메뉴 건너뛰기




Volumn 8, Issue 2, 2015, Pages 196-220

Wharton’s jelly-derived mesenchymal stromal cells as a promising cellular therapeutic strategy for the management of graft-versus-host disease

Author keywords

Allo HCT; GVHD; WJ MSCs

Indexed keywords

GALECTIN 1; GALECTIN 3; GALECTIN 8; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA STIMULATED GENE 6; UNCLASSIFIED DRUG;

EID: 84930196394     PISSN: None     EISSN: 14248247     Source Type: Journal    
DOI: 10.3390/ph8020196     Document Type: Review
Times cited : (27)

References (134)
  • 2
    • 33947546893 scopus 로고    scopus 로고
    • Management of acute graft-versus-host disease
    • Bacigalupo, A. Management of acute graft-versus-host disease. Br. J. Haematol. 2007, 137, 87–98.
    • (2007) Br. J. Haematol , vol.137 , pp. 87-98
    • Bacigalupo, A.1
  • 3
    • 19344363574 scopus 로고    scopus 로고
    • New approaches for preventing and treating chronic graft-versus-host disease
    • Lee, S.J. New approaches for preventing and treating chronic graft-versus-host disease. Blood 2005, 105, 4200–4206.
    • (2005) Blood , vol.105 , pp. 4200-4206
    • Lee, S.J.1
  • 4
    • 23944436856 scopus 로고    scopus 로고
    • Effect of graft-versus-host disease prophylaxis on 3-year disease-free survival in recipients of unrelated donor bone marrow (T-cell Depletion Trial): A multi-centre, randomised phase II-III trial
    • Wagner, J.E.; Thompson, J.S.; Carter, S.L.; Kernan, N.A. Effect of graft-versus-host disease prophylaxis on 3-year disease-free survival in recipients of unrelated donor bone marrow (T-cell Depletion Trial): A multi-centre, randomised phase II-III trial. Lancet 2005, 366, 733–741.
    • (2005) Lancet , vol.366 , pp. 733-741
    • Wagner, J.E.1    Thompson, J.S.2    Carter, S.L.3    Kernan, N.A.4
  • 5
    • 77957753981 scopus 로고    scopus 로고
    • Glucocorticoid-refractory acute graft-versus-host disease
    • Pidala, J.; Anasetti, C. Glucocorticoid-refractory acute graft-versus-host disease. Biol. Blood Marrow Transplant. 2010, 16, 1504–1518.
    • (2010) Biol. Blood Marrow Transplant , vol.16 , pp. 1504-1518
    • Pidala, J.1    Anasetti, C.2
  • 8
    • 0029058771 scopus 로고
    • Acute graft-versus-host disease: Grade and outcome in patients with chronic myelogenous leukemia. Working Party Chronic Leukemia of the European Group for Blood and Marrow Transplantation
    • Gratwohl, A.; Hermans, J.; Apperley, J.; Arcese, W.; Bacigalupo, A.; Bandini, G.; di Bartolomeo, P.; Boogaerts, M.; Bosi, A.; Carreras, E. Acute graft-versus-host disease: Grade and outcome in patients with chronic myelogenous leukemia. Working Party Chronic Leukemia of the European Group for Blood and Marrow Transplantation. Blood 1995, 86, 813–818.
    • (1995) Blood , vol.86 , pp. 813-818
    • Gratwohl, A.1    Hermans, J.2    Apperley, J.3    Arcese, W.4    Bacigalupo, A.5    Bandini, G.6    Di Bartolomeo, P.7    Boogaerts, M.8    Bosi, A.9    Carreras, E.10
  • 9
    • 33244456998 scopus 로고    scopus 로고
    • Measuring therapeutic response in chronic graft-versus-host disease: National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: IV. Response Criteria Working Group report
    • Pavletic, S.Z.; Martin, P.; Lee, S.J.; Mitchell, S.; Jacobsohn, D.; Cowen, E.W.; Turner, M.L.; Akpek, G.; Gilman, A.; McDonald, G.; et al. Measuring therapeutic response in chronic graft-versus-host disease: National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: IV. Response Criteria Working Group report. Biol. Blood Marrow Transplant. 2006, 12, 252–266.
    • (2006) Biol. Blood Marrow Transplant , vol.12 , pp. 252-266
    • Pavletic, S.Z.1    Martin, P.2    Lee, S.J.3    Mitchell, S.4    Jacobsohn, D.5    Cowen, E.W.6    Turner, M.L.7    Akpek, G.8    Gilman, A.9    McDonald, G.10
  • 10
    • 67650607997 scopus 로고    scopus 로고
    • Acute graft-versus-host disease transiently impairs thymic output in young patients after allogeneic hematopoietic stem cell transplantation
    • Clave, E.; Busson, M.; Douay, C.; de Peffault, L.R.; Berrou, J.; Rabian, C.; Carmagnat, M.; Rocha, V.; Charron, D.; Socie, G.; Toubert, A. Acute graft-versus-host disease transiently impairs thymic output in young patients after allogeneic hematopoietic stem cell transplantation. Blood 2009, 113, 6477–6484.
