Risk factors for multiple sclerosis, neuromyelitis optica and transverse myelitis

Multiple Sclerosis

Volumn 21, Issue 6, 2015, Pages 703-709

  Simon, K C ^a,b   Schmidt, H ^c   Loud, S ^c   Ascherio, A ^a  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c Accelerated Cure Project   (United States)

Author keywords

all demyelinating disease (CNS); case control studies; Epstein Barr virus; Multiple sclerosis; neuromyelitis optica; risk factors in epidemiology; transverse myelitis

Indexed keywords

EPSTEIN BARR VIRUS ANTIGEN 1; HLA DR15 ANTIGEN; ANTIBODY; EBV-ENCODED NUCLEAR ANTIGEN 1; EPSTEIN BARR VIRUS ANTIGEN; HLA DR ANTIGEN; HLA-DR15 ANTIGEN;

ADULT; ANTIBODY TITER; ARTICLE; CASE CONTROL STUDY; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; FAMILY HISTORY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICAL HISTORY; MIDDLE AGED; MONONUCLEOSIS; MULTIPLE SCLEROSIS; MYELITIS; MYELOOPTIC NEUROPATHY; RISK ASSESSMENT; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; SMOKING; BLOOD; GENETICS; IMMUNOLOGY; INFECTIOUS MONONUCLEOSIS; MYELITIS, TRANSVERSE; NEUROMYELITIS OPTICA; SEX DIFFERENCE;

ADULT; ANTIBODIES; CASE-CONTROL STUDIES; DISEASE SUSCEPTIBILITY; EPSTEIN-BARR VIRUS NUCLEAR ANTIGENS; FEMALE; HLA-DR SEROLOGICAL SUBTYPES; HUMANS; INFECTIOUS MONONUCLEOSIS; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; MYELITIS, TRANSVERSE; NEUROMYELITIS OPTICA; RISK FACTORS; SEX FACTORS; SMOKING;

EID: 84930521251     PISSN: 13524585     EISSN: 14770970     Source Type: Journal    
DOI: 10.1177/1352458514551780     Document Type: Article

References (24)

1. Ascherio A, Munger KL. Environmental risk factors for multiple sclerosis. Part I: The role of infection. Ann Neurol. 2007 ; 61: 288-299
2. Ascherio A, Munger KL. Environmental risk factors for multiple sclerosis. Part II: Noninfectious factors. Ann Neurol. 2007 ; 61: 504-513
3. Lincoln MR, Ramagopalan SV, Chao MJ, et al. Epistasis among HLA-DRB1, HLA-DQA1, and HLA-DQB1 loci determines multiple sclerosis susceptibility. Proc Natl Acad Sci U S A. 2009 ; 106: 7542-7547
4. De Jager PL, Jia X, Wang J, et al. Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. Nat Genet. 2009 ; 41: 776-782
5. Orton SM, Herrera BM, Yee IM, et al. Sex ratio of multiple sclerosis in Canada: A longitudinal study. Lancet Neurol. 2006 ; 5: 932-936
6. Marrie RA, Gryba C. The incidence and prevalence of neuromyelitis optica: A systematic review. Int J MS Care. 2013 ; 15: 113-118
7. Bhat A, Naguwa S, Cheema G, et al. The epidemiology of transverse myelitis. Autoimmun Rev. 2010 ; 9: A395 - A399
8. Wingerchuk DM, Lennon VA, Lucchinetti CF, et al. The spectrum of neuromyelitis optica. Lancet Neurol. 2007 ; 6: 805-815
9. Ascherio A, Munger KL, Lennette ET, et al. Epstein-Barr virus antibodies and risk of multiple sclerosis: A prospective study. JAMA. 2001 ; 286: 3083-3088
10. DeLorenze GN, Munger KL, Lennette E, et al. Epstein-Barr virus and multiple sclerosis: Evidence of association from a prospective study with long-term follow-up. Arch Neurol. 2006 ; 63: 839-844
11. Munger KL, Levin LI, O'Reilly EJ, et al. Anti-Epstein-Barr virus antibodies as serological markers of multiple sclerosis: A prospective study among United States military personnel. Mult Scler. 2011 ; 17: 1185-1193
12. De Jager PL, Simon KC, Munger KL, et al. Integrating risk factors: HLA-DRB1∗1501 and Epstein-Barr virus in multiple sclerosis. Neurology. 2008 ; 70: 1113-1118
13. Yang Q, Khoury MJ, Flanders WD. Sample size requirements in case-only designs to detect gene-environment interaction. Am J Epidemiol. 1997 ; 146: 713-720
14. Kieff ED, Rickinson AB Fields virology. 5 th ed.Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins, 2007, pp.2603-2654. Knipe DM Howley PM Griffin DE, ed. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins ; 2007: 2603-2654.
15. Dyment DA, Ebers GC, Sadovnick AD. Genetics of multiple sclerosis. Lancet Neurol. 2004 ; 3: 104-110
16. Rothman K, Greenland S Modern epidemiology. 2 nd ed.Philadelphia: Lippincott-Raven Publishers, 1998. Philadelphia: Lippincott-Raven Publishers ; 1998 :
17. Mata S, Lolli F. Neuromyelitis optica: An update. J Neurol Sci. 2011 ; 303: 13-21
18. Borchers AT, Gershwin ME. Transverse myelitis. Autoimmun Rev. 2012 ; 11: 231-248
19. Simon KC, Van der Mei IA, Munger KL, et al. Combined effects of smoking, anti-EBNA antibodies, and HLA-DRB1∗1501 on multiple sclerosis risk. Neurology. 2010 ; 74: 1365-1371
20. Lucas RM, Ponsonby AL, Dear K, et al. Current and past Epstein-Barr virus infection in risk of initial CNS demyelination. Neurology. 2011 ; 77: 371-379
21. Sundström P, Nyström L, Jidell E, et al. EBNA-1 reactivity and HLA DRB1∗1501 as statistically independent risk factors for multiple sclerosis: A case-control study. Mult Scler. 2008 ; 14: 1120-1122
22. Sundström P, Nyström M, Ruuth K, et al. Antibodies to specific EBNA-1 domains and HLA DRB1∗1501 interact as risk factors for multiple sclerosis. J Neuroimmunol. 2009 ; 215: 102-107
23. Nielsen T, Rostgaard K, Askling J, et al. Effects of infectious mononucleosis and HLA-DRB1∗15 in multiple sclerosis. Mult Scler. 2009 ; 15: 431-436
24. Ramagopalan SV, Sadovnick AD, Ebers GC, et al. Effects of infectious mononucleosis and HLA-DRB1∗15 in multiple sclerosis. Mult Scler. 2010 ; 16: 127-128