메뉴 건너뛰기




Volumn 287, Issue 1-2, 2009, Pages 64-68

Methylenetetrahydrofolate reductase polymorphisms and plasma homocysteine in levodopa-treated and non-treated Parkinson's disease patients

Author keywords

A1298C; C677T; Homocysteine; MTHFR; Parkinson's disease; Polymorphism

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); BENSERAZIDE PLUS LEVODOPA; CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE; LEVODOPA;

EID: 70350622591     PISSN: 0022510X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jns.2009.09.007     Document Type: Article
Times cited : (37)

References (36)
  • 1
    • 0033620779 scopus 로고    scopus 로고
    • Homocysteine and vascular disease
    • Hankey G.J., and Eikelboom J.W. Homocysteine and vascular disease. Lancet 354 (1999) 407-413
    • (1999) Lancet , vol.354 , pp. 407-413
    • Hankey, G.J.1    Eikelboom, J.W.2
  • 6
    • 17144464115 scopus 로고    scopus 로고
    • Nigral endothelial dysfunction, homocysteine, and Parkinson's disease
    • Muller T., Werne B., Fowler B., and Kuhn W. Nigral endothelial dysfunction, homocysteine, and Parkinson's disease. Lancet 354 (1999) 126-127
    • (1999) Lancet , vol.354 , pp. 126-127
    • Muller, T.1    Werne, B.2    Fowler, B.3    Kuhn, W.4
  • 7
    • 34447278346 scopus 로고    scopus 로고
    • Neurotoxicity of levodopa: treatment-associated homocysteine increase
    • Muller T., and Kuhn W. Neurotoxicity of levodopa: treatment-associated homocysteine increase. Nat Clin Pract Neuro 3 (2007) E1
    • (2007) Nat Clin Pract Neuro , vol.3
    • Muller, T.1    Kuhn, W.2
  • 9
    • 0035958821 scopus 로고    scopus 로고
    • Decrease of methionine and S-adenosylmethionine and increase of homocysteine in treated patients with Parkinson's disease
    • Muller T., Woitalla D., Hauptmann B., Fowler B., and Kuhn W. Decrease of methionine and S-adenosylmethionine and increase of homocysteine in treated patients with Parkinson's disease. Neurosci Lett 308 (2001) 54-56
    • (2001) Neurosci Lett , vol.308 , pp. 54-56
    • Muller, T.1    Woitalla, D.2    Hauptmann, B.3    Fowler, B.4    Kuhn, W.5
  • 10
    • 0029049553 scopus 로고
    • A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase
    • Frosst P., Blom H.J., Milos R., Goyette P., Sheppard C.A., Matthews R.G., et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 10 (1995) 111-113
    • (1995) Nat Genet , vol.10 , pp. 111-113
    • Frosst, P.1    Blom, H.J.2    Milos, R.3    Goyette, P.4    Sheppard, C.A.5    Matthews, R.G.6
  • 11
    • 0034743914 scopus 로고    scopus 로고
    • The 1298A- > C polymorphism in methylenetetrahydrofolate reductase (MTHFR): in vitro expression and association with homocysteine
    • Weisberg I.S., Jacques P.F., Selhub J., Bostom A.G., Chen Z., Curtis Ellison R., et al. The 1298A- > C polymorphism in methylenetetrahydrofolate reductase (MTHFR): in vitro expression and association with homocysteine. Atherosclerosis 156 (2001) 409-415
    • (2001) Atherosclerosis , vol.156 , pp. 409-415
    • Weisberg, I.S.1    Jacques, P.F.2    Selhub, J.3    Bostom, A.G.4    Chen, Z.5    Curtis Ellison, R.6
  • 12
    • 0037384215 scopus 로고    scopus 로고
    • 5, 10-Methylenetetrahydrofolate reductase 677C- > T and 1298A- > C mutations are genetic determinants of elevated homocysteine
    • Castro R., Rivera I., Ravasco P., Jakobs C., Blom H.J., Camilo M.E., et al. 5, 10-Methylenetetrahydrofolate reductase 677C- > T and 1298A- > C mutations are genetic determinants of elevated homocysteine. QJM 96 (2003) 297-303