    • (2009) Blood , vol.113 , pp. 6477-6484
    • Clave, E.1    Busson, M.2    Douay, C.3    De Peffault, L.R.4    Berrou, J.5    Rabian, C.6    Carmagnat, M.7    Rocha, V.8    Charron, D.9    Socie, G.10    Toubert, A.11
  • 14
    • 84930216934 scopus 로고    scopus 로고
    • Risk-factors for acute graft-versus-host disease and survival after hematopoietic cell transplantation from siblings and unrelated donors—An analysis of the CIBMTR
    • Orlando Florida, 4–7 December, Abstract 897
    • Jagasia, M.; Arora, M.; Flowers, M.; Chao, N.J.; McCarthy, P.L, Antin, J.H.; Bolwell, B.J.; Bredeson, C.; Cahn, J.; Cairo, M.S.; et al. Risk-factors for acute graft-versus-host disease and survival after hematopoietic cell transplantation from siblings and unrelated donors—An analysis of the CIBMTR. In Proceedings of ASH Annual Meeting, Orlando Florida, 4–7 December 2010; Abstract 897.
    • (2010) Proceedings of ASH Annual Meeting
    • Jagasia, M.1    Arora, M.2    Flowers, M.3    Chao, N.J.4    McCarthy, P.L.5    Antin, J.H.6    Bolwell, B.J.7    Bredeson, C.8    Cahn, J.9    Cairo, M.S.10
  • 15
    • 77951149575 scopus 로고    scopus 로고
    • NCI First International Workshop on The Biology, Prevention, and Treatment of Relapse After Allogeneic Hematopoietic Stem Cell Transplantation: Report from the Committee on the Biology Underlying Recurrence of Malignant Disease following Allogeneic HSCT: Graft-versus-Tumor/Leukemia Reaction
    • Miller, J.S.; Warren, E.H.; van den Brink, M.R.; Ritz, J.; Shlomchik, W.D.; Murphy, W.J.; Barrett, A.J.; Kolb, H.J.; Giralt, S.; Bishop, M.R.; et al. NCI First International Workshop on The Biology, Prevention, and Treatment of Relapse After Allogeneic Hematopoietic Stem Cell Transplantation: Report from the Committee on the Biology Underlying Recurrence of Malignant Disease following Allogeneic HSCT: Graft-versus-Tumor/Leukemia Reaction. Biol. Blood Marrow Transplant. 2010, 16, 565–586.
    • (2010) Biol. Blood Marrow Transplant , vol.16 , pp. 565-586
    • Miller, J.S.1    Warren, E.H.2    Van Den Brink, M.R.3    Ritz, J.4    Shlomchik, W.D.5    Murphy, W.J.6    Barrett, A.J.7    Kolb, H.J.8    Giralt, S.9    Bishop, M.R.10
  • 16
    • 78650257628 scopus 로고    scopus 로고
    • Identification of MHC II-restricted minor histocompatibility antigens after HLA-identical stem-cell transplantation
    • Milosevic, S.; Bachnick, B.; Karim, K.; Bornkamm, G.W.; Witter, K.; Gerbitz, A.; Mautner, J.; Behrends, U. Identification of MHC II-restricted minor histocompatibility antigens after HLA-identical stem-cell transplantation. Transplantation 2010, 90, 1030–1035.
    • (2010) Transplantation , vol.90 , pp. 1030-1035
    • Milosevic, S.1    Bachnick, B.2    Karim, K.3    Bornkamm, G.W.4    Witter, K.5    Gerbitz, A.6    Mautner, J.7    Behrends, U.8
  • 18
    • 77955614393 scopus 로고    scopus 로고
    • Current use and outcome of hematopoietic stem cell transplantation: Part I—CIBMTR Summary Slides, 2009
    • Pasquini, M.C.; Wang, Z. Current use and outcome of hematopoietic stem cell transplantation: Part I—CIBMTR Summary Slides, 2009. CIBMTR Newsletter [serial online] 2009, 15, 7–11.
    • (2009) CIBMTR Newsletter [Serial Online] , vol.15 , pp. 7-11
    • Pasquini, M.C.1    Wang, Z.2
  • 19
    • 85047693606 scopus 로고    scopus 로고
    • Current and emerging strategies for the prevention of graft-versus-host disease
    • Choi, S.W.; Reddy, P. Current and emerging strategies for the prevention of graft-versus-host disease. Nat. Rev. Clin. Oncol. 2014, 11, 536–547.
    • (2014) Nat. Rev. Clin. Oncol , vol.11 , pp. 536-547
    • Choi, S.W.1    Reddy, P.2
  • 20
    • 14944339174 scopus 로고    scopus 로고
    • Human mesenchymal stem cells alter antigen-presenting cell maturation and induce T-cell unresponsiveness
    • Beyth, S.; Borovsky, Z.; Mevorach, D.; Liebergall, M.; Gazit, Z.; Aslan, H.; Galun, E.; Rachmilewitz, J. Human mesenchymal stem cells alter antigen-presenting cell maturation and induce T-cell unresponsiveness. Blood 2005, 105, 2214–2219.
