Effects of Acanthus ebracteatus Vahl on tumor angiogenesis and on tumor growth in nude mice implanted with cervical cancer

Cancer Management and Research

Volumn 4, Issue 1, 2012, Pages 269-279

  Mahasiripanth, Taksanee ^a   Hokputsa, Sanya ^b   Niruthisard, Somchai ^a   Bhattarakosol, Parvapan ^a   Patumraj, Suthiluk ^a  

^a CHULALONGKORN UNIVERSITY   (Thailand)

^b Thailand Government Pharmaceutical Organization   (Thailand)

Author keywords

Acanthus ebracteatus Vahl; Capillary vascularity; CaSki cell implanted nude mice; Laser scanning confocal microscopy; Tumor angiogenesis; VEGF

Indexed keywords

ACANTHUS EBRACTEATUS EXTRACT; ANGIOGENESIS INHIBITOR; PLANT EXTRACT; UNCLASSIFIED DRUG; VASCULOTROPIN;

ACANTHACEAE; ACANTHUS EBRACTEATUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIANGIOGENIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CANCER INHIBITION; CELL PROLIFERATION; CELL VIABILITY; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG MEGADOSE; FEMALE; FIBROBLAST CULTURE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IC 50; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; LIVER CELL CARCINOMA; MOUSE; NONHUMAN; NUDE MOUSE; PROTEIN EXPRESSION; TREATMENT DURATION; TUMOR GROWTH; TUMOR VASCULARIZATION; TUMOR VOLUME; UTERINE CERVIX CANCER;

EID: 84930479779     PISSN: None     EISSN: 11791322     Source Type: Journal    
DOI: 10.2147/CMAR.S33596     Document Type: Article

References (54)

1. Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin. 2005;55(2):74-108.
2. Kjaer SK, Tran TN, Sparen P, et al. The burden of genital warts: a study of nearly 70,000 women from the general female population in the 4Nordic countries. J Infect Dis. 2007;196(10):1447-1454.
3. Schiffman M, Castle PE, Jeronimo J, Rodriguez AC, Wacholder S. Human papillomavirus and cervical cancer. Lancet. 2007;370(9590): 890-907.
4. zur Hausen H. Viruses in human cancers. Science. 1991;254(5035): 1167-1173.
5. Doorbar J. Molecular biology of human papillomavirus infection and cervical cancer. Clin Sci (Lond). 2006;110(5):525-541.
6. Munoz N, Castellsague X, de Gonzalez AB, Gissmann L. Chapter 1: HPV in the etiology of human cancer. Vaccine. 2006;24 Suppl 3: S3/1-10.
7. Prendiville W, Davies P. The Health Professional's HPV Handbook 1:Human Papillomavirus and Cervical Cancer. London: Informa Healthcare; 2006.
8. Van Trappen PO, Steele D, Lowe DG, et al. Expression of vascular endothelial growth factor (VEGF)-C and VEGF-D, and their receptor VEGFR-3, during different stages of cervical carcinogenesis. J Pathol. 2003;201(4):544-554.
9. No JH, Jo H, Kim SH, et al. Expression of vascular endothelial growth factor and hypoxia inducible factor-1alpha in cervical neoplasia. Ann N Y Acad Sci. 2009;1171:105-110.
10. Guidi AJ, Abu-Jawdeh G, Berse B, et al. Vascular permeability factor (vascular endothelial growth factor) expression and angiogenesis in cervical neoplasia. J Natl Cancer Inst. 1995;87(16):1237-1245.
11. Dobbs SP, Hewett PW, Johnson IR, Carmichael J, Murray JC. Angiogenesis is associated with vascular endothelial growth factor expression in cervical intraepithelial neoplasia. Br J Cancer. 1997; 76(11):1410-1415.
12. Hammes LS, Tekmal RR, Naud P, et al. Up-regulation of VEGF, c-fms and COX-2 expression correlates with severity of cervical cancer precursor (CIN) lesions and invasive disease. Gynecol Oncol. 2008;110(3): 445-451.
13. Kodama J, Seki N, Tokumo K, et al. Vascular endothelial growth factor is implicated in early invasion in cervical cancer. Eur J Cancer. 1999; 35(3):485-489.
14. Yu H, Zhang S, Zhang R, Zhang L. The role of VEGF-C/D and Flt-4 in the lymphatic metastasis of early-stage invasive cervical carcinoma. J Exp Clin Cancer Res. 2009;28:98.
15. Monk BJ, Willmott LJ, Sumner DA. Anti-angiogenesis agents in metastatic or recurrent cervical cancer. Gynecol Oncol. 2010;116(2): 181-186.
16. Bequet-Romero M, Lopez-Ocejo O. Angiogenesis modulators expression in culture cell lines positives for HPV-16 oncoproteins. Biochem Biophys Res Commun. 2000;277(1):55-61.
17. Lopez-Ocejo O, Viloria-Petit A, Bequet-Romero M, Mukhopadhyay D, Rak J, Kerbel RS. Oncogenes and tumor angiogenesis: the HPV-16 E6 oncoprotein activates the vascular endothelial growth factor (VEGF) gene promoter in a p53independent manner. Oncogene. 2000;19(40): 4611-4620.
18. Tang X, Zhang Q, Nishitani J, Brown J, Shi S, Le AD. Overexpression of human papillomavirus type 16 oncoproteins enhances hypoxia-inducible factor 1 alpha protein accumulation and vascular endothelial growth factor expression in human cervical carcinoma cells. Clin Cancer Res. 2007;13(9):2568-2576.
19. Willmott LJ, Monk BJ. Cervical cancer therapy: current, future and anti-angiogensis targeted treatment. Expert Rev Anticancer Ther. 2009;9(7): 895-903.
20. Tiwari KP, Minicha PK, Masood M. Acanthicifoline-a new alkaloid from Acanthus ilicifolius. Pol J Chem. 1980;54:857-858.
21. Minocha PK, Tiwari KP. A triterpenoidal saponin from roots of Acanthus illicifolius. Phytochemistry. 1981;20(1):135-137.
22. Jensen HFW, Jensen SR, Nielsen BJ. Chemotaxonomy of the acanthaceae. Iridoids and quaternary amines. Phytochemistry. 1988;27(8): 2581-2589.
23. Hokputsa S, Harding SE, Inngjerdingen K, et al. Bioactive polysaccharides from the stems of the Thai medicinal plant Acanthus ebracteatus: their chemical and physical features. Carbohydr Res. 2004;339(4): 753-762.
24. Kanchanapoom T, Kasai R, Picheansoonthon C, Yamasaki K. Megastigmane, aliphatic alcohol and benzoxazinoid glycosides from Acanthus ebracteatus. Phytochemistry. 2001;58(5):811-817.
25. Sittiwet C, Niamsa N, Puangpronpitag D. Antimicrobial activity of Acanthus ebracteatus Vahl aqueous extract: the potential for skin infection treatment. Int J Biol Chem. 2009;3:95-98.
26. Masathien C, Siripong P. In vitro immunopotentiating effect(s) of Acanthus ebracteatus Vahl roots on human lymphocytes. J Med Technol Assoc Thailand. 1991;15:97-103.
27. Babu BH, Shylesh BS, Padikkala J. Antioxidant and hepatoprotective effect of Acanthus ilicifolius. Fitoterapia. 2001;72(3):272-277.
28. Advani SB, Sam J. Potential anticancer and antiviral agents. Substituted 3-[1′(2′,3′,4′-tri-O-benzoyl-β-d-ribopyranosyl)]-2-benzoxazolinones. J Heterocycl Chem. 1968;5(1):119-122.
