메뉴 건너뛰기




Volumn 6, Issue , 2015, Pages

Activating MET kinase rearrangements in melanoma and Spitz tumours

Author keywords

[No Author keywords available]

Indexed keywords

CABOZANTINIB; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PF 04217903; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPASE C GAMMA1; SCATTER FACTOR RECEPTOR; UNCLASSIFIED DRUG; MET PROTEIN, HUMAN;

EID: 84930227386     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms8174     Document Type: Article
Times cited : (131)

References (51)
  • 1
    • 18444374405 scopus 로고    scopus 로고
    • Mutations of the BRAF gene in human cancer
    • Davies, H. et al. Mutations of the BRAF gene in human cancer. Nature 417, 949-954 (2002).
    • (2002) Nature , vol.417 , pp. 949-954
    • Davies, H.1
  • 2
    • 0037228055 scopus 로고    scopus 로고
    • High frequency of BRAF mutations in nevi
    • Pollock, P. M. et al. High frequency of BRAF mutations in nevi. Nat. Genet. 33, 19-20 (2003).
    • (2003) Nat. Genet , vol.33 , pp. 19-20
    • Pollock, P.M.1
  • 3
    • 33749021085 scopus 로고    scopus 로고
    • Somatic activation of KIT in distinct subtypes of melanoma
    • Curtin, J. A., Busam, K., Pinkel, D. & Bastian, B. C. Somatic activation of KIT in distinct subtypes of melanoma. J. Clin. Oncol. 24, 4340-4346 (2006).
    • (2006) J. Clin. Oncol , vol.24 , pp. 4340-4346
    • Curtin, J.A.1    Busam, K.2    Pinkel, D.3    Bastian, B.C.4
  • 4
    • 59049107421 scopus 로고    scopus 로고
    • Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi
    • Van Raamsdonk, C. D. et al. Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi. Nature 457, 599-602 (2009).
    • (2009) Nature , vol.457 , pp. 599-602
    • Van Raamsdonk, C.D.1
  • 5
    • 78651446131 scopus 로고    scopus 로고
    • Mutations in GNA11 in uveal melanoma
    • Van Raamsdonk, C. D. et al. Mutations in GNA11 in uveal melanoma. N. Engl. J. Med. 363, 2191-2199 (2010).
    • (2010) N. Engl. J. Med , vol.363 , pp. 2191-2199
    • Van Raamsdonk, C.D.1
  • 6
    • 84899513979 scopus 로고    scopus 로고
    • Loss of NF1 in cutaneous melanoma is associated with RAS activation and MEK dependence
    • Nissan, M. H. et al. Loss of NF1 in cutaneous melanoma is associated with RAS activation and MEK dependence. Cancer Res. 74, 2340-2350 (2014).
    • (2014) Cancer Res , vol.74 , pp. 2340-2350
    • Nissan, M.H.1
  • 7
    • 84865684161 scopus 로고    scopus 로고
    • Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma
    • Krauthammer, M. et al. Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma. Nat. Genet. 44, 1006-1014 (2012).
    • (2012) Nat. Genet , vol.44 , pp. 1006-1014
    • Krauthammer, M.1
  • 8
    • 84864258996 scopus 로고    scopus 로고
    • A landscape of driver mutations in melanoma
    • Hodis, E. et al. A landscape of driver mutations in melanoma. Cell 150, 251-263 (2012).
    • (2012) Cell , vol.150 , pp. 251-263
    • Hodis, E.1
  • 9
    • 77954526989 scopus 로고    scopus 로고
    • Rearrangements of the RAF kinase pathway in prostate cancer, gastric cancer and melanoma
    • Palanisamy, N. et al. Rearrangements of the RAF kinase pathway in prostate cancer, gastric cancer and melanoma. Nat. Med. 16, 793-798 (2010).
    • (2010) Nat. Med , vol.16 , pp. 793-798
    • Palanisamy, N.1
  • 10
    • 84886292349 scopus 로고    scopus 로고
    • Recurrent BRAF kinase fusions in melanocytic tumors offer an opportunity for targeted therapy
    • Botton, T. et al. Recurrent BRAF kinase fusions in melanocytic tumors offer an opportunity for targeted therapy. Pigment CellMelanoma Res. 26, 845-851 (2013).
    • (2013) Pigment CellMelanoma Res , vol.26 , pp. 845-851
    • Botton, T.1
  • 11
    • 84890621086 scopus 로고    scopus 로고
    • BRAF fusions define a distinct molecular subset of melanomas with potential sensitivity to MEK inhibition
    • Hutchinson, K. E. et al. BRAF fusions define a distinct molecular subset of melanomas with potential sensitivity to MEK inhibition. Clin. Cancer Res. 19, 6696-6702 (2013).
