-
1
-
-
80054098573
-
Antibody conjugate therapeutics: challenges and potential
-
Teicher, B.A. and Chari, R.V. (2011) Antibody conjugate therapeutics: challenges and potential. Clin. Cancer Res., 17 (20), 6389-6397.
-
(2011)
Clin. Cancer Res.
, vol.17
, Issue.20
, pp. 6389-6397
-
-
Teicher, B.A.1
Chari, R.V.2
-
2
-
-
0026354658
-
An immunotoxin prepared with blocked ricin: a natural plant toxin adapted for therapeutic use
-
Lambert, J.M. et al. (1991) An immunotoxin prepared with blocked ricin: a natural plant toxin adapted for therapeutic use. Cancer Res., 51 (23, Pt. 1), 6236-6242.
-
(1991)
Cancer Res.
, vol.51
, Issue.23
, pp. 6236-6242
-
-
Lambert, J.M.1
-
3
-
-
85117336617
-
Antibody-based immunotoxins for the treatment of cancer
-
Becker, N. and Benhar, I. (2012) Antibody-based immunotoxins for the treatment of cancer. Antibodies, 1 (1), 39-69.
-
(2012)
Antibodies
, vol.1
, Issue.1
, pp. 39-69
-
-
Becker, N.1
Benhar, I.2
-
4
-
-
80054118081
-
Antibody fusion proteins: anti-CD22 recombinant immunotoxin moxetumomab pasudotox
-
Kreitman, R.J. and Pastan, I. (2011) Antibody fusion proteins: anti-CD22 recombinant immunotoxin moxetumomab pasudotox. Clin. Cancer Res., 17 (20), 6398-6405.
-
(2011)
Clin. Cancer Res.
, vol.17
, Issue.20
, pp. 6398-6405
-
-
Kreitman, R.J.1
Pastan, I.2
-
5
-
-
84861542159
-
Phase I trial of anti-CD22 recombinant immunotoxin moxetumomab pasudotox (CAT-8015 or HA22) in patients with hairy cell leukemia
-
Kreitman, R.J. et al. (2012) Phase I trial of anti-CD22 recombinant immunotoxin moxetumomab pasudotox (CAT-8015 or HA22) in patients with hairy cell leukemia. J. Clin. Oncol., 30 (15), 1822-1828.
-
(2012)
J. Clin. Oncol.
, vol.30
, Issue.15
, pp. 1822-1828
-
-
Kreitman, R.J.1
-
6
-
-
33748309412
-
Immunotoxins for targeted cancer therapy
-
Kreitman, R.J. (2006) Immunotoxins for targeted cancer therapy. AAPS J., 8 (3), E532-E551.
-
(2006)
AAPS J.
, vol.8
, Issue.3
, pp. E532-E551
-
-
Kreitman, R.J.1
-
7
-
-
64949125849
-
Antibody-cytotoxic agent conjugates:preparation and characterization
-
xiv
-
Singh, R. and Erickson, H.K. (2009) Antibody-cytotoxic agent conjugates:preparation and characterization. Methods Mol. Biol., 525, 445-467, xiv.
-
(2009)
Methods Mol. Biol.
, vol.525
, pp. 445-467
-
-
Singh, R.1
Erickson, H.K.2
-
8
-
-
79955013479
-
-
8th edn, People's Medical Publishing House, Shelton, CT, xxv
-
Hong, W.K. and American Association for Cancer Research (2010) Holland Frei Cancer Medicine 8, 8th edn, People's Medical Publishing House, Shelton, CT, p. xxv, 2,021 p.
-
(2010)
Holland Frei Cancer Medicine 8
-
-
Hong, W.K.1
-
9
-
-
84875490185
-
Cancer genome landscapes
-
Vogelstein, B. et al. (2013) Cancer genome landscapes. Science, 339 (6127), 1546-1558.
-
(2013)
Science
, vol.339
, Issue.6127
, pp. 1546-1558
-
-
Vogelstein, B.1
-
10
-
-
0004235781
-
-
7th edn, Elsevier/Saunders, Philadelphia, PA, x
-
Abbas, A.K., Lichtman, A.H., and Pillai, S. (2012) Cellular and Molecular Immunology, 7th edn, Elsevier/Saunders, Philadelphia, PA, p. x, 545 p.
