메뉴 건너뛰기




Volumn 10, Issue 5, 2015, Pages 537-546

The multifunctional Ebola virus VP40 matrix protein is a promising therapeutic target

Author keywords

antiviral; CTD; Ebola; ESCRT; filovirus; L domain; NTD; oligomerization; therapeutic agent; viral budding; virus like particles; VLPs; VP40

Indexed keywords

ESCRT PROTEIN; PROTEIN VP40;

EID: 84930345554     PISSN: 17460794     EISSN: 17460808     Source Type: Journal    
DOI: 10.2217/fvl.15.6     Document Type: Review
Times cited : (48)

References (86)
  • 1
    • 84897065474 scopus 로고    scopus 로고
    • Discussions and decisions of the 2012-2014 International Committee on Taxonomy of Viruses (ICTV) Filoviridae Study Group
    • Bukreyev AA, Chandran K, Dolnik O et al. Discussions and decisions of the 2012-2014 International Committee on Taxonomy of Viruses (ICTV) Filoviridae Study Group, January 2012-June 2013. Arch. Virol. 159(4), 821-830 (2014
    • (2014) January 2012-June 2013. Arch. Virol , vol.159 , Issue.4 , pp. 821-830
    • Bukreyev, A.A.1    Chandran, K.2    Dolnik, O.3
  • 2
    • 84908072433 scopus 로고    scopus 로고
    • Ebola virus disease in West Africa - The first 9 months of the epidemic and forward projections
    • Team WER. Ebola virus disease in West Africa - the first 9 months of the epidemic and forward projections. N. Engl. J. Med. 371(16), 1481-1495 (2014
    • (2014) N. Engl. J. Med , vol.371 , Issue.16 , pp. 1481-1495
    • Team, W.E.R.1
  • 3
    • 33646584499 scopus 로고    scopus 로고
    • Ebola virus: Unravelling pathogenesis to combat a deadly disease
    • Hoenen T, Groseth A, Falzarano D, Feldmann H. Ebola virus: unravelling pathogenesis to combat a deadly disease. Trends Mol. Med. 12(5), 206-215 (2006
    • (2006) Trends Mol. Med , vol.12 , Issue.5 , pp. 206-215
    • Hoenen, T.1    Groseth, A.2    Falzarano, D.3    Feldmann, H.4
  • 4
    • 0035476472 scopus 로고    scopus 로고
    • The pathogenesis of Ebola hemorrhagic fever
    • Takada A, Kawaoka Y. The pathogenesis of Ebola hemorrhagic fever. Trends Microbiol. 9(10), 506-511 (2001
    • (2001) Trends Microbiol , vol.9 , Issue.10 , pp. 506-511
    • Takada, A.1    Kawaoka, Y.2
  • 5
    • 84912539212 scopus 로고    scopus 로고
    • A case of severe Ebola virus infection complicated by Gram-negative septicemia
    • Kreuels B, Wichmann D, Emmerich P et al. A case of severe Ebola virus infection complicated by Gram-negative septicemia. N. Engl. J. Med. 371(25), 2394-2401 (2014
    • (2014) N. Engl. J. Med , vol.371 , Issue.25 , pp. 2394-2401
    • Kreuels, B.1    Wichmann, D.2    Emmerich, P.3
  • 6
    • 84930371075 scopus 로고    scopus 로고
    • WHO, Mali conf. case ex Guinea, Liberia (Promed Mail Post, 2014-2010-24 00: 49: 04
    • ProMed Mail. PRO/AH/EDR Ebola virus disease - West Africa (196): WHO, Mali conf. case ex Guinea, Liberia (Promed Mail Post, 2014-2010-24 00: 49: 04). http://promedmail.org
    • PRO/AH/EDR Ebola Virus Disease - West Africa , vol.196
    • Mail, P.1
  • 7
    • 84907382350 scopus 로고    scopus 로고
    • Face to face with Ebola - An emergency care center in Sierra Leone
    • Wolz A. Face to face with Ebola - an emergency care center in Sierra Leone. N. Engl. J. Med. 371(12), 1081-1083 (2014
    • (2014) N. Engl. J. Med. , vol.371 , Issue.12 , pp. 1081-1083
    • Wolz, A.1
  • 8
    • 84892619367 scopus 로고    scopus 로고
    • Could the Ebola virus matrix protein VP40 be a drug target?. Expert Opin
    • Stahelin RV. Could the Ebola virus matrix protein VP40 be a drug target?. Expert Opin. Ther. Targets 18(2), 115-120 (2014
    • (2014) Ther. Targets , vol.18 , Issue.2 , pp. 115-120
    • Stahelin, R.V.1
  • 9
    • 79956064784 scopus 로고    scopus 로고
    • A new Ebola virus nonstructural glycoprotein expressed through RNA editing
    • Mehedi M, Falzarano D, Seebach J et al. A new Ebola virus nonstructural glycoprotein expressed through RNA editing. J. Virol. 85(11), 5406-5414 (2011
    • (2011) J. Virol , vol.85 , Issue.11 , pp. 5406-5414
    • Mehedi, M.1    Falzarano, D.2    Seebach, J.3
  • 10
    • 84874326427 scopus 로고    scopus 로고
    • The Ebola virus matrix protein penetrates into the plasma membrane: A key step in viral protein 40 (VP40) oligomerization and viral egress
    • Adu-Gyamfi E, Soni SP, Xue Y, Digman MA, Gratton E, Stahelin RV. The Ebola virus matrix protein penetrates into the plasma membrane: a key step in viral protein 40 (VP40) oligomerization and viral egress. J. Biol. Chem. 288(8), 5779-5789 (2013