    • (2013) Clin. Cancer Res , vol.19 , pp. 6696-6702
    • Hutchinson, K.E.1
  • 12
    • 84892882633 scopus 로고    scopus 로고
    • Kinase fusions are frequent in Spitz tumours and spitzoid melanomas
    • Wiesner, T. et al. Kinase fusions are frequent in Spitz tumours and spitzoid melanomas. Nat. Commun. 5, 3116 (2014).
    • (2014) Nat. Commun , vol.5 , pp. 3116
    • Wiesner, T.1
  • 13
    • 0025805633 scopus 로고
    • Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product
    • Bottaro, D. P. et al. Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product. Science 251, 802-804 (1991).
    • (1991) Science , vol.251 , pp. 802-804
    • Bottaro, D.P.1
  • 14
    • 0023661693 scopus 로고
    • Scatter factor is a fibroblastderived modulator of epithelial cell mobility
    • Stoker, M., Gherardi, E., Perryman, M. & Gray, J. Scatter factor is a fibroblastderived modulator of epithelial cell mobility. Nature 327, 239-242 (1987).
    • (1987) Nature , vol.327 , pp. 239-242
    • Stoker, M.1    Gherardi, E.2    Perryman, M.3    Gray, J.4
  • 15
    • 0033071458 scopus 로고    scopus 로고
    • Hepatocyte growth factor/scatter factor-MET signaling in neural crest-derived melanocyte development
    • Kos, L. et al. Hepatocyte growth factor/scatter factor-MET signaling in neural crest-derived melanocyte development. Pigment Cell Res. Spons. Eur. Soc. 12, 13-21 (1999).
    • (1999) Pigment Cell Res. Spons. Eur. Soc , vol.12 , pp. 13-21
    • Kos, L.1
  • 16
    • 33744531154 scopus 로고    scopus 로고
    • C-Met expression is regulated by Mitf in the melanocyte lineage
    • McGill, G. G., Haq, R., Nishimura, E. K. & Fisher, D. E. c-Met expression is regulated by Mitf in the melanocyte lineage. J. Biol. Chem. 281, 10365-10373 (2006).
    • (2006) J. Biol. Chem , vol.281 , pp. 10365-10373
    • McGill, G.G.1    Haq, R.2    Nishimura, E.K.3    Fisher, D.E.4
  • 17
    • 34347252289 scopus 로고    scopus 로고
    • Up-regulation of MET expression by {alpha}-melanocytestimulating hormone and MITF allows hepatocyte growth factor to protect melanocytes and melanoma cells from apoptosis
    • Beuret, L. et al. Up-regulation of MET expression by {alpha}-melanocytestimulating hormone and MITF allows hepatocyte growth factor to protect melanocytes and melanoma cells from apoptosis. J. Biol. Chem. 282, 14140-14147 (2007).
    • (2007) J. Biol. Chem , vol.282 , pp. 14140-14147
    • Beuret, L.1
  • 18
    • 0021241398 scopus 로고
    • Molecular cloning of a new transforming gene from a chemically transformed human cell line
    • Cooper, C. S. et al. Molecular cloning of a new transforming gene from a chemically transformed human cell line. Nature 311, 29-33 (1984).
    • (1984) Nature , vol.311 , pp. 29-33
    • Cooper, C.S.1
  • 19
    • 0025828180 scopus 로고
    • The TPR-MET oncogenic rearrangement is present and expressed in human gastric carcinoma and precursor lesions
    • Soman, N. R., Correa, P., Ruiz, B. A. & Wogan, G. N. The TPR-MET oncogenic rearrangement is present and expressed in human gastric carcinoma and precursor lesions. Proc. Natl Acad. Sci. 88, 4892-4896 (1991).
    • (1991) Proc. Natl Acad. Sci , vol.88 , pp. 4892-4896
    • Soman, N.R.1    Correa, P.2    Ruiz, B.A.3    Wogan, G.N.4
  • 20
    • 0029993840 scopus 로고    scopus 로고
    • Lack of rearranged Tpr-met mRNA expression in human gastric cancer cell lines and gastric mucosa and carcinoma
    • Osaki, M. et al. Lack of rearranged Tpr-met mRNA expression in human gastric cancer cell lines and gastric mucosa and carcinoma. Anticancer Res. 16, 2881-2884 (1996).