    • (2005) Blood , vol.105 , pp. 2214-2219
    • Beyth, S.1    Borovsky, Z.2    Mevorach, D.3    Liebergall, M.4    Gazit, Z.5    Aslan, H.6    Galun, E.7    Rachmilewitz, J.8
  • 21
    • 77952944678 scopus 로고    scopus 로고
    • Immunomodulatory effect of mesenchymal stem cells. Braz
    • Herrero, C.; Perez-Simon, J.A. Immunomodulatory effect of mesenchymal stem cells. Braz. J. Med. Biol. Res. 2010, 43, 425–430.
    • (2010) J. Med. Biol. Res , vol.43 , pp. 425-430
    • Herrero, C.1    Perez-Simon, J.A.2
  • 22
    • 79751504754 scopus 로고    scopus 로고
    • Mesenchymal stem cells: Mechanisms of inflammation. Annu
    • Singer, N.G.; Caplan, A.I. Mesenchymal stem cells: mechanisms of inflammation. Annu. Rev. Pathol. 2011, 6, 457–478.
    • (2011) Rev. Pathol , vol.6 , pp. 457-478
    • Singer, N.G.1    Caplan, A.I.2
  • 23
    • 0037442264 scopus 로고    scopus 로고
    • Suppression of allogeneic T-cell proliferation by human marrow stromal cells: Implications in transplantation
    • Tse, W.T.; Pendleton, J.D.; Beyer, W.M.; Egalka, M.C.; Guinan, E.C. Suppression of allogeneic T-cell proliferation by human marrow stromal cells: Implications in transplantation. Transplantation 2003, 75, 389–397.
    • (2003) Transplantation , vol.75 , pp. 389-397
    • Tse, W.T.1    Pendleton, J.D.2    Beyer, W.M.3    Egalka, M.C.4    Guinan, E.C.5
  • 24
    • 45249100402 scopus 로고    scopus 로고
    • Co-infusion of donor bone marrow with host mesenchymal stem cells treats GVHD and promotes vascularized skin allograft survival in rats
    • Aksu, A.E.; Horibe, E.; Sacks, J.; Ikeguchi, R.; Breitinger, J.; Scozio, M.; Unadkat, J.; Feili-Hariri, M. Co-infusion of donor bone marrow with host mesenchymal stem cells treats GVHD and promotes vascularized skin allograft survival in rats. Clin. Immunol. 2008, 127, 348–358.
    • (2008) Clin. Immunol , vol.127 , pp. 348-358
    • Aksu, A.E.1    Horibe, E.2    Sacks, J.3    Ikeguchi, R.4    Breitinger, J.5    Scozio, M.6    Unadkat, J.7    Feili-Hariri, M.8
  • 25
    • 33846217749 scopus 로고    scopus 로고
    • Mesenchymal stem cells facilitate the induction of mixed hematopoietic chimerism and islet allograft tolerance without GVHD in the rat
    • Itakura, S.; Asari, S.; Rawson, J.; Ito, T.; Todorov, I.; Liu, C.P.; Sasaki, N.; Kandeel, F.; Mullen, Y. Mesenchymal stem cells facilitate the induction of mixed hematopoietic chimerism and islet allograft tolerance without GVHD in the rat. Am. J. Transplant. 2007, 7, 336–346.
    • (2007) Am. J. Transplant , vol.7 , pp. 336-346
    • Itakura, S.1    Asari, S.2    Rawson, J.3    Ito, T.4    Todorov, I.5    Liu, C.P.6    Sasaki, N.7    Kandeel, F.8    Mullen, Y.9
  • 26
    • 73849105297 scopus 로고    scopus 로고
    • Xenoreactivity of human clonal mesenchymal stem cells in a major histocompatibility complex-matched allogeneic graft-versus-host disease mouse model
    • Jeon, M.S.; Lim, H.J.; Yi, T.G.; Im, M.W.; Yoo, H.S.; Choi, J.H.; Choi, E.Y.; Song, S.U. Xenoreactivity of human clonal mesenchymal stem cells in a major histocompatibility complex-matched allogeneic graft-versus-host disease mouse model. Cell Immunol. 2010, 261, 57–63.
    • (2010) Cell Immunol , vol.261 , pp. 57-63
    • Jeon, M.S.1    Lim, H.J.2    Yi, T.G.3    Im, M.W.4    Yoo, H.S.5    Choi, J.H.6    Choi, E.Y.7    Song, S.U.8
  • 29
    • 34848863384 scopus 로고    scopus 로고
    • Adult mesenchymal stem cells for tissue engineering versus regenerative medicine
    • Caplan, A.I. Adult mesenchymal stem cells for tissue engineering versus regenerative medicine. J. Cell Physiol. 2007, 213, 341–347.
