Vitamin D and multiple sclerosis-from epidemiology to prevention

Acta Neurologica Scandinavica

Volumn 132, Issue S199, 2015, Pages 56-61

  Sundstrom P ^a   Salzer, J ^a  

^a UMEÅ UNIVERSITY   (Sweden)

Author keywords

Epidemiology; Multiple sclerosis; Prevention; Vitamin D

Indexed keywords

CALCITRIOL; OMEGA 3 FATTY ACID; PLACEBO; VITAMIN D; VITAMIN;

ANTIINFLAMMATORY ACTIVITY; CLINICAL TRIAL (TOPIC); DRUG EFFICACY; DRUG MECHANISM; ENVIRONMENTAL FACTOR; GENETIC ANALYSIS; GENETICS; GEOGRAPHY; HUMAN; IMMUNE SYSTEM; INCIDENCE; LATITUDE; MORTALITY; MULTIPLE SCLEROSIS; NONHUMAN; OBESITY; OBSERVATIONAL STUDY; PATHOGENESIS; PREVALENCE; PRIMARY PREVENTION; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; RISK FACTOR; SMOKING; SUN EXPOSURE; TREND STUDY; ULTRAVIOLET RADIATION; VITAMIN SUPPLEMENTATION; DRUG EFFECTS; ENVIRONMENT; SUNLIGHT;

ENVIRONMENT; HUMANS; IMMUNE SYSTEM; MULTIPLE SCLEROSIS; SUNLIGHT; VITAMIN D; VITAMINS;

EID: 84930406669     PISSN: 00016314     EISSN: 16000404     Source Type: Journal    
DOI: 10.1111/ane.12432     Document Type: Review

References (60)

