Neurotrophic factors in depression in response to treatment

Journal of Affective Disorders

Volumn 183, Issue , 2015, Pages 287-294

  Buttenschøn, Henriette N ^a,b   Foldager, Leslie ^a,b   Elfving, Betina ^a   Poulsen, Pia H P ^a   Uher, Rudolf ^c,d   Mors, Ole ^b,e  

^a AARHUS UNIVERSITY   (Denmark)

^b Lundbeck Foundation Initiative for Integrative Psychiatric Research   (Denmark)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d Centre for Integrative Sequencing ISEQ Aarhus University ^*  (Canada)

^e AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Antidepressant treatment; Brain derived neurotrophic factor (BDNF); Depression; Longitudinal; Serum; Vascular endothelial growth factor (VEGF)

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; ESCITALOPRAM; METHIONINE; NORTRIPTYLINE; VALINE; VASCULOTROPIN; ANTIDEPRESSANT AGENT; BRAIN-DERIVED NEUROTROPHIC FACTOR, HUMAN; CITALOPRAM; VASCULOTROPIN A; VEGFA PROTEIN, HUMAN;

ADULT; ARTICLE; BECK DEPRESSION INVENTORY; CONTROLLED STUDY; DEPRESSION; DISEASE SEVERITY; FEMALE; FOLLOW UP; GENOTYPE; HUMAN; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; MONTGOMERY ASBERG DEPRESSION RATING SCALE; PRIORITY JOURNAL; REMISSION; TREATMENT DURATION; TREATMENT RESPONSE; BLOOD; DEPRESSIVE DISORDER, MAJOR; DRUG EFFECTS; TREATMENT OUTCOME;

ANTIDEPRESSIVE AGENTS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CITALOPRAM; DEPRESSIVE DISORDER, MAJOR; FEMALE; HUMANS; MALE; NORTRIPTYLINE; TREATMENT OUTCOME; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84930625562     PISSN: 01650327     EISSN: 15732517     Source Type: Journal    
DOI: 10.1016/j.jad.2015.05.027     Document Type: Article

References (54)

