Hypotestosteronemia is frequent in ST-elevation myocardial infarction patients and is associated with coronary microvascular obstruction

European Journal of Preventive Cardiology

Volumn 22, Issue 7, 2015, Pages 855-863

  Niccoli, Giampaolo ^a   Milardi, Domenico ^a   D'Amario, Domenico ^a   Fracassi, Francesco ^a   Grande, Giuseppe ^a   Panico, Roberta Antonazzo ^a   Roberto, Marco ^a   Mirizzi, Alessandro Mandurino ^a   Canu, Giulia ^a   De Marinis, Laura ^a   Carrozza, Cinzia ^a   Pontecorvi, Alfredo ^a   Crea, Filippo ^a  

^a CATHOLIC UNIVERSITY   (Italy)

Author keywords

hypotestosteronemia; microvascular obstruction; primary percutanous coronary intervention; ST elevation myocardial infarction

Indexed keywords

ABCIXIMAB; ACETYLSALICYLIC ACID; CLOPIDOGREL; FIBRINOGEN RECEPTOR ANTAGONIST; GLYCERYL TRINITRATE; HEPARIN; HIGH DENSITY LIPOPROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INSULIN LIKE FACTOR 3; LOW DENSITY LIPOPROTEIN; RELAXIN LIKE FACTOR; TESTOSTERONE; TROPONIN T; UNCLASSIFIED DRUG; BIOLOGICAL MARKER;

ADULT; ANDROGEN DEFICIENCY; ANGIOCARDIOGRAPHY; ARTICLE; CARDIOVASCULAR RISK; CONTROLLED STUDY; CORONARY ARTERY OBSTRUCTION; CORONARY MICROVASCULAR OBSTRUCTION; CROSS-SECTIONAL STUDY; DIASTOLIC BLOOD PRESSURE; DISEASE ASSOCIATION; DISEASE MARKER; DYSLIPIDEMIA; ELECTROCARDIOGRAPH; ELECTROCARDIOGRAPHY; FEMALE; HEART MUSCLE REPERFUSION; HUMAN; HYPOTESTOSTERONEMIA; ISCHEMIC HEART DISEASE; LEYDIG CELL; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; OBSERVATIONAL STUDY; PATHOGENESIS; PREVALENCE; PRIORITY JOURNAL; PROSPECTIVE STUDY; ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; STABLE ANGINA PECTORIS; SYSTOLIC BLOOD PRESSURE; TESTOSTERONE BLOOD LEVEL; THORAX PAIN; THROMBUS ASPIRATION; AGED; ANGINA, STABLE; BLOOD; CHI SQUARE DISTRIBUTION; COMPARATIVE STUDY; CORONARY ANGIOGRAPHY; CORONARY ARTERY BLOOD FLOW; DEFICIENCY; ITALY; MICROCIRCULATION; MYOCARDIAL INFARCTION; ODDS RATIO; PATHOPHYSIOLOGY; RISK FACTOR; STATISTICAL MODEL;

AGED; ANGINA, STABLE; BIOMARKERS; CHI-SQUARE DISTRIBUTION; CORONARY ANGIOGRAPHY; CORONARY CIRCULATION; CROSS-SECTIONAL STUDIES; ELECTROCARDIOGRAPHY; HUMANS; ITALY; LOGISTIC MODELS; MALE; MICROCIRCULATION; MIDDLE AGED; MULTIVARIATE ANALYSIS; MYOCARDIAL INFARCTION; ODDS RATIO; PREVALENCE; PROSPECTIVE STUDIES; RISK FACTORS; TESTOSTERONE;

EID: 84930579582     PISSN: 20474873     EISSN: 20474881     Source Type: Journal    
DOI: 10.1177/2047487314533084     Document Type: Article

References (36)

