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Volumn 15, Issue 6, 2015, Pages 623-628

Classification of KIT/PDGFRA wild-type gastrointestinal stromal tumors: Implications for therapy

Author keywords

BRAF; GIST; imatinib; KIT; NF1; PDGFRA; SDHA; SDHB; wild type

Indexed keywords

B RAF KINASE; DABRAFENIB; IMATINIB; K RAS PROTEIN; LINSITINIB; NEUROFIBROMIN; PLACEBO; SUCCINATE DEHYDROGENASE; SUNITINIB; ANTINEOPLASTIC AGENT; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; STEM CELL FACTOR RECEPTOR;

EID: 84930460618     PISSN: 14737140     EISSN: 17448328     Source Type: Journal    
DOI: 10.1586/14737140.2015.1032941     Document Type: Review
Times cited : (31)

References (51)
  • 1
    • 84879957303 scopus 로고    scopus 로고
    • A subset of gastrointestinal stromal tumors previously regarded as wild-type tumors carries somatic activating mutations in KIT exon 8 (p.D419del)
    • Huss S, Künstlinger H, Wardelmann E, et al. A subset of gastrointestinal stromal tumors previously regarded as wild-type tumors carries somatic activating mutations in KIT exon 8 (p.D419del). Mod Pathol 2013;26(7):1004-12
    • (2013) Mod Pathol , vol.26 , Issue.7 , pp. 1004-1012
    • Huss, S.1    Künstlinger, H.2    Wardelmann, E.3
  • 2
    • 0032989226 scopus 로고    scopus 로고
    • C-kit proto-oncogene exon 8 in-frame deletion plus insertion mutations in acute myeloid leukaemia
    • Gari M, Goodeve A, Wilson G, et al. c-kit proto-oncogene exon 8 in-frame deletion plus insertion mutations in acute myeloid leukaemia. Br J Haematol 1999;105: 894-900
    • (1999) Br J Haematol , vol.105 , pp. 894-900
    • Gari, M.1    Goodeve, A.2    Wilson, G.3
  • 3
    • 0038170400 scopus 로고    scopus 로고
    • Incidence and prognosis of c-KIT and FLT3 mutations in core binding factor (CBF) acute myeloid leukaemias
    • Care R, Valk P, Goodeve A, et al. Incidence and prognosis of c-KIT and FLT3 mutations in core binding factor (CBF) acute myeloid leukaemias. Br J Haematol 2003;121:775-7
    • (2003) Br J Haematol , vol.121 , pp. 775-777
    • Care, R.1    Valk, P.2    Goodeve, A.3
  • 4
    • 24144503371 scopus 로고    scopus 로고
    • Novel germline mutation of KIT associated with familial gastrointestinal stromal tumor and mastocytosis
    • Hartmann K, Wardelmann E, Ma Y, et al. Novel germline mutation of KIT associated with familial gastrointestinal stromal tumor and mastocytosis. Gastroenterology 2005;129:1042-6
    • (2005) Gastroenterology , vol.129 , pp. 1042-1046
    • Hartmann, K.1    Wardelmann, E.2    Ma, Y.3
  • 5
    • 33750618188 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumors: Pathology and prognosis at different sites
    • Miettinen M, Lasota J. Gastrointestinal stromal tumors: pathology and prognosis at different sites. Semin Diagn Pathol 2006;23: 70-83
    • (2006) Semin Diagn Pathol , vol.23 , pp. 70-83
    • Miettinen, M.1    Lasota, J.2
  • 6
    • 84911480554 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumours: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
    • ESMO/European Sarcoma Network Working Group
    • ESMO/European Sarcoma Network Working Group. Gastrointestinal stromal tumours: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2014;25(Suppl 3): iii21-6