-
(2012)
Cellular and Molecular Immunology
, pp. 545
-
-
Abbas, A.K.1
Lichtman, A.H.2
Pillai, S.3
-
11
-
-
84858785688
-
Antibody therapy of cancer
-
Scott, A.M., Wolchok, J.D., and Old, L.J. (2012) Antibody therapy of cancer. Nat. Rev. Cancer, 12 (4), 278-287.
-
(2012)
Nat. Rev. Cancer
, vol.12
, Issue.4
, pp. 278-287
-
-
Scott, A.M.1
Wolchok, J.D.2
Old, L.J.3
-
12
-
-
79952092706
-
Phase II study of the antibody drug conjugate trastuzumab-DM1 for the treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer after prior HER2-directed therapy
-
Burris, H.A. 3rd, et al. (2011) Phase II study of the antibody drug conjugate trastuzumab-DM1 for the treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer after prior HER2-directed therapy. J. Clin. Oncol., 29 (4), 398-405.
-
(2011)
J. Clin. Oncol.
, vol.29
, Issue.4
, pp. 398-405
-
-
Burris, H.A.1
-
13
-
-
84868520609
-
Trastuzumab emtansine for HER2-positive advanced breast cancer
-
Verma, S. et al. (2012) Trastuzumab emtansine for HER2-positive advanced breast cancer. N. Engl. J. Med., 367 (19), 1783-1791.
-
(2012)
N. Engl. J. Med.
, vol.367
, Issue.19
, pp. 1783-1791
-
-
Verma, S.1
-
14
-
-
33744537358
-
Lysosomal trafficking and cysteine protease metabolism confer target-specific cytotoxicity by peptide-linked anti-CD30-auristatin conjugates
-
Sutherland, M.S. et al. (2006) Lysosomal trafficking and cysteine protease metabolism confer target-specific cytotoxicity by peptide-linked anti-CD30-auristatin conjugates. J. Biol. Chem., 281 (15), 10540-10547.
-
(2006)
J. Biol. Chem.
, vol.281
, Issue.15
, pp. 10540-10547
-
-
Sutherland, M.S.1
-
15
-
-
76049122850
-
Intracellular activation of SGN-35, a potent anti-CD30 antibody-drug conjugate
-
Okeley, N.M. et al. (2010) Intracellular activation of SGN-35, a potent anti-CD30 antibody-drug conjugate. Clin. Cancer Res., 16 (3), 888-897.
-
(2010)
Clin. Cancer Res.
, vol.16
, Issue.3
, pp. 888-897
-
-
Okeley, N.M.1
-
16
-
-
34447573999
-
Phase I/II study of an anti-CD30 monoclonal antibody (MDX-060) in Hodgkin's lymphoma and anaplastic large-cell lymphoma
-
Ansell, S.M. et al. (2007) Phase I/II study of an anti-CD30 monoclonal antibody (MDX-060) in Hodgkin's lymphoma and anaplastic large-cell lymphoma. J. Clin. Oncol., 25 (19), 2764-2769.
-
(2007)
J. Clin. Oncol.
, vol.25
, Issue.19
, pp. 2764-2769
-
-
Ansell, S.M.1
-
17
-
-
80054117546
-
Brentuximab vedotin (SGN-35)
-
Katz, J., Janik, J.E., and Younes, A. (2011) Brentuximab vedotin (SGN-35). Clin. Cancer Res., 17 (20), 6428-6436.
-
(2011)
Clin. Cancer Res.
, vol.17
, Issue.20
, pp. 6428-6436
-
-
Katz, J.1
Janik, J.E.2
Younes, A.3
-
18
-
-
84863676500
-
Results of a pivotal phase II study of brentuximab vedotin for patients with relapsed or refractory Hodgkin's lymphoma
-
Younes, A. et al. (2012) Results of a pivotal phase II study of brentuximab vedotin for patients with relapsed or refractory Hodgkin's lymphoma. J. Clin. Oncol., 30 (18), 2183-2189.
-
(2012)
J. Clin. Oncol.
, vol.30
, Issue.18
, pp. 2183-2189
-
-
Younes, A.1
-
19
-
-
84862752215
-
The effect of different linkers on target cell catabolism and pharmacokinetics/pharmacodynamics of trastuzumab maytansinoid conjugates
-
Erickson, H.K. et al. (2012) The effect of different linkers on target cell catabolism and pharmacokinetics/pharmacodynamics of trastuzumab maytansinoid conjugates. Mol. Cancer Ther., 11 (5), 1133-1142.
