabetes Care 29, 2427-2432 (2006).
    • (2006) Diabetes Care , vol.29 , pp. 2427-2432
    • Lee, J.M.1    Okumura, M.J.2    Davis, M.M.3    Herman, W.H.4    Gurney, J.G.5
  • 2
    • 77950815768 scopus 로고    scopus 로고
    • Cardiovascular and renal complications of type 2 diabetes in obesity: Role of sympathetic nerve activity and insulin resistance
    • Masuo, K., Rakugi, H., Ogihara, T., Esler, M. D. & Lambert, G. W. Cardiovascular and renal complications of type 2 diabetes in obesity: Role of sympathetic nerve activity and insulin resistance. Curr Diabetes Rev 6, 58-67 (2010).
    • (2010) Curr Diabetes Rev , vol.6 , pp. 58-67
    • Masuo, K.1    Rakugi, H.2    Ogihara, T.3    Esler, M.D.4    Lambert, G.W.5
  • 3
    • 0034907012 scopus 로고    scopus 로고
    • Plasma insulin, leptin, and soluble TNF receptors levels in relation to obesity-related atherogenic and thrombogenic cardiovascular disease risk factors among men
    • Chu, N. F. et al. Plasma insulin, leptin, and soluble TNF receptors levels in relation to obesity-related atherogenic and thrombogenic cardiovascular disease risk factors among men. Atherosclerosis 157, 495-503 (2001).
    • (2001) Atherosclerosis , vol.157 , pp. 495-503
    • Chu, N.F.1
  • 4
    • 0033849777 scopus 로고    scopus 로고
    • Obesity and insulin resistance
    • Kahn, B. B. & Flier, J. S. Obesity and insulin resistance. J Clin Invest 106, 473-481 (2000).
    • (2000) J Clin Invest , vol.106 , pp. 473-481
    • Kahn, B.B.1    Flier, J.S.2
  • 5
    • 41149155892 scopus 로고    scopus 로고
    • Treatment of obese diabetic mice with a heme oxygenase inducer reduces visceral and subcutaneous adiposity, increases adiponectin levels, and improves insulin sensitivity and glucose tolerance
    • Li, M. et al. Treatment of obese diabetic mice with a heme oxygenase inducer reduces visceral and subcutaneous adiposity, increases adiponectin levels, and improves insulin sensitivity and glucose tolerance. Diabetes 57, 1526-1535 (2008).
    • (2008) Diabetes , vol.57 , pp. 1526-1535
    • Li, M.1
  • 6
    • 19044393872 scopus 로고    scopus 로고
    • Adipose tissue, inflammation, and cardiovascular disease
    • Berg, A. H. & Scherer, P. E. Adipose tissue, inflammation, and cardiovascular disease. Circ Res 96, 939-949 (2005).
    • (2005) Circ Res , vol.96 , pp. 939-949
    • Berg, A.H.1    Scherer, P.E.2
  • 7
    • 34848872799 scopus 로고    scopus 로고
    • Obesity-associated improvements in metabolic profile through expansion of adipose tissue
    • Kim, J. Y. et al. Obesity-associated improvements in metabolic profile through expansion of adipose tissue. J Clin Invest 117, 2621-2637 (2007).
    • (2007) J Clin Invest , vol.117 , pp. 2621-2637
    • Kim, J.Y.1
  • 8
    • 0036177867 scopus 로고    scopus 로고
    • Control of energy homeostasis and insulin action by adipocyte hormones: Leptin, acylation stimulating protein, and adiponectin
    • Havel, P. J. Control of energy homeostasis and insulin action by adipocyte hormones: Leptin, acylation stimulating protein, and adiponectin. Curr Opin Lipidol 13, 51-59 (2002).
    • (2002) Curr Opin Lipidol , vol.13 , pp. 51-59
    • Havel, P.J.1
  • 9
    • 20844451123 scopus 로고    scopus 로고
    • AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism
    • Kahn, B. B., Alquier, T., Carling, D. & Hardie, D. G. AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab 1, 15-25 (2005).