    • (2003) QJM , vol.96 , pp. 297-303
    • Castro, R.1    Rivera, I.2    Ravasco, P.3    Jakobs, C.4    Blom, H.J.5    Camilo, M.E.6
  • 13
    • 0031687887 scopus 로고    scopus 로고
    • A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity
    • Weisberg I., Tran P., Christensen B., Sibani S., and Rozen R. A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity. Mol Genet Metab 64 (1998) 169-172
    • (1998) Mol Genet Metab , vol.64 , pp. 169-172
    • Weisberg, I.1    Tran, P.2    Christensen, B.3    Sibani, S.4    Rozen, R.5
  • 14
    • 0033845547 scopus 로고    scopus 로고
    • Plasma homocysteine and MTHFR C677T genotype in levodopa-treated patients with PD
    • Yasui K., Kowa H., Nakaso K., Takeshima T., and Nakashima K. Plasma homocysteine and MTHFR C677T genotype in levodopa-treated patients with PD. Neurology 55 (2000) 437-440
    • (2000) Neurology , vol.55 , pp. 437-440
    • Yasui, K.1    Kowa, H.2    Nakaso, K.3    Takeshima, T.4    Nakashima, K.5
  • 15
    • 0035936643 scopus 로고    scopus 로고
    • Plasma homocysteine and MTHFR C677T genotype in levodopa-treated patients with PD
    • author reply-2
    • Kuhn W., Hummel T., Woitalla D., and Muller T. Plasma homocysteine and MTHFR C677T genotype in levodopa-treated patients with PD. Neurology 56 (2001) 281 author reply-2
    • (2001) Neurology , vol.56 , pp. 281
    • Kuhn, W.1    Hummel, T.2    Woitalla, D.3    Muller, T.4
  • 16
    • 0035936643 scopus 로고    scopus 로고
    • Plasma homocysteine and MTHFR C677T genotype in levodopa-treated patients with PD
    • author reply-2
    • Brattstrom L. Plasma homocysteine and MTHFR C677T genotype in levodopa-treated patients with PD. Neurology 56 (2001) 281 author reply-2
    • (2001) Neurology , vol.56 , pp. 281
    • Brattstrom, L.1
  • 17
    • 4544296456 scopus 로고    scopus 로고
    • MTHFR C677T polymorphism, folic acid and hyperhomocysteinemia in levodopa treated patients with Parkinson's disease
    • Woitalla D., Kuhn W., and Muller T. MTHFR C677T polymorphism, folic acid and hyperhomocysteinemia in levodopa treated patients with Parkinson's disease. J Neural Transm Suppl (2004) 15-20
    • (2004) J Neural Transm Suppl , pp. 15-20
    • Woitalla, D.1    Kuhn, W.2    Muller, T.3
  • 18
    • 33745983912 scopus 로고    scopus 로고
    • Hyperhomocysteinemia and methylenetetrahydrofolate reductase polymorphism in patients with Parkinson's disease
    • Religa D., Czyzewski K., Styczynska M., Peplonska B., Lokk J., Chodakowska-Zebrowska M., et al. Hyperhomocysteinemia and methylenetetrahydrofolate reductase polymorphism in patients with Parkinson's disease. Neurosci Lett 404 (2006) 56-60
    • (2006) Neurosci Lett , vol.404 , pp. 56-60
    • Religa, D.1    Czyzewski, K.2    Styczynska, M.3    Peplonska, B.4    Lokk, J.5    Chodakowska-Zebrowska, M.6
  • 19
    • 33750459018 scopus 로고    scopus 로고
    • Homocysteine serum levels and MTHFR C677T genotype in patients with Parkinson's disease, with and without levodopa therapy
    • Todorovic Z., Dzoljic E., Novakovic I., Mirkovic D., Stojanovic R., Nesic Z., et al. Homocysteine serum levels and MTHFR C677T genotype in patients with Parkinson's disease, with and without levodopa therapy. J Neurol Sci 248 (2006) 56-61
    • (2006) J Neurol Sci , vol.248 , pp. 56-61
    • Todorovic, Z.1    Dzoljic, E.2    Novakovic, I.3    Mirkovic, D.4    Stojanovic, R.5    Nesic, Z.6
  • 20
    • 61649100790 scopus 로고    scopus 로고