29. Babu BH, Shylesh BS, Padikkala J. Tumour reducing and anticarcinogenic activity of Acanthus ilicifolius in mice. J Ethnopharmacol. 2002;79(1):27-33.
30. Wu J, Zhang S, Xiao Q, et al. Megastigmane and flavone glycosides from Acanthus ilicifolius. Pharmazie. 2003;58(5):363-364.
31. Laupattarakasem P, Houghton PJ, Hoult JR, Itharat A. An evaluation of the activity related to inflammation of four plants used in Thailand to treat arthritis. J Ethnopharmacol. 2003;85(2-3):207-215.
32. Srivatanakul P, Naka L. Effect of Acanthus ilicifolius Linn. in treatment of leukemic mice. Thai Cancer J. 1981;7:89-93.
33. Siripong P, Kongkathip B, Kanokmedhakul K, Hitosuyanagi Y, Takeya K, Itokawa H. Study on antitumor potential of Acanthus ebracteatus Vahl roots. Thai Cancer J. 1998;24(29-37):29.
34. Tiwawech D, Siripong P, Kupradinun P. Inhibition of diethylnitrosamine (DEN)-induced hepatic foci by pre and post treatment with Acanthus ebracteatus Vahl in rats. Thai Cancer J. 1993;1-2:7-13.
35. Phisalaphong M, Thu Ha N, Siripong P. Desalting of aqueous extract of Acanthus ebracteatus Vahl by nanofiltration. Sep Sci Technol. 2006;41(3):455-470.
36. Moon DO, Lee KJ, Choi YH, Kim GY. Beta-sitosterol-induced-apoptosis is mediated by the activation of ERK and the downregulation of Akt in MCA-102murine fibrosarcoma cells. Int Immunopharmacol. 2007;7(8):1044-1053.
37. Kokpol U, Chittawong V, Miles DH. Chemical constituents of the roots of Acanthus illicifolius. J Nat Prod. 1986;49(2):355-356.
38. Hartwell JL. Types of anticancer agents isolated from plants. Cancer Treat Rep. 1976;60(8):1031-1067.
39. Handa SS, Khanuja SPS, Longo G, Rakesh DD. Extraction Technologies for Medicinal and Aromatic Plants. Trieste: International Centre for Science and High Technology; 2008:266.
40. Lertworapreecha M, Patumraj S, Niruthisard S, Hansasuta P, Bhattarakosol P. Mouse acquired HPV tumor using dorsal skin-fold window chamber. Indian J Exp Biol. 2009;47(5):327-332.
41. Viboolvorakul S, Niimi H, Wongeak-in N, Eksakulkla S, Patumraj S. Increased capillary vascularity in the femur of aged rats by exercise training. Microvasc Res. 2009;78(3):459-463.
42. Patumraj S, Yoysungnoen P, Kachonrattanadet P, Wirachwong P. Tumor neocapillary density in hepatocellular carcinoma cells implanted nude mice model. Clin Hemorheol Microcirc. 2005;33(2):137-144.
43. Tomayko MM, Reynolds CP. Determination of subcutaneous tumor size in athymic (nude) mice. Cancer Chemother Pharmacol. 1989;24(3): 148-154.
44. Fok TCO, Jan A, Peel SAF, Evans AW, Clokie CML, Sándor GKB. Hyperbaric oxygen results in increased vascular endothelial growth factor (VEGF) protein expression in rabbit calvarial critical-sized defects. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008;105(4): 417-422.
45. Choi YH, Kong KR, Kim YA, et al. Induction of Bax and activation of caspases during beta-sitosterol-mediated apoptosis in human colon cancer cells. Int J Oncol. 2003;23(6):1657-1662.
46. Awad AB, Roy R, Fink CS. Beta-sitosterol, a plant sterol, induces apoptosis and activates key caspases in MDA-MB-231 human breast cancer cells. Oncol Rep. 2003;10(2):497-500.
47. Triratanachat S, Niruthisard S, Trivijitsilp P, Tresukosol D, Jarurak N. Angiogenesis in cervical intraepithelial neoplasia and early-staged uterine cervical squamous cell carcinoma: clinical significance. Int J Gynecol Cancer. 2006;16(2):575-580.
48. Obermair A, Bancher-Todesca D, Bilgi S, et al. Correlation of vascular endothelial growth factor expression and microvessel density in cervical intraepithelial neoplasia. J Natl Cancer Inst. 1997;89(16): 1212-1217.
49. Smith-McCune K, Zhu YH, Hanahan D, Arbeit J. Cross-species comparison of angiogenesis during the premalignant stages of squamous carcinogenesis in the human cervix and K14-HPV16 transgenic mice. Cancer Res. 1997;57(7):1294-1300.
50. Nakamura M, Bodily JM, Beglin M, Kyo S, Inoue M, Laimins LA. Hypoxia-specific stabilization of HIF-1alpha by human papillomaviruses. Virology. 2009;387(2):442-448.
51. Agshikar NV, Naik VR, Abraham GJ, Reddy CV, Naqvo SW, Mittal PK. Analgesic anti-inflammatory activity of Acanthus illicifolius Linn. Indian J Exp Biol. 1979;17(11):1257-1258.
52. Liu M, Pelling JC, Ju J, Chu E, Brash DE. Antioxidant action via p53-mediated apoptosis. Cancer Res. 1998;58(8):1723-1729.
53. Maity P, Chakraborty S, Bhattacharya P. Neovascularisation offers a new perspective to glutamine related therapy. Indian J Exp Biol. 2000; 38(1):88-90.
54. Nguyen P, Ho CL, Teo SS, Harikrishna J, Rahim R. Sequence and transcript analyses of antioxidant genes from Acanthus ebracteatus Vahl. Tree Genet Genomes. 2008;4(4):705-713.