-
(2012)
Mol. Cancer Ther.
, vol.11
, Issue.5
, pp. 1133-1142
-
-
Erickson, H.K.1
-
20
-
-
84881305790
-
A phase 3 study of gemtuzumab ozogamicin during induction and postconsolidation therapy in younger patients with acute myeloid leukemia
-
Petersdorf, S.H. et al. (2013) A phase 3 study of gemtuzumab ozogamicin during induction and postconsolidation therapy in younger patients with acute myeloid leukemia. Blood, 121 (24), 4854-4860.
-
(2013)
Blood
, vol.121
, Issue.24
, pp. 4854-4860
-
-
Petersdorf, S.H.1
-
21
-
-
84880245095
-
Gemtuzumab ozogamicin in acute myeloid leukemia: a remarkable saga about an active drug
-
Rowe, J.M. and Lowenberg, B. (2013) Gemtuzumab ozogamicin in acute myeloid leukemia: a remarkable saga about an active drug. Blood, 121 (24), 4838-4841.
-
(2013)
Blood
, vol.121
, Issue.24
, pp. 4838-4841
-
-
Rowe, J.M.1
Lowenberg, B.2
-
22
-
-
18844461704
-
Phase II trial of dolastatin-10 in patients with advanced breast cancer
-
Perez, E.A. et al. (2005) Phase II trial of dolastatin-10 in patients with advanced breast cancer. Invest. New Drugs, 23 (3), 257-261.
-
(2005)
Invest. New Drugs
, vol.23
, Issue.3
, pp. 257-261
-
-
Perez, E.A.1
-
23
-
-
0018184920
-
Initial clinical trials of maytansine, an antitumor plant alkaloid
-
Chabner, B.A. et al. (1978) Initial clinical trials of maytansine, an antitumor plant alkaloid. Cancer Treat. Rep., 62 (3), 429-433.
-
(1978)
Cancer Treat. Rep.
, vol.62
, Issue.3
, pp. 429-433
-
-
Chabner, B.A.1
-
24
-
-
0019296180
-
Phase II study of maytansine in patients with advanced lymphomas: an Eastern Cooperative Oncology Group pilot study
-
Rosenthal, S. et al. (1980) Phase II study of maytansine in patients with advanced lymphomas: an Eastern Cooperative Oncology Group pilot study. Cancer Treat. Rep., 64 (10-11), 1115-1117.
-
(1980)
Cancer Treat. Rep.
, vol.64
, Issue.10-11
, pp. 1115-1117
-
-
Rosenthal, S.1
-
25
-
-
0026593928
-
Immunoconjugates containing novel maytansinoids:promising anticancer drugs
-
Chari, R.V. et al. (1992) Immunoconjugates containing novel maytansinoids:promising anticancer drugs. Cancer Res., 52 (1), 127-131.
-
(1992)
Cancer Res.
, vol.52
, Issue.1
, pp. 127-131
-
-
Chari, R.V.1
-
26
-
-
33745847797
-
Semisynthetic maytansine analogues for the targeted treatment of cancer
-
Widdison, W.C. et al. (2006) Semisynthetic maytansine analogues for the targeted treatment of cancer. J. Med. Chem., 49 (14), 4392-4408.
-
(2006)
J. Med. Chem.
, vol.49
, Issue.14
, pp. 4392-4408
-
-
Widdison, W.C.1
-
27
-
-
67449158986
-
Superior antitumor activity of SAR3419 to rituximab in xenograft models for non-Hodgkin's lymphoma
-
Al-Katib, A.M. et al. (2009) Superior antitumor activity of SAR3419 to rituximab in xenograft models for non-Hodgkin's lymphoma. Clin. Cancer Res., 15 (12), 4038-4045.
-
(2009)
Clin. Cancer Res.
, vol.15
, Issue.12
, pp. 4038-4045
-
-
Al-Katib, A.M.1
-
28
-
-
80054095609
-
SAR3419: an anti-CD19-Maytansinoid Immunoconjugate for the treatment of B-cell malignancies
-
Blanc, V. et al. (2011) SAR3419: an anti-CD19-Maytansinoid Immunoconjugate for the treatment of B-cell malignancies. Clin. Cancer Res., 17 (20), 6448-6458.