    • (2013) J. Biol. Chem , vol.288 , Issue.8 , pp. 5779-5789
    • Adu-Gyamfi, E.1    Soni, S.P.2    Xue, Y.3    Digman, M.A.4    Gratton, E.5    Stahelin, R.V.6
  • 11
    • 0037303217 scopus 로고    scopus 로고
    • Biochemical and functional characterization of the Ebola virus VP24 protein: Implications for a role in virus assembly and budding
    • Han Z, Boshra H, Sunyer JO, Zwiers SH, Paragas J, Harty RN. Biochemical and functional characterization of the Ebola virus VP24 protein: implications for a role in virus assembly and budding. J. Virol. 77(3), 1793-1800 (2003
    • (2003) J. Virol , vol.77 , Issue.3 , pp. 1793-1800
    • Han, Z.1    Boshra, H.2    Sunyer, J.O.3    Zwiers, S.H.4    Paragas, J.5    Harty, R.N.6
  • 12
    • 38449115120 scopus 로고    scopus 로고
    • Regions in Ebola virus VP24 that are important for nucleocapsid formation
    • Noda T, Halfmann P, Sagara H, Kawaoka Y. Regions in Ebola virus VP24 that are important for nucleocapsid formation. J. Infect. Dis. 196(Suppl. 2), S247-S250 (2007
    • (2007) J. Infect. Dis , vol.196 , pp. S247-S250
    • Noda, T.1    Halfmann, P.2    Sagara, H.3    Kawaoka, Y.4
  • 13
    • 38449115436 scopus 로고    scopus 로고
    • Ebola virus (EBOV) VP24 inhibits transcription and replication of the EBOV genome
    • Watanabe S, Noda T, Halfmann P, Jasenosky L, Kawaoka Y. Ebola virus (EBOV) VP24 inhibits transcription and replication of the EBOV genome. J. Infect. Dis. 196(Suppl. 2), S284-S290 (2007
    • (2007) J. Infect. Dis , vol.196 , pp. S284-S290
    • Watanabe, S.1    Noda, T.2    Halfmann, P.3    Jasenosky, L.4    Kawaoka, Y.5
  • 14
    • 80054767647 scopus 로고    scopus 로고
    • Knockdown of Ebola virus VP24 impairs viral nucleocapsid assembly and prevents virus replication
    • Mateo M, Carbonnelle C, Martinez MJ et al. Knockdown of Ebola virus VP24 impairs viral nucleocapsid assembly and prevents virus replication. J. Infect. Dis. 204(Suppl. 3), S892-S896 (2011
    • (2011) J. Infect. Dis , vol.204 , pp. S892-S896
    • Mateo, M.1    Carbonnelle, C.2    Martinez, M.J.3
  • 15
    • 84860903741 scopus 로고    scopus 로고
    • The Ebola virus interferon antagonist VP24 directly binds STAT1 and has a novel, pyramidal fold
    • Zhang AP, Bornholdt ZA, Liu T et al. The Ebola virus interferon antagonist VP24 directly binds STAT1 and has a novel, pyramidal fold. PLoS Pathog. 8(2), e1002550 (2012
    • (2012) PLoS Pathog , vol.8 , Issue.2 , pp. e1002550
    • Zhang, A.P.1    Bornholdt, Z.A.2    Liu, T.3
  • 16
    • 84906342319 scopus 로고    scopus 로고
    • A novel life cycle modeling system for Ebola virus shows a genome length-dependent role of VP24 in virus infectivity
    • Watt A, Moukambi F, Banadyga L et al. A novel life cycle modeling system for Ebola virus shows a genome length-dependent role of VP24 in virus infectivity. J. Virol. 88(18), 10511-10524 (2014
    • (2014) J. Virol , vol.88 , Issue.18 , pp. 10511-10524
    • Watt, A.1    Moukambi, F.2    Banadyga, L.3
  • 17
    • 80052851832 scopus 로고    scopus 로고
    • Ebola virus entry requires the cholesterol transporter Niemann-Pick C1
    • Carette JE, Raaben M, Wong AC et al. Ebola virus entry requires the cholesterol transporter Niemann-Pick C1. Nature 477(7364), 340-343 (2011
    • (2011) Nature , vol.477 , Issue.7364 , pp. 340-343
    • Carette, J.E.1    Raaben, M.2    Wong, A.C.3
  • 18
    • 80052868218 scopus 로고    scopus 로고
    • Small molecule inhibitors reveal Niemann-Pick C1 is essential for Ebola virus infection
    • Côté M, Misasi J, Ren T et al. Small molecule inhibitors reveal Niemann-Pick C1 is essential for Ebola virus infection. Nature 477(7364), 344-348 (2011
    • (2011) Nature , vol.477 , Issue.7364 , pp. 344-348
    • Côté, M.1    Misasi, J.2    Ren, T.3
  • 19
    • 0035423215 scopus 로고    scopus 로고
    • Vaccine potential of Ebola virus VP24, VP30, VP35, and VP40 proteins
    • Wilson JA, Bray M, Bakken R, Hart MK. Vaccine potential of Ebola virus VP24, VP30, VP35, and VP40 proteins. Virology 286(2), 384-390 (2001
    • (2001) Virology , vol.286 , Issue.2 , pp. 384-390
    • Wilson, J.A.1    Bray, M.2    Bakken, R.3    Hart, M.K.4
  • 20
    • 38449100363 scopus 로고    scopus 로고
    • Ebola virus-like particle-based vaccine protects nonhuman primates against lethal Ebola virus challenge
