Intermittent aerosol delivery to the lungs during high-flow nasal cannula therapy

Respiratory Care

Volumn 59, Issue 10, 2014, Pages 1476-1486

  Golshahi, Laleh ^a   Worth Longest, P ^a   Azimi, Mandana ^a   Syed, Aamer ^b   Hindle, Michael ^a  

^a Department of Pharmaceutics ^*  (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Condensational growth; High flow nasal cannula therapy; In vitro airway model; Nasal cannula; Pulmonary drug delivery; Submicrometer aerosol

Indexed keywords

SALBUTAMOL SULFATE; SODIUM CHLORIDE; AEROSOL; BRONCHODILATING AGENT; SALBUTAMOL;

ADULT; AEROSOL; ARTICLE; BREATHING RATE; COMPUTER ASSISTED TOMOGRAPHY; COMPUTER MODEL; CONTINUOUS AEROSOL DELIVERY; DRUG DELIVERY SYSTEM; ENHANCED CONDENSATIONAL GROWTH; EXCIPIENT ENHANCED GROWTH; FLOW RATE; HIGH FLOW NASAL CANNULA THERAPY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INTERMITTENT AEROSOL DELIVERY; LUNG; MALE; NASAL CANNULA; NONINVASIVE VENTILATION; NORMAL HUMAN; OXYGEN THERAPY; PARAMETERS; PEAK INSPIRATORY FLOW; PROCESS DESIGN; TIDAL VOLUME; ADMINISTRATION AND DOSAGE; DEVICES; EQUIPMENT DESIGN; IN VITRO STUDY; INHALATIONAL DRUG ADMINISTRATION; INTRANASAL DRUG ADMINISTRATION; MIDDLE AGED; NEBULIZER; PARTICLE SIZE;

ADMINISTRATION, INHALATION; ADMINISTRATION, INTRANASAL; ADULT; AEROSOLS; ALBUTEROL; BRONCHODILATOR AGENTS; DRUG DELIVERY SYSTEMS; EQUIPMENT DESIGN; HUMANS; IN VITRO TECHNIQUES; MALE; MIDDLE AGED; NEBULIZERS AND VAPORIZERS; PARTICLE SIZE;

EID: 84930452367     PISSN: 00201324     EISSN: 19433654     Source Type: Journal    
DOI: 10.4187/respcare.02903     Document Type: Article

References (26)

