Epigenome profiling reveals significant DNA demethylation of interferon signature genes in lupus neutrophils

Journal of Autoimmunity

Volumn 58, Issue , 2015, Pages 59-66

  Coit, Patrick ^a   Yalavarthi, Srilakshmi ^a   Ognenovski, Mikhail ^a   Zhao, Wenpu ^b   Hasni, Sarfaraz ^b   Wren, Jonathan D ^c,d   Kaplan, Mariana J ^b   Sawalha, Amr H ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES   (United States)

^c OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

^d UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

Epigenetics; LDG; Lupus; Methylome; Neutrophils

Indexed keywords

AZATHIOPRINE; BISULFITE; HYDROXYCHLOROQUINE; MEPACRINE; MYCOPHENOLIC ACID; PREDNISONE; RITUXIMAB; TOLL LIKE RECEPTOR 9; CHROMATIN; INTERFERON;

ADULT; ARTICLE; BIOINFORMATICS; CELL FUNCTION; CHROMATIN STRUCTURE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOSKELETON; DNA METHYLATION; DNA SEQUENCE; EPIGENETICS; FEMALE; GENE; GENE LOCUS; GRANULOCYTE; HUMAN; HUMAN CELL; LABORATORY DEVICE; NEUTROPHIL; PRIORITY JOURNAL; PROMOTER REGION; RAC1 GENE; SYSTEMIC LUPUS ERYTHEMATOSUS; CHROMATIN; GENE EXPRESSION PROFILING; GENETIC EPIGENESIS; GENETICS; IMMUNOLOGY; METABOLISM; MICROARRAY ANALYSIS; MIDDLE AGED; SKIN LUPUS ERYTHEMATOSUS; UPREGULATION; YOUNG ADULT;

ADULT; CHROMATIN; DNA METHYLATION; EPIGENESIS, GENETIC; EPIGENOMICS; FEMALE; GENE EXPRESSION PROFILING; HUMANS; INTERFERON TYPE I; LUPUS ERYTHEMATOSUS, CUTANEOUS; MICROARRAY ANALYSIS; MIDDLE AGED; NEUTROPHILS; UP-REGULATION; YOUNG ADULT;

EID: 84930379392     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2015.01.004     Document Type: Article

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