    • (1996) Anticancer Res , vol.16 , pp. 2881-2884
    • Osaki, M.1
  • 21
    • 0034868238 scopus 로고    scopus 로고
    • Absence of tpr-met and expression of c-met in human gastric mucosa and carcinoma
    • Heideman, D. A. M. et al. Absence of tpr-met and expression of c-met in human gastric mucosa and carcinoma. J. Pathol. 194, 428-435 (2001).
    • (2001) J. Pathol , vol.194 , pp. 428-435
    • Heideman, D.A.M.1
  • 22
    • 0027055114 scopus 로고
    • Frequent amplification of the c-met gene in scirrhous type stomach cancer
    • Kuniyasu, H. et al. Frequent amplification of the c-met gene in scirrhous type stomach cancer. Biochem. Biophys. Res. Commun. 189, 227-232 (1992).
    • (1992) Biochem. Biophys. Res. Commun , vol.189 , pp. 227-232
    • Kuniyasu, H.1
  • 23
    • 0028946604 scopus 로고
    • Overexpression and amplification of the met/HGF receptor gene during the progression of colorectal cancer
    • Di Renzo, M. F. et al. Overexpression and amplification of the met/HGF receptor gene during the progression of colorectal cancer. Clin. Cancer Res. 1, 147-154 (1995).
    • (1995) Clin. Cancer Res , vol.1 , pp. 147-154
    • Di Renzo, M.F.1
  • 24
    • 0028890409 scopus 로고
    • Amplification of the MET gene in glioma
    • Fischer, U. et al. Amplification of the MET gene in glioma. Genes Chromosomes Cancer 12, 63-65 (1995).
    • (1995) Genes Chromosomes Cancer , vol.12 , pp. 63-65
    • Fischer, U.1
  • 25
    • 41749097250 scopus 로고    scopus 로고
    • MET gene copy number in non-small cell lung cancer: Molecular analysis in a targeted tyrosine kinase inhibitor naïve cohort
    • Beau-Faller, M. et al. MET gene copy number in non-small cell lung cancer: molecular analysis in a targeted tyrosine kinase inhibitor naïve cohort. J. Thorac. Oncol. 3, 331-339 (2008).
    • (2008) J. Thorac. Oncol , vol.3 , pp. 331-339
    • Beau-Faller, M.1
  • 26
    • 79961028656 scopus 로고    scopus 로고
    • Gene amplification and protein overexpression of MET are common events in ovarian clear-cell adenocarcinoma: Their roles in tumor progression and prognostication of the patient
    • Yamamoto, S. et al. Gene amplification and protein overexpression of MET are common events in ovarian clear-cell adenocarcinoma: their roles in tumor progression and prognostication of the patient. Mod. Pathol. 24, 1146-1155 (2011).
    • (2011) Mod. Pathol , vol.24 , pp. 1146-1155
    • Yamamoto, S.1
  • 27
    • 38049150665 scopus 로고    scopus 로고
    • MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib
    • Bean, J. et al. MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib. Proc. Natl Acad. Sci. USA 104, 20932-20937 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 20932-20937
    • Bean, J.1
  • 28
    • 34249075147 scopus 로고    scopus 로고
    • MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
    • Engelman, J. A. et al. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science 316, 1039-1043 (2007).
    • (2007) Science , vol.316 , pp. 1039-1043
    • Engelman, J.A.1
  • 29
    • 84878862323 scopus 로고    scopus 로고
    • Amplification of the MET receptor drives resistance to anti-EGFR therapies in colorectal cancer
    • Bardelli, A. et al. Amplification of the MET receptor drives resistance to anti-EGFR therapies in colorectal cancer. Cancer Discov 3, 658-673 (2013).
    • (2013) Cancer Discov , vol.3 , pp. 658-673
    • Bardelli, A.1
  • 30
    • 31544462584 scopus 로고    scopus 로고
    • Somatic mutations lead to an oncogenic deletion of met in lung cancer
    • Kong-Beltran, M. et al. Somatic mutations lead to an oncogenic deletion of met in lung cancer. Cancer Res. 66, 283-289 (2006).
    • (2006) Cancer Res , vol.66 , pp. 283-289
    • Kong-Beltran, M.1
  • 31
    • 84905029258 scopus 로고    scopus 로고
    • Comprehensive molecular profiling of lung adenocarcinoma
    • Cancer Genome Atlas Research Network
    • Cancer Genome Atlas Research Network. Comprehensive molecular profiling of lung adenocarcinoma. Nature 511, 543-550 (2014).