    • (2007) J. Cell Physiol , vol.213 , pp. 341-347
    • Caplan, A.I.1
  • 30
    • 79956188417 scopus 로고    scopus 로고
    • Mesenchymal stem cells and progenitor cells in connective tissue engineering and regenerative medicine: Is there a future for transplantation? Langenbecks
    • Hilfiker, A.; Kasper, C.; Hass, R.; Haverich, A. Mesenchymal stem cells and progenitor cells in connective tissue engineering and regenerative medicine: Is there a future for transplantation? Langenbecks Arch. Surg. 2011, 4, 489–497.
    • (2011) Arch. Surg , vol.4 , pp. 489-497
    • Hilfiker, A.1    Kasper, C.2    Hass, R.3    Haverich, A.4
  • 33
    • 0037093058 scopus 로고    scopus 로고
    • Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli
    • Di Nicola, M.; Carlo-Stella, C.; Magni, M.; Milanesi, M.; Longoni, P.D.; Matteucci, P.; Grisanti, S.; Gianni, A.M. Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood 2002, 99, 3838–3843.
    • (2002) Blood , vol.99 , pp. 3838-3843
    • Di Nicola, M.1    Carlo-Stella, C.2    Magni, M.3    Milanesi, M.4    Longoni, P.D.5    Matteucci, P.6    Grisanti, S.7    Gianni, A.M.8
  • 34
    • 13544249606 scopus 로고    scopus 로고
    • Human mesenchymal stem cells modulate allogeneic immune cell responses
    • Aggarwal, S.; Pittenger, M.F. Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood 2005, 105, 1815–1822.
    • (2005) Blood , vol.105 , pp. 1815-1822
    • Aggarwal, S.1    Pittenger, M.F.2
  • 36
    • 2342482526 scopus 로고    scopus 로고
    • Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells
    • Le Blanc, K.; Rasmusson, I.; Sundberg, B.; Gotherstrom, C.; Hassan, M.; Uzunel, M.; Ringden, O. Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells. Lancet 2004, 363, 1439–1441.
    • (2004) Lancet , vol.363 , pp. 1439-1441
    • Le Blanc, K.1    Rasmusson, I.2    Sundberg, B.3    Gotherstrom, C.4    Hassan, M.5    Uzunel, M.6    Ringden, O.7
  • 38
    • 77749289235 scopus 로고    scopus 로고
    • Single intra-arterial injection of mesenchymal stromal cells for treatment of steroid-refractory acute graft-versus-host disease: A pilot study
    • Arima, N.; Nakamura, F.; Fukunaga, A.; Hirata, H.; Machida, H.; Kouno, S.; Ohgushi, H. Single intra-arterial injection of mesenchymal stromal cells for treatment of steroid-refractory acute graft-versus-host disease: a pilot study. Cytotherapy 2010, 12, 265–268.
    • (2010) Cytotherapy , vol.12 , pp. 265-268
    • Arima, N.1    Nakamura, F.2    Fukunaga, A.3    Hirata, H.4    Machida, H.5    Kouno, S.6    Ohgushi, H.7
  • 39
    • 77952584405 scopus 로고    scopus 로고
    • Cotransplantation of mesenchymal stem cells might prevent death from graft-versus-host disease (GVHD) without abrogating graft-versus-tumor effects after HLA-mismatched allogeneic transplantation following nonmyeloablative conditioning
    • Baron, F.; Lechanteur, C.; Willems, E.; Bruck, F.; Baudoux, E.; Seidel, L.; Vanbellinghen, J.F.; Hafraoui, K.; Lejeune, M.; Gothot, A.; Fillet, G.; Beguin, Y. Cotransplantation of mesenchymal stem cells might prevent death from graft-versus-host disease (GVHD) without abrogating graft-versus-tumor effects after HLA-mismatched allogeneic transplantation following nonmyeloablative conditioning. Biol. Blood Marrow Transplant. 2010, 16, 838–847.
    • (2010) Biol. Blood Marrow Transplant , vol.16 , pp. 838-847
    • Baron, F.1    Lechanteur, C.2    Willems, E.3    Bruck, F.4    Baudoux, E.5    Seidel, L.6    Vanbellinghen, J.F.7    Hafraoui, K.8    Lejeune, M.9    Gothot, A.10    Fillet, G.11    Beguin, Y.12
  • 40
    • 33747371731 scopus 로고    scopus 로고
    • Treatment of severe therapy-resistant acute graft-versus-host disease with human adipose tissue-derived mesenchymal stem cells
    • Fang, B.; Song, Y.P.; Liao, L.M.; Han, Q.; Zhao, R.C. Treatment of severe therapy-resistant acute graft-versus-host disease with human adipose tissue-derived mesenchymal stem cells. Bone Marrow Transplant. 2006, 38, 389–390.
    • (2006) Bone Marrow Transplant , vol.38 , pp. 389-390
    • Fang, B.1    Song, Y.P.2    Liao, L.M.3    Han, Q.4    Zhao, R.C.5
  • 41
    • 34250178003 scopus 로고    scopus 로고
    • Using human adipose tissue-derived mesenchymal stem cells as salvage therapy for hepatic graft-versus-host disease resembling acute hepatitis
    • Fang, B.; Song, Y.; Zhao, R.C.; Han, Q.; Lin, Q. Using human adipose tissue-derived mesenchymal stem cells as salvage therapy for hepatic graft-versus-host disease resembling acute hepatitis. Transplant. Proc. 2007, 39, 1710–1713.
