Effects of ambient coarse, fine, and ultrafine particles and their biological constituents on systemic biomarkers: A controlled human exposure study

Environmental Health Perspectives

Volumn 123, Issue 6, 2015, Pages 534-540

  Liu, Ling ^a   Urch, Bruce ^b,c   Poon, Raymond ^a   Szyszkowicz, Mieczyslaw ^a   Speck, Mary ^b,d   Gold, Diane R ^e   Wheeler, Amanda J ^a,f   Scott, James A ^g   Brook, Jeffrey R ^g,h   Thorne, Peter S ⁱ   Silverman, Frances S ^b,c,d,g  

^a Environmental Health Center   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d ST MICHAEL'S HOSPITAL   (Canada)

^e BRIGHAM AND WOMEN S HOSPITAL   (United States)

^f EDITH COWAN UNIVERSITY   (Australia)

^g UNIVERSITY OF TORONTO   (Canada)

^h ENVIRONMENT CANADA   (Canada)

ⁱ UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; BIOLOGICAL MARKER; C REACTIVE PROTEIN; CARBON MONOXIDE; ENDOTHELIN 1; ENDOTOXIN; GLUCAN; INTERLEUKIN 6; MALONALDEHYDE; NITROGEN DIOXIDE; OZONE; SULFUR DIOXIDE; VASCULOTROPIN; AIR POLLUTANT; PARTICULATE MATTER;

ADULT; AIRBORNE PARTICLE; ARTICLE; BLOOD ANALYSIS; BODY MASS; CONTROLLED STUDY; FEMALE; HUMAN; LIPID OXIDATION; LIPID PEROXIDATION; MALE; NORMAL HUMAN; OXIDATIVE STRESS; PARTICLE SIZE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; URINALYSIS; ADOLESCENT; ADVERSE EFFECTS; AGED; AIR POLLUTANT; BLOOD; CHEMICALLY INDUCED; CROSSOVER PROCEDURE; DRUG EFFECTS; EXPOSURE; INFLAMMATION; MIDDLE AGED; ONTARIO; PARTICULATE MATTER; SINGLE BLIND PROCEDURE; TIME FACTOR; TOXICITY; URINE; VASCULAR DISEASE; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AIR POLLUTANTS; BIOMARKERS; CROSS-OVER STUDIES; FEMALE; HUMANS; INFLAMMATION; INHALATION EXPOSURE; MALE; MIDDLE AGED; ONTARIO; OXIDATIVE STRESS; PARTICLE SIZE; PARTICULATE MATTER; SINGLE-BLIND METHOD; TIME FACTORS; VASCULAR DISEASES; YOUNG ADULT;

EID: 84930510737     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.1408387     Document Type: Article

References (35)