    • Warfield KL, Swenson DL, Olinger GG, Kalina WV, Aman MJ, Bavari S. Ebola virus-like particle-based vaccine protects nonhuman primates against lethal Ebola virus challenge. J. Infect. Dis. 196(Suppl. 2), S430-S437 (2007
    • (2007) J. Infect. Dis , vol.196 , pp. S430-S437
    • Warfield, K.L.1    Swenson, D.L.2    Olinger, G.G.3    Kalina, W.V.4    Aman, M.J.5    Bavari, S.6
  • 21
    • 77956436149 scopus 로고    scopus 로고
    • Advanced antisense therapies for postexposure protection against lethal filovirus infections
    • Warren TK, Warfield KL, Wells J et al. Advanced antisense therapies for postexposure protection against lethal filovirus infections. Nat. Med. 16(9), 991-994 (2010
    • (2010) Nat. Med , vol.16 , Issue.9 , pp. 991-994
    • Warren, T.K.1    Warfield, K.L.2    Wells, J.3
  • 22
    • 77951240331 scopus 로고    scopus 로고
    • Antiviral activity of a small-molecule inhibitor of filovirus infection
    • Warren TK, Warfield KL, Wells J et al. Antiviral activity of a small-molecule inhibitor of filovirus infection. Antimicrob. Agents Chemother. 54(5), 2152-2159 (2010
    • (2010) Antimicrob. Agents Chemother , vol.54 , Issue.5 , pp. 2152-2159
    • Warren, T.K.1    Warfield, K.L.2    Wells, J.3
  • 23
    • 79952590815 scopus 로고    scopus 로고
    • Identification of a small-molecule entry inhibitor for filoviruses
    • Basu A, Li B, Mills DM et al. Identification of a small-molecule entry inhibitor for filoviruses. J. Virol. 85(7), 3106-3119 (2011
    • (2011) J. Virol , vol.85 , Issue.7 , pp. 3106-3119
    • Basu, A.1    Li, B.2    Mills, D.M.3
  • 24
    • 84870580050 scopus 로고    scopus 로고
    • Discovery and early development of AVI-7537 and AVI-7288 for the treatment of Ebola virus and Marburg virus infections
    • Iversen PL, Warren TK, Wells JB et al. Discovery and early development of AVI-7537 and AVI-7288 for the treatment of Ebola virus and Marburg virus infections. Viruses 4(11), 2806-2830 (2012
    • (2012) Viruses , vol.4 , Issue.11 , pp. 2806-2830
    • Iversen, P.L.1    Warren, T.K.2    Wells, J.B.3
  • 25
    • 84875965830 scopus 로고    scopus 로고
    • A systematic screen of FDA-approved drugs for inhibitors of biological threat agents
    • Madrid PB, Chopra S, Manger ID et al. A systematic screen of FDA-approved drugs for inhibitors of biological threat agents. PLoS ONE 8(4), e60579 (2013
    • (2013) PLoS ONE , vol.8 , Issue.4 , pp. e60579
    • Madrid, P.B.1    Chopra, S.2    Manger, I.D.3
  • 26
    • 84899439262 scopus 로고    scopus 로고
    • Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430
    • Warren TK, Wells J, Panchal RG et al. Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430. Nature 508(7496), 402-405 (2014
    • (2014) Nature , vol.508 , Issue.7496 , pp. 402-405
    • Warren, T.K.1    Wells, J.2    Panchal, R.G.3
  • 27
    • 84922325609 scopus 로고    scopus 로고
    • Clinical features and pathobiology of Ebola virus infection
    • Ansari AA. Clinical features and pathobiology of Ebola virus infection. J. Autoimmun. 55, 1-9 (2014
    • (2014) J. Autoimmun , vol.55 , pp. 1-9
    • Ansari, A.A.1
  • 28
    • 84870601170 scopus 로고    scopus 로고
    • Vesicular stomatitis virus-based vaccines for prophylaxis and treatment of filovirus infections
    • Marzi A, Feldmann H, Geisbert TW, Falzarano D. Vesicular stomatitis virus-based vaccines for prophylaxis and treatment of filovirus infections. J. Bioterror Biodef. S1(4) (2011
    • (2011) J. Bioterror Biodef , vol.S1 , Issue.4
    • Marzi, A.1    Feldmann, H.2    Geisbert, T.W.3    Falzarano, D.4
  • 29
    • 84873202509 scopus 로고    scopus 로고
    • Antibodies are necessary for rVSV/ZEBOV-GP-mediated protection against lethal Ebola virus challenge in nonhuman primates
    • Marzi A, Engelmann F, Feldmann F et al. Antibodies are necessary for rVSV/ZEBOV-GP-mediated protection against lethal Ebola virus challenge in nonhuman primates. Proc. Natl Acad. Sci. USA 110(5), 1893-1898 (2013
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , Issue.5 , pp. 1893-1898
    • Marzi, A.1    Engelmann, F.2    Feldmann, F.3
  • 30
    • 84896471849 scopus 로고    scopus 로고
    • Ebola virus vaccines: An overview of current approaches
    • Marzi A, Feldmann H. Ebola virus vaccines: an overview of current approaches. Expert Rev. Vaccines 13(4), 521-531 (2014
    • (2014) Expert Rev. Vaccines , vol.13 , Issue.4 , pp. 521-531