    • (2005) Cell Metab , vol.1 , pp. 15-25
    • Kahn, B.B.1    Alquier, T.2    Carling, D.3    Hardie, D.G.4
  • 10
    • 0028793697 scopus 로고
    • Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action
    • Frederich, R. C. et al. Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action. Nat Med 1, 1311-1314 (1995).
    • (1995) Nat Med , vol.1 , pp. 1311-1314
    • Frederich, R.C.1
  • 11
    • 0034881391 scopus 로고    scopus 로고
    • The adipocyte-secreted protein Acrp30 enhances hepatic insulin action
    • Berg, A. H., Combs, T. P., Du, X., Brownlee, M. & Scherer, P. E. The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat Med 7, 947-953 (2001).
    • (2001) Nat Med , vol.7 , pp. 947-953
    • Berg, A.H.1    Combs, T.P.2    Du, X.3    Brownlee, M.4    Scherer, P.E.5
  • 12
    • 34547609888 scopus 로고    scopus 로고
    • Selective downregulation of the high molecular weight form of adiponectin in hyperinsulinemia and in type 2 diabetes: Differential regulation from nondiabetic subjects
    • Basu, R., Pajvani, U. B., Rizza, R. A. & Scherer, P. E. Selective downregulation of the high molecular weight form of adiponectin in hyperinsulinemia and in type 2 diabetes: Differential regulation from nondiabetic subjects. Diabetes 56, 2174-2177 (2007).
    • (2007) Diabetes , vol.56 , pp. 2174-2177
    • Basu, R.1    Pajvani, U.B.2    Rizza, R.A.3    Scherer, P.E.4
  • 13
    • 0036063777 scopus 로고    scopus 로고
    • Diet-induced insulin resistance in mice lacking adiponectin/ACRP30
    • Maeda, N. et al. Diet-induced insulin resistance in mice lacking adiponectin/ACRP30. Nat Med 8, 731-737 (2002).
    • (2002) Nat Med , vol.8 , pp. 731-737
    • Maeda, N.1
  • 14
    • 0034641647 scopus 로고    scopus 로고
    • Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMPdependent pathway
    • Ouchi, N. et al. Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMPdependent pathway. Circulation 102, 1296-1301 (2000).
    • (2000) Circulation , vol.102 , pp. 1296-1301
    • Ouchi, N.1
  • 15
    • 0042670073 scopus 로고    scopus 로고
    • Changes in aerobic capacity and visceral fat but not myocyte lipid levels predict increased insulin action after exercise in overweight and obese men
    • Gan, S. K. et al. Changes in aerobic capacity and visceral fat but not myocyte lipid levels predict increased insulin action after exercise in overweight and obese men. Diabetes Care 26, 1706-1713 (2003).
    • (2003) Diabetes Care , vol.26 , pp. 1706-1713
    • Gan, S.K.1
  • 16
    • 44249095590 scopus 로고    scopus 로고
    • Heme oxygenase-mediated increases in adiponectin decrease fat content and inflammatory cytokines tumor necrosis factor-alpha and interleukin-6 in Zucker rats and reduce adipogenesis in human mesenchymal stem cells
    • Kim, D. H. et al. Heme oxygenase-mediated increases in adiponectin decrease fat content and inflammatory cytokines tumor necrosis factor-alpha and interleukin-6 in Zucker rats and reduce adipogenesis in human mesenchymal stem cells. J Pharmacol Exp Ther 325, 833-840 (2008).
    • (2008) J Pharmacol Exp Ther , vol.325 , pp. 833-840
    • Kim, D.H.1
  • 17
    • 77954941113 scopus 로고    scopus 로고
    • Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5
    • Choi, J. H. et al. Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5. Nature 466, 451-456 (2010).
    • (2010) Nature , vol.466 , pp. 451-456
    • Choi, J.H.1
  • 18
    • 0037677767 scopus 로고    scopus 로고
    • Induction of adiponectin, a fat-derived antidiabetic and antiatherogenic factor, by nuclear receptors
    • Iwaki, M. et al. Induction of adiponectin, a fat-derived antidiabetic and antiatherogenic factor, by nuclear receptors. Diabetes 52, 1655-1663 (2003).
