-
1
-
-
18444374405
-
Mutations of the BRAF gene in human cancer
-
Davies, H. et al. Mutations of the BRAF gene in human cancer. Nature 417, 949-954 (2002).
-
(2002)
Nature
, vol.417
, pp. 949-954
-
-
Davies, H.1
-
2
-
-
0037228055
-
High frequency of BRAF mutations in nevi
-
Pollock, P. M. et al. High frequency of BRAF mutations in nevi. Nat. Genet. 33, 19-20 (2003).
-
(2003)
Nat. Genet
, vol.33
, pp. 19-20
-
-
Pollock, P.M.1
-
3
-
-
33749021085
-
Somatic activation of KIT in distinct subtypes of melanoma
-
Curtin, J. A., Busam, K., Pinkel, D. & Bastian, B. C. Somatic activation of KIT in distinct subtypes of melanoma. J. Clin. Oncol. 24, 4340-4346 (2006).
-
(2006)
J. Clin. Oncol
, vol.24
, pp. 4340-4346
-
-
Curtin, J.A.1
Busam, K.2
Pinkel, D.3
Bastian, B.C.4
-
4
-
-
59049107421
-
Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi
-
Van Raamsdonk, C. D. et al. Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi. Nature 457, 599-602 (2009).
-
(2009)
Nature
, vol.457
, pp. 599-602
-
-
Van Raamsdonk, C.D.1
-
5
-
-
78651446131
-
Mutations in GNA11 in uveal melanoma
-
Van Raamsdonk, C. D. et al. Mutations in GNA11 in uveal melanoma. N. Engl. J. Med. 363, 2191-2199 (2010).
-
(2010)
N. Engl. J. Med
, vol.363
, pp. 2191-2199
-
-
Van Raamsdonk, C.D.1
-
6
-
-
84899513979
-
Loss of NF1 in cutaneous melanoma is associated with RAS activation and MEK dependence
-
Nissan, M. H. et al. Loss of NF1 in cutaneous melanoma is associated with RAS activation and MEK dependence. Cancer Res. 74, 2340-2350 (2014).
-
(2014)
Cancer Res
, vol.74
, pp. 2340-2350
-
-
Nissan, M.H.1
-
7
-
-
84865684161
-
Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma
-
Krauthammer, M. et al. Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma. Nat. Genet. 44, 1006-1014 (2012).
-
(2012)
Nat. Genet
, vol.44
, pp. 1006-1014
-
-
Krauthammer, M.1
-
8
-
-
84864258996
-
A landscape of driver mutations in melanoma
-
Hodis, E. et al. A landscape of driver mutations in melanoma. Cell 150, 251-263 (2012).
-
(2012)
Cell
, vol.150
, pp. 251-263
-
-
Hodis, E.1
-
9
-
-
77954526989
-
Rearrangements of the RAF kinase pathway in prostate cancer, gastric cancer and melanoma
-
Palanisamy, N. et al. Rearrangements of the RAF kinase pathway in prostate cancer, gastric cancer and melanoma. Nat. Med. 16, 793-798 (2010).
-
(2010)
Nat. Med
, vol.16
, pp. 793-798
-
-
Palanisamy, N.1
-
10
-
-
84886292349
-
Recurrent BRAF kinase fusions in melanocytic tumors offer an opportunity for targeted therapy
-
Botton, T. et al. Recurrent BRAF kinase fusions in melanocytic tumors offer an opportunity for targeted therapy. Pigment CellMelanoma Res. 26, 845-851 (2013).
-
(2013)
Pigment CellMelanoma Res
, vol.26
, pp. 845-851
-
-
Botton, T.1
-
11
-
-
84890621086
-
BRAF fusions define a distinct molecular subset of melanomas with potential sensitivity to MEK inhibition
-
Hutchinson, K. E. et al. BRAF fusions define a distinct molecular subset of melanomas with potential sensitivity to MEK inhibition. Clin. Cancer Res. 19, 6696-6702 (2013).
-
(2013)
Clin. Cancer Res
, vol.19
, pp. 6696-6702
-
-
Hutchinson, K.E.1
-
12
-
-
84892882633
-
Kinase fusions are frequent in Spitz tumours and spitzoid melanomas
-
Wiesner, T. et al. Kinase fusions are frequent in Spitz tumours and spitzoid melanomas. Nat. Commun. 5, 3116 (2014).