    • (2014) Ann Oncol , vol.25 , pp. iii21-iii26
  • 7
    • 12144291080 scopus 로고    scopus 로고
    • Use of c-kit/PDGFRA mutational analysis to predict the clinical response to imatinib in patients with advanced gastrointestinal stromal tumours entered on phase i and II studies of the EORTC Soft Tissue and Bone Sarcoma Group
    • Debiec-Rychter M, Dumez H, Judson I, et al. Use of c-kit/PDGFRA mutational analysis to predict the clinical response to imatinib in patients with advanced gastrointestinal stromal tumours entered on phase I and II studies of the EORTC Soft Tissue and Bone Sarcoma Group. Eur J Cancer 2004;40:689-95
    • (2004) Eur J Cancer , vol.40 , pp. 689-695
    • Debiec-Rychter, M.1    Dumez, H.2    Judson, I.3
  • 8
    • 0642368571 scopus 로고    scopus 로고
    • Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumors
    • Heinrich MC, Corless CL, Demetri GD, et al. Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumors. J Clin Oncol 2003;21:4342-9
    • (2003) J Clin Oncol , vol.21 , pp. 4342-4349
    • Heinrich, M.C.1    Corless, C.L.2    Demetri, G.D.3
  • 9
    • 84859187987 scopus 로고    scopus 로고
    • Twelve versus 36 months of adjuvant imatinib (IM) as treatment of operable GIST with a high risk of recurrence: Final results of a randomized trial (SSGXVIII/AIO)
    • Joensuu H, Eriksson M, Hartmann J, et al. Twelve versus 36 months of adjuvant imatinib (IM) as treatment of operable GIST with a high risk of recurrence: final results of a randomized trial (SSGXVIII/AIO). JAMA 2011;307(12):1265-72
    • (2011) JAMA , vol.307 , Issue.12 , pp. 1265-1272
    • Joensuu, H.1    Eriksson, M.2    Hartmann, J.3
  • 10
    • 62849096370 scopus 로고    scopus 로고
    • Adjuvant imatinib mesylate after resection of localised, primary gastrointestinal stromal tumour: A randomised, double-blind, placebo-controlled trial
    • American College of Surgeons Oncology Group (ACOSOG) Intergroup Adjuvant GIST Study Team
    • Dematteo R, Ballman K, Antonescu C, American College of Surgeons Oncology Group (ACOSOG) Intergroup Adjuvant GIST Study Team. Adjuvant imatinib mesylate after resection of localised, primary gastrointestinal stromal tumour: a randomised, double-blind, placebo-controlled trial. Lancet 2009;373: 1097-104
    • (2009) Lancet , vol.373 , pp. 1097-1104
    • Dematteo, R.1    Ballman, K.2    Antonescu, C.3
  • 11
    • 0042338788 scopus 로고    scopus 로고
    • Deletion of Trp-557 and Lys-558 in the juxtamembrane domain of the c-kit protooncogene is associated with metastatic behavior of gastrointestinal stromal tumors
    • Wardelmann E, Losen I, Hans V, et al. Deletion of Trp-557 and Lys-558 in the juxtamembrane domain of the c-kit protooncogene is associated with metastatic behavior of gastrointestinal stromal tumors. Int J Cancer 2003;106:887-95
    • (2003) Int J Cancer , vol.106 , pp. 887-895
    • Wardelmann, E.1    Losen, I.2    Hans, V.3
  • 12
    • 24944536236 scopus 로고    scopus 로고
    • Deletions affecting codons 557-558 of the c-KIT gene indicate a poor prognosis in patients with completely resected gastrointestinal stromal tumors: A study by the Spanish Group for Sarcoma Research (GEIS)