    • (2003) Diabetes , vol.52 , pp. 1655-1663
    • Iwaki, M.1
  • 19
    • 0043268709 scopus 로고    scopus 로고
    • Heme oxygenase-1: Unleashing the protective properties of heme
    • Otterbein, L. E., Soares, M. P., Yamashita, K. & Bach, F. H. Heme oxygenase-1: Unleashing the protective properties of heme. Trends Immunol 24, 449-455 (2003).
    • (2003) Trends Immunol , vol.24 , pp. 449-455
    • Otterbein, L.E.1    Soares, M.P.2    Yamashita, K.3    Bach, F.H.4
  • 20
    • 66449100734 scopus 로고    scopus 로고
    • The heme oxygenase system abates hyperglycemia in Zucker diabetic fatty rats by potentiating insulin-sensitizing pathways
    • Ndisang, J. F., Lane, N. & Jadhav, A. The heme oxygenase system abates hyperglycemia in Zucker diabetic fatty rats by potentiating insulin-sensitizing pathways. Endocrinology 150, 2098-2108 (2009).
    • (2009) Endocrinology , vol.150 , pp. 2098-2108
    • Ndisang, J.F.1    Lane, N.2    Jadhav, A.3
  • 21
    • 0036664867 scopus 로고    scopus 로고
    • Microsatellite polymorphism in promoter of heme oxygenase-1 gene is associated with susceptibility to coronary artery disease in type 2 diabetic patients
    • Chen, Y. H. et al. Microsatellite polymorphism in promoter of heme oxygenase-1 gene is associated with susceptibility to coronary artery disease in type 2 diabetic patients. Hum Genet 111, 1-8 (2002).
    • (2002) Hum Genet , vol.111 , pp. 1-8
    • Chen, Y.H.1
  • 22
    • 0042822096 scopus 로고    scopus 로고
    • Intramuscular heat shock protein 72 and heme oxygenase-1 mRNA are reduced in patients with type 2 diabetes: Evidence that insulin resistance is associated with a disturbed antioxidant defense mechanism
    • Bruce, C. R., Carey, A. L., Hawley, J. A. & Febbraio, M. A. Intramuscular heat shock protein 72 and heme oxygenase-1 mRNA are reduced in patients with type 2 diabetes: Evidence that insulin resistance is associated with a disturbed antioxidant defense mechanism. Diabetes 52, 2338-2345 (2003).
    • (2003) Diabetes , vol.52 , pp. 2338-2345
    • Bruce, C.R.1    Carey, A.L.2    Hawley, J.A.3    Febbraio, M.A.4
  • 23
    • 36248997802 scopus 로고    scopus 로고
    • Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with iron status in persons with type 2 diabetes mellitus
    • Arredondo, M., Jorquera, D., Carrasco, E., Albala, C. & Hertrampf, E. Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with iron status in persons with type 2 diabetes mellitus. Am J Clin Nutr 86, 1347-1353 (2007).
    • (2007) Am J Clin Nutr , vol.86 , pp. 1347-1353
    • Arredondo, M.1    Jorquera, D.2    Carrasco, E.3    Albala, C.4    Hertrampf, E.5
  • 24
    • 70450270702 scopus 로고    scopus 로고
    • Diminished upregulation of visceral adipose heme oxygenase-1 correlates with waist-to-hip ratio and insulin resistance
    • Lond
    • Shakeri-Manesch, S. et al. Diminished upregulation of visceral adipose heme oxygenase-1 correlates with waist-to-hip ratio and insulin resistance. Int J Obes (Lond) 33, 1257-1264 (2009).
    • (2009) Int J Obes , vol.33 , pp. 1257-1264
    • Shakeri-Manesch, S.1
  • 25
    • 34250343823 scopus 로고    scopus 로고
    • Interdiction of the diabetic state in NOD mice by sustained induction of heme oxygenase: Possible role of carbon monoxide and bilirubin
    • Li, M. et al. Interdiction of the diabetic state in NOD mice by sustained induction of heme oxygenase: Possible role of carbon monoxide and bilirubin. Antioxid Redox Signal 9, 855-863 (2007).