-
(2014)
Nat. Commun
, vol.5
, pp. 3116
-
-
Wiesner, T.1
-
13
-
-
0025805633
-
Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product
-
Bottaro, D. P. et al. Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product. Science 251, 802-804 (1991).
-
(1991)
Science
, vol.251
, pp. 802-804
-
-
Bottaro, D.P.1
-
14
-
-
0023661693
-
Scatter factor is a fibroblastderived modulator of epithelial cell mobility
-
Stoker, M., Gherardi, E., Perryman, M. & Gray, J. Scatter factor is a fibroblastderived modulator of epithelial cell mobility. Nature 327, 239-242 (1987).
-
(1987)
Nature
, vol.327
, pp. 239-242
-
-
Stoker, M.1
Gherardi, E.2
Perryman, M.3
Gray, J.4
-
15
-
-
0033071458
-
Hepatocyte growth factor/scatter factor-MET signaling in neural crest-derived melanocyte development
-
Kos, L. et al. Hepatocyte growth factor/scatter factor-MET signaling in neural crest-derived melanocyte development. Pigment Cell Res. Spons. Eur. Soc. 12, 13-21 (1999).
-
(1999)
Pigment Cell Res. Spons. Eur. Soc
, vol.12
, pp. 13-21
-
-
Kos, L.1
-
16
-
-
33744531154
-
C-Met expression is regulated by Mitf in the melanocyte lineage
-
McGill, G. G., Haq, R., Nishimura, E. K. & Fisher, D. E. c-Met expression is regulated by Mitf in the melanocyte lineage. J. Biol. Chem. 281, 10365-10373 (2006).
-
(2006)
J. Biol. Chem
, vol.281
, pp. 10365-10373
-
-
McGill, G.G.1
Haq, R.2
Nishimura, E.K.3
Fisher, D.E.4
-
17
-
-
34347252289
-
Up-regulation of MET expression by {alpha}-melanocytestimulating hormone and MITF allows hepatocyte growth factor to protect melanocytes and melanoma cells from apoptosis
-
Beuret, L. et al. Up-regulation of MET expression by {alpha}-melanocytestimulating hormone and MITF allows hepatocyte growth factor to protect melanocytes and melanoma cells from apoptosis. J. Biol. Chem. 282, 14140-14147 (2007).
-
(2007)
J. Biol. Chem
, vol.282
, pp. 14140-14147
-
-
Beuret, L.1
-
18
-
-
0021241398
-
Molecular cloning of a new transforming gene from a chemically transformed human cell line
-
Cooper, C. S. et al. Molecular cloning of a new transforming gene from a chemically transformed human cell line. Nature 311, 29-33 (1984).
-
(1984)
Nature
, vol.311
, pp. 29-33
-
-
Cooper, C.S.1
-
19
-
-
0025828180
-
The TPR-MET oncogenic rearrangement is present and expressed in human gastric carcinoma and precursor lesions
-
Soman, N. R., Correa, P., Ruiz, B. A. & Wogan, G. N. The TPR-MET oncogenic rearrangement is present and expressed in human gastric carcinoma and precursor lesions. Proc. Natl Acad. Sci. 88, 4892-4896 (1991).
-
(1991)
Proc. Natl Acad. Sci
, vol.88
, pp. 4892-4896
-
-
Soman, N.R.1
Correa, P.2
Ruiz, B.A.3
Wogan, G.N.4
-
20
-
-
0029993840
-
Lack of rearranged Tpr-met mRNA expression in human gastric cancer cell lines and gastric mucosa and carcinoma
-
Osaki, M. et al. Lack of rearranged Tpr-met mRNA expression in human gastric cancer cell lines and gastric mucosa and carcinoma. Anticancer Res. 16, 2881-2884 (1996).
-
(1996)
Anticancer Res
, vol.16
, pp. 2881-2884
-
-
Osaki, M.1
-
21
-
-
0034868238
-
Absence of tpr-met and expression of c-met in human gastric mucosa and carcinoma
-
Heideman, D. A. M. et al. Absence of tpr-met and expression of c-met in human gastric mucosa and carcinoma. J. Pathol. 194, 428-435 (2001).