    • (2007) Transplant. Proc , vol.39 , pp. 1710-1713
    • Fang, B.1    Song, Y.2    Zhao, R.C.3    Han, Q.4    Lin, Q.5
  • 42
    • 34848834006 scopus 로고    scopus 로고
    • Human adipose tissue-derived mesenchymal stromal cells as salvage therapy for treatment of severe refractory acute graft- versus-host disease in two children
    • Fang, B.; Song, Y.; Lin, Q.; Zhang, Y.; Cao, Y.; Zhao, R.C.; Ma, Y. Human adipose tissue-derived mesenchymal stromal cells as salvage therapy for treatment of severe refractory acute graft- versus-host disease in two children. Pediatr. Transplant. 2007, 11, 814–817.
    • (2007) Pediatr. Transplant , vol.11 , pp. 814-817
    • Fang, B.1    Song, Y.2    Lin, Q.3    Zhang, Y.4    Cao, Y.5    Zhao, R.C.6    Ma, Y.7
  • 43
    • 65549124547 scopus 로고    scopus 로고
    • Cotransplantation of haploidentical mesenchymal stem cells to enhance engraftment of hematopoietic stem cells and to reduce the risk of graft failure in two children with severe aplastic anemia
    • Fang, B.; Li, N.; Song, Y.; Li, J.; Zhao, R.C.; Ma, Y. Cotransplantation of haploidentical mesenchymal stem cells to enhance engraftment of hematopoietic stem cells and to reduce the risk of graft failure in two children with severe aplastic anemia. Pediatr. Transplant. 2009, 13, 499–502.
    • (2009) Pediatr. Transplant , vol.13 , pp. 499-502
    • Fang, B.1    Li, N.2    Song, Y.3    Li, J.4    Zhao, R.C.5    Ma, Y.6
  • 45
    • 84893106561 scopus 로고    scopus 로고
    • Allogeneic human mesenchymal stem cell therapy (Remestemcel-L, Prochymal) as a rescue agent for severe refractory acute graft-versus-host disease in pediatric patients
    • Kurtzberg, J.; Prockop, S.; Teira, P.; Bittencourt, H.; Lewis, V.; Chan, K.W.; Horn, B.; Yu, L.; Talano, J.A.; Nemecek, E.; et al. Allogeneic human mesenchymal stem cell therapy (remestemcel-L, Prochymal) as a rescue agent for severe refractory acute graft-versus-host disease in pediatric patients. Biol. Blood Marrow Transplant. 2014, 20, 229–235.
    • (2014) Biol. Blood Marrow Transplant , vol.20 , pp. 229-235
    • Kurtzberg, J.1    Prockop, S.2    Teira, P.3    Bittencourt, H.4    Lewis, V.5    Chan, K.W.6    Horn, B.7    Yu, L.8    Talano, J.A.9    Nemecek, E.10
  • 48
    • 77955518690 scopus 로고    scopus 로고
    • Prochymal improves response rates In patients with steroid-refractory acute graft versus host disease (SR-GVHD) involving the liver and gut: Results of a randomized, placebo-controlled, multicenter phase III trial In GVHD
    • Martin, P.J.; Uberti, J.P.; Soiffer, R.J.; Klingemann, H.; Waller, E.K.; Daly, A.S.; Herrmann, R.P.; Kebriaei, P. Prochymal improves response rates In patients with steroid-refractory acute graft versus host disease (SR-GVHD) involving the liver and gut: Results of a randomized, placebo-controlled, multicenter phase III trial In GVHD. Biol.Blood Marrow Transplant. 2010, 16, S169–S170.
    • (2010) Biol.Blood Marrow Transplant , vol.16
    • Martin, P.J.1    Uberti, J.P.2    Soiffer, R.J.3    Klingemann, H.4    Waller, E.K.5    Daly, A.S.6    Herrmann, R.P.7    Kebriaei, P.8
  • 52
    • 75949085506 scopus 로고    scopus 로고
    • Efficacy of bone marrow-derived mesenchymal stem cells in the treatment of sclerodermatous chronic graft-versus-host disease: Clinical report
    • Zhou, H.; Guo, M.; Bian, C.; Sun, Z.; Yang, Z.; Zeng, Y.; Ai, H.; Zhao, R.C. Efficacy of bone marrow-derived mesenchymal stem cells in the treatment of sclerodermatous chronic graft-versus-host disease: Clinical report. Biol. Blood Marrow Transplant. 2010, 16, 403–412.