    • (2007) Antioxid Redox Signal , vol.9 , pp. 855-863
    • Li, M.1
  • 26
    • 61749098712 scopus 로고    scopus 로고
    • Heme oxygenase-1 induction remodels adipose tissue and improves insulin sensitivity in obesity-induced diabetic rats
    • Nicolai, A. et al. Heme oxygenase-1 induction remodels adipose tissue and improves insulin sensitivity in obesity-induced diabetic rats. Hypertension 53, 508-515 (2009).
    • (2009) Hypertension , vol.53 , pp. 508-515
    • Nicolai, A.1
  • 27
    • 67549134935 scopus 로고    scopus 로고
    • Targeting heme oxygenase: Therapeutic implications for diseases of the cardiovascular system
    • Peterson, S. J., Frishman, W. H. & Abraham, N. G. Targeting heme oxygenase: Therapeutic implications for diseases of the cardiovascular system. Cardiol Rev 17, 99-111 (2009).
    • (2009) Cardiol Rev , vol.17 , pp. 99-111
    • Peterson, S.J.1    Frishman, W.H.2    Abraham, N.G.3
  • 28
    • 84896870948 scopus 로고    scopus 로고
    • Bilirubin increases insulin sensitivity in leptin-receptor deficient and diet-induced obese mice through suppression of ER stress and chronic inflammation
    • Dong, H. et al. Bilirubin increases insulin sensitivity in leptin-receptor deficient and diet-induced obese mice through suppression of ER stress and chronic inflammation. Endocrinology 155, 818-828 (2014).
    • (2014) Endocrinology , vol.155 , pp. 818-828
    • Dong, H.1
  • 29
    • 4544386856 scopus 로고    scopus 로고
    • Antioxidant activities of bile pigments
    • Stocker, R. Antioxidant activities of bile pigments. Antioxid Redox Signal 6, 841-849 (2004).
    • (2004) Antioxid Redox Signal , vol.6 , pp. 841-849
    • Stocker, R.1
  • 30
    • 0028084319 scopus 로고
    • Association of low serum concentration of bilirubin with increased risk of coronary artery disease
    • Schwertner, H. A., Jackson, W. G. & Tolan, G. Association of low serum concentration of bilirubin with increased risk of coronary artery disease. Clin Chem 40, 18-23 (1994).
    • (1994) Clin Chem , vol.40 , pp. 18-23
    • Schwertner, H.A.1    Jackson, W.G.2    Tolan, G.3
  • 31
    • 84878535419 scopus 로고    scopus 로고
    • Protection from age-related increase in lipid biomarkers and inflammation contributes to cardiovascular protection in Gilbert's syndrome
    • Lond
    • Wallner, M. et al. Protection from age-related increase in lipid biomarkers and inflammation contributes to cardiovascular protection in Gilbert's syndrome. Clin Sci (Lond) 125, 257-264 (2013).
    • (2013) Clin Sci , vol.125 , pp. 257-264
    • Wallner, M.1
  • 32
    • 77957735569 scopus 로고    scopus 로고
    • Serum bilirubin and genes controlling bilirubin concentrations as biomarkers for cardiovascular disease
    • Lin, J. P., Vitek, L. & Schwertner, H. A. Serum bilirubin and genes controlling bilirubin concentrations as biomarkers for cardiovascular disease. Clin Chem 56, 1535-1543 (2010).
    • (2010) Clin Chem , vol.56 , pp. 1535-1543
    • Lin, J.P.1    Vitek, L.2    Schwertner, H.A.3
  • 33
    • 0028819709 scopus 로고
    • Serum bilirubin and risk of ischemic heart disease in middle-aged British men
    • Breimer, L. H., Wannamethee, G., Ebrahim, S. & Shaper, A. G. Serum bilirubin and risk of ischemic heart disease in middle-aged British men. Clin Chem 41, 1504-1508 (1995).
    • (1995) Clin Chem , vol.41 , pp. 1504-1508
    • Breimer, L.H.1    Wannamethee, G.2    Ebrahim, S.3    Shaper, A.G.4
  • 34
    • 84875750146 scopus 로고    scopus 로고
    • Bilirubin and beyond: A review of lipid status in Gilbert's syndrome and its relevance to cardiovascular disease protection
    • Bulmer, A. C., Verkade, H. J. & Wagner, K. H. Bilirubin and beyond: A review of lipid status in Gilbert's syndrome and its relevance to cardiovascular disease protection. Prog Lipid Res 52, 193-205 (2013).