-
(2001)
J. Pathol
, vol.194
, pp. 428-435
-
-
Heideman, D.A.M.1
-
22
-
-
0027055114
-
Frequent amplification of the c-met gene in scirrhous type stomach cancer
-
Kuniyasu, H. et al. Frequent amplification of the c-met gene in scirrhous type stomach cancer. Biochem. Biophys. Res. Commun. 189, 227-232 (1992).
-
(1992)
Biochem. Biophys. Res. Commun
, vol.189
, pp. 227-232
-
-
Kuniyasu, H.1
-
23
-
-
0028946604
-
Overexpression and amplification of the met/HGF receptor gene during the progression of colorectal cancer
-
Di Renzo, M. F. et al. Overexpression and amplification of the met/HGF receptor gene during the progression of colorectal cancer. Clin. Cancer Res. 1, 147-154 (1995).
-
(1995)
Clin. Cancer Res
, vol.1
, pp. 147-154
-
-
Di Renzo, M.F.1
-
24
-
-
0028890409
-
Amplification of the MET gene in glioma
-
Fischer, U. et al. Amplification of the MET gene in glioma. Genes Chromosomes Cancer 12, 63-65 (1995).
-
(1995)
Genes Chromosomes Cancer
, vol.12
, pp. 63-65
-
-
Fischer, U.1
-
25
-
-
41749097250
-
MET gene copy number in non-small cell lung cancer: Molecular analysis in a targeted tyrosine kinase inhibitor naïve cohort
-
Beau-Faller, M. et al. MET gene copy number in non-small cell lung cancer: molecular analysis in a targeted tyrosine kinase inhibitor naïve cohort. J. Thorac. Oncol. 3, 331-339 (2008).
-
(2008)
J. Thorac. Oncol
, vol.3
, pp. 331-339
-
-
Beau-Faller, M.1
-
26
-
-
79961028656
-
Gene amplification and protein overexpression of MET are common events in ovarian clear-cell adenocarcinoma: Their roles in tumor progression and prognostication of the patient
-
Yamamoto, S. et al. Gene amplification and protein overexpression of MET are common events in ovarian clear-cell adenocarcinoma: their roles in tumor progression and prognostication of the patient. Mod. Pathol. 24, 1146-1155 (2011).
-
(2011)
Mod. Pathol
, vol.24
, pp. 1146-1155
-
-
Yamamoto, S.1
-
27
-
-
38049150665
-
MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib
-
Bean, J. et al. MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib. Proc. Natl Acad. Sci. USA 104, 20932-20937 (2007).
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 20932-20937
-
-
Bean, J.1
-
28
-
-
34249075147
-
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
-
Engelman, J. A. et al. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science 316, 1039-1043 (2007).
-
(2007)
Science
, vol.316
, pp. 1039-1043
-
-
Engelman, J.A.1
-
29
-
-
84878862323
-
Amplification of the MET receptor drives resistance to anti-EGFR therapies in colorectal cancer
-
Bardelli, A. et al. Amplification of the MET receptor drives resistance to anti-EGFR therapies in colorectal cancer. Cancer Discov 3, 658-673 (2013).
-
(2013)
Cancer Discov
, vol.3
, pp. 658-673
-
-
Bardelli, A.1
-
30
-
-
31544462584
-
Somatic mutations lead to an oncogenic deletion of met in lung cancer
-
Kong-Beltran, M. et al. Somatic mutations lead to an oncogenic deletion of met in lung cancer. Cancer Res. 66, 283-289 (2006).
-
(2006)
Cancer Res
, vol.66
, pp. 283-289
-
-
Kong-Beltran, M.1
-
31
-
-
84905029258
-
Comprehensive molecular profiling of lung adenocarcinoma
-
Cancer Genome Atlas Research Network
-
Cancer Genome Atlas Research Network. Comprehensive molecular profiling of lung adenocarcinoma. Nature 511, 543-550 (2014).
-
(2014)
Nature
, vol.511
, pp. 543-550
-
-
-
32
-
-
84927166354
-
RNA-seq of 272 gliomas revealed a novel, recurrent PTPRZ1- MET fusion transcript in secondary glioblastomas
-
Bao, Z.-S. et al. RNA-seq of 272 gliomas revealed a novel, recurrent PTPRZ1- MET fusion transcript in secondary glioblastomas. Genome Res. 24, 1765-1773 (2014).
