Repositioning of memantine as a potential novel therapeutic agent against meningitic E. coli - Induced pathogenicities through disease-associated alpha7 cholinergic pathway and RNA sequencing-based transcriptome analysis of host inflammatory responses

PLoS ONE

Volumn 10, Issue 5, 2015, Pages

  Yu, Jing Yi ^a,b   Zhang, Bao ^a,b   Peng, Liang ^b,c   Wu, Chun Hua ^b   Cao, Hong ^a   Zhong, John F ^b,d   Hoffman, Jill ^b   Huang, Sheng He ^a,b  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c GUANGZHOU MEDICAL UNIVERSITY   (China)

^d UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPICILLIN; BUNGAROTOXIN RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN RECEPTOR SUBSTRATE 1; INTERLEUKIN 18; INTERLEUKIN 33; MEMANTINE; STROMELYSIN 2; TRANSCRIPTOME; NICOTINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTEREMIA; BACTERIAL GROWTH; BACTERIAL MENINGITIS; BACTERIAL SURVIVAL; BACTERIAL VIRULENCE; BLOOD BRAIN BARRIER; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENTIATION; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTION; GENE EXPRESSION; IMMUNE RESPONSE; MOUSE; NEWBORN; NEWBORN SEPSIS; NONHUMAN; RNA SEQUENCE; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; DRUG EFFECTS; GROWTH, DEVELOPMENT AND AGING; MENINGITIS, ESCHERICHIA COLI; METABOLISM; MOLECULAR GENETICS; PATHOGENICITY; SEQUENCE ANALYSIS;

BACTERIA (MICROORGANISMS); MUS; NEGIBACTERIA;

ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR; ANIMALS; ANIMALS, NEWBORN; BLOOD-BRAIN BARRIER; ESCHERICHIA COLI; MEMANTINE; MENINGITIS, ESCHERICHIA COLI; MICE; MOLECULAR SEQUENCE DATA; NICOTINE; SEQUENCE ANALYSIS, RNA; TRANSCRIPTOME;

EID: 84930624700     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0121911     Document Type: Article

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