    • (2013) Prog Lipid Res , vol.52 , pp. 193-205
    • Bulmer, A.C.1    Verkade, H.J.2    Wagner, K.H.3
  • 35
    • 84896870948 scopus 로고    scopus 로고
    • Bilirubin increases insulin sensitivity in leptin-receptor deficient and diet-induced obese mice through suppression of er stress and Chronic Inflammation
    • Dong, H. et al. Bilirubin Increases Insulin Sensitivity in Leptin-Receptor Deficient and Diet-Induced Obese Mice Through Suppression of ER Stress and Chronic Inflammation. Endocrinology, en20131667 (2014).
    • (2014) Endocrinology , pp. e20131667
    • Dong, H.1
  • 36
    • 30944438500 scopus 로고    scopus 로고
    • Bilirubin can induce tolerance to islet allografts
    • Wang, H. et al. Bilirubin can induce tolerance to islet allografts. Endocrinology 147, 762-768 (2006).
    • (2006) Endocrinology , vol.147 , pp. 762-768
    • Wang, H.1
  • 37
    • 47649112255 scopus 로고    scopus 로고
    • Improved resistance to serum oxidation in Gilbert's syndrome: A mechanism for cardiovascular protection
    • Bulmer, A. C., Blanchfield, J. T., Toth, I., Fassett, R. G. & Coombes, J. S. Improved resistance to serum oxidation in Gilbert's syndrome: A mechanism for cardiovascular protection. Atherosclerosis 199, 390-396 (2008).
    • (2008) Atherosclerosis , vol.199 , pp. 390-396
    • Bulmer, A.C.1    Blanchfield, J.T.2    Toth, I.3    Fassett, R.G.4    Coombes, J.S.5
  • 38
    • 79651471926 scopus 로고    scopus 로고
    • Decreased small dense LDL levels in Gilbert's syndrome
    • Tapan, S. et al. Decreased small dense LDL levels in Gilbert's syndrome. Clin Biochem 44, 300-303 (2011).
    • (2011) Clin Biochem , vol.44 , pp. 300-303
    • Tapan, S.1
  • 39
    • 84861047353 scopus 로고    scopus 로고
    • Reduced circulating oxidized LDL is associated with hypocholesterolemia and enhanced thiol status in Gilbert syndrome
    • Boon, A. C. et al. Reduced circulating oxidized LDL is associated with hypocholesterolemia and enhanced thiol status in Gilbert syndrome. Free Radic Biol Med 52, 2120-2127 (2012).
    • (2012) Free Radic Biol Med , vol.52 , pp. 2120-2127
    • Boon, A.C.1
  • 40
    • 5044232017 scopus 로고    scopus 로고
    • Liver regeneration: From myth to mechanism
    • Taub, R. Liver regeneration: From myth to mechanism. Nat Rev Mol Cell Biol 5, 836-847 (2004).
    • (2004) Nat Rev Mol Cell Biol , vol.5 , pp. 836-847
    • Taub, R.1
  • 41
    • 84881664404 scopus 로고    scopus 로고
    • Haem catabolism: A novel modulator of inflammation in Gilbert's syndrome
    • Wallner, M. et al. Haem catabolism: A novel modulator of inflammation in Gilbert's syndrome. Eur J Clin Invest 43, 912-919 (2013).
    • (2013) Eur J Clin Invest , vol.43 , pp. 912-919
    • Wallner, M.1
  • 42
    • 24344468717 scopus 로고    scopus 로고
    • Increased expression of PPARgamma in high fat diet-induced liver steatosis in mice
    • Inoue, M. et al. Increased expression of PPARgamma in high fat diet-induced liver steatosis in mice. Biochem Biophys Res Commun 336, 215-222 (2005).
    • (2005) Biochem Biophys Res Commun , vol.336 , pp. 215-222
    • Inoue, M.1
  • 43
    • 84860402707 scopus 로고    scopus 로고
    • Black tea prevents high fat diet-induced non-alcoholic steatohepatitis
    • Karmakar, S. et al. Black tea prevents high fat diet-induced non-alcoholic steatohepatitis. Phytother Res 25, 1073-1081 (2011).
