Endoplasmic reticulum Ca2+ content decrease by PKA-dependent hyperphosphorylation of type 1 IP3 receptor contributes to prostate cancer cell resistance to androgen deprivation

Cell Calcium

Volumn 57, Issue 4, 2015, Pages 312-320

  Boutin, Benoît ^a   Tajeddine, Nicolas ^a   Monaco, Giovanni ^b   Molgo, Jordi ^c   Vertommen, Didier ^d   Rider, Mark ^d   Parys, Jan B ^b   Bultynck, Geert ^b   Gailly, Philippe ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^b LABORATORY OF MOLECULAR AND CELLULAR SIGNALING   (Belgium)

^c CNRS   (France)

^d DE DUVE INSTITUTE   (Belgium)

Author keywords

Apoptosis; Endoplasmic reticulum; Hormone therapy; IP3R1; PKA; Prostate cancer

Indexed keywords

CALCIUM ION; CYCLIC AMP DEPENDENT PROTEIN KINASE; INOSITOL 1,4,5 TRISPHOSPHATE RECEPTOR; INOSITOL 1,4,5 TRISPHOSPHATE RECEPTOR 1; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; ANDROGEN; ATP2A2 PROTEIN, HUMAN; CALCIUM; ISOQUINOLINE DERIVATIVE; N-(2-(4-BROMOCINNAMYLAMINO)ETHYL)-5-ISOQUINOLINESULFONAMIDE; PEPTIDE FRAGMENT; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; SULFONAMIDE; TESTOSTERONE;

AMINO ACID SEQUENCE; ANDROGEN DEPRIVATION THERAPY; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CANCER CELL; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RECEPTOR DOWN REGULATION; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; DRUG RESISTANCE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; MALE; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; PROSTATIC NEOPLASMS; TRANSGENE; TUMOR CELL LINE; TUMOR ESCAPE;

ANDROGENS; APOPTOSIS; CALCIUM; CELL LINE, TUMOR; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DRUG RESISTANCE, NEOPLASM; ENDOPLASMIC RETICULUM; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS; ISOQUINOLINES; MALE; PEPTIDE FRAGMENTS; PHOSPHORYLATION; PROSTATIC NEOPLASMS; RNA, SMALL INTERFERING; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; SULFONAMIDES; TESTOSTERONE; TRANSGENES; TUMOR ESCAPE;

EID: 84930376255     PISSN: 01434160     EISSN: 15321991     Source Type: Journal    
DOI: 10.1016/j.ceca.2015.02.004     Document Type: Article

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