    • Marzi, A.1    Feldmann, H.2
  • 31
    • 84907263545 scopus 로고    scopus 로고
    • Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp
    • Qiu X, Wong G, Audet J et al. Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp. Nature 514(7520), 47-53 (2014
    • (2014) Nature , vol.514 , Issue.7520 , pp. 47-53
    • Qiu, X.1    Wong, G.2    Audet, J.3
  • 32
    • 84891886396 scopus 로고    scopus 로고
    • Emerging targets and novel approaches to Ebola virus prophylaxis and treatment
    • Choi JH, Croyle MA. Emerging targets and novel approaches to Ebola virus prophylaxis and treatment. BioDrugs 27(6), 565-583 (2013
    • (2013) BioDrugs , vol.27 , Issue.6 , pp. 565-583
    • Choi, J.H.1    Croyle, M.A.2
  • 34
    • 84861883930 scopus 로고    scopus 로고
    • Investigation of Ebola VP40 assembly and oligomerization in live cells using number and brightness analysis
    • Adu-Gyamfi E, Digman MA, Gratton E, Stahelin RV. Investigation of Ebola VP40 assembly and oligomerization in live cells using number and brightness analysis. Biophys. J. 102(11), 2517-2525 (2012
    • (2012) Biophys. J. , vol.102 , Issue.11 , pp. 2517-2525
    • Adu-Gyamfi, E.1    Digman, M.A.2    Gratton, E.3    Stahelin, R.V.4
  • 35
    • 0034610295 scopus 로고    scopus 로고
    • A PPxY motif within the VP40 protein of Ebola virus interacts physically and functionally with a ubiquitin ligase: Implications for filovirus budding
    • Harty RN, Brown ME, Wang G, Huibregtse J, Hayes FP. A PPxY motif within the VP40 protein of Ebola virus interacts physically and functionally with a ubiquitin ligase: implications for filovirus budding. Proc. Natl Acad. Sci. USA 97(25), 13871-13876 (2000
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , Issue.25 , pp. 13871-13876
    • Harty, R.N.1    Brown, M.E.2    Wang, G.3    Huibregtse, J.4    Hayes, F.P.5
  • 36
    • 0029591306 scopus 로고
    • Differentiation of filoviruses by electron microscopy
    • Geisbert TW, Jahrling PB. Differentiation of filoviruses by electron microscopy. Virus Res. 39(2-3), 129-150 (1995
    • (1995) Virus Res , vol.39 , Issue.2-3 , pp. 129-150
    • Geisbert, T.W.1    Jahrling, P.B.2
  • 37
    • 0036235725 scopus 로고    scopus 로고
    • Ebola virus VP40 drives the formation of virus-like filamentous particles along with GP
    • Noda T, Sagara H, Suzuki E, Takada A, Kida H, Kawaoka Y. Ebola virus VP40 drives the formation of virus-like filamentous particles along with GP. J. Virol. 76(10), 4855-4865 (2002
    • (2002) J. Virol , vol.76 , Issue.10 , pp. 4855-4865
    • Noda, T.1    Sagara, H.2    Suzuki, E.3    Takada, A.4    Kida, H.5    Kawaoka, Y.6
  • 38
    • 84882787658 scopus 로고    scopus 로고
    • Structural rearrangement of Ebola virus VP40 begets multiple functions in the virus life cycle
    • Bornholdt ZA, Noda T, Abelson DM et al. Structural rearrangement of Ebola virus VP40 begets multiple functions in the virus life cycle. Cell 154(4), 763-774 (2013
    • (2013) Cell , vol.154 , Issue.4 , pp. 763-774
    • Bornholdt, Z.A.1    Noda, T.2    Abelson, D.M.3
  • 39
    • 0027467193 scopus 로고
    • Homology between Marburg and Ebola viruses
    • The VP35 and VP40 proteins of filoviruses
    • Bukreyev AA, Volchkov VE, Blinov VM, Netesov SV. The VP35 and VP40 proteins of filoviruses. Homology between Marburg and Ebola viruses. FEBS Lett. 322(1), 41-46 (1993
    • (1993) FEBS Lett , vol.322 , Issue.1 , pp. 41-46
    • Bukreyev, A.A.1    Volchkov, V.E.2    Blinov, V.M.3    Netesov, S.V.4
  • 40
    • 0037303193 scopus 로고    scopus 로고
    • Overlapping motifs (PTAP and PPEY) within the Ebola virus VP40 protein function independently as late budding domains: Involvement of host proteins TSG101 and VPS-4
    • L-domain motifs in EBOV VLP assembly and budding
    • Licata JM, Simpson-Holley M, Wright NT, Han Z, Paragas J, Harty RN. Overlapping motifs (PTAP and PPEY) within the Ebola virus VP40 protein function independently as late budding domains: involvement of host proteins TSG101 and VPS-4. J. Virol. 77(3), 1812-1819 (2003). L-domain motifs in EBOV VLP assembly and budding
    • (2003) J. Virol , vol.77 , Issue.3 , pp. 1812-1819
    • Licata, J.M.1    Simpson-Holley, M.2    Wright, N.T.3    Han, Z.4    Paragas, J.5    Harty, R.N.6
  • 42
    • 9644303143 scopus 로고    scopus 로고
    • Filovirus budding
    • Jasenosky LD, Kawaoka Y. Filovirus budding. Virus Res. 106(2), 181-188 (2004