    • Martin J, Poveda A, Llombart-Bosch A, et al. Deletions affecting codons 557-558 of the c-KIT gene indicate a poor prognosis in patients with completely resected gastrointestinal stromal tumors: a study by the Spanish Group for Sarcoma Research (GEIS). J Clin Oncol 2005;23:6190-8
    • (2005) J Clin Oncol , vol.23 , pp. 6190-6198
    • Martin, J.1    Poveda, A.2    Llombart-Bosch, A.3
  • 13
    • 77954300616 scopus 로고    scopus 로고
    • Prognostic time dependence of deletions affecting codons 557 and/or 558 of KIT gene for relapse-free survival (RFS) in localized GIST: A Spanish Group for Sarcoma Research (GEIS) Study
    • Martin-Broto J, Gutierrez A, Garcia-del-Muro X, et al. Prognostic time dependence of deletions affecting codons 557 and/or 558 of KIT gene for relapse-free survival (RFS) in localized GIST: a Spanish Group for Sarcoma Research (GEIS) Study. Ann Oncol 2010;21:1552-7
    • (2010) Ann Oncol , vol.21 , pp. 1552-1557
    • Martin-Broto, J.1    Gutierrez, A.2    Garcia-Del-Muro, X.3
  • 14
    • 84917706867 scopus 로고    scopus 로고
    • Tumor genotype is an independent prognostic factor in primary gastrointestinal stromal tumors of gastric origin: A European multicenter analysis based on ConticaGIST
    • Wozniak A, Rutkowski P, Schöffski P, et al. Tumor genotype is an independent prognostic factor in primary gastrointestinal stromal tumors of gastric origin: a European multicenter analysis based on ConticaGIST. Clin Cancer Res 2014;20(23):6105-16.
    • (2014) Clin Cancer Res , vol.20 , Issue.23 , pp. 6105-6116
    • Wozniak, A.1    Rutkowski, P.2    Schöffski, P.3
  • 15
    • 84860290527 scopus 로고    scopus 로고
    • Treatment guidelines for gastrointestinal stromal tumors in children and young adults
    • Janeway KA, Pappo A. Treatment guidelines for gastrointestinal stromal tumors in children and young adults. J Pediatr Hematol Oncol 2012;34(Suppl 2):S69-72
    • (2012) J Pediatr Hematol Oncol , vol.34 , pp. S69-72
    • Janeway, K.A.1    Pappo, A.2
  • 16
    • 78651082042 scopus 로고    scopus 로고
    • Pediatric and Wild-Type GIST Clinic. Defects in succinate dehydrogenase in gastrointestinal stromal tumors lacking KIT and PDGFRA mutations
    • Janeway KA, Kim SY, Lodish M, et al; Pediatric and Wild-Type GIST Clinic. Defects in succinate dehydrogenase in gastrointestinal stromal tumors lacking KIT and PDGFRA mutations. Proc Natl Acad Sci USA 2011;108(1):314-18
    • (2011) Proc Natl Acad Sci USA , vol.108 , Issue.1 , pp. 314-318
    • Janeway, K.A.1    Kim, S.Y.2    Lodish, M.3
  • 17
    • 84868200205 scopus 로고    scopus 로고
    • Patterns of deregulation of insulin growth factor signalling pathway in paediatric and adult gastrointestinal stromal tumours
    • Italiano A, Chen J, Zhang L, et al. Patterns of deregulation of insulin growth factor signalling pathway in paediatric and adult gastrointestinal stromal tumours. Eur J Cancer 2012;48(17):3215-22
    • (2012) Eur J Cancer , vol.48 , Issue.17 , pp. 3215-3222
    • Italiano, A.1    Chen, J.2    Zhang, L.3
  • 18
    • 50249152932 scopus 로고    scopus 로고
    • Novel V600E BRAF mutations in imatinib-naive and imatinib-resistant gastrointestinal stromal tumors
    • Agaram N, Wong G, Guo T, et al. Novel V600E BRAF mutations in imatinib-naive and imatinib-resistant gastrointestinal stromal tumors. Genes Chromosomes Cancer 2008;47(10):853-9.
