Progesterone receptor membrane component-1 (PGRMC1) and PGRMC-2 Interact to suppress entry into the cell cycle in spontaneously immortalized rat granulosa cells

Biology of Reproduction

Volumn 91, Issue 5, 2014, Pages

  Peluso, John J ^a   Griffin, Daniel ^a,b   Liu, Xiufang ^a   Horne, Meghan ^a,c  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^b Boston IVF at The Women's Hospital   (United States)

^c Department of Obstetrics Gynecology   (United States)

Author keywords

Apoptosis; Granulosa cells; Mitosis; PGRMC1; PGRMC2

Indexed keywords

BINDING PROTEIN; GTPASE ACTIVATING PROTEIN BINDING PROTEIN 2; HYBRID PROTEIN; PROGESTERONE RECEPTOR; PROGESTERONE RECEPTOR MEMBRANE COMPONENT 1; PROGESTERONE RECEPTOR MEMBRANE COMPONENT 2; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; MEMBRANE PROTEIN; PGRMC1 PROTEIN, RAT; PGRMC2 PROTEIN, RAT; PROTEIN BINDING;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL IMMORTALIZATION; CELL PROLIFERATION; COMPLEX FORMATION; GRANULOSA CELL; METAPHASE; MITOSIS; MITOSIS SPINDLE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; RAT; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CYCLE; DOWN REGULATION; DRUG EFFECTS; FEMALE; GENETICS; METABOLISM; PHYSIOLOGY; TRANSFORMED CELL LINE;

RATTUS;

ANIMALS; CELL CYCLE; CELL LINE, TRANSFORMED; CELL PROLIFERATION; DOWN-REGULATION; FEMALE; G1 PHASE; GRANULOSA CELLS; MEMBRANE PROTEINS; MITOSIS; PROTEIN BINDING; RATS; RECEPTORS, PROGESTERONE; RNA, SMALL INTERFERING;

EID: 84930509896     PISSN: 00063363     EISSN: 15297268     Source Type: Journal    
DOI: 10.1095/biolreprod.114.122986     Document Type: Article

References (31)