-
(2014)
Genome Res
, vol.24
, pp. 1765-1773
-
-
Bao, Z.-S.1
-
33
-
-
84897018336
-
The molecular pathology of melanoma: An integrated taxonomy of melanocytic neoplasia
-
Bastian, B. C. The molecular pathology of melanoma: an integrated taxonomy of melanocytic neoplasia. Annu. Rev. Pathol. Mech. Dis. 9, 239-271 (2014).
-
(2014)
Annu. Rev. Pathol. Mech. Dis
, vol.9
, pp. 239-271
-
-
Bastian, B.C.1
-
34
-
-
0035930341
-
Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein
-
Peschard, P. et al. Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein. Mol. Cell 8, 995-1004 (2001).
-
(2001)
Mol. Cell
, vol.8
, pp. 995-1004
-
-
Peschard, P.1
-
35
-
-
0023145290
-
A line of non-tumorigenic mouse melanocytes, syngeneic with the B16 melanoma and requiring a tumour promoter for growth
-
Bennett, D. C., Cooper, P. J. & Hart, I. R. A line of non-tumorigenic mouse melanocytes, syngeneic with the B16 melanoma and requiring a tumour promoter for growth. Int. J. Cancer 39, 414-418 (1987).
-
(1987)
Int. J. Cancer
, vol.39
, pp. 414-418
-
-
Bennett, D.C.1
Cooper, P.J.2
Hart, I.R.3
-
36
-
-
84890571003
-
Cabozantinib in progressive medullary thyroid cancer
-
Elisei, R. et al. Cabozantinib in progressive medullary thyroid cancer. J. Clin. Oncol. 31, 3639-3646 (2013).
-
(2013)
J. Clin. Oncol
, vol.31
, pp. 3639-3646
-
-
Elisei, R.1
-
37
-
-
84866872286
-
Discovery of a novel class of exquisitely selective mesenchymalepithelial transition factor (c-MET) protein kinase inhibitors and identification of the clinical candidate 2-(4-(1-(quinolin-6-ylmethyl)-1H-[1, 2, 3]triazolo[4, 5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethanol (PF-04217903) for the treatment of cancer
-
Cui, J. J. et al. Discovery of a novel class of exquisitely selective mesenchymalepithelial transition factor (c-MET) protein kinase inhibitors and identification of the clinical candidate 2-(4-(1-(quinolin-6-ylmethyl)-1H-[1, 2, 3]triazolo[4, 5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethanol (PF-04217903) for the treatment of cancer. J. Med. Chem. 55, 8091-8109 (2012).
-
(2012)
J. Med. Chem
, vol.55
, pp. 8091-8109
-
-
Cui, J.J.1
-
38
-
-
13044250462
-
Atypical Spitz nevi/tumors: Lack of consensus for diagnosis, discrimination from melanoma, and prediction of outcome
-
Barnhill, R. L. et al. Atypical Spitz nevi/tumors: lack of consensus for diagnosis, discrimination from melanoma, and prediction of outcome. Hum. Pathol. 30, 513-520 (1999).
-
(1999)
Hum. Pathol
, vol.30
, pp. 513-520
-
-
Barnhill, R.L.1
-
39
-
-
19044391610
-
Expression of the ETV6-NTRK3 gene fusion as a primary event in human secretory breast carcinoma
-
Tognon, C. et al. Expression of the ETV6-NTRK3 gene fusion as a primary event in human secretory breast carcinoma. Cancer Cell 2, 367-376 (2002).
-
(2002)
Cancer Cell
, vol.2
, pp. 367-376
-
-
Tognon, C.1
-
40
-
-
84899471648
-
ALK, ROS1 and RET fusions in 1139 lung adenocarcinomas: A comprehensive study of common and fusion pattern-specific clinicopathologic, histologic and cytologic features
-
Pan, Y. et al. ALK, ROS1 and RET fusions in 1139 lung adenocarcinomas: A comprehensive study of common and fusion pattern-specific clinicopathologic, histologic and cytologic features. Lung Cancer 84, 121-126 (2014).
-
(2014)
Lung Cancer
, vol.84
, pp. 121-126
-
-
Pan, Y.1
-
41
-
-
84915770151
-
Comprehensive genomic profiling of pancreatic acinar cell carcinomas identifies recurrent RAF fusions and frequent inactivation of DNA repair genes
-
Chmielecki, J. et al. Comprehensive genomic profiling of pancreatic acinar cell carcinomas identifies recurrent RAF fusions and frequent inactivation of DNA repair genes. Cancer Discov. 4, 1398-1405 (2014).