    • (2008) Genes Chromosomes Cancer , vol.47 , Issue.10 , pp. 853-859
    • Agaram, N.1    Wong, G.2    Guo, T.3
  • 19
    • 18444374405 scopus 로고    scopus 로고
    • Mutations of the BRAF gene in human cancer
    • Davies H, Bignell GR, Cox C, et al. Mutations of the BRAF gene in human cancer. Nature 2002;417(6892):949-54
    • (2002) Nature , vol.417 , Issue.6892 , pp. 949-954
    • Davies, H.1    Bignell, G.R.2    Cox, C.3
  • 20
    • 12144289677 scopus 로고    scopus 로고
    • Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF
    • Wan PT, Garnett MJ, Roe SM, et al. Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF. Cell 2004;116(6):855-67
    • (2004) Cell , vol.116 , Issue.6 , pp. 855-867
    • Wan, P.T.1    Garnett, M.J.2    Roe, S.M.3
  • 21
    • 73949094832 scopus 로고    scopus 로고
    • BRAF mutation status in gastrointestinal stromal tumors
    • Hostein I, Faur N, Primois C, et al. BRAF mutation status in gastrointestinal stromal tumors. Am J Clin Pathol 2010;133(1): 141-8
    • (2010) Am J Clin Pathol , vol.133 , Issue.1 , pp. 141-148
    • Hostein, I.1    Faur, N.2    Primois, C.3
  • 22
    • 67650480850 scopus 로고    scopus 로고
    • V600E BRAF mutations are alternative early molecular events in a subset of KIT/PDGFRA wild-type gastrointestinal stromal tumours
    • Agaimy A, Terracciano LM, Dirnhofer S, et al. V600E BRAF mutations are alternative early molecular events in a subset of KIT/PDGFRA wild-type gastrointestinal stromal tumours. J Clin Pathol 2009;62(7):613-16
    • (2009) J Clin Pathol , vol.62 , Issue.7 , pp. 613-616
    • Agaimy, A.1    Terracciano, L.M.2    Dirnhofer, S.3
  • 23
    • 68049123582 scopus 로고    scopus 로고
    • Low frequency of MAP kinase pathway alterations in KIT and PDGFRA wild-type GISTs
    • Martinho O, Gouveia A, Viana-Pereira M, et al. Low frequency of MAP kinase pathway alterations in KIT and PDGFRA wild-type GISTs. Histopathology 2009;55(1):53-62
    • (2009) Histopathology , vol.55 , Issue.1 , pp. 53-62
    • Martinho, O.1    Gouveia, A.2    Viana-Pereira, M.3
  • 24
    • 84875761522 scopus 로고    scopus 로고
    • BRAF mutant gastrointestinal stromal tumor: First report of regression with BRAF inhibitor dabrafenib (GSK2118436) and whole exomic sequencing for analysis of acquired resistance
    • Falchook GS, Trent JC, Heinrich MC, et al. BRAF mutant gastrointestinal stromal tumor: first report of regression with BRAF inhibitor dabrafenib (GSK2118436) and whole exomic sequencing for analysis of acquired resistance. Oncotarget 2013;4(2): 310-15
    • (2013) Oncotarget , vol.4 , Issue.2 , pp. 310-315
    • Falchook, G.S.1    Trent, J.C.2    Heinrich, M.C.3
  • 25
    • 84858179982 scopus 로고    scopus 로고
    • KRAS and BRAF mutations predict primary resistance to imatinib in gastrointestinal stromal tumors