    • (2004) Virus Res , vol.106 , Issue.2 , pp. 181-188
    • Jasenosky, L.D.1    Kawaoka, Y.2
  • 43
    • 38449122318 scopus 로고    scopus 로고
    • Mapping of a region of Ebola virus VP40 that is important in the production of virus-like particles
    • Yamayoshi S, Kawaoka Y. Mapping of a region of Ebola virus VP40 that is important in the production of virus-like particles. J. Infect. Dis. 196(Suppl. 2) S291-S295 (2007
    • (2007) J. Infect. Dis , vol.196 , pp. S291-S295
    • Yamayoshi, S.1    Kawaoka, Y.2
  • 44
    • 77649220531 scopus 로고    scopus 로고
    • Conserved motifs within Ebola and Marburg virus VP40 proteins are important for stability, localization, and subsequent budding of viruslike particles
    • Liu Y, Cocka L, Okumura A, Zhang YA, Sunyer JO, Harty RN. Conserved motifs within Ebola and Marburg virus VP40 proteins are important for stability, localization, and subsequent budding of viruslike particles. J. Virol. 84(5), 2294-2303 (2010
    • (2010) J. Virol , vol.84 , Issue.5 , pp. 2294-2303
    • Liu, Y.1    Cocka, L.2    Okumura, A.3    Zhang, Y.A.4    Sunyer, J.O.5    Harty, R.N.6
  • 45
    • 34247633960 scopus 로고    scopus 로고
    • Interaction of Tsg101 with Marburg virus VP40 depends on the PPPY motif, but not the PT/SAP motif as in the case of Ebola virus, and Tsg101 plays a critical role in the budding of Marburg virus-like particles induced by VP40, NP, and G.P
    • Urata S, Noda T, Kawaoka Y, Morikawa S, Yokosawa H, Yasuda J. Interaction of Tsg101 with Marburg virus VP40 depends on the PPPY motif, but not the PT/SAP motif as in the case of Ebola virus, and Tsg101 plays a critical role in the budding of Marburg virus-like particles induced by VP40, NP, and GP. J. Virol. 81(9), 4895-4899 (2007
    • (2007) J Virol , vol.81 , Issue.9 , pp. 4895-4899
    • Urata, S.1    Noda, T.2    Kawaoka, Y.3    Morikawa, S.4    Yokosawa, H.5    Yasuda, J.6
  • 47
    • 84904904016 scopus 로고    scopus 로고
    • Membrane binding and bending in Ebola VP40 assembly and egress
    • Stahelin RV. Membrane binding and bending in Ebola VP40 assembly and egress. Front. Microbiol. 5, 300 (2014
    • (2014) Front. Microbiol , vol.5 , Issue.300
    • Stahelin, R.V.1
  • 48
    • 0034663762 scopus 로고    scopus 로고
    • Crystal structure of the matrix protein VP40 from Ebola virus
    • Dessen A, Volchkov V, Dolnik O, Klenk HD, Weissenhorn W. Crystal structure of the matrix protein VP40 from Ebola virus. EMBO J. 19(16), 4228-4236 (2000
    • (2000) EMBO J. , vol.19 , Issue.16 , pp. 4228-4236
    • Dessen, A.1    Volchkov, V.2    Dolnik, O.3    Klenk, H.D.4    Weissenhorn, W.5
  • 49
    • 0035031534 scopus 로고    scopus 로고
    • Ebola virus VP40-induced particle formation and association with the lipid bilayer
    • Jasenosky LD, Neumann G, Lukashevich I, Kawaoka Y. Ebola virus VP40-induced particle formation and association with the lipid bilayer. J. Virol. 75(11), 5205-5214 (2001
    • (2001) J. Virol , vol.75 , Issue.11 , pp. 5205-5214
    • Jasenosky, L.D.1    Neumann, G.2    Lukashevich, I.3    Kawaoka, Y.4
  • 50
    • 0037389018 scopus 로고    scopus 로고
    • The matrix protein VP40 from Ebola virus octamerizes into pore-like structures with specific RNA binding properties
    • Gomis-Rüth FX, Dessen A, Timmins J et al. The matrix protein VP40 from Ebola virus octamerizes into pore-like structures with specific RNA binding properties. Structure 11(4), 423-433 (2003
    • (2003) Structure , vol.11 , Issue.4 , pp. 423-433
    • Gomis-Rüth, F.X.1    Dessen, A.2    Timmins, J.3
  • 51
    • 35148830331 scopus 로고    scopus 로고
    • Role for amino acids 212KLR214 of Ebola virus VP40 in assembly and budding
    • McCarthy SE, Johnson RF, Zhang YA, Sunyer JO, Harty RN. Role for amino acids 212KLR214 of Ebola virus VP40 in assembly and budding. J. Virol. 81(20), 11452-11460 (2007
    • (2007) J. Virol , vol.81 , Issue.20 , pp. 11452-11460
    • McCarthy, S.E.1    Johnson, R.F.2    Zhang, Y.A.3    Sunyer, J.O.4    Harty, R.N.5
  • 52
    • 0346734116 scopus 로고    scopus 로고
    • In vivo oligomerization and raft localization of Ebola virus protein VP40 during vesicular budding
    • Panchal RG, Ruthel G, Kenny TA et al. In vivo oligomerization and raft localization of Ebola virus protein VP40 during vesicular budding. Proc. Natl Acad. Sci. USA 100(26), 15936-15941 (2003