    • (2014) Nature , vol.511 , pp. 543-550
  • 32
    • 84927166354 scopus 로고    scopus 로고
    • RNA-seq of 272 gliomas revealed a novel, recurrent PTPRZ1- MET fusion transcript in secondary glioblastomas
    • Bao, Z.-S. et al. RNA-seq of 272 gliomas revealed a novel, recurrent PTPRZ1- MET fusion transcript in secondary glioblastomas. Genome Res. 24, 1765-1773 (2014).
    • (2014) Genome Res , vol.24 , pp. 1765-1773
    • Bao, Z.-S.1
  • 33
    • 84897018336 scopus 로고    scopus 로고
    • The molecular pathology of melanoma: An integrated taxonomy of melanocytic neoplasia
    • Bastian, B. C. The molecular pathology of melanoma: an integrated taxonomy of melanocytic neoplasia. Annu. Rev. Pathol. Mech. Dis. 9, 239-271 (2014).
    • (2014) Annu. Rev. Pathol. Mech. Dis , vol.9 , pp. 239-271
    • Bastian, B.C.1
  • 34
    • 0035930341 scopus 로고    scopus 로고
    • Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein
    • Peschard, P. et al. Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein. Mol. Cell 8, 995-1004 (2001).
    • (2001) Mol. Cell , vol.8 , pp. 995-1004
    • Peschard, P.1
  • 35
    • 0023145290 scopus 로고
    • A line of non-tumorigenic mouse melanocytes, syngeneic with the B16 melanoma and requiring a tumour promoter for growth
    • Bennett, D. C., Cooper, P. J. & Hart, I. R. A line of non-tumorigenic mouse melanocytes, syngeneic with the B16 melanoma and requiring a tumour promoter for growth. Int. J. Cancer 39, 414-418 (1987).
    • (1987) Int. J. Cancer , vol.39 , pp. 414-418
    • Bennett, D.C.1    Cooper, P.J.2    Hart, I.R.3
  • 36
    • 84890571003 scopus 로고    scopus 로고
    • Cabozantinib in progressive medullary thyroid cancer
    • Elisei, R. et al. Cabozantinib in progressive medullary thyroid cancer. J. Clin. Oncol. 31, 3639-3646 (2013).
    • (2013) J. Clin. Oncol , vol.31 , pp. 3639-3646
    • Elisei, R.1
  • 37
    • 84866872286 scopus 로고    scopus 로고
    • Discovery of a novel class of exquisitely selective mesenchymalepithelial transition factor (c-MET) protein kinase inhibitors and identification of the clinical candidate 2-(4-(1-(quinolin-6-ylmethyl)-1H-[1, 2, 3]triazolo[4, 5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethanol (PF-04217903) for the treatment of cancer
    • Cui, J. J. et al. Discovery of a novel class of exquisitely selective mesenchymalepithelial transition factor (c-MET) protein kinase inhibitors and identification of the clinical candidate 2-(4-(1-(quinolin-6-ylmethyl)-1H-[1, 2, 3]triazolo[4, 5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethanol (PF-04217903) for the treatment of cancer. J. Med. Chem. 55, 8091-8109 (2012).
    • (2012) J. Med. Chem , vol.55 , pp. 8091-8109
    • Cui, J.J.1
  • 38
    • 13044250462 scopus 로고    scopus 로고
    • Atypical Spitz nevi/tumors: Lack of consensus for diagnosis, discrimination from melanoma, and prediction of outcome
    • Barnhill, R. L. et al. Atypical Spitz nevi/tumors: lack of consensus for diagnosis, discrimination from melanoma, and prediction of outcome. Hum. Pathol. 30, 513-520 (1999).
    • (1999) Hum. Pathol , vol.30 , pp. 513-520
    • Barnhill, R.L.1
  • 39
    • 19044391610 scopus 로고    scopus 로고
    • Expression of the ETV6-NTRK3 gene fusion as a primary event in human secretory breast carcinoma
    • Tognon, C. et al. Expression of the ETV6-NTRK3 gene fusion as a primary event in human secretory breast carcinoma. Cancer Cell 2, 367-376 (2002).
    • (2002) Cancer Cell , vol.2 , pp. 367-376
    • Tognon, C.1
  • 40
    • 84899471648 scopus 로고    scopus 로고
    • ALK, ROS1 and RET fusions in 1139 lung adenocarcinomas: A comprehensive study of common and fusion pattern-specific clinicopathologic, histologic and cytologic features
    • Pan, Y. et al. ALK, ROS1 and RET fusions in 1139 lung adenocarcinomas: A comprehensive study of common and fusion pattern-specific clinicopathologic, histologic and cytologic features. Lung Cancer 84, 121-126 (2014).
