Distribution of different efflux pump genes in clinical isolates of multidrug-resistant Acinetobacter baumannii and their correlation with antimicrobial resistance

Journal of Microbiology, Immunology and Infection

Volumn 50, Issue 2, 2017, Pages 224-231

  Lin, Ming Feng ^a,b   Lin, Yun You ^b   Tu, Chi Chao ^c   Lan, Chung Yu ^b  

^a NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^b NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^c KEELUNG HOSPITAL   (Taiwan)

Author keywords

Acinetobacter baumannii; antibiotic resistance; efflux pumps

Indexed keywords

AMIKACIN; ANTIBIOTIC AGENT; IMIPENEM; TIGECYCLINE; ADEA PROTEIN, ACINETOBACTER BAUMANNII; ADEB PROTEIN, ACINETOBACTER BAUMANNII; ADEC PROTEIN, ACINETOBACTER BAUMANNII; ANTIINFECTIVE AGENT; BACTERIAL DNA; BACTERIAL PROTEIN; BACTERIAL RNA; CARRIER PROTEIN; EMRA PROTEIN, BACTERIA; MEMBRANE PROTEIN;

ABEM GENE; ABES GENE; ACINETOBACTER INFECTION; ADEB GENE; ADEJ GENE; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIUM ISOLATE; CONTROLLED STUDY; CRAA GENE; EMRA LIKE GENE; EMRB LIKE GENE; GENE EXPRESSION; HUMAN; MACB GENE; MULTIDRUG RESISTANCE; NONHUMAN; QUANTITATIVE ASSAY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TAIWAN; UPREGULATION; ACINETOBACTER BAUMANNII; DRUG EFFECTS; GENETICS; METABOLISM; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY;

ACINETOBACTER BAUMANNII; ACINETOBACTER INFECTIONS; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; DNA, BACTERIAL; DRUG RESISTANCE, MULTIPLE, BACTERIAL; GENES, BACTERIAL; HUMANS; MEMBRANE PROTEINS; MEMBRANE TRANSPORT PROTEINS; MICROBIAL SENSITIVITY TESTS; RNA, BACTERIAL;

EID: 84930331317     PISSN: 16841182     EISSN: 19959133     Source Type: Journal    
DOI: 10.1016/j.jmii.2015.04.004     Document Type: Article

References (34)