    • Miranda C, Nucifora M, Molinari F, et al. KRAS and BRAF mutations predict primary resistance to imatinib in gastrointestinal stromal tumors. Clin Cancer Res 2012; 18(6):1769-76
    • (2012) Clin Cancer Res , vol.18 , Issue.6 , pp. 1769-1776
    • Miranda, C.1    Nucifora, M.2    Molinari, F.3
  • 26
    • 84890523346 scopus 로고    scopus 로고
    • On the prevalence of KRAS mutations in GISTs
    • Ricci R, Dei Tos AP, Rindi G. On the prevalence of KRAS mutations in GISTs. Virchows Arch 2013;463(6):847
    • (2013) Virchows Arch , vol.463 , Issue.6 , pp. 847
    • Ricci, R.1    Dei Tos, A.P.2    Rindi, G.3
  • 27
    • 84887111618 scopus 로고    scopus 로고
    • No KRAS mutations found in gastrointestinal stromal tumors (GISTs): Molecular genetic study of 514 cases
    • Lasota J, Xi L, Coates T, et al. No KRAS mutations found in gastrointestinal stromal tumors (GISTs): molecular genetic study of 514 cases. Mod Pathol 2013;26(11): 1488-91
    • (2013) Mod Pathol , vol.26 , Issue.11 , pp. 1488-1491
    • Lasota, J.1    Xi, L.2    Coates, T.3
  • 28
    • 84921464373 scopus 로고    scopus 로고
    • Novel oncogene and tumor suppressor mutations in KIT and PDGFRA wild type gastrointestinal stromal tumors revealed by next generation sequencing
    • Hechtman JF, Zehir A, Mitchell T, et al. Novel oncogene and tumor suppressor mutations in KIT and PDGFRA wild type gastrointestinal stromal tumors revealed by next generation sequencing. Genes Chromosomes Cancer 2014;54(3):177-84.
    • (2014) Genes Chromosomes Cancer , vol.54 , Issue.3 , pp. 177-184
    • Hechtman, J.F.1    Zehir, A.2    Mitchell, T.3
  • 29
    • 0030960182 scopus 로고    scopus 로고
    • Malignant and benign tumors in patients with neurofibromatosis type 1 in a defined Swedish population
    • Zoller ME, Rembeck B, Oden A, et al. Malignant and benign tumors in patients with neurofibromatosis type 1 in a defined Swedish population. Cancer 1997;79: 2125-31
    • (1997) Cancer , vol.79 , pp. 2125-2131
    • Zoller, M.E.1    Rembeck, B.2    Oden, A.3
  • 30
    • 51649112019 scopus 로고    scopus 로고
    • Therapeutic consequences from molecular biology for GIST patients affected by neurofibromatosis type i
    • Mussi C, Schildhaus H, Gronchi A, et al. Therapeutic consequences from molecular biology for GIST patients affected by neurofibromatosis type I. Clin Cancer Res 2008;14(14):4550-5
    • (2008) Clin Cancer Res , vol.14 , Issue.14 , pp. 4550-4555
    • Mussi, C.1    Schildhaus, H.2    Gronchi, A.3
  • 31
    • 84907398280 scopus 로고    scopus 로고
    • Integrated genomic study of quadruple-WT GIST (KIT/PDGFRA/SDH/RAS pathway wild-type GIST)
    • Nannini M, Astolfi A, Urbini M, et al. Integrated genomic study of quadruple-WT GIST (KIT/PDGFRA/SDH/RAS pathway wild-type GIST). BMC Cancer 2014;14:685.
