Human metapneumovirus infection activates the TSLP pathway that drives excessive pulmonary inflammation and viral replication in mice

European Journal of Immunology

Volumn 45, Issue 6, 2015, Pages 1680-1695

  Lay, Margarita K ^a   Céspedes, Pablo F ^a   Palavecino, Christian E ^a   León, Miguel A ^a   Díaz, Rodrigo A ^a   Salazar, Francisco J ^a   Méndez, Gonzalo P ^b   Bueno, Susan M ^a,c   Kalergis, Alexis M ^a,b,c  

^a PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

^b PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

^c INSERM   (France)

Author keywords

Dendritic cells; HMPV; Inflammation; Neutrophils; OX40L; TSLP; Viral replication

Indexed keywords

CD11B ANTIGEN; INTERLEUKIN 13; INTERLEUKIN 33; INTERLEUKIN 5; INTERLEUKIN 8; NUCLEOPROTEIN; OX40 LIGAND; THYMIC STROMAL LYMPHOPOIETIN; THYMUS AND ACTIVATION REGULATED CHEMOKINE; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; CRLF2 PROTEIN, HUMAN; CYTOKINE; CYTOKINE RECEPTOR; IL33 PROTEIN, HUMAN; INTERLEUKIN DERIVATIVE; MONOCLONAL ANTIBODY;

A549 CELL LINE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; DENDRITIC CELL; HUMAN; HUMAN CELL; HUMAN METAPNEUMOVIRUS INFECTION; LUNG ALVEOLUS EPITHELIUM CELL; LUNG INFILTRATE; MOUSE; NEUTROPHIL COUNT; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; VIRUS REPLICATION; WILD TYPE; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; DEFICIENCY; DISEASE MODEL; DRUG EFFECTS; EPITHELIUM CELL; GENE EXPRESSION; GENETICS; IMMUNOLOGY; LUNG ALVEOLUS MACROPHAGE; METABOLISM; METAPNEUMOVIRUS; NEUTROPHIL; PARAMYXOVIRIDAE INFECTIONS; PATHOLOGY; PHYSIOLOGY; PNEUMONIA, VIRAL; T LYMPHOCYTE SUBPOPULATION; VIROLOGY;

ANIMALS; ANTIBODIES, MONOCLONAL; CELL LINE; CYTOKINES; DENDRITIC CELLS; DISEASE MODELS, ANIMAL; EPITHELIAL CELLS; GENE EXPRESSION; HUMANS; INTERLEUKIN-8; INTERLEUKINS; MACROPHAGES, ALVEOLAR; METAPNEUMOVIRUS; MICE; NEUTROPHILS; OX40 LIGAND; PARAMYXOVIRIDAE INFECTIONS; PNEUMONIA, VIRAL; RECEPTORS, CYTOKINE; SIGNAL TRANSDUCTION; T-LYMPHOCYTE SUBSETS; VIRUS REPLICATION;

EID: 84930415545     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201445021     Document Type: Article

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