1. Anderson JL, Carlquist JF, Muhlestein JB, Horne BD, Elmer SP. 1998. Evaluation of C-reactive protein, an inflammatory marker, and infectious serology as risk factors for coronary artery disease and myocardial infarction. J Am Coll Cardiol 32:35–41.
2. Behbod B, Urch B, Speck M, Scott JA, Liu L, Poon R, et al. 2013. Endotoxin in concentrated coarse and fine ambient particles induces acute systemic inflammation in controlled human exposures. Occup Environ Med 70:761–767.
3. Bräuner EV, Møller P, Barregard L, Dragsted LO, Glasius M, Wåhlin P, et al. 2008. Exposure to ambient concentrations of particulate air pollution does not influence vascular function or inflamma-tory pathways in young healthy individuals. Part Fibre Toxicol 5:13; doi:10.1186/1743-8977-5-13.
4. Brook RD, Bard RL, Kaplan MJ, Yalavarthi S, Morishita M, Dvonch JT, et al. 2013. The effect of acute exposure to coarse particulate matter air pollution in a rural location on circulating endo-thelial progenitor cells: Results from a randomized controlled study. Inhal Toxicol 25:587–592.
5. Calderón-Garcidueñas L, Vincent R, Mora- Tiscareño A, Franco-Lira M, Henríquez-Roldán C, Barragán-Mejía G, et al. 2007. Elevated plasma endothelin-1 and pulmonary arterial pressure in children exposed to air pollution. Environ Health Perspect 115:1248–1253; doi:10.1289/ehp.9641.
6. Cho SH, Tong H, McGee JK, Baldauf RW, Krantz QT, Gilmour MI. 2009. Comparative toxicity of size-fractionated airborne particulate matter collected at different distances from an urban highway. Environ Health Perspect 117:1682–1689; doi:10.1289/ehp.0900730.
7. Chuang KJ, Chan CC, Su TC, Lee CT, Tang CS. 2007. The effect of urban air pollution on inflammation, oxidative stress, coagulation, and autonomic dysfunction in young adults. Am J Respir Crit Care Med 176:370–376.
8. Copeland S, Warren HS, Lowry SF, Calvano SE, Remick D, Inflammation and the Host Response to Injury Investigators. 2005. Acute inflammatory response to endotoxin in mice and humans. Clin Diagn Lab Immunol 12:60–67.
9. Dales R, Miller D, Ruest K, Guay M, Judek S. 2006. Airborne endotoxin is associated with respiratory illness in the first 2 years of life. Environ Health Perspect 114:610–614; doi:10.1289/ehp.8142.
10. Delfino RJ, Staimer N, Tjoa T, Gillen DL, Polidori A, Arhami M, et al. 2009. Air pollution exposures and circulating biomarkers of effect in a susceptible population: clues to potential causal compo-nent mixtures and mechanisms. Environ Health Perspect 117:1232–1238; doi:10.1289/ehp.0800194.
11. Douwes J, Zuidhof A, Dowkes G, van der Zee S, Wouters I, Boezen HM, et al. 2000. (1→3)-β-d-glucan and endotoxin in house dust and peak flow variability in children. Am J Respir Crit Care Med 162:1348–1354.
12. Dye JA, Adler KB, Richards JH, Dreher KL. 1997. Epithelial injury induced by exposure to residual oil fly-ash particles: Role of reactive oxygen species? Am J Respir Cell Mol Biol 17:625–633.
13. Fogelmark B, Sjöstrand M, Rylander R. 1994. Pulmonary inflammation induced by repeated inhalations of β(1,3)-d-glucan and endotoxin. Int J Exp Pathol 75:85–90.
14. Graff DW, Cascio WE, Rappold A, Zhou H, Huang YC, Devlin RB. 2009. Exposure to concentrated coarse air pollution particles causes mild cardiopulmonary effects in healthy young adults. Environ Health Perspect 117:1089–1094; doi:10.1289/ehp0900558.
15. Haberzettl P, Lee J, Duggineni D, McCracken J, Bollanowski D, O’Tool TE, et al. 2012. Exposure to ambient air fine particulate matter prevents VEGF-induced mobilization of endothelial progenitor cells from the bone marrow. Environ Health Perspect 120:848–856; doi:10.1289/ehp.1104206.
16. Haynes WG, Ferro CJ, O’Kane KP, Somerville D, Lomax CC, Webb DJ. 1996. Systemic endothelin receptor blockade decreases peripheral vascular resistance and blood pressure in humans. Circulation 93:1860–1870.
17. HEI Review Panel on Ultrafine Particles. 2013. Understanding the Health Effects of Ambient Ultrafine Particles. HEI Perspectives 3.Boston, MA:Health Effects Institute.
18. Janero DR. 1990. Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxi-dation and peroxidative tissue injury. Free Rad Biol Med 9:515–540.