    • (2014) BMC Cancer , vol.14 , pp. 685
    • Nannini, M.1    Astolfi, A.2    Urbini, M.3
  • 32
    • 0036499042 scopus 로고    scopus 로고
    • Familial paraganglioma and gastric stromal sarcoma: A new syndrome distinct from the Carney triad
    • Carney J, Stratakis C. Familial paraganglioma and gastric stromal sarcoma: a new syndrome distinct from the Carney triad. Am J Med Genet 2002;108:132-9
    • (2002) Am J Med Genet , vol.108 , pp. 132-139
    • Carney, J.1    Stratakis, C.2
  • 33
    • 77958164441 scopus 로고    scopus 로고
    • SDHA is a tumor suppressor gene causing paraganglioma
    • Burnichon N, Briere JJ, Libe R, et al. SDHA is a tumor suppressor gene causing paraganglioma. Hum Mol Genet 2010;19: 3011-20
    • (2010) Hum Mol Genet , vol.19 , pp. 3011-3020
    • Burnichon, N.1    Briere, J.J.2    Libe, R.3
  • 34
    • 37349074531 scopus 로고    scopus 로고
    • Clinical and molecular genetics of patients with the Carney-Stratakis syndrome and germline mutations of the genes coding for the succinate dehydrogenase subunits SDHB, SDHC, and SDHD
    • Pasini B, McWhinney SR, Bei T, et al. Clinical and molecular genetics of patients with the Carney-Stratakis syndrome and germline mutations of the genes coding for the succinate dehydrogenase subunits SDHB, SDHC, and SDHD. Eur J Hum Genet 2008;16(1):79-88
    • (2008) Eur J Hum Genet , vol.16 , Issue.1 , pp. 79-88
    • Pasini, B.1    McWhinney, S.R.2    Bei, T.3
  • 35
    • 80055020285 scopus 로고    scopus 로고
    • Succinate dehydrogenase-deficient GIST: A clinicopathologic, immunohistochemical, and molecular genetic study of 66 gastric GIST with predilection to young age
    • Miettinen M, Wang Z, Sarlomo-Rikala M, et al. Succinate dehydrogenase-deficient GIST: a clinicopathologic, immunohistochemical, and molecular genetic study of 66 gastric GIST with predilection to young age. Am J Surg Pathol 2011;35:1712-21
    • (2011) Am J Surg Pathol , vol.35 , pp. 1712-1721
    • Miettinen, M.1    Wang, Z.2    Sarlomo-Rikala, M.3
  • 36
    • 79959715470 scopus 로고    scopus 로고
    • SDHA loss-of-function mutations in KIT-PDGFRA wild-type gastrointestinal stromal tumors identified by massively parallel sequencing
    • Pantaleo M, Astolfi A, Indio V, et al. SDHA loss-of-function mutations in KIT-PDGFRA wild-type gastrointestinal stromal tumors identified by massively parallel sequencing. J Natl Cancer Inst 2011;103(12):983-7
    • (2011) J Natl Cancer Inst , vol.103 , Issue.12 , pp. 983-987
    • Pantaleo, M.1    Astolfi, A.2    Indio, V.3
  • 37
    • 84890807165 scopus 로고    scopus 로고
    • Analysis of all subunits, SDHA, SDHB, SDHC, SDHD, of the succinate dehydrogenase complex in KIT/PDGFRA wild-type GIST
    • Pantaleo M, Astolfi A, Urbini M, et al. Analysis of all subunits, SDHA, SDHB, SDHC, SDHD, of the succinate dehydrogenase complex in KIT/PDGFRA wild-type GIST. Eur J of Hum Genet 2014;22:32-9.
    • (2014) Eur J of Hum Genet , vol.22 , pp. 32-39
    • Pantaleo, M.1    Astolfi, A.2    Urbini, M.3
  • 38
    • 34548386693 scopus 로고    scopus 로고
    • Familial gastrointestinal stromal tumors and germ-line mutations
    • International Carney Triad and Carney-Stratakis Syndrome Consortium
    • McWhinney SR, Pasini B, Stratakis CA; International Carney Triad and Carney-Stratakis Syndrome Consortium. Familial gastrointestinal stromal tumors and germ-line mutations. N Engl J Med 2007; 357(10):1054-6
    • (2007) N Engl J Med , vol.357 , Issue.10 , pp. 1054-1056
    • McWhinney, S.R.1    Pasini, B.2    Stratakis, C.A.3
  • 39
    • 84905973034 scopus 로고    scopus 로고
    • Aberrant DNA hypermethylation of SDHC: A novel mechanism of tumor development in Carney triad
    • Haller F, Moskalev EA, Faucz FR, et al. Aberrant DNA hypermethylation of SDHC: a novel mechanism of tumor development in Carney triad. Endocr Relat Cancer 2014; 21(4):567-77.