-
(2014)
Cancer Discov
, vol.4
, pp. 1398-1405
-
-
Chmielecki, J.1
-
42
-
-
84922373207
-
The landscape of kinase fusions in cancer
-
Stransky, N., Cerami, E., Schalm, S., Kim, J. L. & Lengauer, C. The landscape of kinase fusions in cancer. Nat. Commun. 5, 4846 (2014).
-
(2014)
Nat. Commun
, vol.5
, pp. 4846
-
-
Stransky, N.1
Cerami, E.2
Schalm, S.3
Kim, J.L.4
Lengauer, C.5
-
43
-
-
67649884743
-
Fast and accurate short read alignment with Burrows- Wheeler transform
-
Li, H. & Durbin, R. Fast and accurate short read alignment with Burrows- Wheeler transform. Bioinforma. Oxf. Engl. 25, 1754-1760 (2009).
-
(2009)
Bioinforma. Oxf. Engl
, vol.25
, pp. 1754-1760
-
-
Li, H.1
Durbin, R.2
-
44
-
-
77956295988
-
The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data
-
McKenna, A. et al. The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data. Genome Res. 20, 1297-1303 (2010).
-
(2010)
Genome Res
, vol.20
, pp. 1297-1303
-
-
McKenna, A.1
-
45
-
-
77956534324
-
Functional annotation of genetic variants from high-throughput sequencing data
-
Wang, K., Li, M. & Hakonarson, H. ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. Nucleic Acids Res. 38, e164-e164 (2010; .
-
(2010)
Nucleic Acids Res
, vol.38
, pp. e164-e164
-
-
Wang, K.1
Li, M.2
Annovar, H.H.3
-
46
-
-
77949587649
-
Fast and accurate short read alignment with Burrows- Wheeler transform
-
Li, H. & Durbin, R. Fast and accurate short read alignment with Burrows- Wheeler transform. Bioinforma. Oxf. Engl. 26, 589-595 (2010).
-
(2010)
Bioinforma. Oxf. Engl
, vol.26
, pp. 589-595
-
-
Li, H.1
Durbin, R.2
-
47
-
-
79961007031
-
CREST maps somatic structural variation in cancer genomes with base-pair resolution
-
Wang, J. et al. CREST maps somatic structural variation in cancer genomes with base-pair resolution. Nat. Methods 8, 652-654 (2011).
-
(2011)
Nat. Methods
, vol.8
, pp. 652-654
-
-
Wang, J.1
-
48
-
-
84875634162
-
Integrative Genomics Viewer (IGV): High-performance genomics data visualization and exploration
-
Thorvaldsdóttir, H., Robinson, J. T. & Mesirov, J. P. Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration. Brief Bioinform. 14, 178-192 (2013).
-
(2013)
Brief Bioinform
, vol.14
, pp. 178-192
-
-
Thorvaldsdóttir, H.1
Robinson, J.T.2
Mesirov, J.P.3
-
49
-
-
84871809302
-
STAR: Ultrafast universal RNA-seq aligner
-
Dobin, A. et al. STAR: ultrafast universal RNA-seq aligner. Bioinformatics 29, 15-21 (2013).
-
(2013)
Bioinformatics
, vol.29
, pp. 15-21
-
-
Dobin, A.1
-
50
-
-
0023145290
-
A line of non-tumorigenic mouse melanocytes, syngeneic with the B16 melanoma and requiring a tumour promoter for growth
-
Bennett, D. C., Cooper, P. J. & Hart, I. R. A line of non-tumorigenic mouse melanocytes, syngeneic with the B16 melanoma and requiring a tumour promoter for growth. Int. J. Cancer 39, 414-418 (1987).
-
(1987)
Int. J. Cancer
, vol.39
, pp. 414-418
-
-
Bennett, D.C.1
Cooper, P.J.2
Hart, I.R.3
-
51
-
-
83355166909
-
Cabozantinib (XL184), a Novel MET and VEGFR2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growth
-
Yakes, F. M. et al. Cabozantinib (XL184), a Novel MET and VEGFR2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growth. Mol. Cancer Ther 10, 2298-2308 (2011).
-
(2011)
Mol. Cancer Ther
, vol.10
, pp. 2298-2308
-
-
Yakes, F.M.1
|