    • (2010) Biol. Blood Marrow Transplant , vol.16 , pp. 403-412
    • Zhou, H.1    Guo, M.2    Bian, C.3    Sun, Z.4    Yang, Z.5    Zeng, Y.6    Ai, H.7    Zhao, R.C.8
  • 53
    • 84886404127 scopus 로고    scopus 로고
    • Multiple infusions of mesenchymal stromal cells induce sustained remission in children with steroid-refractory, grade III-IV acute graft-versus-host disease
    • Ball, L.M.; Bernardo, M.E.; Roelofs, H.; van Tol, M.J.; Contoli, B.; Zwaginga, J.J.; Avanzini, M.A.; Conforti, A.; Bertaina, A.; Giorgiani, G.; et al. Multiple infusions of mesenchymal stromal cells induce sustained remission in children with steroid-refractory, grade III-IV acute graft-versus-host disease. Br. J. Haematol. 2013, 163, 501–509.
    • (2013) Br. J. Haematol , vol.163 , pp. 501-509
    • Ball, L.M.1    Bernardo, M.E.2    Roelofs, H.3    Van Tol, M.J.4    Contoli, B.5    Zwaginga, J.J.6    Avanzini, M.A.7    Conforti, A.8    Bertaina, A.9    Giorgiani, G.10
  • 58
    • 79958770457 scopus 로고    scopus 로고
    • Effective treatment of severe steroid-resistant acute graft-versus-host disease with umbilical cord-derived mesenchymal stem cells
    • Wu, K.H.; Chan, C.K.; Tsai, C.; Chang, Y.H.; Sieber, M.; Chiu, T.H.; Ho, M.; Peng, C.T.; Wu, H.P.; Huang, J.L. Effective treatment of severe steroid-resistant acute graft-versus-host disease with umbilical cord-derived mesenchymal stem cells. Transplantation 2011, 91, 1412–1416.
    • (2011) Transplantation , vol.91 , pp. 1412-1416
    • Wu, K.H.1    Chan, C.K.2    Tsai, C.3    Chang, Y.H.4    Sieber, M.5    Chiu, T.H.6    Ho, M.7    Peng, C.T.8    Wu, H.P.9    Huang, J.L.10
  • 59
  • 60
    • 79952624644 scopus 로고    scopus 로고
    • Efficacy and safety of ex vivo cultured adult human mesenchymal stem cells (Prochymal) in pediatric patients with severe refractory acute graft-versus-host disease in a compassionate use study
    • Prasad, V.K.; Lucas, K.G.; Kleiner, G.I.; Talano, J.A.; Jacobsohn, D.; Broadwater, G.; Monroy, R.; Kurtzberg, J. Efficacy and safety of ex vivo cultured adult human mesenchymal stem cells (Prochymal) in pediatric patients with severe refractory acute graft-versus-host disease in a compassionate use study. Biol. Blood Marrow Transplant. 2011, 17, 534–541.
    • (2011) Biol. Blood Marrow Transplant , vol.17 , pp. 534-541
    • Prasad, V.K.1    Lucas, K.G.2    Kleiner, G.I.3    Talano, J.A.4    Jacobsohn, D.5    Broadwater, G.6    Monroy, R.7    Kurtzberg, J.8
  • 61
    • 84900986769 scopus 로고    scopus 로고
    • Expanded cryopreserved mesenchymal stromal cells as an optimal source for graft-versus-host disease treatment
    • Holubova, M.; Lysak, D.; Vlas, T.; Vannucci, L.; Jindra, P. Expanded cryopreserved mesenchymal stromal cells as an optimal source for graft-versus-host disease treatment. Biologicals 2014, 42, 139–144.
    • (2014) Biologicals , vol.42 , pp. 139-144
    • Holubova, M.1    Lysak, D.2    Vlas, T.3    Vannucci, L.4    Jindra, P.5
  • 62
    • 37349132289 scopus 로고    scopus 로고
    • Comparative growth behaviour and characterization of stem cells from human Wharton’s jelly
    • Fong, C.Y.; Richards, M.; Manasi, N.; Biswas, A.; Bongso, A. Comparative growth behaviour and characterization of stem cells from human Wharton’s jelly. Reprod Biomed Online 2007, 15, 708–718.
    • (2007) Reprod Biomed Online , vol.15 , pp. 708-718
    • Fong, C.Y.1    Richards, M.2    Manasi, N.3    Biswas, A.4    Bongso, A.5
  • 63
    • 33744973827 scopus 로고    scopus 로고
    • Human umbilical cord matrix stem cells: Preliminary characterization and effect of transplantation in a rodent model of Parkinson’s disease
    • Weiss, M.L.; Medicetty, S.; Bledsoe, A.R.; Rachakatla, R.S.; Choi, M.; Merchav, S.; Luo, Y.; Rao, M.S.; Velagaleti, G.; Troyer, D. Human umbilical cord matrix stem cells: preliminary characterization and effect of transplantation in a rodent model of Parkinson’s disease. Stem Cells 2006, 24, 781–792.