    • (2014) Endocr Relat Cancer , vol.21 , Issue.4 , pp. 567-577
    • Haller, F.1    Moskalev, E.A.2    Faucz, F.R.3
  • 40
    • 0017736213 scopus 로고
    • The triad of gastric leiomyosarcoma, functioning extra-adrenal paraganglioma and pulmonary chondroma
    • Carney JA, Sheps SG, Go VL, Gordon H. The triad of gastric leiomyosarcoma, functioning extra-adrenal paraganglioma and pulmonary chondroma. N Engl J Med 1977;296:1517-18
    • (1977) N Engl J Med , vol.296 , pp. 1517-1518
    • Carney, J.A.1    Sheps, S.G.2    Go, V.L.3    Gordon, H.4
  • 41
    • 70349904764 scopus 로고    scopus 로고
    • Carney triad: A syndrome featuring paraganglionic, adrenocortical, and possibly other endocrine tumors
    • Carney JA. Carney triad: a syndrome featuring paraganglionic, adrenocortical, and possibly other endocrine tumors. J Clin Endocrinol Metab 2009;94:3656-62
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 3656-3662
    • Carney, J.A.1
  • 42
    • 66849135214 scopus 로고    scopus 로고
    • The triad of paragangliomas, gastric stromal tumours and pulmonary chondromas (Carney triad), and the dyad of paragangliomas and gastric stromal sarcomas (Carney-Stratakis syndrome): Molecular genetics and clinical implications
    • Stratakis CA, Carney JA. The triad of paragangliomas, gastric stromal tumours and pulmonary chondromas (Carney triad), and the dyad of paragangliomas and gastric stromal sarcomas (Carney-Stratakis syndrome): molecular genetics and clinical implications. J Intern Med 2009;266(1): 43-52
    • (2009) J Intern Med , vol.266 , Issue.1 , pp. 43-52
    • Stratakis, C.A.1    Carney, J.A.2
  • 43
    • 73949152219 scopus 로고    scopus 로고
    • Gastric stromal tumors in Carney triad are different clinically, pathologically, and behaviorally from sporadic gastric gastrointestinal stromal tumors: Findings in 104 cases
    • Zhang L, Smyrk T, Young WJ, et al. Gastric stromal tumors in Carney triad are different clinically, pathologically, and behaviorally from sporadic gastric gastrointestinal stromal tumors: findings in 104 cases. Am J Surg Pathol 2010;34:53-6
    • (2010) Am J Surg Pathol , vol.34 , pp. 53-56
    • Zhang, L.1    Smyrk, T.2    Young, W.J.3
  • 44
    • 84919725463 scopus 로고    scopus 로고
    • Recurrent epimutation of SDHC in gastrointestinal stromal tumors
    • Killian JK, Miettinen M, Walker RL, et al. Recurrent epimutation of SDHC in gastrointestinal stromal tumors. Sci Transl Med 2014;6(268):268ra177
    • (2014) Sci Transl Med , vol.6 , Issue.268 , pp. 268ra177
    • Killian, J.K.1    Miettinen, M.2    Walker, R.L.3
  • 45
    • 80055020285 scopus 로고    scopus 로고
    • Succinate dehydrogenase-deficient GISTs: A clinicopathologic, immunohistochemical, and molecular genetic study of 66 gastric GISTs with predilection to young age
    • Miettinen M, Wang ZF, Sarlomo-Rikala M, et al. Succinate dehydrogenase-deficient GISTs: a clinicopathologic, immunohistochemical, and molecular genetic study of 66 gastric GISTs with predilection to young age. Am J Surg Pathol 2011;35(11):1712-21
    • (2011) Am J Surg Pathol , vol.35 , Issue.11 , pp. 1712-1721
    • Miettinen, M.1    Wang, Z.F.2    Sarlomo-Rikala, M.3
  • 46
    • 84930434522 scopus 로고    scopus 로고
    • Good survival outcome of metastatic SDH-deficient gastrointestinal stromal tumors harboring SDHA mutations
