Dose-dependent suppression of human photoparoxysmal response with the competitive AMPA/kainate receptor antagonist BGG492: Clear PK/PD relationship

Epilepsia

Volumn 56, Issue 6, 2015, Pages 924-932

  Kasteleijn Nolst Trenité, Dorotheé ^a   Brandt, Christian ^b   Mayer, Thomas ^c   Rosenow, Felix ^d,e   Schmidt, Bernd ^f   Steinhoff, Bernhard J ^g   Gardin, Anne ^h   Imbert, Georges ^h   Johns, Donald ⁱ   Sagkriotis, Alexandros ^h   Kucher, Klaus ^h  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b EPILEPSY CENTER BETHEL   (Germany)

^c Saxonian Epilepsy Center   (Germany)

^d PHILIPPS UNIVERSITY MARBURG   (Germany)

^e GOETHE UNIVERSITY   (Germany)

^f Neurology and Psychiatry Clinic   (Germany)

^g EPILEPSIEZENTRUM KORK   (Germany)

^h NOVARTIS PHARMA AG   (Switzerland)

ⁱ BIOGEN   (United States)

Author keywords

Antiepileptic drugs; BGG492; Kainate; Photoparoxysmal; Selurampanel; Amino 3 hydroxy 5 methyl 4 isoxazolepropionic acid

Indexed keywords

PLACEBO; SELURAMPANEL; ANTICONVULSIVE AGENT; QUINAZOLINONE DERIVATIVE;

ADULT; ARTICLE; BLURRED VISION; COHORT ANALYSIS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DIZZINESS; DOSE RESPONSE; DRUG EFFICACY; DRUG SAFETY; DRUG SCREENING; DRUG TOLERABILITY; ELECTROENCEPHALOGRAPHY; EPILEPSY; EPILEPTIC DISCHARGE; FATIGUE; FEMALE; HEADACHE; HUMAN; MALE; MAXIMUM PLASMA CONCENTRATION; MIDDLE AGED; MULTICENTER STUDY; NORMAL HUMAN; PHARMACOLOGICAL PARAMETERS; PHASE 2 CLINICAL TRIAL; PHOTOPAROXYSMAL RESPONSE; PHOTOSENSITIVE EPILEPSY; PHOTOSENSITIVITY; PRIORITY JOURNAL; RHINOPHARYNGITIS; SINGLE DRUG DOSE; STANDARDIZED PHOTOPAROXYSMAL RESPONSE; STROBOSCOPY; YOUNG ADULT; ADOLESCENT; ADVERSE EFFECTS; AGED; AREA UNDER THE CURVE; BLOOD; CLINICAL TRIAL; EPILEPSY, REFLEX; PHOTOSTIMULATION; SINGLE BLIND PROCEDURE;

ADOLESCENT; ADULT; AGED; ANTICONVULSANTS; AREA UNDER CURVE; COHORT STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROENCEPHALOGRAPHY; EPILEPSY, REFLEX; FEMALE; HUMANS; MALE; MIDDLE AGED; PHOTIC STIMULATION; QUINAZOLINONES; SINGLE-BLIND METHOD; YOUNG ADULT;

EID: 84930473213     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/epi.13008     Document Type: Article

References (22)