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , Issue.26 , pp. 15936-15941
    • Panchal, R.G.1    Ruthel, G.2    Kenny, T.A.3
  • 53
    • 84868557277 scopus 로고    scopus 로고
    • Single-particle tracking demonstrates that actin coordinates the movement of the Ebola virus matrix protein
    • Adu-Gyamfi E, Digman MA, Gratton E, Stahelin RV. Single-particle tracking demonstrates that actin coordinates the movement of the Ebola virus matrix protein. Biophys. J. 103(9), L41-L43 (2012
    • (2012) Biophys. J. , vol.103 , Issue.9 , pp. L41-L43
    • Adu-Gyamfi, E.1    Digman, M.A.2    Gratton, E.3    Stahelin, R.V.4
  • 54
    • 84880345503 scopus 로고    scopus 로고
    • Host IQGAP1 and Ebola virus VP40 interactions facilitate virus-like particle egress
    • Lu J, Qu Y, Liu Y et al. Host IQGAP1 and Ebola virus VP40 interactions facilitate virus-like particle egress. J. Virol. 87(13), 7777-7780 (2013
    • (2013) J. Virol , vol.87 , Issue.13 , pp. 7777-7780
    • Lu, J.1    Qu, Y.2    Liu, Y.3
  • 55
    • 84877287665 scopus 로고    scopus 로고
    • The Ebola virus matrix protein deeply penetrates the plasma membrane: An important step in viral egress
    • Soni SP, Adu-Gyamfi E, Yong SS, Jee CS, Stahelin RV. The Ebola virus matrix protein deeply penetrates the plasma membrane: an important step in viral egress. Biophys. J. 104(9), 1940-1949 (2013
    • (2013) Biophys. J. , vol.104 , Issue.9 , pp. 1940-1949
    • Soni, S.P.1    Adu-Gyamfi, E.2    Yong, S.S.3    Jee, C.S.4    Stahelin, R.V.5
  • 56
    • 0013025819 scopus 로고    scopus 로고
    • Oligomerization and polymerization of the filovirus matrix protein VP40
    • Weissenhorn W. Oligomerization and polymerization of the filovirus matrix protein VP40. Virology 312(2), 359-368 (2003
    • (2003) Virology , vol.312 , Issue.2 , pp. 359-368
    • Weissenhorn, W.1
  • 57
    • 13744259224 scopus 로고    scopus 로고
    • VP40 octamers are essential for Ebola virus replication
    • Hoenen T, Volchkov V, Kolesnikova L et al. VP40 octamers are essential for Ebola virus replication. J. Virol. 79(3), 1898-1905 (2005
    • (2005) J. Virol , vol.79 , Issue.3 , pp. 1898-1905
    • Hoenen, T.1    Volchkov, V.2    Kolesnikova, L.3
  • 58
    • 0028971135 scopus 로고
    • Freed EO. P6Gag is required for particle production from full-length human immunodeficiency virus type 1 molecular clones expressing protease
    • Huang M, Orenstein JM, Martin MA, Freed EO. p6Gag is required for particle production from full-length human immunodeficiency virus type 1 molecular clones expressing protease. J. Virol. 69(11), 6810-6818 (1995
    • (1995) J. Virol , vol.69 , Issue.11 , pp. 6810-6818
    • Huang, M.1    Orenstein, J.M.2    Ma, M.3
  • 59
    • 18844392879 scopus 로고    scopus 로고
    • Functional characterization of Ebola virus L-domains using VSV recombinants
    • Irie T, Licata JM, Harty RN. Functional characterization of Ebola virus L-domains using VSV recombinants. Virology 336(2), 291-298 (2005
    • (2005) Virology , vol.336 , Issue.2 , pp. 291-298
    • Irie, T.1    Licata, J.M.2    Harty, R.N.3
  • 60
    • 0141570508 scopus 로고    scopus 로고
    • Nedd4 regulates egress of Ebola virus-like particles from host cells
    • Yasuda J, Nakao M, Kawaoka Y, Shida H. Nedd4 regulates egress of Ebola virus-like particles from host cells. J. Virol. 77(18), 9987-9992 (2003
    • (2003) J. Virol , vol.77 , Issue.18 , pp. 9987-9992
    • Yasuda, J.1    Nakao, M.2    Kawaoka, Y.3    Shida, H.4
  • 61
    • 38449117567 scopus 로고    scopus 로고
    • Involvement of vacuolar protein sorting pathway in Ebola virus release independent of TSG101 interaction
    • Silvestri LS, Ruthel G, Kallstrom G et al. Involvement of vacuolar protein sorting pathway in Ebola virus release independent of TSG101 interaction. J. Infect. Dis. 196(Suppl. 2), S264-S270 (2007
    • (2007) J. Infect. Dis , vol.196 , pp. S264-S270
    • Silvestri, L.S.1    Ruthel, G.2    Kallstrom, G.3
  • 62
    • 84908242356 scopus 로고    scopus 로고
    • A Loop region in the N-terminal domain of Ebola virus VP40 is important in viral assembly, budding, and egress
    • Adu-Gyamfi E, Soni SP, Jee CS, Digman MA, Gratton E, Stahelin RV. A Loop region in the N-terminal domain of Ebola virus VP40 is important in viral assembly, budding, and egress. Viruses 6(10), 3837-3854 (2014
    • (2014) Viruses , vol.6 , Issue.10 , pp. 3837-3854