19. Lipsett MJ, Tsai FC, Roger L, Woo M, Ostro BD. 2006. Coarse particles and heart rate variability among older adults with coronary artery disease in the Coachella Valley, California. Environ Health Perspect 114:1215–1220; doi:10.1289/ehp.8856.
20. Liu L, Poon R, Chen L, Frescura AM, Montuschi P, Ciabattoni G, et al. 2009a. Acute effects of air pollution on pulmonary function, airway inflammation and oxidative stress in asthmatic children. Environ Health Perspect 117:668–674; doi:10.1289/ehp.11813.
21. Liu L, Ruddy T, Dalipaj M, Poon R, Szyszkowicz M, You H, et al. 2009b. Effects of indoor, outdoor, and personal exposure to particulate air pollution on cardiovascular physiology and systemic mediators in seniors. J Occup Environ Med 51:1088–1098.
22. Nishimoto N, Kishimoto T. 2006. Interleukin 6: from bench to bedside. Nat Clin Pract Rheumatol 2:619–626.
23. Park JW, Floyd RA. 1992. Lipid peroxidation products mediate the formation of 8-hydroxydeoxyguanosine in DNA. Free Rad Biol Med 12:245–250.
24. Pekkanen J, Peters A, Hoek G, Tiittanen P, Brunekreef B, de Hartog J, et al. 2002. Particulate air pollution and risk of ST-segment depression during repeated submaximal exercise tests among subjects with coronary heart disease: the Exposure and Risk Assessment for Fine and Ultrafine Particles in Ambient Air (ULTRA) study. Circulation 106:933–938.
25. Pope CA III, Hansen ML, Long RW, Nielsen KR, Eatough NL, Wilson WE, et al. 2004. Ambient particulate air pollution, heart rate variability, and blood markers of inflammation in a panel of elderly subjects. Environ Health Perspect 112:339–345.
26. Rastogi N, McWhinney RD, Akhtar US, Urch B, Fila M, Abbatt JPD, et al. 2012. Physical characterization of the University of Toronto coarse, fine, and ultrafine high-volume particle concentrator systems. Aerosol Sci Technol 46:1015–1024.
27. Rückerl R, Greven S, Ljungman P, Aalto P, Antoniades C, Bellander T, et al. 2007. Air pollution and inflammation (interleukin-6, C-reactive protein, fibrinogen) in myocardial infarction survivors. Environ Health Perspect 115:1072–1080; doi:10.1289/ehp.10021.
28. Samet JM, Graff D, Berntsen J, Ghio AJ, Huang YC, Devlin RB. 2007. A comparison of studies on the effects of controlled exposure to fine, coarse and ultrafine ambient particulate matter from a single location. Inhal Toxicol 19(suppl 1):29–32.
29. Samet JM, Rappold A, Graff D, Cascio WE, Berntsen JH, Huang YC, et al. 2009. Concentrated ambient ultrafine particle exposure induces cardiac changes in young healthy volunteers. Am J Respir Crit Care Med 179:1034–1042.
30. Schins RPF, Lightbody JH, Borm PJA, Shi T, Donaldson K, Stone V. 2004. Inflammatory effects of coarse and fine particulate matter in relation to chemical and biological constituents. Toxicol Appl Pharmacol 195:1–11.
31. Song S, Paek D, Park C, Lee C, Lee JH, Yu SD. 2013. Exposure to ambient ultrafine particles and urinary 8-hydroxyl-2-deoxyguanosine in children with and without eczema. Sci Total Environ 458–460:408–413.
32. Stafoggia M, Samoli E, Alessandrini E, Cadum E, Ostro B, Berti G, et al. 2013. Short-term associations between fine and coarse particulate matter and hospitalizations in southern Europe: Results from the MED-PARTICLES project. Environ Health Perspect 121:1026–1033; doi:10.1289/ehp.1206151.
33. Urch B, Speck M, Corey P, Wasserstein D, Manno M, Lukic KZ, et al. 2010. Concentrated ambient fine particles and not ozone induce a systemic interleukin-6 response in humans. Inhal Toxicol 22:210–218.
34. World Health Organization. 2013. Review of Evidence on Health Aspects of Air Pollution—REVIHAAP Project. Technical Report. Copenhagen:WHO Regional Office for Europe. Available: http://www.euro.who.int/en/health-topics/environment-and-health/air-quality/publications/2013/review-of-evidence- on-health-aspects-of-air-pollution-revihaap-projectfinaltechnical-report [accessed 9 December 2014].
35. Zanobetti A, Schwartz J. 2009. The effect of fine and coarse particulate air pollution on mortality: A national analysis. Environ Health Perspect 117:898–903; doi:10.1289/ehp.0800108.