1. Wu FC, von Eckardstein A. Androgens and coronary artery disease. Endocr Rev. 2003 ; 24: 183-217
2. Hak AE, Witteman JC, de Jong FH, et al. Low levels of endogenous androgens increase the risk of atherosclerosis in elderly men: the Rotterdam study. J Clin Endocrinol Metab. 2002 ; 87: 3632-3639
3. Selvin E, Feinleib M, Zhang L, et al. Androgens and diabetes in men: results from the Third National Health and Nutrition Examination Survey (NHANES III). Diabetes Care. 2007 ; 30: 234-238
4. Boyanov MA, Boneva Z, Christov VG. Testosterone supplementation in men with type 2 diabetes, visceral obesity and partial androgen deficiency. Aging Male. 2003 ; 6: 1-7
5. Haring R, Baumeister SE, Volzke H, et al. Prospective association of low total testosterone concentrations with an adverse lipid profile and increased incident dyslipidemia. Eur J Cardiovasc Prev Rehabil. 2011 ; 18: 86-96
6. Foresta C, Caretta N, Lana A, et al. Reduced number of circulating endothelial progenitor cells in hypogonadal men. J Clin Endocrinol Metab. 2006 ; 91: 4599-4602
7. Jones RD, Pugh PJ, Jones TH, et al. The vasodilatory action of testosterone: a potassium-channel opening or a calcium antagonistic action?. Br J Pharmacol. 2003 ; 138: 733-744
8. Webb CM, Elkington AG, Kraidly MM, et al. Effects of oral testosterone treatment on myocardial perfusion and vascular function in men with low plasma testosterone and coronary heart disease. Am J Cardiol. 2008 ; 101: 618-624
9. Malkin CJ, Pugh PJ, Jones RD, et al. The effect of testosterone replacement on endogenous inflammatory cytokines and lipid profiles in hypogonadal men. J Clin Endocrinol Metab. 2004 ; 89: 3313-3318
10. Guler N, Batyraliev T, Dulger H, et al. The effects of short term (3 weeks) testosterone treatment on serum inflammatory markers in men undergoing coronary artery stenting. Int J Cardiol. 2006 ; 109: 339-343
11. Miyatake A, Morimoto Y, Oishi T, et al. Circadian rhythm of serum testosterone and its relation to sleep: comparison with the variation in serum luteinizing hormone, prolactin, and cortisol in normal men. J Clin Endocrinol Metab. 1980 ; 51: 1365-1371
12. Foresta C, Di Mambro A, Pagano C, et al. Insulin-like factor 3 as a marker of testicular function in obese men. Clin Endocrinol (Oxf). 2009 ; 71: 722-726
13. Sorajja P, Gersh BJ, Costantini C, et al. Combined prognostic utility of ST-segment recovery and myocardial blush after primary percutaneous coronary intervention in acute myocardial infarction. Eur Heart J. 2005 ; 26: 667-674
14. Kaufman JM, Vermeulen A. The decline of androgen levels in elderly men and its clinical and therapeutic implications. Endocr Rev. 2005 ; 26: 833-876
15. van 't Hof AW, Liem A, Suryapranata H, et al. Angiographic assessment of myocardial reperfusion in patients treated with primary angioplasty for acute myocardial infarction: myocardial blush grade. Zwolle Myocardial Infarction Study Group. Circulation. 1998 ; 97: 2302-2306
16. Phase I findings. TIMI Study Group. N Engl J Med. 1985 ; 312: 932-936
17. Gibson CM, Murphy SA, Morrow DA, et al. Angiographic perfusion score: an angiographic variable that integrates both epicardial and tissue level perfusion before and after facilitated percutaneous coronary intervention in acute myocardial infarction. Am Heart J. 2004 ; 148: 336-340
18. Alexandersen P, Haarbo J, Christiansen C. The relationship of natural androgens to coronary heart disease in males: a review. Atherosclerosis. 1996 ; 125: 1-13