    • Adu-Gyamfi, E.1    Soni, S.P.2    Jee, C.S.3    Digman, M.A.4    Gratton, E.5    Stahelin, R.V.6
  • 63
    • 78650546282 scopus 로고    scopus 로고
    • Small molecule inhibition of phosphatidylinositol-3, 4, 5-triphosphate (PIP3) binding to pleckstrin homology domains
    • Miao B, Skidan I, Yang J et al. Small molecule inhibition of phosphatidylinositol-3, 4, 5-triphosphate (PIP3) binding to pleckstrin homology domains. Proc. Natl Acad. Sci. USA 107(46), 20126-20131 (2010
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , Issue.46 , pp. 20126-20131
    • Miao, B.1    Skidan, I.2    Yang, J.3
  • 64
    • 84912096164 scopus 로고    scopus 로고
    • The Ebola virus matrix protein VP40 selectively induces vesiculation from phosphatidylserine-enriched membranes
    • Soni SP, Stahelin RV. The Ebola virus matrix protein VP40 selectively induces vesiculation from phosphatidylserine-enriched membranes. J. Biol. Chem. 289(48), 33590-33597 (2014
    • (2014) J. Biol. Chem , vol.289 , Issue.48 , pp. 33590-33597
    • Soni, S.P.1    Stahelin, R.V.2
  • 65
    • 84924987424 scopus 로고    scopus 로고
    • Conformational plasticity of the Ebola virus matrix protein
    • Radzimanowski J, Effantin G, Weissenhorn W. Conformational plasticity of the Ebola virus matrix protein. Protein Sci. 23(11), 1519-1527 (2014
    • (2014) Protein Sci , vol.23 , Issue.11 , pp. 1519-1527
    • Radzimanowski, J.1    Effantin, G.2    Weissenhorn, W.3
  • 66
    • 77953742423 scopus 로고    scopus 로고
    • Oligomerization of Ebola virus VP40 is essential for particle morphogenesis and regulation of viral transcription
    • Hoenen T, Biedenkopf N, Zielecki F et al. Oligomerization of Ebola virus VP40 is essential for particle morphogenesis and regulation of viral transcription. J. Virol. 84(14), 7053-7063 (2010
    • (2010) J. Virol , vol.84 , Issue.14 , pp. 7053-7063
    • Hoenen, T.1    Biedenkopf, N.2    Zielecki, F.3
  • 67
    • 84872078381 scopus 로고    scopus 로고
    • Analysis of small molecule ligands targeting the HIV-1 matrix protein-RNA binding site
    • Alfadhli A, McNett H, Eccles J et al. Analysis of small molecule ligands targeting the HIV-1 matrix protein-RNA binding site. J. Biol. Chem. 288(1), 666-676 (2013
    • (2013) J. Biol. Chem , vol.288 , Issue.1 , pp. 666-676
    • Alfadhli, A.1    McNett, H.2    Eccles, J.3
  • 69
    • 84867604576 scopus 로고    scopus 로고
    • Cellular ESCRT complex and its roles in enveloped viruses budding
    • Li Z, Tian H, Liu T. Cellular ESCRT complex and its roles in enveloped viruses budding. Sheng Wu Gong Cheng Xue Bao 28(9), 1031-1037 (2012
    • (2012) Sheng Wu Gong Cheng Xue Bao , vol.28 , Issue.9 , pp. 1031-1037
    • Li, Z.1    Tian, H.2    Liu, T.3
  • 70
    • 84883894715 scopus 로고    scopus 로고
    • Virus budding and the ESCRT pathway
    • Votteler J, Sundquist WI. Virus budding and the ESCRT pathway. Cell Host Microbe 14(3), 232-241 (2013
    • (2013) Cell Host Microbe , vol.14 , Issue.3 , pp. 232-241
    • Votteler, J.1    Sundquist, W.I.2
  • 71
    • 23244442927 scopus 로고    scopus 로고
    • Ebola virus VP40 late domains are not essential for viral replication in cell culture
    • Neumann G, Ebihara H, Takada A et al. Ebola virus VP40 late domains are not essential for viral replication in cell culture. J. Virol. 79(16), 10300-10307 (2005
    • (2005) J. Virol , vol.79 , Issue.16 , pp. 10300-10307
    • Neumann, G.1    Ebihara, H.2    Takada, A.3
  • 72
    • 84897483012 scopus 로고    scopus 로고
    • A host-oriented inhibitor of Junin Argentine hemorrhagic fever virus egress
    • Lu J, Han Z, Liu Y et al. A host-oriented inhibitor of Junin Argentine hemorrhagic fever virus egress. J. Virol. 88(9), 4736-4743 (2014
    • (2014) J. Virol , vol.88 , Issue.9 , pp. 4736-4743
    • Lu, J.1    Han, Z.2    Liu, Y.3
  • 73
    • 84901999764 scopus 로고    scopus 로고
    • Small-molecule probes targeting the viral PPxY-host Nedd4 interface block egress of a broad range of RNA viruses
    • Han Z, Lu J, Liu Y et al. Small-molecule probes targeting the viral PPxY-host Nedd4 interface block egress of a broad range of RNA viruses. J. Virol. 88(13), 7294-7306 (2014
    • (2014) J. Virol , vol.88 , Issue.13 , pp. 7294-7306
    • Han, Z.1    Lu, J.2    Liu, Y.3
  • 74
    • 39549095341 scopus 로고    scopus 로고
    • Mechanisms for enveloped virus budding: Can some viruses do without an ESCRT?
