Self-assembled micelles based on pH-sensitive PAE-g-MPEG-cholesterol block copolymer for anticancer drug delivery

International Journal of Nanomedicine

Volumn 9, Issue , 2014, Pages 4923-4933

  Zhang, Can Yang ^a   Xiong, Di ^a   Sun, Yao ^a   Zhao, Bin ^a   Lin, Wen Jing ^a   Zhang, Li Juan ^a  

^a SOUTH CHINA UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

Cholesterol; Drug delivery; Micelle; pH sensitive; Poly( amino ester)

Indexed keywords

CHOLESTEROL; COPOLYMER; DOXORUBICIN; POLYMER; MACROGOL DERIVATIVE; MICELLE; NANOPARTICLE; POLY(BETA-AMINO ESTER); POLYETHYLENE GLYCOL-CHOLESTEROL;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROPHOBICITY; MICELLE; PARTICLE SIZE; PH; PHASE TRANSITION; PHYSICAL CHEMISTRY; SENSITIVITY ANALYSIS; ANALOGS AND DERIVATIVES; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; HEPG2 CELL LINE; HUMAN; PROCEDURES;

CELL SURVIVAL; CHOLESTEROL; DOXORUBICIN; DRUG DELIVERY SYSTEMS; HEP G2 CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; MICELLES; NANOPARTICLES; PARTICLE SIZE; POLYETHYLENE GLYCOLS; POLYMERS;

EID: 84930250836     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S69493     Document Type: Article

References (44)