    • Homocysteine is not associated with global motor or cognitive measures in nondemented older Parkinson's disease patients
    • Camicioli R.M., Bouchard T.P., and Somerville M.J. Homocysteine is not associated with global motor or cognitive measures in nondemented older Parkinson's disease patients. Mov Disord 24 (2009) 176-182
    • (2009) Mov Disord , vol.24 , pp. 176-182
    • Camicioli, R.M.1    Bouchard, T.P.2    Somerville, M.J.3
  • 21
    • 36248991812 scopus 로고    scopus 로고
    • Effect of MTHFR polymorphisms on hyperhomocysteinemia in levodopa-treated Parkinsonian patients
    • Caccamo D., Gorgone G., Curro M., Parisi G., Di Iorio W., Menichetti C., et al. Effect of MTHFR polymorphisms on hyperhomocysteinemia in levodopa-treated Parkinsonian patients. Neuromolecular Med 9 (2007) 249-254
    • (2007) Neuromolecular Med , vol.9 , pp. 249-254
    • Caccamo, D.1    Gorgone, G.2    Curro, M.3    Parisi, G.4    Di Iorio, W.5    Menichetti, C.6
  • 22
    • 0026514953 scopus 로고
    • Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases
    • Hughes A.J., Daniel S.E., Kilford L., and Lees A.J. Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry 55 (1992) 181-184
    • (1992) J Neurol Neurosurg Psychiatry , vol.55 , pp. 181-184
    • Hughes, A.J.1    Daniel, S.E.2    Kilford, L.3    Lees, A.J.4
  • 23
    • 0347296358 scopus 로고    scopus 로고
    • Association of the C677T and A1298C polymorphisms in the 5, 10 methylenetetrahydrofolate reductase gene in patients with migraine risk
    • Kara I., Sazci A., Ergul E., Kaya G., and Kilic G. Association of the C677T and A1298C polymorphisms in the 5, 10 methylenetetrahydrofolate reductase gene in patients with migraine risk. Brain Res Mol Brain Res 111 (2003) 84-90
    • (2003) Brain Res Mol Brain Res , vol.111 , pp. 84-90
    • Kara, I.1    Sazci, A.2    Ergul, E.3    Kaya, G.4    Kilic, G.5
  • 24
    • 0037426415 scopus 로고    scopus 로고
    • Effect of L-dopa on plasma homocysteine in PD patients: relationship to B-vitamin status
    • Miller J.W., Selhub J., Nadeau M.R., Thomas C.A., Feldman R.G., and Wolf P.A. Effect of L-dopa on plasma homocysteine in PD patients: relationship to B-vitamin status. Neurology 60 (2003) 1125-1129
    • (2003) Neurology , vol.60 , pp. 1125-1129
    • Miller, J.W.1    Selhub, J.2    Nadeau, M.R.3    Thomas, C.A.4    Feldman, R.G.5    Wolf, P.A.6
  • 28
    • 2442486956 scopus 로고    scopus 로고
    • Levodopa elevates homocysteine: is this a problem?
    • O'Suilleabhain P., and Diaz-Arrastia R. Levodopa elevates homocysteine: is this a problem?. Arch Neurol 61 (2004) 633-634
    • (2004) Arch Neurol , vol.61 , pp. 633-634
    • O'Suilleabhain, P.1    Diaz-Arrastia, R.2
  • 29
    • 17144430912 scopus 로고    scopus 로고
    • Hyperhomocysteinemia in L-dopa treated Parkinson's disease patients: effect of cobalamin and folate administration
    • Lamberti P., Zoccolella S., Armenise E., Lamberti S.V., Fraddosio A., de Mari M., et al. Hyperhomocysteinemia in L-dopa treated Parkinson's disease patients: effect of cobalamin and folate administration. Eur J Neurol 12 (2005) 365-368
    • (2005) Eur J Neurol , vol.12 , pp. 365-368
    • Lamberti, P.1    Zoccolella, S.2    Armenise, E.3    Lamberti, S.V.4    Fraddosio, A.5    de Mari, M.6
  • 30
    • 33745911598 scopus 로고    scopus 로고
    • Vitamins and entacapone in levodopa-induced hyperhomocysteinemia: a randomized controlled study
    • Postuma R.B., Espay A.J., Zadikoff C., Suchowersky O., Martin W.R., Lafontaine A.L., et al. Vitamins and entacapone in levodopa-induced hyperhomocysteinemia: a randomized controlled study. Neurology 66 (2006) 1941-1943