1. Limburg CC. The geographic distribution of multiple sclerosis and its estimated prevalence in the United States. Res Publ Assoc Res Nerv Ment Dis 1950;28:15-24.
2. Gale CR, Martyn CN. Migrant studies in multiple sclerosis. Prog Neurobiol 1995;47:425-48.
3. Sloka S, Silva C, Pryse-Phillips W, Patten S, Metz L, Yong VW. A quantitative analysis of suspected environmental causes of MS. Can J Neurol Sci 2011;38:98-105.
4. Beretich BD, Beretich TM. Explaining multiple sclerosis prevalence by ultraviolet exposure: a geospatial analysis. Mult Scler 2009;15:891-8.
5. Orton SM, Wald L, Confavreux C et al. Association of UV radiation with multiple sclerosis prevalence and sex ratio in France. Neurology 2011;76:425-31.
6. Koch-Henriksen N, Sorensen PS. The changing demographic pattern of multiple sclerosis epidemiology. Lancet Neurol 2010;9:520-32.
7. Alcalde-Cabero E, Almazan-Isla J, Garcia-Merino A, de Sa J, De Pedro-Cuesta J. Incidence of multiple sclerosis among European Economic Area populations, 1985-2009: the framework for monitoring. BMC Neurol 2013;13:58.
8. Kingwell E, Marriott JJ, Jette N et al. Incidence and prevalence of multiple sclerosis in Europe: a systematic review. BMC Neurol 2013;13:128.
9. Diaz V, Barahona J, Antinao J et al. Incidence of multiple sclerosis in Chile. A hospital registry study. Acta Neurol Scand 2012;125:71-5.
10. Kampman MT, Wilsgaard T, Mellgren SI. Outdoor activities and diet in childhood and adolescence relate to MS risk above the Arctic Circle. J Neurol 2007;254:471-7.
11. Spanier JA, Nashold FE, Olson JK, Hayes CE. The Ifng gene is essential for Vdr gene expression and vitamin D(3)-mediated reduction of the pathogenic T cell burden in the central nervous system in experimental autoimmune encephalomyelitis, a multiple sclerosis model. J Immunol 2012;189:3188-97.
12. Mowry EM, Waubant E, McCulloch CE et al. Vitamin D status predicts new brain magnetic resonance imaging activity in multiple sclerosis. Ann Neurol 2012;72:234-40.
13. Simpson S JR, Taylor B, Blizzard L et al. Higher 25-hydroxyvitamin D is associated with lower relapse risk in multiple sclerosis. Ann Neurol 2010;68:193-203.
14. Mowry EM, Krupp LB, Milazzo M et al. Vitamin D status is associated with relapse rate in pediatric-onset multiple sclerosis. Ann Neurol 2010;67:618-24.
15. Banwell B, Bar-Or A, Arnold DL et al. Clinical, environmental, and genetic determinants of multiple sclerosis in children with acute demyelination: a prospective national cohort study. Lancet Neurol 2011;10:436-45.
16. Ascherio A, Munger KL, White R et al. Vitamin D as an early predictor of multiple sclerosis activity and progression. JAMA Neurol 2014;71:306-14.
17. Pierrot-Deseilligny C, Rivaud-Pechoux S, Clerson P, de Paz R, Souberbielle JC. Relationship between 25-OH-D serum level and relapse rate in multiple sclerosis patients before and after vitamin D supplementation. Ther Adv Neurol Disord 2012;5:187-98.
18. Munger KL, Levin LI, Hollis BW, Howard NS, Ascherio A. Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis. JAMA 2006;296:2832-8.
19. Salzer J, Hallmans G, Nystrom M, Stenlund H, Wadell G, Sundstrom P. Vitamin D as a protective factor in multiple sclerosis. Neurology 2012;79:2140-5.
20. Ueda P, Rafatnia F, Baarnhielm M et al. Neonatal vitamin D status and risk of multiple sclerosis. Ann Neurol 2014;76:338-46.
21. Munger KL, Zhang SM, O'Reilly E et al. Vitamin D intake and incidence of multiple sclerosis. Neurology 2004;62:60-5.
22. Baarnhielm M, Olsson T, Alfredsson L. Fatty fish intake is associated with decreased occurrence of multiple sclerosis. Mult Scler 2014;20:726-32.
23. Pozuelo-Moyano B, Benito-Leon J, Mitchell AJ, Hernandez-Gallego J. A systematic review of randomized, double-blind, placebo-controlled trials examining the clinical efficacy of vitamin D in multiple sclerosis. Neuroepidemiology 2012;40:147-53.
24. Salzer J, Bistrom M, Sundstrom P. Vitamin D and multiple sclerosis: where do we go from here? Expert Rev Neurother 2014;14:9-18.
25. Bergman P, Norlin AC, Hansen S et al. Vitamin D3 supplementation in patients with frequent respiratory tract infections: a randomised and double-blind intervention study. BMJ Open 2012;2:e001663.
26. Murdoch DR, Slow S, Chambers ST et al. Effect of vitamin D3 supplementation on upper respiratory tract infections in healthy adults: the VIDARIS randomized controlled trial. JAMA 2012;308:1333-9.
27. Jons D, Sundstrom P, Andersen O. Targeting Epstein-Barr virus infection as an intervention against multiple sclerosis. Acta Neurol Scand 2015;131:69-79.
28. Ramagopalan SV, Handel AE, Giovannoni G, Rutherford Siegel S, Ebers GC, Chaplin G. Relationship of UV exposure to prevalence of multiple sclerosis in England. Neurology 2011;76:1410-4.
29. Lossius A, Vartdal F, Holmoy T. Vitamin D sensitive EBNA-1 specific T cells in the cerebrospinal fluid of patients with multiple sclerosis. J Neuroimmunol 2011;240-241:87-96.