-
(2011)
Clin. Cancer Res.
, vol.17
, Issue.20
, pp. 6448-6458
-
-
Blanc, V.1
-
29
-
-
79955022475
-
Disulfidelinked antibody-maytansinoid conjugates:optimization of in vivo activity by varying the steric hindrance at carbon atoms adjacent to the disulfide linkage
-
Kellogg, B.A. et al. (2011) Disulfidelinked antibody-maytansinoid conjugates:optimization of in vivo activity by varying the steric hindrance at carbon atoms adjacent to the disulfide linkage. Bioconjugate Chem., 22 (4), 717-727.
-
(2011)
Bioconjugate Chem.
, vol.22
, Issue.4
, pp. 717-727
-
-
Kellogg, B.A.1
-
30
-
-
33645500289
-
Antibodymaytansinoid conjugates are activated in targeted cancer cells by lysosomal degradation and linker-dependent intracellular processing
-
Erickson, H.K. et al. (2006) Antibodymaytansinoid conjugates are activated in targeted cancer cells by lysosomal degradation and linker-dependent intracellular processing. Cancer Res., 66 (8), 4426-4433.
-
(2006)
Cancer Res.
, vol.66
, Issue.8
, pp. 4426-4433
-
-
Erickson, H.K.1
-
31
-
-
10744222473
-
Development of potent monoclonal antibody auristatin conjugates for cancer therapy
-
Doronina, S.O. et al. (2003) Development of potent monoclonal antibody auristatin conjugates for cancer therapy. Nat. Biotechnol., 21 (7), 778-784.
-
(2003)
Nat. Biotechnol.
, vol.21
, Issue.7
, pp. 778-784
-
-
Doronina, S.O.1
-
32
-
-
0042738861
-
cAC10-vcMMAE, an anti-CD30-monomethyl auristatin E conjugate with potent and selective antitumor activity
-
Francisco, J.A. et al. (2003) cAC10-vcMMAE, an anti-CD30-monomethyl auristatin E conjugate with potent and selective antitumor activity. Blood, 102 (4), 1458-1465.
-
(2003)
Blood
, vol.102
, Issue.4
, pp. 1458-1465
-
-
Francisco, J.A.1
-
33
-
-
31544441685
-
Enhanced activity of monomethylauristatin F through monoclonal antibody delivery:effects of linker technology on efficacy and toxicity
-
Doronina, S.O. et al. (2006) Enhanced activity of monomethylauristatin F through monoclonal antibody delivery:effects of linker technology on efficacy and toxicity. Bioconjugate Chem., 17 (1), 114-124.
-
(2006)
Bioconjugate Chem.
, vol.17
, Issue.1
, pp. 114-124
-
-
Doronina, S.O.1
-
34
-
-
0033960022
-
Sustained intracellular retention of dolastatin 10 causes its potent antimitotic activity
-
Verdier-Pinard, P. et al. (2000) Sustained intracellular retention of dolastatin 10 causes its potent antimitotic activity. Mol. Pharmacol., 57 (1), 180-187.
-
(2000)
Mol. Pharmacol.
, vol.57
, Issue.1
, pp. 180-187
-
-
Verdier-Pinard, P.1
-
35
-
-
0036074253
-
Cathepsin B-labile dipeptide linkers for lysosomal release of doxorubicin from internalizing immunoconjugates: model studies of enzymatic drug release and antigenspecific in vitro anticancer activity
-
Dubowchik, G.M. et al. (2002) Cathepsin B-labile dipeptide linkers for lysosomal release of doxorubicin from internalizing immunoconjugates: model studies of enzymatic drug release and antigenspecific in vitro anticancer activity. Bioconjugate Chem., 13 (4), 855-869.
-
(2002)
Bioconjugate Chem.
, vol.13
, Issue.4
, pp. 855-869
-
-
Dubowchik, G.M.1
-
36
-
-
0037068501
-
Monoclonal antibody conjugates of doxorubicin prepared with branched peptide linkers: inhibition of aggregation by methoxytriethyleneglycol chains
-
King, H.D. et al. (2002) Monoclonal antibody conjugates of doxorubicin prepared with branched peptide linkers: inhibition of aggregation by methoxytriethyleneglycol chains. J. Med. Chem., 45 (19), 4336-4343.