1. O. Aydemir, A. Deveci, and F. Taneli The effect of chronic antidepressant treatment on serum brain derived neurotrophic factor levels in depressed patients: a preliminary study Prog. Neuropsychopharmacol. Biol. Psychiatry 29 2 2005 261 265
2. A.T. Beck, C.H. Ward, M. Mendelson, J. Mock, and J. Erbaugh An inventory for measuring depression Arch. Gen. Psychiatry 4 1961 561 571
3. S. Begliuomini, E. Casarosa, N. Pluchino, E. Lenzi, M. Centofanti, L. Freschi, M. Pieri, A.D. Genazzani, S. Luisi, and A.R. Genazzani Influence of endogenous and exogenous sex hormones on plasma brain-derived neurotrophic factor Hum. Reprod. 22 2007 995 1002
4. B.A. Bus, M.L. Molendijk, B.J. Penninx, J.K. Buitelaar, G. Kenis, J. Prickaerts, B.M. Elzinga, and R.C. Voshaar Determinants of serum brain-derived neurotrophic factor Psychoneuroendocrinology 36 2011 228 239
5. H.N. Buttenschon, A.S. Kristensen, H.N. Buch, J.H. Andersen, J.P. Bonde, M. Grynderup, A.M. Hansen, H. Kolstad, A. Kaergaard, L. Kaerlev, S. Mikkelsen, J.F. Thomsen, P. Koefoed, A. Erhardt, D.P. Woldbye, A.D. Borglum, and O. Mors The norepinephrine transporter gene is a candidate gene for panic disorder J. Neural Transm. 118 2011 969 976
6. A. Cattaneo, M. Gennarelli, R. Uher, G. Breen, A. Farmer, K.J. Aitchison, I.W. Craig, C. Anacker, P.A. Zunsztain, P. McGuffin, and C.M. Pariante Candidate genes expression profile associated with antidepressants response in the GENDEP study: differentiating between baseline 'predictors' and longitudinal 'targets' Neuropsychopharmacology 38 2013 377 385
7. A. Clark-Raymond, and A. Halaris VEGF and depression: a comprehensive assessment of clinical data J. Psychiatr. Res. 47 8 2013 1080 1087
8. R.B. Dalby, B. Elfving, P.H. Poulsen, L. Foldager, J. Frandsen, P. Videbech, and R. Rosenberg Plasma brain-derived neurotrophic factor and prefrontal white matter integrity in late-onset depression and normal aging Acta Psychiatr. Scand. 128 2013 387 396
9. M. Deuschle, M. Gilles, B. Scharnholz, F. Lederbogen, U.E. Lang, and R. Hellweg Changes of serum concentrations of brain-derived neurotrophic factor (BDNF) during treatment with venlafaxine and mirtazapine: role of medication and response to treatment Pharmacopsychiatry 46 2 2013 54 58
10. P. Dome, Z. Teleki, Z. Rihmer, L. Peter, J. Dobos, I. Kenessey, J. Tovari, J. Timar, S. Paku, G. Kovacs, and B. Dome Circulating endothelial progenitor cells and depression: a possible novel link between heart and soul Mol. Psychiatry 14 2009 523 531
11. R.S. Duman Synaptic plasticity and mood disorders Mol. Psychiatry 7 1 2002 S29 S34
12. R.S. Duman, and L.M. Monteggia A neurotrophic model for stress-related mood disorders Biol. Psychiatry 59 12 2006 1116 1127
13. L.E. Duncan, K.E. Hutchison, G. Carey, and W.E. Craighead Variation in brain-derived neurotrophic factor (BDNF) gene is associated with symptoms of depression J. Affect. Disord. 115 1-2 2009 215 219
14. B. Elfving, H.N. Buttenschon, L. Foldager, P.H. Poulsen, M.B. Grynderup, A.M. Hansen, H.A. Kolstad, L. Kaerlev, S. Mikkelsen, A.D. Borglum, G. Wegener, and O. Mors Depression and BMI influences the serum vascular endothelial growth factor level Int. J. Neuropsychopharmacol. 17 2014 1409 1417
15. B. Elfving, H.N. Buttenschon, L. Foldager, P.H. Poulsen, J.H. Andersen, M.B. Grynderup, A.M. Hansen, H.A. Kolstad, L. Kaerlev, S. Mikkelsen, J.F. Thomsen, A.D. Borglum, G. Wegener, and O. Mors Depression, the Val66Met polymorphism, age, and gender influence the serum BDNF level J. Psychiatr. Res. 46 2012 1118 1125
16. M. Fornaro, G. Rocchi, A. Escelsior, P. Contini, M. Ghio, S. Colicchio, B.D. De, M. Amore, P. Fornaro, and M. Martino VEGF plasma level variations in duloxetine-treated patients with major depression J. Affect. Disord. 151 2013 590 595
17. N.M. Fournier, and R.S. Duman Role of vascular endothelial growth factor in adult hippocampal neurogenesis: implications for the pathophysiology and treatment of depression Behav. Brain Res. 227 2 2012 440 449
18. N. Gervasoni, J.M. Aubry, G. Bondolfi, C. Osiek, M. Schwald, G. Bertschy, and F. Karege Partial normalization of serum brain-derived neurotrophic factor in remitted patients after a major depressive episode Neuropsychobiology 51 2005 234 238
19. Z. Halmai, P. Dome, J. Dobos, X. Gonda, A. Szekely, M. Sasvari-Szekely, G. Faludi, and J. Lazary Peripheral vascular endothelial growth factor level is associated with antidepressant treatment response: results of a preliminary study J. Affect. Disord. 144 2013 269 273