30. Salzer J, Nystrom M, Hallmans G, Stenlund H, Wadell G, Sundstrom P. Epstein-Barr virus antibodies and vitamin D in prospective multiple sclerosis biobank samples. Mult Scler 2013;19:1587-91.
31. Brot C, Jorgensen NR, Sorensen OH. The influence of smoking on vitamin D status and calcium metabolism. Eur J Clin Nutr 1999;53:920-6.
32. Vimaleswaran KS, Berry DJ, Lu C et al. Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts. PLoS Med 2013;10:e1001383.
33. Hedstrom AK, Hillert J, Olsson T, Alfredsson L. Alcohol as a modifiable lifestyle factor affecting multiple sclerosis risk. JAMA neurology 2014;71:300-5.
34. Jaaskelainen T, Knekt P, Marniemi J et al. Vitamin D status is associated with sociodemographic factors, lifestyle and metabolic health. Eur J Nutr 2013;52:513-25.
35. Hedstrom AK, Akerstedt T, Hillert J, Olsson T, Alfredsson L. Shift work at young age is associated with increased risk for multiple sclerosis. Ann Neurol 2011;70:733-41.
36. Bjornevik K, Riise T, Casetta I et al. Sun exposure and multiple sclerosis risk in Norway and Italy: the EnvIMS study. Mult Scler 2014;20:1042-9.
37. Munger KL, Chitnis T, Ascherio A. Body size and risk of MS in two cohorts of US women. Neurology 2009;73:1543-50.
38. Lin R, Charlesworth J, van der Mei I, Taylor BV. The genetics of multiple sclerosis. Pract Neurol 2012;12:279-88.
39. Kalman B, Toldy E. Genomic binding sites and biological effects of the vitamin D: VDR complex in multiple sclerosis. NeuroMol Med 2014;16:265-79.
40. Orton SM, Morris AP, Herrera BM et al. Evidence for genetic regulation of vitamin D status in twins with multiple sclerosis. Am J Clin Nutr 2008;88:441-7.
41. Ramagopalan SV, Dyment DA, Cader MZ et al. Rare variants in the CYP27B1 gene are associated with multiple sclerosis. Ann Neurol 2011;70:881-6.
42. Ban M, Caillier S, Mero IL et al. No evidence of association between mutant alleles of the CYP27B1 gene and multiple sclerosis. Ann Neurol 2013;73:430-2.
43. Sawcer S, Hellenthal G, Pirinen M et al. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature 2011;476:214-9.
44. Wang TJ, Zhang F, Richards JB et al. Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet 2010;376:180-8.
45. Tajouri L, Ovcaric M, Curtain R et al. Variation in the vitamin D receptor gene is associated with multiple sclerosis in an Australian population. J Neurogenet 2005;19:25-38.
46. Cox MB, Ban M, Bowden NA, Baker A, Scott RJ, Lechner-Scott J. Potential association of vitamin D receptor polymorphism Taq1 with multiple sclerosis. Mult Scler 2012;18:16-22.
47. Garcia-Martin E, Agundez JA, Martinez C et al. Vitamin D3 receptor (VDR) gene rs2228570 (Fok1) and rs731236 (Taq1) variants are not associated with the risk for multiple sclerosis: results of a new study and a meta-analysis. PLoS ONE 2013;8:e65487.
48. Ramagopalan SV, Heger A, Berlanga AJ et al. A ChIP-seq defined genome-wide map of vitamin D receptor binding: associations with disease and evolution. Genome Res 2010;20:1352-60.
49. Disanto G, Sandve GK, Berlanga-Taylor AJ et al. Vitamin D receptor binding, chromatin states and association with multiple sclerosis. Hum Mol Genet 2012;21:3575-86.
50. Holick MF. Vitamin D deficiency. N Engl J Med 2007;357:266-81.
51. Sintov AC, Yarmolinsky L, Dahan A, Ben-Shabat S. Pharmacological effects of vitamin D and its analogs: recent developments. Drug Discovery Today 2014;19:1769-74.
52. Hart PH, Gorman S, Finlay-Jones JJ. Modulation of the immune system by UV radiation: more than just the effects of vitamin D? Nat Rev Immunol 2011;11:584-96.
53. Ramagopalan SV, Maugeri NJ, Handunnetthi L et al. Expression of the multiple sclerosis-associated MHC class II Allele HLA-DRB1*1501 is regulated by vitamin D. PLoS Genet 2009;5:e1000369.
54. Munger KL, Kochert K, Simon KC et al. Molecular mechanism underlying the impact of vitamin D on disease activity of MS. Ann Clin Transl Neurol 2014;1:605-17.
55. Schwarz A, Navid F, Sparwasser T, Clausen BE, Schwarz T. 1, 25-dihydroxyvitamin D exerts similar immunosuppressive effects as UVR but is dispensable for local UVR-induced immunosuppression. J Invest Dermatol 2012;132:2762-9.
56. Breuer J, Schwab N, Schneider-Hohendorf T et al. Ultraviolet B light attenuates the systemic immune response in central nervous system autoimmunity. Ann Neurol 2014;75:739-58.
57. Hypponen E, Laara E, Reunanen A, Jarvelin MR, Virtanen SM. Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study. Lancet 2001;358:1500-3.
58. Manson JE, Bassuk SS, Lee IM et al. The VITamin D and OmegA-3 TriaL (VITAL): rationale and design of a large randomized controlled trial of vitamin D and marine omega-3 fatty acid supplements for the primary prevention of cancer and cardiovascular disease. Contemp Clin Trials 2012;33:159-71.
59. Disanto G, Handel AE, Damoiseaux J et al. Vitamin D supplementation and antibodies against the Epstein-Barr virus in multiple sclerosis patients. Mult Scler 2013;19:1679-80.
60. Fragoso YD, Adoni T, Damasceno A et al. Unfavorable outcomes during treatment of multiple sclerosis with high doses of vitamin D. J Neurol Sci 2014;346:341-2.