-
(2002)
J. Med. Chem.
, vol.45
, Issue.19
, pp. 4336-4343
-
-
King, H.D.1
-
37
-
-
6044223544
-
Effects of drug loading on the antitumor activity of a monoclonal antibody drug conjugate
-
Hamblett, K.J. et al. (2004) Effects of drug loading on the antitumor activity of a monoclonal antibody drug conjugate. Clin. Cancer Res., 10 (20), 7063-7070.
-
(2004)
Clin. Cancer Res.
, vol.10
, Issue.20
, pp. 7063-7070
-
-
Hamblett, K.J.1
-
38
-
-
58149161759
-
Potent anticarcinoma activity of the humanized anti-CD70 antibody h1F6 conjugated to the tubulin inhibitor auristatin via an uncleavable linker
-
Oflazoglu, E. et al. (2008) Potent anticarcinoma activity of the humanized anti-CD70 antibody h1F6 conjugated to the tubulin inhibitor auristatin via an uncleavable linker. Clin. Cancer Res., 14 (19), 6171-6180.
-
(2008)
Clin. Cancer Res.
, vol.14
, Issue.19
, pp. 6171-6180
-
-
Oflazoglu, E.1
-
39
-
-
0023820894
-
Calicheamicin gamma 1I: an antitumor antibiotic that cleaves double-stranded DNA site specifically
-
Zein, N. et al. (1988) Calicheamicin gamma 1I: an antitumor antibiotic that cleaves double-stranded DNA site specifically. Science, 240 (4856), 1198-1201.
-
(1988)
Science
, vol.240
, Issue.4856
, pp. 1198-1201
-
-
Zein, N.1
-
40
-
-
10744229449
-
Antibodytargeted chemotherapy with CMC-544:a CD22-targeted immunoconjugate of calicheamicin for the treatment of Blymphoid malignancies
-
DiJoseph, J.F. et al. (2004) Antibodytargeted chemotherapy with CMC-544:a CD22-targeted immunoconjugate of calicheamicin for the treatment of Blymphoid malignancies. Blood, 103 (5), 1807-1814.
-
(2004)
Blood
, vol.103
, Issue.5
, pp. 1807-1814
-
-
DiJoseph, J.F.1
-
41
-
-
77951648118
-
Safety, pharmacokinetics, and preliminary clinical activity of inotuzumab ozogamicin, a novel immunoconjugate for the treatment of B-cell non-Hodgkin's lymphoma: results of a phase I study
-
Advani, A. et al. (2010) Safety, pharmacokinetics, and preliminary clinical activity of inotuzumab ozogamicin, a novel immunoconjugate for the treatment of B-cell non-Hodgkin's lymphoma: results of a phase I study. J. Clin. Oncol., 28 (12), 2085-2093.
-
(2010)
J. Clin. Oncol.
, vol.28
, Issue.12
, pp. 2085-2093
-
-
Advani, A.1
-
42
-
-
22344432668
-
Anti-CD74 antibody-doxorubicin conjugate, IMMU-110, in a human multiple myeloma xenograft and in monkeys
-
Sapra, P. et al. (2005) Anti-CD74 antibody-doxorubicin conjugate, IMMU-110, in a human multiple myeloma xenograft and in monkeys. Clin. Cancer Res., 11 (14), 5257-5264.
-
(2005)
Clin. Cancer Res.
, vol.11
, Issue.14
, pp. 5257-5264
-
-
Sapra, P.1
-
43
-
-
70349685092
-
CEACAM5-targeted therapy of human colonic and pancreatic cancer xenografts with potent labetuzumab-SN-38 immunoconjugates
-
Govindan, S.V. et al. (2009) CEACAM5-targeted therapy of human colonic and pancreatic cancer xenografts with potent labetuzumab-SN-38 immunoconjugates. Clin. Cancer Res., 15 (19), 6052-6061.
-
(2009)
Clin. Cancer Res.