1. Dysart K, Miller TL, Wolfson MR, Shaffer TH. Research in high flow therapy: mechanisms of action. Respir Med 2009;103(10):1400-1405.
2. Ward JJ. High-flow oxygen administration by nasal cannula for adult and perinatal patients. Respir Care 2013;58(1):98-122.
3. Bhashyam AR, Wolf MT, Marcinkowski AL, Saville A, Thomas K, Carcillo JA, Corcoran TE. Aerosol delivery through nasal cannulas: an in vitro study. J Aerosol Med Pulm Drug Deliv 2008;21(2):181-188.
4. Ari A, Harwood R, Sheard M, Dailey P, Fink JB. In vitro comparison of heliox and oxygen in aerosol delivery using pediatric high flow nasal cannula. Pediatr Pulmonol 2011;46(8):795-801.
5. Perry S, Kesser K, Geller D, Selhorst D, Rendle J, Hertzog J. Influences of cannula size and flow rate on aerosol drug delivery through the Vapotherm humidified high-flow nasal cannula system. Pediatr Crit Care Med 2013;14(5):250-256.
6. Rubin BK. Pediatric aerosol therapy: new devices and new drugs. Respir Care 2011;56(9):1411-1421; discussion 1421-1423.
7. Longest PW, Golshahi L, Hindle M. Improving pharmaceutical aerosol delivery during noninvasive ventilation: effects of streamlined components. Ann Biomed Eng 2013;41(6):1217-1232.
8. Dhand R. Aerosol therapy in patients receiving noninvasive positive pressure ventilation. J Aerosol Med Pulm Drug Deliv 2012;25(2): 63-78.
9. Longest PW, Tian G, Hindle M. Improving the lung delivery of nasally administered aerosols during noninvasive ventilation: an application of enhanced condensational growth (ECG). J Aerosol Med Pulm Drug Deliv 2011;24(2):103-118.
10. Hindle M, Longest PW. Condensational growth of combination drugexcipient submicrometer particles for targeted high-efficiency pulmonary delivery: evaluation of formulation and delivery device. J Pharm Pharmacol 2012;64(9):1254-1263.
11. Longest PW, Tian G, Li X, Son YJ, Hindle M. Performance of combination drug and hygroscopic excipient submicrometer particles from a softmist inhaler in a characteristic model of the airways. Ann Biomed Eng 2012;40(12):2596-2610.
12. Son YJ, Longest PW, Tian G, Hindle M. Evaluation and modification of commercial dry powder inhalers for the aerosolization of a submicrometer excipient enhanced growth (EEG) formulation. Eur J Pharm Sci 2013;49(3):390-399.
13. Golshahi L, Tian G, Azimi M, Son YJ, Walenga R, Longest PW, Hindle M. The use of condensational growth methods for efficient drug delivery to the lungs during noninvasive ventilation high flow therapy. Pharm Res 2013;30(11):2917-2930.
14. Longest PW, Walenga RL, Son YJ, Hindle M. High efficiency generation and delivery of aerosols through nasal cannula during noninvasive ventilation. J Aerosol Med Pulm Drug Deliv 2013;26(5): 266-279.
15. Ari A, Restrepo RD. Aerosol delivery device selection for spontaneously breathing patients 2012. Respir Care 2012;57(4):613-626.
16. Möller W, Schuschnig U, Khadem Saba G, Meyer G, Junge-Hu¨lsing B, Keller M, Haüssinger K. Pulsating aerosols for drug delivery to the sinuses in healthy volunteers. Otolaryngol Head Neck Surg 2010; 142(3):382-388.
17. Dolovich MB, Killian D, Wolff RK, Obminski G, Newhouse MT. Pulmonary aerosol deposition in chronic bronchitis: intermittent positive pressure breathing versus quiet breathing. Am Rev Respir Dis 1977;115(3):397-402.
18. Camargo CA Jr, Spooner CH, Rowe BH. Continuous versus intermittent beta-agonists in the treatment of acute asthma. Cochrane Database Syst Rev 2003;(4):CD001115.
19. Bisceglia M, Belcastro A, Poerio V, Raimondi F, Mesuraca L, Crugliano C, Corapi UP. A comparison of nasal intermittent versus continuous positive pressure delivery for the treatment of moderate respiratory syndrome in preterm infants. Minerva Pediatr 2007;59(2): 91-95.
20. Mehta S, Hill NS. Noninvasive ventilation. Am J Respir Crit Care Med 2001;163(2):540-577.
21. Guilmette RA, Wicks JD, Wolff RK. Morphometry of human nasal airways using magnetic resonance imaging. J Aerosol Med 1989; 2(4):365-377.
22. Delvadia RR, Longest PW, Hindle M, Byron PR. In vitro tests for aerosol deposition. III. Effect of inhaler insertion angel on aerosol deposition. J Aerosol Med Pulm Drug Deliv 2013;26(3):145-156.
23. Hess DR. The mask for noninvasive ventilation: principles of design and effects on aerosol delivery. J Aerosol Med 2007;20(Suppl 1): S85-S98.
24. Parkes SN, Bersten AD. Aerosol kinetics and bronchodilator efficacy during continuous positive airway pressure delivered by face mask. Thorax 1997;52(2):171-175.
25. Dhand R. Inhalation therapy in invasive and noninvasive mechanical ventilation. Curr Opin Crit Care 2007;13(1):27-38.
26. Duarte AG, Momii K, Bidani A. Bronchodilator therapy with metered- dose inhaler and spacer versus nebulizer in mechanically-ventilated patients: comparison of magnitude and duration of response. Respir Care 2000;45(7):817-823.