20. M. Hamilton A rating scale for depression J. Neurol. Neurosurg. Psychiatry 23 1960 56 62
21. R. Hellweg, A. Ziegenhorn, I. Heuser, and M. Deuschle Serum concentrations of nerve growth factor and brain-derived neurotrophic factor in depressed patients before and after antidepressant treatment Pharmacopsychiatry 41 2 2008 66 71
22. J. Iga, S. Ueno, K. Yamauchi, S. Numata, S. Tayoshi-Shibuya, S. Kinouchi, M. Nakataki, H. Song, K. Hokoishi, H. Tanabe, A. Sano, and T. Ohmori Gene expression and association analysis of vascular endothelial growth factor in major depressive disorder Prog. Neuropsychopharmacol. Biol. Psychiatry 31 2007 658 663
23. K. Jin, Y. Zhu, Y. Sun, X.O. Mao, L. Xie, and D.A. Greenberg Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo Proc. Natl. Acad. Sci. USA 99 18 2002 11946 11950
24. K.G. Kahl, S. Bens, K. Ziegler, S. Rudolf, A. Kordon, L. Dibbelt, and U. Schweiger Angiogenic factors in patients with current major depressive disorder comorbid with borderline personality disorder Psychoneuroendocrinology 34 2009 353 357
25. F. Karege, G. Perret, G. Bondolfi, M. Schwald, G. Bertschy, and J.M. Aubry Decreased serum brain-derived neurotrophic factor levels in major depressed patients Psychiatry Res. 109 2 2002 143 148
26. Z. Kotan, E. Sarandol, E. Kirhan, G. Ozkaya, and S. Kirli Serum brain-derived neurotrophic factor, vascular endothelial growth factor and leptin levels in patients with a diagnosis of severe major depressive disorder with melancholic features Ther. Adv. Psychopharmacol. 2 2 2012 65 74
27. M. Kubera, E. Obuchowicz, L. Goehler, J. Brzeszcz, and M. Maes In animal models, psychosocial stress-induced (neuro)inflammation, apoptosis and reduced neurogenesis are associated to the onset of depression Prog. Neuropsychopharmacol. Biol. Psychiatry 35 3 2011 744 759
28. U.E. Lang, R. Hellweg, T. Sander, and J. Gallinat The Met allele of the BDNF Val66Met polymorphism is associated with increased BDNF serum concentrations Mol. Psychiatry 14 2 2009 120 122
29. B.H. Lee, and Y.K. Kim Increased plasma VEGF levels in major depressive or manic episodes in patients with mood disorders J. Affect. Disord. 136 1-2 2012 181 184
30. H.Y. Lee, and Y.K. Kim Plasma brain-derived neurotrophic factor as a peripheral marker for the action mechanism of antidepressants Neuropsychobiology 57 4 2008 194 199
31. D.W. Leung, G. Cachianes, W.J. Kuang, D.V. Goeddel, and N. Ferrara Vascular endothelial growth factor is a secreted angiogenic mitogen Science 246 1989 1306 1309
32. F. Matrisciano, S. Bonaccorso, A. Ricciardi, S. Scaccianoce, I. Panaccione, L. Wang, A. Ruberto, R. Tatarelli, F. Nicoletti, P. Girardi, and R.C. Shelton Changes in BDNF serum levels in patients with major depression disorder (MDD) after 6 months treatment with sertraline, escitalopram, or venlafaxine J. Psychiatr. Res. 43 2009 247 254
33. T. Mikoteit, J. Beck, A. Eckert, U. Hemmeter, S. Brand, R. Bischof, E. Holsboer-Trachsler, and A. ini-Stula High baseline BDNF serum levels and early psychopathological improvement are predictive of treatment outcome in major depression Psychopharmacology (Berl) 231 2014 2955 2965
34. A. Minelli, R. Zanardini, M. Abate, M. Bortolomasi, M. Gennarelli, and L. Bocchio-Chiavetto Vascular Endothelial Growth Factor (VEGF) serum concentration during electroconvulsive therapy (ECT) in treatment resistant depressed patients Prog. Neuropsychopharmacol. Biol. Psychiatry 35 5 2011 1322 1325
35. A. Minelli, E. Maffioletti, M. Bortolomasi, A. Conca, R. Zanardini, L. Rillosi, M. Abate, M. Giacopuzzi, G. Maina, M. Gennarelli, and L. Bocchio-Chiavetto Association between baseline serum vascular endothelial growth factor levels and response to electroconvulsive therapy Acta Psychiatr. Scand. 129 2014 461 466
36. M.L. Molendijk, P. Spinhoven, M. Polak, B.A. Bus, B.W. Penninx, and B.M. Elzinga Serum BDNF concentrations as peripheral manifestations of depression: evidence from a systematic review and meta-analyses on 179 associations (N=9484) Mol. Psychiatry 19 7 2014 791 800
37. M.L. Molendijk, B.A. Bus, P. Spinhoven, B.W. Penninx, G. Kenis, J. Prickaerts, R.C. Voshaar, and B.M. Elzinga Serum levels of brain-derived neurotrophic factor in major depressive disorder: state-trait issues, clinical features and pharmacological treatment Mol. Psychiatry 16 2011 1088 1095