, vol.15
, Issue.19
, pp. 6052-6061
-
-
Govindan, S.V.1
-
44
-
-
17544404888
-
Targeting of renal cell carcinoma with iodine-131-labeled chimeric monoclonal antibody G250
-
Steffens, M.G. et al. (1997) Targeting of renal cell carcinoma with iodine-131-labeled chimeric monoclonal antibody G250. J. Clin. Oncol., 15 (4), 1529-1537.
-
(1997)
J. Clin. Oncol.
, vol.15
, Issue.4
, pp. 1529-1537
-
-
Steffens, M.G.1
-
45
-
-
56449129810
-
Targeting HER2-positive breast cancer with trastuzumab-DM1, an antibody-cytotoxic drug conjugate
-
Lewis Phillips, G.D. et al. (2008) Targeting HER2-positive breast cancer with trastuzumab-DM1, an antibody-cytotoxic drug conjugate. Cancer Res., 68 (22), 9280-9290.
-
(2008)
Cancer Res.
, vol.68
, Issue.22
, pp. 9280-9290
-
-
Lewis Phillips, G.D.1
-
46
-
-
84862228236
-
Clinical pharmacology of trastuzumab emtansine (T-DM1): an antibody-drug conjugate in development for the treatment of HER2-positive cancer
-
Girish, S. et al. (2012) Clinical pharmacology of trastuzumab emtansine (T-DM1): an antibody-drug conjugate in development for the treatment of HER2-positive cancer. Cancer Chemother. Pharmacol., 69 (5), 1229-1240.
-
(2012)
Cancer Chemother. Pharmacol.
, vol.69
, Issue.5
, pp. 1229-1240
-
-
Girish, S.1
-
47
-
-
33644787435
-
Antibody-drug conjugates designed to eradicate tumors with homogeneous and heterogeneous expression of the target antigen
-
Kovtun, Y.V. et al. (2006) Antibody-drug conjugates designed to eradicate tumors with homogeneous and heterogeneous expression of the target antigen. Cancer Res., 66 (6), 3214-3221.
-
(2006)
Cancer Res.
, vol.66
, Issue.6
, pp. 3214-3221
-
-
Kovtun, Y.V.1
-
48
-
-
74949139946
-
Tumor delivery and in vivo processing of disulfide-linked and thioether-linked antibody-maytansinoid conjugates
-
Erickson, H.K. et al. (2010) Tumor delivery and in vivo processing of disulfide-linked and thioether-linked antibody-maytansinoid conjugates. Bioconjugate Chem., 21 (1), 84-92.
-
(2010)
Bioconjugate Chem.
, vol.21
, Issue.1
, pp. 84-92
-
-
Erickson, H.K.1
-
49
-
-
79957730092
-
Synthesis and evaluation of hydrophilic linkers for antibody-maytansinoid conjugates
-
Zhao, R.Y. et al. (2011) Synthesis and evaluation of hydrophilic linkers for antibody-maytansinoid conjugates. J. Med. Chem., 54 (10), 3606-3623.
-
(2011)
J. Med. Chem.
, vol.54
, Issue.10
, pp. 3606-3623
-
-
Zhao, R.Y.1
-
50
-
-
79955042204
-
Design of antibodymaytansinoid conjugates allows for efficient detoxification via liver metabolism
-
Sun, X. et al. (2011) Design of antibodymaytansinoid conjugates allows for efficient detoxification via liver metabolism. Bioconjugate Chem., 22 (4), 728-735.
-
(2011)
Bioconjugate Chem.
, vol.22
, Issue.4
, pp. 728-735
-
-
Sun, X.1
-
51
-
-
78049515807
-
Brentuximab vedotin (SGN-35) for relapsed CD30-positive lymphomas
-
Younes, A. et al. (2010) Brentuximab vedotin (SGN-35) for relapsed CD30-positive lymphomas. N. Engl. J. Med., 363 (19), 1812-1821.
-
(2010)
N. Engl. J. Med.
, vol.363
, Issue.19
, pp. 1812-1821
-
-
Younes, A.1
-
52
-
-
21244469077
-
Analysis of the composition of immunoconjugates using size-exclusion chromatography coupled to mass spectrometry
-
Lazar, A.C. et al. (2005) Analysis of the composition of immunoconjugates using size-exclusion chromatography coupled to mass spectrometry. Rapid Commun. Mass Spectrom., 19 (13), 1806-1814.
-
(2005)
Rapid Commun. Mass Spectrom.
