Cdc37 as a co-chaperone to Hsp90

Subcellular Biochemistry

Volumn 78, Issue , 2015, Pages 103-112

  Calderwood, Stuart K ^a,b  

^a Center for Life Science   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Cancer; Cdc37; Hsp90; Protein kinase

Indexed keywords

CDC37 PROTEIN, HUMAN; CELL CYCLE PROTEIN; CHAPERONIN; HEAT SHOCK PROTEIN 90; PROTEIN AGGREGATE;

ANIMAL; AUTOPHAGY; CELL PROLIFERATION; CHEMISTRY; ENZYMOLOGY; HUMAN; METABOLISM; NEOPLASM; PATHOLOGY; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN PROCESSING; PROTEINOSIS; SIGNAL TRANSDUCTION;

ANIMALS; AUTOPHAGY; CELL CYCLE PROTEINS; CELL PROLIFERATION; CHAPERONINS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; NEOPLASMS; PROTEIN AGGREGATES; PROTEIN AGGREGATION, PATHOLOGICAL; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; SIGNAL TRANSDUCTION;

EID: 84930207925     PISSN: 03060225     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-319-11731-7_5     Document Type: Article

References (42)

1. Bitting RL, Armstrong AJ (2013) Targeting the PI3K/Akt/mTOR pathway in castration-resistant prostate cancer. Endocr Relat Cancer 20:83–99
2. Boellmann F, Guettouche T, Guo Y, Fenna M, Mnayer L, Voellmy R (2004) DAXX interacts with heat shock factor 1 during stress activation and enhances its transcriptional activity. Proc Natl Acad Sci U S A 101:4100–4105
3. Calderwood SK (2013) Molecular cochaperones: tumor growth and cancer treatment. Scientifica 2013:217513
4. Calderwood SK, Gong J (2012) Molecular chaperones in mammary cancer growth and breast tumor therapy. J Cell Biochem 113:1096–1103
5. Calderwood SK, Khaleque MA, Sawyer DB, Ciocca DR (2006) Heat shock proteins in cancer: chaperones of tumorigenesis. Trends Biochem Sci 31:164–172
6. Calderwood SK, Murshid A, Prince T (2009) The shock of aging: molecular chaperones and the heat shock response in longevity and aging-a mini-review. Gerontology 55:550–558
7. Caplan AJ, Ma’ayan A, Willis IM (2007a) Multiple kinases and system robustness: a link between Cdc37 and genome integrity. Cell Cycle 6:3145–3147
8. Caplan AJ, Mandal AK, Theodoraki MA (2007b) Molecular chaperones and protein kinase quality control. Trends Cell Biol 17:87–92
9. Ciocca DR, Calderwood SK (2005) Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications. Cell Stress Chaperones 10:86–103
10. Ciocca DR, Arrigo AP, Calderwood SK (2013) Heat shock proteins and heat shock factor 1 in carcinogenesis and tumor development: an update. Arch Toxicol 87:19–48
11. Cox MB, Johnson JL (2011) The role of p23, Hop, immunophilins, and other co-chaperones in regulating Hsp90 function. Methods Mol Biol 787:45–66
12. Dey B, Lightbody JJ, Boschelli F (1996) CDC37 is required for p60v-src activity in yeast. Mol Biol Cell 7:1405–1417
13. Ellis RJ (2007) Protein misassembly: macromolecular crowding and molecular chaperones. Adv Exp Med Biol 594:1–13
14. Fliss AE, Fang Y, Boschelli F, Caplan AJ (1997) Differential in vivo regulation of steroid hormone receptor activation by Cdc37p. Mol Biol Cell 8:2501–2509
15. Gray PJ Jr, Stevenson MA, Calderwood SK (2007) Targeting Cdc37 inhibits multiple signalling pathways and induces growth arrest in prostate cancer cells. Cancer Res 67:11942–11950
16. Gray PJ Jr, Prince T, Cheng J, Stevenson MA, Calderwood SK (2008) Targeting the oncogene and kinome chaperone CDC37. Nat Rev Cancer 8:491–495
17. Heinlein CA, Chang C (2004) Androgen receptor in prostate cancer. Endocr Rev 25:276–308
18. Jinwal UK, Abisambra JF, Zhang J, Dharia S, O’Leary JC, Patel T, Braswell K, Jani T, Gestwicki JE, Dickey CA (2012) Cdc37/Hsp90 protein complex disruption triggers an autophagic clearance cascade for TDP-43 protein. J Biol Chem 287:24814–24820
19. Joo JH, Dorsey FC, Joshi A, Hennessy-Walters KM, Rose KL, McCastlain K, Zhang J, Iyengar R, Jung CH, Suen DF et al (2011) Hsp90-Cdc37 chaperone complex regulates Ulk1- and Atg13-mediated mitophagy. Mol Cell 43:572–585
20. Karnitz LM, Felts SJ (2007) Cdc37 regulation of the kinome: when to hold’em and when to fold’em. Sci STKE 2007:pe22
