Predictive value of procalcitonin for excluding bloodstream infection: Results of a retrospective study and utility of a rapid, quantitative test for procalcitonin

Journal of International Medical Research

Volumn 41, Issue 5, 2013, Pages 1671-1681

  Wang, Huan ^a   Yin, Fan ^a   Shen, Ding Xia ^a   Zhang, You Jiang ^a   Luo, Yan Ping ^a   Liu, Chao Jun ^a   Wang, Kai fei ^a   Zhou, Guang ^a   Ye, Li Yan ^a   Chen, Gang ^a   Wang, Xiao Ning ^b  

^a CHINESE PLA GENERAL HOSPITAL   (China)

^b JILIN UNIVERSITY   (China)

Author keywords

area under the curve; bloodstream infection; C reactive protein; percentage of neutrophils; predictive value; Procalcitonin

Indexed keywords

C REACTIVE PROTEIN; PROCALCITONIN;

ADOLESCENT; ADULT; AGED; ARTICLE; BACTERIUM CONTAMINATION; BLOOD CULTURE; BLOODSTREAM INFECTION; CHILD; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; DIAGNOSTIC VALUE; FEMALE; HUMAN; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; NEUTROPHIL COUNT; PREDICTIVE VALUE; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; QUANTITATIVE ANALYSIS; RECEIVER OPERATING CHARACTERISTIC; REFERENCE VALUE; RETROSPECTIVE STUDY; SCHOOL CHILD; SENSITIVITY ANALYSIS; YOUDEN INDEX;

AREA UNDER THE CURVE; BLOODSTREAM INFECTION; C-REACTIVE PROTEIN; PERCENTAGE OF NEUTROPHILS; PREDICTIVE VALUE; PROCALCITONIN;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BACTEREMIA; BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; CALCITONIN; CHILD; DIAGNOSIS, DIFFERENTIAL; FEMALE; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; HUMANS; LEUKOCYTE COUNT; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; PROTEIN PRECURSORS; RETROSPECTIVE STUDIES; ROC CURVE; SEPSIS; STATISTICS, NONPARAMETRIC;

EID: 84887314391     PISSN: 03000605     EISSN: 14732300     Source Type: Journal    
DOI: 10.1177/0300060513497558     Document Type: Article

References (26)

1. Angus DC,Linde-Zwirble WT,Lidicker J, et al.Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care.Crit Care Med. 2001;29:1303-1310.
2. Dombrovskiy VY,Martin AA,Sunderram J, et al.Rapid increase in hospitalization and mortality rates for severe sepsis in the United States: a trend analysis from 1993 to 2003.Crit Care Med. 2007;35:1244-1250.
3. Kibe S,Adams K,Barlow G.Diagnostic and prognostic biomarkers of sepsis in critical care.J Antimicrob Chemother. 2011;66:ii33-ii40.
4. Ballot DE,Perovic O,Galpin J, et al.Serum procalcitonin as an early marker of neonatal sepsis.S Afr Med J. 2004;94:851-854.
5. Aikawa N,Fujishima S,Endo S, et al.Multicenter prospective study of procalcitonin as an indicator of sepsis.J Infect Chemother. 2005;11:152-159.
6. Lai CC,Chen SY,Wang CY, et al.Diagnostic value of procalcitonin for bacterial infection in elderly patients in the emergency department.J Am Geriatr Soc. 2010;58:518-522.
7. Liaudat S,Dayer E,Praz G, et al.Usefulness of procalcitonin serum level for the diagnosis of bacteremia.Eur J Clin Microbiol Infect Dis. 2001;20:524-527.
8. Tsangaris I,Plachouras D,Kavatha D, et al.Diagnostic and prognostic value of procalcitonin among febrile critically ill patients with prolonged ICU stay.BMC Infect Dis. 2009;9:213-213.
9. Schneider CP,Yilmaz Y,Kleespies A, et al.Accuracy of procalcitonin for outcome prediction in unselected postoperative critically ill patients.Shock. 2009;31:568-573.
10. Assicot M,Gendrel D,Carsin H, et al.High serum procalcitonin concentrations in patients with sepsis and infection.Lancet. 1993;341:515-518.
11. Bogar L,Molnar Z,Kenyeres P, et al.Sedimentation characteristics of leucocytes can predict bacteraemia in critical care patients.J Clin Pathol. 2006;59:523-525.
12. Jereb M,Kotar T,Jurca T, et al.Usefulness of procalcitonin for diagnosis of infective endocarditis.Intern Emerg Med. 2009;4:221-226.
13. Jones AE,Fiechtl JF,Brown MD, et al.Procalcitonin test in the diagnosis of bacteremia: a meta-analysis.Ann Emerg Med. 2007;50:34-41.
14. Schuetz P,Mueller B,Trampuz A.Serum procalcitonin for discrimination of blood contamination from bloodstream infection due to coagulase-negative staphylococci.Infection. 2007;35:352-355.
15. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 1992; 20: 864-874.
16. Nakamura A,Wada H,Ikejiri M, et al.Efficacy of procalcitonin in the early diagnosis of bacterial infections in a critical care unit.Shock. 2009;31:586-591.
17. Tang BM,Eslick GD,Craig JC, et al.Accuracy of procalcitonin for sepsis diagnosis in critically ill patients: systematic review and meta-analysis.Lancet Infect Dis. 2007;7:210-217.
18. Nijsten MW,Olinga P,The TH, et al.Procalcitonin behaves as a fast responding acute phase protein in vivo and in vitro.Crit Care Med. 2000;28:458-461.
19. Gendrel D,Raymond J,Coste J, et al.Comparison of procalcitonin with C-reactive protein, interleukin 6 and interferon-alpha for differentiation of bacterial vs. viral infections.Pediatr Infect Dis J. 1999;18:875-881.
20. Charles PE,Tinel C,Barbar S, et al.Procalcitonin kinetics within the first days of sepsis: relationship with the appropriateness of antibiotic therapy and the outcome.Crit Care. 2009;13:R38-R38.
21. Becker KL,Snider R,Nylen ES.Procalcitonin assay in systemic inflammation, infection, and sepsis: clinical utility and limitations.Crit Care Med. 2008;36:941-952.
22. Sponholz C,Sakr Y,Reinhart K, et al.Diagnostic value and prognostic implications of serum procalcitonin after cardiac surgery: a systematic review of the literature.Crit Care. 2006;10:R145-R145.
23. Uzzan B,Cohen R,Nicolas P, et al.Procalcitonin as a diagnostic test for sepsis in critically ill adults and after surgery or trauma: a systematic review and meta-analysis.Crit Care Med. 2006;34:1996-2003.
24. Brunkhorst FM,Heinz U,Forycki ZF.Kinetics of procalcitonin in iatrogenic sepsis.Intensive Care Med. 1998;24:888-889.
25. Richter SS,Beekmann SE,Croco JL, et al.Minimizing the workup of blood culture contaminants: implementation and evaluation of a laboratory-based algorithm.J Clin Microbiol. 2002;40:2437-2444.
26. Weinstein MP,Reller LB,Murphy JR, et al.The clinical significance of positive blood cultures: a comprehensive analysis of 500 episodes of bacteremia and fungemia in adults. I. Laboratory and epidemiologic observations.Rev Infect Dis. 1983;5:35-53.