    • (2006) Neurology , vol.66 , pp. 1941-1943
    • Postuma, R.B.1    Espay, A.J.2    Zadikoff, C.3    Suchowersky, O.4    Martin, W.R.5    Lafontaine, A.L.6
  • 31
    • 12244291003 scopus 로고    scopus 로고
    • Hypertrophy of IMC of carotid artery in Parkinson's disease is associated with L-DOPA, homocysteine, and MTHFR genotype
    • Nakaso K., Yasui K., Kowa H., Kusumi M., Ueda K., Yoshimoto Y., et al. Hypertrophy of IMC of carotid artery in Parkinson's disease is associated with L-DOPA, homocysteine, and MTHFR genotype. J Neurol Sci 207 (2003) 19-23
    • (2003) J Neurol Sci , vol.207 , pp. 19-23
    • Nakaso, K.1    Yasui, K.2    Kowa, H.3    Kusumi, M.4    Ueda, K.5    Yoshimoto, Y.6
  • 32
    • 0037225458 scopus 로고    scopus 로고
    • Elevated plasma homocysteine levels in patients treated with levodopa. Association with vascular disease
    • Rogers J.D., Sanchez-Saffon A., Frol A.B., and Diaz-Arrastia R. Elevated plasma homocysteine levels in patients treated with levodopa. Association with vascular disease. Arch Neurol 60 (2003) 59-64
    • (2003) Arch Neurol , vol.60 , pp. 59-64
    • Rogers, J.D.1    Sanchez-Saffon, A.2    Frol, A.B.3    Diaz-Arrastia, R.4
  • 33
    • 2942525889 scopus 로고    scopus 로고
    • Elevated plasma homocysteine level in patients with Parkinson disease: motor, affective, and cognitive associations
    • O'Suilleabhain P.E., Sung V., Hernandez C., Lacritz L., Dewey R.J., Bottiglieri T., et al. Elevated plasma homocysteine level in patients with Parkinson disease: motor, affective, and cognitive associations. Arch Neurol 61 (2004) 865-868
    • (2004) Arch Neurol , vol.61 , pp. 865-868
    • O'Suilleabhain, P.E.1    Sung, V.2    Hernandez, C.3    Lacritz, L.4    Dewey, R.J.5    Bottiglieri, T.6
  • 34
    • 27744465570 scopus 로고    scopus 로고
    • Plasma homocysteine levels in L-dopa-treated Parkinson's disease patients with cognitive dysfunctions
    • Zoccolella S., Lamberti P., Iliceto G., Diroma C., Armenise E., Defazio G., et al. Plasma homocysteine levels in L-dopa-treated Parkinson's disease patients with cognitive dysfunctions. Clin Chem Lab Med 43 (2005) 1107-1110
    • (2005) Clin Chem Lab Med , vol.43 , pp. 1107-1110
    • Zoccolella, S.1    Lamberti, P.2    Iliceto, G.3    Diroma, C.4    Armenise, E.5    Defazio, G.6
  • 35
    • 33845407001 scopus 로고    scopus 로고
    • Plasma homocysteine levels in patients treated with levodopa: motor and cognitive associations
    • Ozer F., Meral H., Hanoglu L., Aydemir T., Yilsen M., Cetin S., et al. Plasma homocysteine levels in patients treated with levodopa: motor and cognitive associations. Neurol Res 28 (2006) 853-858
    • (2006) Neurol Res , vol.28 , pp. 853-858
    • Ozer, F.1    Meral, H.2    Hanoglu, L.3    Aydemir, T.4    Yilsen, M.5    Cetin, S.6
  • 36
    • 36849088639 scopus 로고    scopus 로고
    • Management of L-Dopa related hyperhomocysteinemia: catechol-O-methyltransferase (COMT) inhibitors or B vitamins? Results from a review
    • Zoccolella S., Iliceto G., deMari M., Livrea P., and Lamberti P. Management of L-Dopa related hyperhomocysteinemia: catechol-O-methyltransferase (COMT) inhibitors or B vitamins? Results from a review. Clin Chem Lab Med 45 (2007) 1607-1613
    • (2007) Clin Chem Lab Med , vol.45 , pp. 1607-1613
    • Zoccolella, S.1    Iliceto, G.2    deMari, M.3    Livrea, P.4    Lamberti, P.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.