1. Cahill MA. Progesterone receptor membrane component 1: an integrative review. J Steroid Biochem Mol Biol 2007; 105:16-36.
2. Peluso JJ. Progesterone receptor membrane component 1 and its role in ovarian follicle growth. Front Neurosci 2013; 7:99, 1-7.
3. Peluso JJ, Pru J. Non-canonical progesterone signaling in granulosa cell function. Reproduction 2014; R169-R178.
4. Falkenstein E, Meyer C, Eisen C, Scriba PC, Wehling M. Full-length cDNA sequence of a progesterone membrane-binding protein from porcine vascular smooth muscle cells. Biochem Biophys Res Commun 1996; 229:86-89.
5. Mansouri MR, Schuster J, Badhai J, Stattin EL, Losel R, Wehling M, Carlsson B, Hovatta O, Karlstrom PO, Golovleva I, Toniolo D, Bione S, et al. Alterations in the expression, structure and function of progesterone receptor membrane component-1 (PGRMC1) in premature ovarian failure. Hum Mol Genet 2008; 17:3776-3783.
6. Schuster J, Karlsson T, Karlstrom PO, Poromaa IS, Dahl N. Downregulation of progesterone receptor membrane component 1 (PGRMC1) in peripheral nucleated blood cells associated with premature ovarian failure (POF) and polycystic ovary syndrome (PCOS). Reprod Biol Endocrinol 2010; 8:58.
7. Elassar A, Liu X, Scranton V, Wu CA, Peluso JJ. The relationship between follicle development and progesterone receptor membrane component-1 expression in women undergoing in vitro fertilization. Fertil Steril 2012; 97:572-578.
8. Gerdes D, Wehling M, Leube B, Falkenstein E. Cloning and tissue expression of two putative steroid membrane receptors. Biol Chem 1998; 379:907-911.
9. Skiadas CC, Duan S, Correll M, Rubio R, Karaca N, Ginsburg ES, Quackenbush J, Racowsky C. Ovarian reserve status in young women is associated with altered gene expression in membrana granulosa cells. Mol Hum Reprod 2012; 18:362-371.
10. Griffin D, Liu X, Pru C, Pru JK, Peluso JJ. Expression of progesterone receptor membrane component-2 within the immature rat ovary and its role in regulating mitosis and apoptosis of spontaneously immortalized granulosa cells. Biol Reprod 2014; 91(2):36:1-11.
11. Peluso JJ, Liu X, Gawkowska A, Johnston-MacAnanny E. Progesterone activates a progesterone receptor membrane component 1-dependent mechanism that promotes human granulosa/luteal cell survival but not progesterone secretion. J Clin Endocrinol Metab 2009; 94:2644-2649.
12. Peluso JJ, Pappalardo A, Losel R, Wehling M. Progesterone membrane receptor component 1 expression in the immature rat ovary and its role in mediating progesterone's antiapoptotic action. Endocrinology 2006; 147: 3133-3140.
13. Peluso JJ, Liu X, Gawkowska A, Lodde V, Wu CA. Progesterone inhibits apoptosis in part by PGRMC1-regulated gene expression. Mol Cell Endocrinol 2010; 320:153-161.
14. Peluso JJ, Romak J, Liu X. Progesterone receptor membrane component-1 (PGRMC1) is the mediator of progesterone's antiapoptotic action in spontaneously immortalized granulosa cells as revealed by PGRMC1 small interfering ribonucleic acid treatment and functional analysis of PGRMC1 mutations. Endocrinology 2008; 149:534-543.
15. Peluso JJ, DeCerbo J, Lodde V. Evidence for a genomic mechanism of action for progesterone receptor membrane component-1. Steroids 2012; 77:1007-1012.
16. Peluso JJ, Lodde V, Liu X. Progesterone regulation of progesterone receptor membrane component 1 (PGRMC1) sumoylation and transcriptional activity in spontaneously immortalized granulosa cells. Endocrinology 2012; 153:3929-3939.
17. Bunnell BA, Heath LS, Adams DE, Lahti JM, Kidd VJ. Increased expression of a 58-kDa protein kinase leads to changes in the CHO cell cycle. Proc Natl Acad Sci U S A 1990; 87:7467-7471.
18. Franck N, Montembault E, Rome P, Pascal A, Cremet JY, Giet R. CDK11(p58) is required for centriole duplication and Plk4 recruitment to mitotic centrosomes. PLoS One 2011; 6:e14600.
19. Stein LS, Stoica G, Tilley R, Burghardt RC. Rat ovarian granulosa cell culture: a model system for the study of cell-cell communication during multistep transformation. Cancer Res 1991; 51:696-706.
20. Peluso JJ, Yuan A, Liu X, Lodde V. Plasminogen activator inhibitor 1 RNA binding protein interacts with progesterone receptor membrane component 1 to regulate progesterone's ability to maintain the viability of spontaneously immortalized granulosa cells and rat granulosa cells. Biol Reprod 2013; 88(1) 20, 1-10.
21. Albrecht C, Huck V, Wehling M, Wendler A. In vitro inhibition of SKOV-3 cell migration as a distinctive feature of progesterone receptor membrane component type 2 versus type 1. Steroids 2012; 77:1543-1550.
22. Wendler A, Wehling M. PGRMC2, a yet uncharacterized protein with potential as tumor suppressor, migration inhibitor, and regulator of cytochrome P450 enzyme activity. Steroids 2013; 78(6):555-558.
23. Peluso JJ, Liu X, Romak J. Progesterone maintains basal intracellular adenosine triphosphate levels and viability of spontaneously immortalized granulosa cells by promoting an interaction between 14-3-3sigma and ATP synthase beta/precursor through a protein kinase G-dependent mechanism. Endocrinology 2007; 148:2037-2044.
24. Lodde V, Peluso JJ. A novel role for progesterone and progesterone receptor membrane component 1 in regulating spindle microtubule stability during rat and human ovarian cell mitosis. Biol Reprod 2011; 84:715-722.
25. Bo WJ, Krueger WA, Rudeen PK. Effects of ethanol on superovulation in the immature rat following pregnant mare's serum gonadotropin (PMSG) or PMSG and human chorionic gonadotropin treatment. Biol Reprod 1983; 28:956-961.
26. Hirshfield AN. Rescue of atretic follicles in vitro and in vivo. Biol Reprod 1989; 40:181-190.
27. Biological General Repository for Interaction [Internet]. Datasets. http:// thebiogrid.org/115237/summary/homo-sapiens/g3bp2.html. Accessed 8 October 2014.
28. Prigent M, Barlat I, Langen H, Dargemont C. IkappaBalpha and IkappaBalpha /NF-kappa B complexes are retained in the cytoplasm through interaction with a novel partner, RasGAP SH3-binding protein 2. J Biol Chem 2000; 275:36441-36449.
29. Guttridge DC, Albanese C, Reuther JY, Pestell RG, Baldwin AS, Jr. NFkappaB controls cell growth and differentiation through transcriptional regulation of cyclin D1. Mol Cell Biol 1999; 19:5785-5799.
30. Barre B, Perkins ND. A cell cycle regulatory network controlling NFkappaB subunit activity and function. EMBO J 2007; 26:4841-4855.
31. Hand RA, Craven RJ. Hpr6.6 protein mediates cell death from oxidative damage in MCF-7 human breast cancer cells. J Cell Biochem 2003; 90: 534-547.