    • Chen BJ, Lamb RA. Mechanisms for enveloped virus budding: can some viruses do without an ESCRT?. Virology 372(2), 221-232 (2008
    • (2008) Virology , vol.372 , Issue.2 , pp. 221-232
    • Chen, B.J.1    Lamb, R.A.2
  • 75
    • 84886748172 scopus 로고    scopus 로고
    • HIV assembly and budding: Ca2+) signaling and non-ESCRT proteins set the stage
    • Ehrlich LS, Carter CA. HIV assembly and budding: Ca(2+) signaling and non-ESCRT proteins set the stage. Mol. Biol. Int. doi: 10.1155/2012/851670 851670 (2012
    • (2012) Mol. Biol. Int , pp. 851670
    • Ehrlich, L.S.1    Carter, C.A.2
  • 76
    • 84857309195 scopus 로고    scopus 로고
    • The ESCRT machinery
    • Teis SA. The ESCRT machinery. Science 22(4), R116-R120 (2012
    • (2012) Science , vol.22 , Issue.4 , pp. R116-R120
    • Teis, S.A.1
  • 78
    • 37849024338 scopus 로고    scopus 로고
    • Structural and functional studies of ALIX interactions with YPX(n)L late domains of HIV-1 and EIAV
    • Zhai Q, Fisher RD, Chung HY, Myszka DG, Sundquist WI, Hill CP. Structural and functional studies of ALIX interactions with YPX(n)L late domains of HIV-1 and EIAV. Nat. Struct. Mol. Biol. 15(1), 43-49 (2008
    • (2008) Nat. Struct. Mol. Biol , vol.15 , Issue.1 , pp. 43-49
    • Zhai, Q.1    Fisher, R.D.2    Chung, H.Y.3    Myszka, D.G.4    Sundquist, W.I.5    Hill, C.P.6
  • 80
    • 0141844660 scopus 로고    scopus 로고
    • 1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding
    • AIP
    • Strack B, Calistri A, Craig S, Popova E, Göttlinger HG. AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding. Cell 114(6), 689-699 (2003
    • (2003) Cell , vol.114 , Issue.6 , pp. 689-699
    • Strack, B.1    Calistri, A.2    Craig, S.3    Popova, E.4    Göttlinger, H.G.5
  • 81
    • 78149301835 scopus 로고    scopus 로고
    • Rescue of HIV-1 release by targeting widely divergent NEDD4-type ubiquitin ligases and isolated catalytic HECT domains to Gag
    • Weiss ER, Popova E, Yamanaka H, Kim HC, Huibregtse JM, Göttlinger H. Rescue of HIV-1 release by targeting widely divergent NEDD4-type ubiquitin ligases and isolated catalytic HECT domains to Gag. PLoS Pathog. 6(9), e1001107 (2010
    • (2010) PLoS Pathog , vol.6 , Issue.9 , pp. e1001107
    • Weiss, E.R.1    Popova, E.2    Yamanaka, H.3    Kim, H.C.4    Huibregtse, J.M.5    Göttlinger, H.6
  • 82
    • 84857693882 scopus 로고    scopus 로고
    • Productive replication of Ebola virus is regulated by the c-Abl1 tyrosine kinase
    • García M, Cooper A, Shi W et al. Productive replication of Ebola virus is regulated by the c-Abl1 tyrosine kinase. Sci. Transl. Med. 4(123), 123ra124 (2012
    • (2012) Sci. Transl. Med , vol.4 , Issue.123 , pp. 123ra124
    • García, M.1    Cooper, A.2    Shi, W.3
  • 83
    • 33646754920 scopus 로고    scopus 로고
    • Ebola virus VP24 binds karyopherin alpha1 and blocks STAT1 nuclear accumulation
    • Reid SP, Leung LW, Hartman AL et al. Ebola virus VP24 binds karyopherin alpha1 and blocks STAT1 nuclear accumulation. J. Virol. 80(11), 5156-5167 (2006
    • (2006) J. Virol , vol.80 , Issue.11 , pp. 5156-5167
    • Reid, S.P.1    Leung, L.W.2    Hartman, A.L.3
  • 84
    • 80054723843 scopus 로고    scopus 로고
    • The Ebola virus VP24 protein blocks phosphorylation of p38 mitogen-activated protein kinase
    • Halfmann P, Neumann G, Kawaoka Y. The Ebola virus VP24 protein blocks phosphorylation of p38 mitogen-activated protein kinase. J. Infect. Dis. 204(Suppl. 3), S953-S956 (2011
    • (2011) J. Infect. Dis , vol.204 , pp. S953-S956
    • Halfmann, P.1    Neumann, G.2    Kawaoka, Y.3
  • 85
    • 80054734483 scopus 로고    scopus 로고
    • The importance of the NP: VP35 ratio in Ebola virus nucleocapsid formation
    • Noda T, Kolesnikova L, Becker S, Kawaoka Y. The importance of the NP: VP35 ratio in Ebola virus nucleocapsid formation. J. Infect. Dis. 204(Suppl. 3), S878-S883 (2011
    • (2011) J. Infect. Dis , vol.204 , pp. S878-S883
    • Noda, T.1    Kolesnikova, L.2    Becker, S.3    Kawaoka, Y.4
  • 86
    • 84880345503 scopus 로고    scopus 로고
    • Host IQGAP1 and Ebola virus VP40 interactions facilitate virus-like particle egress
    • Lu J, Qu Y, Liu Y et al. Host IQGAP1 and Ebola virus VP40 interactions facilitate virus-like particle egress. J. Virol. 87(13), 7777-7780 (2013
    • (2013) J. Virol , vol.87 , Issue.13 , pp. 7777-7780
    • Lu, J.1    Qu, Y.2    Liu, Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.