21. Lavictoire SJ, Parolin DA, Klimowicz AC, Kelly JF, Lorimer IA (2003) Interaction of Hsp90 with the nascent form of the mutant epidermal growth factor receptor EGFRvIII. J Biol Chem 278:5292–5299
22. MacLean M, Picard D (2003) Cdc37 goes beyond Hsp90 and kinases. Cell Stress Chaperones 8:114–119
23. Miyata Y, Nishida E (2005) CK2 binds, phosphorylates, and regulates its pivotal substrate Cdc37, an Hsp90-cochaperone. Mol Cell Biochem 274:171–179
24. Mollapour M, Tsutsumi S, Truman AW, Xu W, Vaughan CK, Beebe K, Konstantinova A, Vourganti S, Panaretou B, Piper PW et al (2011) Threonine 22 phosphorylation attenuates Hsp90 interaction with cochaperones and affects its chaperone activity. Mol Cell 41:672–681
25. Pearl LH (2005) Hsp90 and Cdc37- a chaperone cancer conspiracy. Curr Opin Gen Dev 15:55–61
26. Perdew GH, Wiegand H, Vanden Heuvel JP, Mitchell C, Singh SS (1997) A 50 kilodalton protein associated with raf and pp60(v-src) protein kinases is a mammalian homolog of the cell cycle control protein cdc37. Biochemistry 36:3600–3607
27. Rao J, Lee P, Benzeno S, Cardozo C, Albertus J, Robins DM, Caplan AJ (2001) Functional interaction of human Cdc37 with the androgen receptor but not with the glucocorticoid receptor. J Biol Chem 276:5814–5820
28. Reed SI (1980) The selection of amber mutations in genes required for completion of start, the controlling event of the cell division cycle of S. cerevisiae. Genetics 95:579–588
29. Salminen A, Lehtonen M, Paimela T, Kaarniranta K (2010) Celastrol: molecular targets of Thunder God Vine. Biochem Biophys Res Commun 394:439–442
30. Santagata S, Hu R, Lin NU, Mendillo ML, Collins LC, Hankinson SE, Schnitt SJ, Whitesell L, Tamimi RM, Lindquist S et al (2011) High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancer. Proc Natl Acad Sci U S A 108:18378–18383
31. Smith JR, Workman P (2009) Targeting CDC37: an alternative, kinase-directed strategy for disruption of oncogenic chaperoning. Cell Cycle 8:362–372
32. Stepanova L, Finegold M, DeMayo F, Schmidt EV, Harper JW (2000a) The oncoprotein kinase chaperone CDC37 functions as an oncogene in mice and collaborates with both c-myc and cyclin D1 in transformation of multiple tissues. Mol Cell Biol 20:4462–4473
33. Stepanova L, Yang G, DeMayo F, Wheeler TM, Finegold M, Thompson TC, Harper JW (2000b) Induction of human Cdc37 in prostate cancer correlates with the ability of targeted Cdc37 expression to promote prostatic hyperplasia. Oncogene 19:2186–2193
34. Summy JM, Sudol M, Eck MJ, Monteiro AN, Gatesman A, Flynn DC (2003) Specificity in signalling by c-Yes. Front Biosci 8:185–205
35. Taipale M, Jarosz DF, Lindquist S (2010) HSP90 at the hub of protein homeostasis: emerging mechanistic insights. Nat Rev Mol Cell Biol 11:515–528
36. Taipale M, Krykbaeva I, Koeva M, Kayatekin C, Westover KD, Karras GI, Lindquist S (2012) Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. Cell 150:987–1001
37. Turnbull EL, Martin IV, Fantes PA (2005) Cdc37 maintains cellular viability in Schizosaccharomyces pombe independently of interactions with heat-shock protein 90. FEBS J 272:4129–4140
38. Vaughan CK, Gohlke U, Sobott F, Good VM, Ali MM, Prodromou C, Robinson CV, Saibil HR, Pearl LH (2006) Structure of an Hsp90-Cdc37-Cdk4 complex. Mol Cell 23:697–707
39. Wu F, Peacock SO, Rao S, Lemmon SK, Burnstein KL (2013) Novel interaction between the cochaperone Cdc37 and Rho GTPase exchange factor Vav3 promotes androgen receptor activity and prostate cancer growth. J Biol Cell 288:5463–5474
40. Xu W, Neckers L (2012) The double edge of the HSP90-CDC37 chaperone machinery: opposing determinants of kinase stability and activity. Future Oncol 8:939–942
41. Xu W, Mollapour M, Prodromou C, Wang S, Scroggins BT, Palchick Z, Beebe K, Siderius M, Lee MJ, Couvillon A et al (2012). Dynamic tyrosine phosphorylation modulates cycling of the HSP90-P50(CDC37)-AHA1 chaperone machine. Mol Cell 47:434–443
42. Zou J, Guo Y, Guettouche T, Smith DF, Voellmy R (1998) Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1. Cell 94:471–480