1. 1 Roca, I., Espinal, P., Vila-Farres, X., Vila, J., The Acinetobacter baumannii oxymoron: commensal hospital dweller turned pan-drug-resistant menace. Front Microbiol, 3, 2012, 148.
2. 2 Visca, P., Seifert, H., Towner, K.J., Acinetobacter infection—an emerging threat to human health. IUBMB Life 63 (2011), 1048–1054.
3. 3 Morfin-Otero, R., Dowzicky, M.J., Changes in MIC within a global collection of Acinetobacter baumannii collected as part of the Tigecycline Evaluation and Surveillance Trial, 2004 to 2009. Clin Ther 34 (2012), 101–112.
4. 4 Mendes, R.E., Farrell, D.J., Sader, H.S., Jones, R.N., Comprehensive assessment of tigecycline activity tested against a worldwide collection of Acinetobacter spp. (2005–2009). Diagn Microbiol Infect Dis 68 (2010), 307–311.
5. 5 Gordon, N.C., Wareham, D.W., Multidrug-resistant Acinetobacter baumannii: mechanisms of virulence and resistance. Int J Antimicrob Agents 35 (2010), 219–226.
6. 6 Esterly, J., Richardson, C.L., Eltoukhy, N.S., Qi, C., Scheetz, M.H., Genetic mechanisms of antimicrobial resistance of Acinetobacter baumannii. Ann Pharmacother 45 (2011), 218–228.
7. 7 Hooper, D.C., Efflux pumps and nosocomial antibiotic resistance: a primer for hospital epidemiologists. Clin Infect Dis 40 (2005), 1811–1817.
8. 8 Coyne, S., Courvalin, P., Perichon, B., Efflux-mediated antibiotic resistance in Acinetobacter spp. Antimicrob Agents Chemother 55 (2011), 947–953.
9. 9 Vila, J., Marti, S., Sanchez-Cespedes, J., Porins, efflux pumps and multidrug resistance in Acinetobacter baumannii. J Antimicrob Chemother 59 (2007), 1210–1215.
10. 10 Zgurskaya, H.I., Nikaido, H., Multidrug resistance mechanisms: drug efflux across two membranes. Mol Microbiol 37 (2000), 219–225.
11. 11 Poole, K., Efflux pumps as antimicrobial resistance mechanisms. Ann Med 39 (2007), 162–176.
12. 12 Magnet, S., Courvalin, P., Lambert, T., Resistance–nodulation–cell division-type efflux pump involved in aminoglycoside resistance in Acinetobacter baumannii strain BM4454. Antimicrob Agents Chemother 45 (2001), 3375–3380.
13. 13 Ruzin, A., Keeney, D., Bradford, P.A., AdeABC multidrug efflux pump is associated with decreased susceptibility to tigecycline in Acinetobacter calcoaceticus–Acinetobacter baumannii complex. J Antimicrob Chemother 59 (2007), 1001–1004.
14. 14 Damier-Piolle, L., Magnet, S., Bremont, S., Lambert, T., Courvalin, P., AdeIJK, a resistance–nodulation–cell division pump effluxing multiple antibiotics in Acinetobacter baumannii. Antimicrob Agents Chemother 52 (2008), 557–562.
15. 15 Coyne, S., Rosenfeld, N., Lambert, T., Courvalin, P., Perichon, B., Overexpression of resistance–nodulation–cell division pump AdeFGH confers multidrug resistance in Acinetobacter baumannii. Antimicrob Agents Chemother 54 (2010), 4389–4393.
16. 16 Ribera, A., Roca, I., Ruiz, J., Gibert, I., Vila, J., Partial characterization of a transposon containing the tet(A) determinant in a clinical isolate of Acinetobacter baumannii. J Antimicrob Chemother 52 (2003), 477–480.
17. 17 Roca, I., Marti, S., Espinal, P., Martinez, P., Gibert, I., Vila, J., CraA, a major facilitator superfamily efflux pump associated with chloramphenicol resistance in Acinetobacter baumannii. Antimicrob Agents Chemother 53 (2009), 4013–4014.
18. 18 Rajamohan, G., Srinivasan, V.B., Gebreyes, W.A., Molecular and functional characterization of a novel efflux pump, AmvA, mediating antimicrobial and disinfectant resistance in Acinetobacter baumannii. J Antimicrob Chemother 65 (2010), 1919–1925.
19. 19 Srinivasan, V.B., Rajamohan, G., Gebreyes, W.A., Role of AbeS, a novel efflux pump of the SMR family of transporters, in resistance to antimicrobial agents in Acinetobacter baumannii. Antimicrob Agents Chemother 53 (2009), 5312–5316.
20. +-coupled Acinetobacter baumannii multidrug efflux pump belonging to the MATE family of transporters. Antimicrob Agents Chemother 49 (2005), 4362–4364.
21. 21 Fournier, P.E., Vallenet, D., Barbe, V., Audic, S., Ogata, H., Poirel, L., et al. Comparative genomics of multidrug resistance in Acinetobacter baumannii. PLoS Genet, 2, 2006, e7.
22. 22 Tanabe, M., Szakonyi, G., Brown, K.A., Henderson, P.J., Nield, J., Byrne, B., The multidrug resistance efflux complex, EmrAB from Escherichia coli forms a dimer in vitro. Biochem Biophys Res Commun 380 (2009), 338–342.
23. 23 Kobayashi, N., Nishino, K., Yamaguchi, A., Novel macrolide-specific ABC-type efflux transporter in Escherichia coli. J Bacteriol 183 (2001), 5639–5644.
24. 24 Chen, T.L., Siu, L.K., Wu, R.C., Shaio, M.F., Huang, L.Y., Fung, C.P., et al. Comparison of one-tube multiplex PCR, automated ribotyping and intergenic spacer (ITS) sequencing for rapid identification of Acinetobacter baumannii. Clin Microbiol Infect 13 (2007), 801–806.
25. 25 Lin, M.F., Lin, Y.Y., Yeh, H.W., Lan, C.Y., Role of the BaeSR two-component system in the regulation of Acinetobacter baumannii adeAB genes and its correlation with tigecycline susceptibility. BMC Microbiol, 14, 2014, 119.
26. 26 Kuo, H.Y., Chang, K.C., Kuo, J.W., Yueh, H.W., Liou, M.L., Imipenem: a potent inducer of multidrug resistance in Acinetobacter baumannii. Int J Antimicrob Agents 39 (2012), 33–38.
27. 27 Li, J., Rayner, C.R., Nation, R.L., Owen, R.J., Spelman, D., Tan, K.E., et al. Heteroresistance to colistin in multidrug-resistant Acinetobacter baumannii. Antimicrob Agents Chemother 50 (2006), 2946–2950.
28. 28 CLSI, Performance Standards for Antimicrobial Susceptibility Testing; Twenty-Fourth Informational Supplement. CLSI document M100-S24, 2014, Clinical and Laboratory Standards Institute, Wayne, PA.
29. 29 Sambrook, J., Russell, W., Molecular cloning: a laboratory manual. 3rd ed., 2001, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
30. 30 Ruzin, A., Immermann, F.W., Bradford, P.A., RT-PCR and statistical analyses of adeABC expression in clinical isolates of Acinetobacter calcoaceticus–Acinetobacter baumannii complex. Microb Drug Resist 16 (2010), 87–89.
31. 31 Pannek, S., Higgins, P.G., Steinke, P., Jonas, D., Akova, M., Bohnert, J.A., et al. Multidrug efflux inhibition in Acinetobacter baumannii: comparison between 1-(1-naphthylmethyl)-piperazine and phenyl-arginine-beta-naphthylamide. J Antimicrob Chemother 57 (2006), 970–974.
32. 32 Deng, M., Zhu, M.H., Li, J.J., Bi, S., Sheng, Z.K., Hu, F.S., et al. Molecular epidemiology and mechanisms of tigecycline resistance in clinical isolates of Acinetobacter baumannii from a Chinese university hospital. Antimicrob Agents Chemother 58 (2014), 297–303.
33. 33 Piddock, L.J., Multidrug-resistance efflux pumps — not just for resistance. Nat Rev Microbiol 4 (2006), 629–636.
34. 34 Kuo, S.C., Chang, S.C., Wang, H.Y., Lai, J.F., Chen, P.C., Shiau, Y.R., et al. Emergence of extensively drug-resistant Acinetobacter baumannii complex over 10 years: nationwide data from the Taiwan Surveillance of Antimicrobial Resistance (TSAR) program. BMC Infect Dis, 12, 2012, 200.