38. M.L. Molendijk, J.P. Haffmans, B.A. Bus, P. Spinhoven, B.W. Penninx, J. Prickaerts, R.C. Oude Voshaar, and B.M. Elzinga Serum BDNF concentrations show strong seasonal variation and correlations with the amount of ambient sunlight PLoS One 7 2012 e48046
39. P. Monteleone, C. Serritella, V. Martiadis, and M. Maj Decreased levels of serum brain-derived neurotrophic factor in both depressed and euthymic patients with unipolar depression and in euthymic patients with bipolar I and II disorders Bipolar Disord. 10 1 2008 95 100
40. S.A. Montgomery, and M. Asberg A new depression scale designed to be sensitive to change Br. J. Psychiatry 134 1979 382 389
41. M.M. Nowacka, and E. Obuchowicz Vascular endothelial growth factor (VEGF) and its role in the central nervous system: a new element in the neurotrophic hypothesis of antidepressant drug action Neuropeptides 46 1 2012 1 10
42. P. Pallavi, R. Sagar, M. Mehta, S. Sharma, A. Subramanium, F. Shamshi, U. Sengupta, R. Qadri, R.M. Pandey, and A.K. Mukhopadhyay Serum neurotrophic factors in adolescent depression: gender difference and correlation with clinical severity J. Affect. Disord. 150 2013 415 423
43. A. Piccinni, D. Marazziti, M. Catena, L. Domenici, D.A. Del, C. Bianchi, C. Mannari, C. Martini, P.E. Da, E. Schiavi, A. Mariotti, I. Roncaglia, A. Palla, G. Consoli, L. Giovannini, G. Massimetti, and L. Dell'Osso Plasma and serum brain-derived neurotrophic factor (BDNF) in depressed patients during 1 year of antidepressant treatments J. Affect. Disord. 105 2008 279 283
44. R.S. Robinson, K.J. Woad, A.J. Hammond, M. Laird, M.G. Hunter, and G.E. Mann Angiogenesis and vascular function in the ovary Reproduction 138 2009 869 881
45. E. Shimizu, K. Hashimoto, N. Okamura, K. Koike, N. Komatsu, C. Kumakiri, M. Nakazato, H. Watanabe, N. Shinoda, S. Okada, and M. Iyo Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants Biol. Psychiatry 54 2003 70 75
46. R. Uher, W. Maier, J. Hauser, A. Marusic, C. Schmael, O. Mors, N. Henigsberg, D. Souery, A. Placentino, M. Rietschel, A. Zobel, M. Dmitrzak-Weglarz, A. Petrovic, L. Jorgensen, P. Kalember, C. Giovannini, M. Barreto, A. Elkin, S. Landau, A. Farmer, K.J. Aitchison, and P. McGuffin Differential efficacy of escitalopram and nortriptyline on dimensional measures of depression Br. J. Psychiatry 194 2009 252 259
47. R. Uher, A. Farmer, W. Maier, M. Rietschel, J. Hauser, A. Marusic, O. Mors, A. Elkin, R.J. Williamson, C. Schmael, N. Henigsberg, J. Perez, J. Mendlewicz, J.G. Janzing, A. Zobel, M. Skibinska, D. Kozel, A.S. Stamp, M. Bajs, A. Placentino, M. Barreto, P. McGuffin, and K.J. Aitchison Measuring depression: comparison and integration of three scales in the GENDEP study Psychol. Med. 38 2008 289 300
48. M. Ventriglia, R. Zanardini, L. Pedrini, A. Placentino, M.G. Nielsen, M. Gennarelli, and L. Bocchio-Chiavetto VEGF serum levels in depressed patients during SSRI antidepressant treatment Prog. Neuropsychopharmacol. Biol. Psychiatry 33 2009 146 149
49. M. Verhagen, M.A. van der, P.A. van Deurzen, J.G. Janzing, A. rias-Vasquez, J.K. Buitelaar, and B. Franke Meta-analysis of the BDNF Val66Met polymorphism in major depressive disorder: effects of gender and ethnicity Mol. Psychiatry 15 2010 260 271
50. O.M. Wolkowitz, J. Wolf, W. Shelly, R. Rosser, H.M. Burke, G.K. Lerner, V.I. Reus, J.C. Nelson, E.S. Epel, and S.H. Mellon Serum BDNF levels before treatment predict SSRI response in depression Prog. Neuropsychopharmacol. Biol. Psychiatry 35 2011 1623 1630
51. R. Yoshimura, M. Mitoma, A. Sugita, H. Hori, T. Okamoto, W. Umene, N. Ueda, and J. Nakamura Effects of paroxetine or milnacipran on serum brain-derived neurotrophic factor in depressed patients Prog. Neuropsychopharmacol. Biol. Psychiatry 31 2007 1034 1037
52. R. Yoshimura, T. Kishi, A. Suzuki, W. Umene-Nakano, A. Ikenouchi-Sugita, H. Hori, K. Otani, N. Iwata, and J. Nakamura The brain-derived neurotrophic factor (BDNF) polymorphism Val66Met is associated with neither serum BDNF level nor response to selective serotonin reuptake inhibitors in depressed Japanese patients Prog. Neuropsychopharmacol. Biol. Psychiatry 35 2011 1022 1025
53. R. Yoshimura, T. Kishi, H. Hori, A. Katsuki, A. Sugita-Ikenouchi, W. Umene-Nakano, K. Atake, N. Iwata, and J. Nakamura Serum levels of brain-derived neurotrophic factor at 4 weeks and response to treatment with SSRIs Psychiatry Investig. 11 1 2014 84 88
54. S.L. Zeger, and K.Y. Liang Longitudinal data analysis for discrete and continuous outcomes Biometrics 42 1 1986 121 130