    • (2006) Stem Cells , vol.24 , pp. 781-792
    • Weiss, M.L.1    Medicetty, S.2    Bledsoe, A.R.3    Rachakatla, R.S.4    Choi, M.5    Merchav, S.6    Luo, Y.7    Rao, M.S.8    Velagaleti, G.9    Troyer, D.10
  • 64
    • 84862296213 scopus 로고    scopus 로고
    • Mesenchymal stromal cells do not increase the risk of viral reactivation nor the severity of viral events in recipients of allogeneic stem cell transplantation
    • Lucchini, G.; Dander, E.; Pavan, F.; Di Ceglie, I.; Balduzzi, A.; Perseghin, P.; Gaipa, G.; Algarotti, A.; Introna, M.; Rambaldi, A.; et al. Mesenchymal stromal cells do not increase the risk of viral reactivation nor the severity of viral events in recipients of allogeneic stem cell transplantation. Stem Cells Int. 2012, 2012, 690236.
    • (2012) Stem Cells Int , vol.2012
    • Lucchini, G.1    Dander, E.2    Pavan, F.3    Di Ceglie, I.4    Balduzzi, A.5    Perseghin, P.6    Gaipa, G.7    Algarotti, A.8    Introna, M.9    Rambaldi, A.10
  • 65
    • 34547122719 scopus 로고    scopus 로고
    • Comparison of proliferative and multilineage differentiation potential of human mesenchymal stem cells derived from umbilical cord and bone marrow
    • Baksh, D.; Yao, R.; Tuan, R.S. Comparison of proliferative and multilineage differentiation potential of human mesenchymal stem cells derived from umbilical cord and bone marrow. Stem Cells 2007, 25, 1384–1392.
    • (2007) Stem Cells , vol.25 , pp. 1384-1392
    • Baksh, D.1    Yao, R.2    Tuan, R.S.3
  • 66
    • 33847675933 scopus 로고    scopus 로고
    • Cells isolated from umbilical cord tissue rescue photoreceptors and visual functions in a rodent model of retinal disease
    • Lund, R.D.; Wang, S.; Lu, B.; Girman, S.; Holmes, T.; Sauve, Y.; Messina, D.J.; Harris, I.R.; Kihm, A.J.; Harmon, A.M.; et al. Cells isolated from umbilical cord tissue rescue photoreceptors and visual functions in a rodent model of retinal disease. Stem Cells 2007, 25, 602–611.
    • (2007) Stem Cells , vol.25 , pp. 602-611
    • Lund, R.D.1    Wang, S.2    Lu, B.3    Girman, S.4    Holmes, T.5    Sauve, Y.6    Messina, D.J.7    Harris, I.R.8    Kihm, A.J.9    Harmon, A.M.10
  • 67
    • 68749116404 scopus 로고    scopus 로고
    • A comparison of human bone marrow-derived mesenchymal stem cells and human umbilical cord-derived mesenchymal stromal cells for cartilage tissue engineering
    • Wang, L.; Tran, I.; Seshareddy, K.; Weiss, M.L.; Detamore, M.S. A comparison of human bone marrow-derived mesenchymal stem cells and human umbilical cord-derived mesenchymal stromal cells for cartilage tissue engineering. Tissue Eng. Part A 2009, 15, 2259–2266.
    • (2009) Tissue Eng , vol.15 , pp. 2259-2266
    • Wang, L.1    Tran, I.2    Seshareddy, K.3    Weiss, M.L.4    Detamore, M.S.5
  • 69
    • 27144501816 scopus 로고    scopus 로고
    • Increasing donor age adversely impacts beneficial effects of bone marrow but not smooth muscle myocardial cell therapy
    • Zhang, H.; Fazel, S.; Tian, H.; Mickle, D.A.; Weisel, R.D.; Fujii, T.; Li, R.K. Increasing donor age adversely impacts beneficial effects of bone marrow but not smooth muscle myocardial cell therapy. Am. J. Physiol. Heart Circ. Physiol. 2005, 289, H2089–H2096.
    • (2005) Am. J. Physiol. Heart Circ. Physiol , vol.289
    • Zhang, H.1    Fazel, S.2    Tian, H.3    Mickle, D.A.4    Weisel, R.D.5    Fujii, T.6    Li, R.K.7
  • 70
    • 59849114318 scopus 로고    scopus 로고
    • Superior osteogenic capacity for bone tissue engineering of fetal compared with perinatal and adult mesenchymal stem cells
    • Zhang, Z.Y.; Teoh, S.H.; Chong, M.S.; Schantz, J.T.; Fisk, N.M.; Choolani, M.A.; Chan, J. Superior osteogenic capacity for bone tissue engineering of fetal compared with perinatal and adult mesenchymal stem cells. Stem Cells 2009, 27, 126–137.
    • (2009) Stem Cells , vol.27 , pp. 126-137
    • Zhang, Z.Y.1    Teoh, S.H.2    Chong, M.S.3    Schantz, J.T.4    Fisk, N.M.5    Choolani, M.A.6    Chan, J.7
  • 72
    • 77955093312 scopus 로고    scopus 로고
    • The umbilical cord matrix is a better source of mesenchymal stem cells (MSC) than the umbilical cord blood
    • Zeddou, M.; Briquet, A.; Relic, B.; Josse, C.; Malaise, M.G.; Gothot, A.; Lechanteur, C.; Beguin, Y. The umbilical cord matrix is a better source of mesenchymal stem cells (MSC) than the umbilical cord blood. Cell Biol. Int. 2010, 34, 693–701.