19. Glueck CJ, Glueck HI, Stroop D, et al. Endogenous testosterone, fibrinolysis, and coronary heart disease risk in hyperlipidemic men. J Lab Clin Med. 1993 ; 122: 412-420
20. English KM, Mandour O, Steeds RP, et al. Men with coronary artery disease have lower levels of androgens than men with normal coronary angiograms. Eur Heart J. 2000 ; 21: 890-894
21. Rosano GM, Sheiban I, Massaro R, et al. Low testosterone levels are associated with coronary artery disease in male patients with angina. Int J Impot Res. 2007 ; 19: 176-182
22. Hu X, Rui L, Zhu T, et al. Low testosterone level in middle-aged male patients with coronary artery disease. Eur J Intern Med. 2011 ; 22: e133 - e136
23. Li L, Guo CY, Jia EZ, et al. Testosterone is negatively associated with the severity of coronary atherosclerosis in men. Asian J Androl. 2012 ; 14: 875-878
24. Uyanik BS, Ari Z, Gumus B, et al. Beneficial effects of testosterone undecanoate on the lipoprotein profiles in healthy elderly men. A placebo controlled study. Jpn Heart J. 1997 ; 38: 73-82
25. English KM, Steeds RP, Jones TH, et al. Low-dose transdermal testosterone therapy improves angina threshold in men with chronic stable angina: a randomized, double-blind, placebo-controlled study. Circulation. 2000 ; 102: 1906-1911
26. Burkhardt E, Adham IM, Brosig B, et al. Structural organization of the porcine and human genes coding for a Leydig cell-specific insulin-like peptide (LEY I-L) and chromosomal localization of the human gene (INSL3). Genomics. 1994 ; 20: 13-19
27. Callies F, Stromer H, Schwinger RH, et al. Administration of testosterone is associated with a reduced susceptibility to myocardial ischemia. Endocrinology. 2003 ; 144: 4478-4483
28. Bekesi G, Kakucs R, Varbiro S, et al. In vitro effects of different steroid hormones on superoxide anion production of human neutrophil granulocytes. Steroids. 2000 ; 65: 889-894
29. Chatrath R, Ronningen KL, Severson SR, et al. Endothelium-dependent responses in coronary arteries are changed with puberty in male pigs. Am J Physiol Heart Circ Physiol. 2003 ; 285: H1168 - H1176
30. Campelo AE, Cutini PH, Massheimer VL. Testosterone modulates platelet aggregation and endothelial cell growth through nitric oxide pathway. J Endocrinol. 2012 ; 213: 77-87
31. Li S, Li X, Li J, et al. Inhibition of oxidative-stress-induced platelet aggregation by androgen at physiological levels via its receptor is associated with the reduction of thromboxane A2 release from platelets. Steroids. 2007 ; 72: 875-880
32. Segal MS, Sautina L, Li S, et al. Relaxin increases human endothelial progenitor cell NO and migration and vasculogenesis in mice. Blood. 2012 ; 119: 629-636
33. Nijveldt R, Beek AM, Hirsch A, et al. Functional recovery after acute myocardial infarction: comparison between angiography, electrocardiography, and cardiovascular magnetic resonance measures of microvascular injury. J Am Coll Cardiol. 2008 ; 52: 181-189
34. Porto I, Burzotta F, Brancati M, et al. Relation of myocardial blush grade to microvascular perfusion and myocardial infarct size after primary or rescue percutaneous coronary intervention. Am J Cardiol. 2007 ; 99: 1671-1673
35. Bolognese L, Carrabba N, Parodi G, et al. Impact of microvascular dysfunction on left ventricular remodeling and long-term clinical outcome after primary coronary angioplasty for acute myocardial infarction. Circulation 2004; 109(9): 1121-1126.
36. Niccoli G, Cosentino N, Lombardo A, et al. Angiographic patterns of myocardial reperfusion after primary angioplasty and ventricular remodeling. Coron Artery Dis 2011; 22(7): 507-514.