, vol.19
, Issue.13
, pp. 1806-1814
-
-
Lazar, A.C.1
-
53
-
-
79952718320
-
Analytical methods for physicochemical characterization of antibody drug conjugates
-
Wakankar, A. et al. (2011) Analytical methods for physicochemical characterization of antibody drug conjugates. mAbs, 3 (2), 161-172.
-
(2011)
mAbs
, vol.3
, Issue.2
, pp. 161-172
-
-
Wakankar, A.1
-
54
-
-
49449087300
-
Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index
-
Junutula, J.R. et al. (2008) Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index. Nat. Biotechnol., 26 (8), 925-932.
-
(2008)
Nat. Biotechnol.
, vol.26
, Issue.8
, pp. 925-932
-
-
Junutula, J.R.1
-
55
-
-
0034730518
-
Site-specific conjugation on serine right-arrow cysteine variant monoclonal antibodies
-
Stimmel, J.B. et al. (2000) Site-specific conjugation on serine right-arrow cysteine variant monoclonal antibodies. J. Biol. Chem., 275 (39), 30445-30450.
-
(2000)
J. Biol. Chem.
, vol.275
, Issue.39
, pp. 30445-30450
-
-
Stimmel, J.B.1
-
56
-
-
84863012529
-
Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates
-
Shen, B.Q. et al. (2012) Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates. Nat. Biotechnol., 30 (2), 184-189.
-
(2012)
Nat. Biotechnol.
, vol.30
, Issue.2
, pp. 184-189
-
-
Shen, B.Q.1
-
57
-
-
84867040452
-
Synthesis of sitespecific antibody-drug conjugates using unnatural amino acids
-
Axup, J.Y. et al. (2012) Synthesis of sitespecific antibody-drug conjugates using unnatural amino acids. Proc. Natl. Acad. Sci. U.S.A., 109 (40), 16101-16106.
-
(2012)
Proc. Natl. Acad. Sci. U.S.A.
, vol.109
, Issue.40
, pp. 16101-16106
-
-
Axup, J.Y.1
-
58
-
-
84874300889
-
Location matters:site of conjugation modulates stability and pharmacokinetics of antibody drug conjugates
-
Strop, P. et al. (2013) Location matters:site of conjugation modulates stability and pharmacokinetics of antibody drug conjugates. Chem. Biol., 20 (2), 161-167.
-
(2013)
Chem. Biol.
, vol.20
, Issue.2
, pp. 161-167
-
-
Strop, P.1
-
59
-
-
79960555564
-
Site-specific modification of ED-B-targeting antibody using intein-fusion technology
-
Mohlmann, S. et al. (2011) Site-specific modification of ED-B-targeting antibody using intein-fusion technology. BMC Biotechnol., 11, 76.
-
(2011)
BMC Biotechnol.
, vol.11
, pp. 76
-
-
Mohlmann, S.1
-
60
-
-
84859295427
-
Site-specific traceless coupling of potent cytotoxic drugs to recombinant antibodies for pharmacodelivery
-
Casi, G. et al. (2012) Site-specific traceless coupling of potent cytotoxic drugs to recombinant antibodies for pharmacodelivery. J. Am. Chem. Soc., 134 (13), 5887-5892.
-
(2012)
J. Am. Chem. Soc.
, vol.134
, Issue.13
, pp. 5887-5892
-
-
Casi, G.1
-
61
-
-
77950080700
-
Improving effector functions of antibodies for cancer treatment: enhancing ADCC and CDC
-
Natsume, A., Niwa, R., and Satoh, M. (2009) Improving effector functions of antibodies for cancer treatment: enhancing ADCC and CDC. Drug Des. Dev. Ther., 3, 7-16.
-
(2009)
Drug Des. Dev. Ther.
, vol.3
, pp. 7-16
-
-
Natsume, A.1
Niwa, R.2
Satoh, M.3
-
62
-
-
53349175018
-
Anti-CD30 diabody-drug conjugates with potent antitumor activity
-
Kim, K.M. et al. (2008) Anti-CD30 diabody-drug conjugates with potent antitumor activity. Mol. Cancer Ther., 7 (8), 2486-2497.
-
(2008)
Mol. Cancer Ther.
, vol.7
, Issue.8
, pp. 2486-2497
-
-
Kim, K.M.1
|