    • (2011) Phytother Res , vol.25 , pp. 1073-1081
    • Karmakar, S.1
  • 44
    • 77954904046 scopus 로고    scopus 로고
    • Carotenoid lutein protects rats from paracetamol-, carbon tetrachlorideand ethanol-induced hepatic damage
    • Sindhu, E. R., Firdous, A. P., Preethi, K. C. & Kuttan, R. Carotenoid lutein protects rats from paracetamol-, carbon tetrachlorideand ethanol-induced hepatic damage. J Pharm Pharmacol 62, 1054-1060 (2010).
    • (2010) J Pharm Pharmacol , vol.62 , pp. 1054-1060
    • Sindhu, E.R.1    Firdous, A.P.2    Preethi, K.C.3    Kuttan, R.4
  • 45
    • 0011221256 scopus 로고
    • Stimulation of bilirubin catabolism in jaundiced Gunn rats by an induced of microsomal mixedfunction monooxygenases
    • Kapitulnik, J. & Ostrow, J. D. Stimulation of bilirubin catabolism in jaundiced Gunn rats by an induced of microsomal mixedfunction monooxygenases. Proc Natl Acad Sci U S A 75, 682-685 (1978).
    • (1978) Proc Natl Acad Sci U.S.A. , vol.75 , pp. 682-685
    • Kapitulnik, J.1    Ostrow, J.D.2
  • 46
    • 0024324099 scopus 로고
    • Inducible bilirubin-degrading system in the microsomal fraction of rat liver
    • De Matteis, F., Trenti, T., Gibbs, A. H. & Greig, J. B. Inducible bilirubin-degrading system in the microsomal fraction of rat liver. Mol Pharmacol 35, 831-838 (1989).
    • (1989) Mol Pharmacol , vol.35 , pp. 831-838
    • De Matteis, F.1    Trenti, T.2    Gibbs, A.H.3    Greig, J.B.4
  • 47
    • 0025718905 scopus 로고
    • Inducible bilirubin-degrading system of rat liver microsomes: Role of cytochrome P450IA1
    • De Matteis, F., Dawson, S. J., Boobis, A. R. & Comoglio, A. Inducible bilirubin-degrading system of rat liver microsomes: Role of cytochrome P450IA1. Mol Pharmacol 40, 686-691 (1991).
    • (1991) Mol Pharmacol , vol.40 , pp. 686-691
    • De Matteis, F.1    Dawson, S.J.2    Boobis, A.R.3    Comoglio, A.4
  • 48
    • 0030861704 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptor-dependent induction of cyp1a1 by bilirubin in mouse hepatoma hepa 1c1c7 cells
    • Sinal, C. J. & Bend, J. R. Aryl hydrocarbon receptor-dependent induction of cyp1a1 by bilirubin in mouse hepatoma hepa 1c1c7 cells. Mol Pharmacol 52, 590-599 (1997).
    • (1997) Mol Pharmacol , vol.52 , pp. 590-599
    • Sinal, C.J.1    Bend, J.R.2
  • 49
    • 84883760615 scopus 로고    scopus 로고
    • Serum bilirubin may serve as a marker for increased heme oxygenase activity and inducibility in tissues-A rationale for the versatile health protection associated with elevated plasma bilirubin
    • McCarty, M. F. Serum bilirubin may serve as a marker for increased heme oxygenase activity and inducibility in tissues-A rationale for the versatile health protection associated with elevated plasma bilirubin. Med Hypotheses 81, 607-610 (2013).
    • (2013) Med Hypotheses , vol.81 , pp. 607-610
    • McCarty, M.F.1
  • 50
    • 17844402768 scopus 로고    scopus 로고
    • Donor treatment with carbon monoxide can yield islet allograft survival and tolerance
    • Wang, H. et al. Donor treatment with carbon monoxide can yield islet allograft survival and tolerance. Diabetes 54, 1400-1406 (2005).
    • (2005) Diabetes , vol.54 , pp. 1400-1406
    • Wang, H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.