An On-Chip Small Intestine–Liver Model for Pharmacokinetic Studies

Journal of Laboratory Automation

Volumn 20, Issue 3, 2015, Pages 265-273

  Kimura, Hiroshi ^a,b,c   Ikeda, Takashi ^a   Nakayama, Hidenari ^a   Sakai, Yasuyuki ^a,c   Fujii, Teruo ^a,c  

^a INSTITUTE OF INDUSTRIAL SCIENCE   (Japan)

^b TOKAI UNIVERSITY   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

ADME; lab on a chip; microfluidics; microtechnology

Indexed keywords

ANIMALS; CELL CULTURE; LAB-ON-A-CHIP; LIVER; MICROFLUIDICS; PHARMACOKINETICS;

ADME; INTERNAL CIRCULATIONS; MICRO POROUS MEMBRANES; MICRO TOTAL ANALYSIS SYSTEMS; MICRO-FLUIDIC DEVICES; MICROTECHNOLOGY; PHARMACOKINETIC STUDIES; PHYSIOLOGICAL PARAMETERS;

PHYSIOLOGICAL MODELS;

4 HYDROXYCYCLOPHOSPHAMIDE; CYCLOPHOSPHAMIDE; CYTOCHROME P450 2B6; DIMETICONE; EPIRUBICIN; IRINOTECAN; POLYETHYLENE TEREPHTHALATE; CAMPTOTHECIN;

ARTICLE; BLOOD FLOW VELOCITY; CELL VIABILITY; COCULTURE; CYTOTOXICITY; DRUG MECHANISM; FLOW RATE; HEPATIC ARTERY; HUMAN; HUMAN CELL; INTESTINE FUNCTION; LAB ON A CHIP; LIVER FUNCTION; LUNG MODEL; MICROFLUIDIC ANALYSIS; MICROTECHNOLOGY; ORGAN SIZE; PARTICLE IMAGE VELOCIMETRY; SMALL INTESTINE; ANALOGS AND DERIVATIVES; ANIMAL; CACO 2 CELL LINE; COMPUTER SIMULATION; DRUG EFFECTS; DRUG SCREENING; HEPG2 CELL LINE; LIVER; LIVER NEOPLASMS; LUNG; LUNG NEOPLASMS; ORGAN CULTURE TECHNIQUE; PHYSIOLOGY; STOMACH NEOPLASMS; UTILIZATION;

ANIMALS; CACO-2 CELLS; CAMPTOTHECIN; COMPUTER SIMULATION; CYCLOPHOSPHAMIDE; DRUG SCREENING ASSAYS, ANTITUMOR; EPIRUBICIN; HEP G2 CELLS; HUMANS; INTESTINE, SMALL; LAB-ON-A-CHIP DEVICES; LIVER; LIVER NEOPLASMS; LUNG; LUNG NEOPLASMS; ORGAN CULTURE TECHNIQUES; STOMACH NEOPLASMS;

EID: 84930246473     PISSN: 22110682     EISSN: 22110690     Source Type: Journal    
DOI: 10.1177/2211068214557812     Document Type: Article

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