1. Rogawski MA,. Revisiting AMPA receptors as an antiepileptic drug target. Epilepsy Curr 2011; 11: 56-63.
2. Vincent P, Mulle C,. Kainate receptors in epilepsy and excitotoxicity. Neuroscience 2009; 158: 309-323.
3. Eisai Inc. Fycompa™ (perampanel) summary of product characteristics. Updated Dec 2013.
4. Eisai Inc. Fycompa™ (perampanel) prescribing information. Updated Oct 2013.
5. Faught E,. BGG492 (selurampanel), an AMPA/kainate receptor antagonist drug for epilepsy. Expert Opin Investig Drugs 2014; 23: 107-113.
6. Binnie CD, Kasteleijn-Nolst Trenite DG, De Korte R,. Photosensitivity as a model for acute antiepileptic drug studies. Electroencephalogr Clin Neurophysiol 1986; 63: 35-41.
7. Kasteleijn-Nolst Trenite DG, Marescaux C, Stodieck S, et al., Photosensitive epilepsy: a model to study the effects of antiepileptic drugs. Evaluation of the piracetam analogue, levetiracetam. Epilepsy Res 1996; 25: 225-230.
8. Kasteleijn-Nolst Trenite DG, Genton P, Parain D, et al., Evaluation of brivaracetam, a novel SV2A ligand, in the photosensitivity model. Neurology 2007; 69: 1027-1034.
9. Yuen ES, Sims JR,. How predictive are photosensitive epilepsy models as proof of principle trials for epilepsy? Seizure 2014; 23: 490-493.
10. Schmidt B,. Clinical development of antiepileptic drugs in adults. Neurotherapeutics 2007; 4: 62-69.
11. Kasteleijn-Nolst Trenite D, Parain D, Genton P, et al., Efficacy of the histamine 3 receptor (H3R) antagonist pitolisant (formerly known as tiprolisant; BF2.649) in epilepsy: dose-dependent effects in the human photosensitivity model. Epilepsy Behav 2013; 28: 66-70.
12. Kasteleijn-Nolst Trenite DG, Biton V, French JA, et al., Kv7 potassium channel activation with ICA-105665 reduces photoparoxysmal EEG responses in patients with epilepsy. Epilepsia 2013; 54: 1437-1443.
13. Kasteleijn-Nolst Trenite D, Rubboli G, Hirsch E, et al., Methodology of photic stimulation revisited: updated European algorithm for visual stimulation in the EEG laboratory. Epilepsia 2012; 53: 16-24.
14. Kasteleijn-Nolst Trenite DG, Hirsch E, Reed RC, et al., Comment from Dorothee G.A. Kasteleijn-Nolst Trenite, Edouard Hirsch, Ronald C. Reed, Bassel Abou-Khalil, and Bernd Schmidt on: how predictive are photosensitive epilepsy models as proof of principle trials for epilepsy? Seizure 2014; 23: 922-923.
15. Rowan AJ, Binnie CD, Warfield CA, et al., The delayed effect of sodium valproate on the photoconvulsive response in man. Epilepsia 1979; 20: 61-68.
16. Rimmer EM, Milligan NM, Richens A,. A comparison of the acute effect of single doses of vigabatrin and sodium valproate on photosensitivity in epileptic patients. Epilepsy Res 1987; 1: 339-346.
17. Moller A, Jensen LH, Skrumsager B, et al., Inhibition of photosensitive seizures in man by the beta-carboline, ZK 95962, a selective benzodiazepine receptor agonist. Epilepsy Res 1990; 5: 155-159.
18. Saenz-Lope E, Herranz-Tanarro FJ, Masdeu JC, et al., Familial photosensitive epilepsy: effectiveness of clonazepam. Clin Electroencephalogr 1984; 15: 47-52.
19. Binnie CD, van Emde Boas W, Kasteleijn-Nolste-Trenite DG, et al., Acute effects of lamotrigine (BW430C) in persons with epilepsy. Epilepsia 1986; 27: 248-254.
20. Trenite DG, French JA, Hirsch E, et al., Evaluation of carisbamate, a novel antiepileptic drug, in photosensitive patients: an exploratory, placebo-controlled study. Epilepsy Res 2007; 74: 193-200.
21. Kasteleijn-Nolst Trenite DG, van Emde Boas W, Groenhout CM, et al., Preliminary assessment of the efficacy of Org 6370 in photosensitive epileptic patients: paradoxical enhancement of photosensitivity and provocation of myoclonic seizures. Epilepsia 1992; 33: 135-141.
22. Kasteleijn-Nolst Trenite DG, Guerrini R, Binnie CD, et al., Visual sensitivity and epilepsy: a proposed terminology and classification for clinical and EEG phenomenology. Epilepsia 2001; 42: 692-701.