    • [Epub ahead of print]
    • Pantaleo MA, Lolli C, Nannini M, et al. Good survival outcome of metastatic SDH-deficient gastrointestinal stromal tumors harboring SDHA mutations. Genet Med 2014. [Epub ahead of print]
    • (2014) Genet Med
    • Pantaleo, M.A.1    Lolli, C.2    Nannini, M.3
  • 47
    • 33746401591 scopus 로고    scopus 로고
    • EORTC Soft Tissue and Bone Sarcoma Group; Italian Sarcoma Group; Australasian GastroIntestinal Trials Group. KIT mutations and dose selection for imatinib in patients with advanced gastrointestinal stromal tumours
    • Debiec-Rychter M, Sciot R, Le Cesne A, et al. EORTC Soft Tissue and Bone Sarcoma Group; Italian Sarcoma Group; Australasian GastroIntestinal Trials Group. KIT mutations and dose selection for imatinib in patients with advanced gastrointestinal stromal tumours. Eur J Cancer 2006;42(8):1093-103
    • (2006) Eur J Cancer , vol.42 , Issue.8 , pp. 1093-1103
    • Debiec-Rychter, M.1    Sciot, R.2    Le Cesne, A.3
  • 48
    • 56749098278 scopus 로고    scopus 로고
    • Primary and secondary kinase genotypes correlate with the biological and clinical activity of sunitinib in imatinib-resistant gastrointestinal stromal tumor
    • Heinrich MC, Maki RG, Corless CL, et al. Primary and secondary kinase genotypes correlate with the biological and clinical activity of sunitinib in imatinib-resistant gastrointestinal stromal tumor. J Clin Oncol 2008;26(33):5352-9
    • (2008) J Clin Oncol , vol.26 , Issue.33 , pp. 5352-5359
    • Heinrich, M.C.1    Maki, R.G.2    Corless, C.L.3
  • 49
    • 78649673624 scopus 로고    scopus 로고
    • Relation of tumor pathologic and molecular features to outcome after surgical resection of localized primary gastrointestinal stromal tumor (GIST): Results of the intergroup phase III trial ACOSOG Z9001
    • 10006
    • Corless C, Ballman KV, Antonescu C, et al. Relation of tumor pathologic and molecular features to outcome after surgical resection of localized primary gastrointestinal stromal tumor (GIST): results of the intergroup phase III trial ACOSOG Z9001. J Clin Oncol 2010;28(15 Suppl):abstract 10006
    • (2010) J Clin Oncol , vol.28 , Issue.15
    • Corless, C.1    Ballman, K.V.2    Antonescu, C.3
  • 50
    • 84927531892 scopus 로고    scopus 로고
    • Results of SARC 022, a phase II multicenter study of linsitinib in pediatric and adult wild-type (WT) gastrointestinal stromal tumors (GIST)
    • 10507
    • von Mehren M, George S, Heinrich MC, et al. Results of SARC 022, a phase II multicenter study of linsitinib in pediatric and adult wild-type (WT) gastrointestinal stromal tumors (GIST). J Clin Oncol 2014; 32(5 Suppl):abstract 10507
    • (2014) J Clin Oncol , vol.32 , Issue.5
    • Von Mehren, M.1    George, S.2    Heinrich, M.C.3
  • 51
    • 84880570416 scopus 로고    scopus 로고
    • Adrenal cortical adenomas: The fourth component of the Carney triad and an association with subclinical Cushing syndrome
    • Carney JA, Stratakis CA, Young WF Jr. Adrenal cortical adenomas: the fourth component of the Carney triad and an association with subclinical Cushing syndrome. Am J Surg Pathol 2013;37: 1140-9
    • (2013) Am J Surg Pathol , vol.37 , pp. 1140-1149
    • Carney, J.A.1    Stratakis, C.A.2    Young, W.F.3


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