    • (2014) Lung Cancer , vol.84 , pp. 121-126
    • Pan, Y.1
  • 41
    • 84915770151 scopus 로고    scopus 로고
    • Comprehensive genomic profiling of pancreatic acinar cell carcinomas identifies recurrent RAF fusions and frequent inactivation of DNA repair genes
    • Chmielecki, J. et al. Comprehensive genomic profiling of pancreatic acinar cell carcinomas identifies recurrent RAF fusions and frequent inactivation of DNA repair genes. Cancer Discov. 4, 1398-1405 (2014).
    • (2014) Cancer Discov , vol.4 , pp. 1398-1405
    • Chmielecki, J.1
  • 43
    • 67649884743 scopus 로고    scopus 로고
    • Fast and accurate short read alignment with Burrows- Wheeler transform
    • Li, H. & Durbin, R. Fast and accurate short read alignment with Burrows- Wheeler transform. Bioinforma. Oxf. Engl. 25, 1754-1760 (2009).
    • (2009) Bioinforma. Oxf. Engl , vol.25 , pp. 1754-1760
    • Li, H.1    Durbin, R.2
  • 44
    • 77956295988 scopus 로고    scopus 로고
    • The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data
    • McKenna, A. et al. The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data. Genome Res. 20, 1297-1303 (2010).
    • (2010) Genome Res , vol.20 , pp. 1297-1303
    • McKenna, A.1
  • 45
    • 77956534324 scopus 로고    scopus 로고
    • Functional annotation of genetic variants from high-throughput sequencing data
    • Wang, K., Li, M. & Hakonarson, H. ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. Nucleic Acids Res. 38, e164-e164 (2010; .
    • (2010) Nucleic Acids Res , vol.38 , pp. e164-e164
    • Wang, K.1    Li, M.2    Annovar, H.H.3
  • 46
    • 77949587649 scopus 로고    scopus 로고
    • Fast and accurate short read alignment with Burrows- Wheeler transform
    • Li, H. & Durbin, R. Fast and accurate short read alignment with Burrows- Wheeler transform. Bioinforma. Oxf. Engl. 26, 589-595 (2010).
    • (2010) Bioinforma. Oxf. Engl , vol.26 , pp. 589-595
    • Li, H.1    Durbin, R.2
  • 47
    • 79961007031 scopus 로고    scopus 로고
    • CREST maps somatic structural variation in cancer genomes with base-pair resolution
    • Wang, J. et al. CREST maps somatic structural variation in cancer genomes with base-pair resolution. Nat. Methods 8, 652-654 (2011).
    • (2011) Nat. Methods , vol.8 , pp. 652-654
    • Wang, J.1
  • 48
    • 84875634162 scopus 로고    scopus 로고
    • Integrative Genomics Viewer (IGV): High-performance genomics data visualization and exploration
    • Thorvaldsdóttir, H., Robinson, J. T. & Mesirov, J. P. Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration. Brief Bioinform. 14, 178-192 (2013).
    • (2013) Brief Bioinform , vol.14 , pp. 178-192
    • Thorvaldsdóttir, H.1    Robinson, J.T.2    Mesirov, J.P.3
  • 49
    • 84871809302 scopus 로고    scopus 로고
    • STAR: Ultrafast universal RNA-seq aligner
    • Dobin, A. et al. STAR: ultrafast universal RNA-seq aligner. Bioinformatics 29, 15-21 (2013).
    • (2013) Bioinformatics , vol.29 , pp. 15-21
    • Dobin, A.1
  • 50
    • 0023145290 scopus 로고
    • A line of non-tumorigenic mouse melanocytes, syngeneic with the B16 melanoma and requiring a tumour promoter for growth
    • Bennett, D. C., Cooper, P. J. & Hart, I. R. A line of non-tumorigenic mouse melanocytes, syngeneic with the B16 melanoma and requiring a tumour promoter for growth. Int. J. Cancer 39, 414-418 (1987).
    • (1987) Int. J. Cancer , vol.39 , pp. 414-418
    • Bennett, D.C.1    Cooper, P.J.2    Hart, I.R.3
  • 51
    • 83355166909 scopus 로고    scopus 로고
    • Cabozantinib (XL184), a Novel MET and VEGFR2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growth
    • Yakes, F. M. et al. Cabozantinib (XL184), a Novel MET and VEGFR2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growth. Mol. Cancer Ther 10, 2298-2308 (2011).
    • (2011) Mol. Cancer Ther , vol.10 , pp. 2298-2308
    • Yakes, F.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.