1. Tang S, Yin Q, Zhang Z, et al. Co-delivery of doxorubicin and RNA using pH-sensitive poly (β-amino ester) nanoparticles for reversal of multidrug resistance of breast cancer. Biomaterials. 2014; 35(23): 6047-6059.
2. Zhou Z, Li L, Yang Y, Xu X, Huang Y. Tumor targeting by pH-sensitive, biodegradable, cross-linked N-(2-hydroxypropyl) methacrylamide copolymer micelles. Biomaterials. 2014; 35(24): 6622-6635.
3. Felber AE, Dufresne MH, Leroux JC. pH-sensitive vesicles, polymeric micelles, and nanospheres prepared with polycarboxylates. Adv Drug Deliv Rev. 2012; 64(11): 979-992.
4. Schlossbauer A, Dohmen C, Schaffert D, Wagner E, Bein T. pH-responsive release of acetal-linked melittin from SBA-15 mesoporous silica. Angew Chem Int Edit. 2011; 50(30): 6828-6830.
5. Husseini GA, Pitt WG. Micelles and nanoparticles for ultrasonic drug and gene delivery. Adv Drug Deliv Rev. 2008; 60(10): 1137-1152.
6. Guo XD, Zhang LJ, Chen Y, Qian Y. Core/shell pH-sensitive micelles self-assembled from cholesterol conjugated oligopeptides for anticancer drug delivery. AIChE J. 2010; 56(7): 1922-1931.
7. Cao J, Su T, Zhang L, et al. Polymeric micelles with citraconic amide as pH-sensitive bond in backbone for anticancer drug delivery. Int J Pharm. 2014; 471(1-2): 28-36.
8. Zhang Q, Vakili MR, Li XF, Lavasanifar A, Le XC. Polymeric micelles for GSH-triggered delivery of arsenic species to cancer cells. Biomaterials. 2014; 35(25): 7088-7100.
9. Lee JE, Ahn E, Bak JM, et al. Polymeric micelles based on photocleavable linkers tethered with a model drug. Polymer. 2014; 55(6): 1436-1442.
10. Gao GH, Li Y, Lee DS. Environmental pH-sensitive polymeric micelles for cancer diagnosis and targeted therapy. J Control Release. 2013; 169(3): 180-184.
11. Desale SS, Cohen SM, Zhao Y, Kabanov AV, Bronich TK. Biodegradable hybrid polymer micelles for combination drug therapy in ovarian cancer. J Control Release. 2013; 171(3): 339-348.
12. Chatterjee K, Sarkar S, Jagajjanani Rao K, Paria S. Core/shell nanoparticles in biomedical applications. Adv Colloid Interfac. 2014; 209: 8-39.
13. Mitragotri S, Lahann J. Physical approaches to biomaterial design. Nat Mater. 2009; 8(1): 15-23.
14. Ganta S, Devalapally H, Shahiwala A, Amiji M. A review of stimuli-responsive nanocarriers for drug and gene delivery. J Control Release. 2008; 126(3): 187-204.
15. Dohmen C, Edinger D, Frohlich T, et al. Nanosized multifunctional polyplexes for receptor-mediated siRNA delivery. ACS Nano. 2012; 6(6): 5198-5208.
16. Mickler FM, Mockl L, Ruthardt N, Ogris M, Wagner E, Bräuchle C. Tuning nanoparticle uptake: live-cell imaging reveals two distinct endocytosis mechanisms mediated by natural and artificial EGFR targeting ligand. Nano Lett. 2012; 12(7): 3417-3423.
17. Sarker DK. Engineering of nanoemulsions for drug delivery. Curr Drug Deliv. 2005; 2(4): 297-310.
18. Chiang YT, Lo CL. pH-responsive polymer-liposomes for intracellular drug delivery and tumor extracellular matrix switched-on targeted cancer therapy. Biomaterials. 2014; 35(20): 5414-5424.
19. Ninomiya K, Yamashita T, Kawabata S, Shimizu N. Targeted and ultrasound-triggered drug delivery using liposomes co-modified with cancer cell-targeting aptamers and a thermosensitive polymer. Ultrason Sonochem. 2014; 21(4): 1482-1488.
20. Li XY, Zhao Y, Sun MG, et al. Multifunctional liposomes loaded with paclitaxel and artemether for treatment of invasive brain glioma. Biomaterials. 2014; 35(21): 5591-5604.
21. Kedar U, Phutane P, Shidhaye S, Kadam V. Advances in polymeric micelles for drug delivery and tumor targeting. Nanomedicine. 2010; 6(6): 714-729.
22. Keeney M, Ong SG, Padilla A, et al. Development of Poly(β-amino ester)-based biodegradable nanoparticles for nonviral delivery of minicircle DNA. ACS Nano. 2013; 7(8): 7241-7250.
23. Kozielski KL, Tzeng SY, Green JJ. A bioreducible linear poly(β-amino ester) for siRNA delivery. Chem Commun. 2013; 49(46): 5319-5321.
24. Shen Y, Tang H, Zhan Y, Van Kirk EA, Murdoch WJ. Degradable poly(β-amino ester) nanoparticles for cancer cytoplasmic drug delivery. Nanomedicine. 2009; 5(2): 192-201.
25. Danusso F, Ferruti P. Synthesis of tertiary amine polymers. Polymer. 1970; 11(2): 88-113.
26. Lynn DM, Langer R. Degradable poly(β-amino esters): synthesis, characterization, and self-assembly with plasmid DNA. J Am Chem Soc. 2000; 122(44): 10761-10768.
27. Lynn DM, Amiji MM, Langer R. pH-responsive polymer microspheres: rapid release of encapsulated material within the range of intracellular pH. Angew Chem Int Edit. 2001; 40(9): 1707-1710.
28. Shenoy D, Little S, Langer R, Amiji M. Poly(ethylene oxide)-modified poly(beta-amino ester) nanoparticles as a pH-sensitive system for tumor-targeted delivery of hydrophobic drugs. 1. In vitro evaluations. Mol Pharm. 2005; 2(5): 357-366.
29. Ko J, Park K, Kim YS, et al. Tumoral acidic extracellular pH targeting of pH-responsive MPEG-poly(beta-amino ester) block copolymer micelles for cancer therapy. J Control Release. 2007; 123(2): 109-115.
30. Hwang S, Kim M, Han J, et al. pH-sensitivity control of PEG-poly(β-amino ester) block copolymer micelle. Macromol Res. 2007; 15(5): 437-442.
31. Zhang CY, Yang YQ, Huang TX, et al. Self-assembled pH-responsive MPEG-b-(PLA-co-PAE) block copolymer micelles for anticancer drug delivery. Biomaterials. 2012; 33(26): 6273-6283.
32. Schmid SL, Fuchs R, Male P, Mellman I. Two distinct subpopulations of endosomes involved in membrane recycling and transport to lysosomes. Cell. 1988; 52(1): 73-83.
33. Engin K, Leeper DB, Cater JR, Thistlethwaite AJ, Tupchong L, Mcfarlane JD. Extracellular pH distribution in human tumours. Int J Hyperthermia. 1995; 11(2): 211-216.
34. Schmid S, Fuchs R, Kielian M, Helenius A, Mellman I. Acidification of endosome subpopulations in wild-type Chinese hamster ovary cells and temperature-sensitive acidification-defective mutants. J Cell Biol. 1989; 108(4): 1291-1300.
35. Qin Z, Chen Y, Zhou W, He X, Bai F, Wan M. Synthesis and properties of polymer brushes composed of poly(diphenylacetylene) main chain and poly(ethylene glycol) side chains. Eur Polym J. 2008; 44(11): 3732-3740.
36. Hussain H, Mya KY, He C. Self-assembly of brush-like poly[poly(ethylene glycol) methyl ether methacrylate] synthesized via aqueous atom transfer radical polymerization. Langmuir. 2008; 24(23): 13279-13286.
37. Ikonen E. Cellular cholesterol trafficking and compartmentalization. Nat Rev Mol Cell Biol. 2008; 9(2): 125-138.
38. Hosta-Rigau L, Zhang Y, Teo BM, Postma A, Städler B. Cholesterol-a biological compound as a building block in bionanotechnology. Nanoscale. 2013; 5(1): 89-109.
39. Wang Y, Zhang X, Yu P, Li C. Glycopolymer micelles with reducible ionic cores for hepatocytes-targeting delivery of DOX. Int J Pharm. 2013; 441(1-2): 170-180.
40. Yang YQ, Guo XD, Lin WJ, Zhang LJ, Zhang CY, Qian Y. Amphiphilic copolymer brush with random pH-sensitive/hydrophobic structure: synthesis and self-assembled micelles for sustained drug delivery. Soft Mater. 2012; 8(2): 454-464.
41. Wang Y, Ibrahim NL, Jiang J, Gao S, Erathodiyil N, Ying JY. Construction of block copolymers for the coordinated delivery of doxorubicin and magnetite nanocubes. J Control Release. 2013; 169(3): 211-219.
42. Xu L, Zhang H, Wu Y. Dendrimer advances for the central nervous system delivery of therapeutics. ACS Chem Neurosci. 2014; 5(1): 2-13.
43. Chen Z, Zhang P, Cheetham AG, et al. Controlled release of free doxorubicin from peptide-drug conjugates by drug loading. J Control Release. 2014; 191: 123-130.
44. Malarvizhi GL, Retnakumari AP, Nair S, Koyakutty M. Transferrin targeted core-shell nanomedicine for combinatorial delivery of doxorubicin and sorafenib against hepatocellular carcinoma. Nanomedicine. 2014; 14: S1549-S9634.