    • (2010) Cell Biol. Int , vol.34 , pp. 693-701
    • Zeddou, M.1    Briquet, A.2    Relic, B.3    Josse, C.4    Malaise, M.G.5    Gothot, A.6    Lechanteur, C.7    Beguin, Y.8
  • 73
    • 78149265779 scopus 로고    scopus 로고
    • Adipose-tissue-derived and Wharton's jelly-derived mesenchymal stromal cells suppress lymphocyte responses by secreting leukemia inhibitory factor
    • Najar, M.; Raicevic, G.; Boufker, H.I.; Fayyad-Kazan, H.; De, B.C.; Meuleman, N.; Bron, D.; Toungouz, M.; Lagneaux, L. Adipose-tissue-derived and Wharton's jelly-derived mesenchymal stromal cells suppress lymphocyte responses by secreting leukemia inhibitory factor. Tissue Eng. Part A 2010, 16, 3537–3546.
    • (2010) Tissue Eng , vol.16 , pp. 3537-3546
    • Najar, M.1    Raicevic, G.2    Boufker, H.I.3    Fayyad-Kazan, H.4    De, B.C.5    Meuleman, N.6    Bron, D.7    Toungouz, M.8    Lagneaux, L.9
  • 74
    • 77949308137 scopus 로고    scopus 로고
    • Pro-inflammatory cytokines, IFNgamma and TNFalpha, influence immune properties of human bone marrow and Wharton jelly mesenchymal stem cells differentially
    • Prasanna, S.J.; Gopalakrishnan, D.; Shankar, S.R.; Vasandan, A.B. Pro-inflammatory cytokines, IFNgamma and TNFalpha, influence immune properties of human bone marrow and Wharton jelly mesenchymal stem cells differentially. PLoS One 2010, 5, e9016.
    • (2010) Plos One , vol.5
    • Prasanna, S.J.1    Gopalakrishnan, D.2    Shankar, S.R.3    Vasandan, A.B.4
  • 76
    • 49149102464 scopus 로고    scopus 로고
    • Immunomodulatory effect of mesenchymal stromal cells: Possible mechanisms
    • Nasef, A.; Ashammakhi, N.; Fouillard, L. Immunomodulatory effect of mesenchymal stromal cells: possible mechanisms. Regen. Med. 2008, 3, 531–546.
    • (2008) Regen. Med , vol.3 , pp. 531-546
    • Nasef, A.1    Ashammakhi, N.2    Fouillard, L.3
  • 77
    • 33745231146 scopus 로고    scopus 로고
    • Immune modulation by mesenchymal stem cells
    • Rasmusson, I. Immune modulation by mesenchymal stem cells. Exp. Cell Res. 2006, 312, 2169–2179.
    • (2006) Exp. Cell Res , vol.312 , pp. 2169-2179
    • Rasmusson, I.1
  • 78
    • 78649333063 scopus 로고    scopus 로고
    • Immunosuppressive properties of human umbilical cord-derived mesenchymal stem cells: Role of B7-H1 and IDO
    • Tipnis, S.; Viswanathan, C.; Majumdar, A.S. Immunosuppressive properties of human umbilical cord-derived mesenchymal stem cells: Role of B7-H1 and IDO. Immunol. Cell Biol. 2010, 88, 795–806.
    • (2010) Immunol. Cell Biol , vol.88 , pp. 795-806
    • Tipnis, S.1    Viswanathan, C.2    Majumdar, A.S.3
  • 79
    • 61849123247 scopus 로고    scopus 로고
    • Cell contact, prostaglandin E(2) and transforming growth factor beta 1 play non-redundant roles in human mesenchymal stem cell induction of CD4+CD25(High) forkhead box P3+ regulatory T cells
    • English, K.; Ryan, J.M.; Tobin, L.; Murphy, M.J.; Barry, F.P.; Mahon, B.P. Cell contact, prostaglandin E(2) and transforming growth factor beta 1 play non-redundant roles in human mesenchymal stem cell induction of CD4+CD25(High) forkhead box P3+ regulatory T cells. Clin. Exp. Immunol. 2009, 156, 149–160.
    • (2009) Clin. Exp. Immunol , vol.156 , pp. 149-160
    • English, K.1    Ryan, J.M.2    Tobin, L.3    Murphy, M.J.4    Barry, F.P.5    Mahon, B.P.6
  • 80
    • 2942595706 scopus 로고    scopus 로고
    • Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradation
    • Meisel, R.; Zibert, A.; Laryea, M.; Gobel, U.; Daubener, W.; Dilloo, D. Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradation. Blood 2004, 103, 4619–4621.
    • (2004) Blood , vol.103 , pp. 4619-4621
    • Meisel, R.1    Zibert, A.2    Laryea, M.3    Gobel, U.4    Daubener, W.5    Dilloo, D.6
  • 81
    • 33846006154 scopus 로고    scopus 로고
    • Nitric oxide plays a critical role in suppression of T-cell proliferation by mesenchymal stem cells
    • Sato, K.; Ozaki, K.; Oh, I.; Meguro, A.; Hatanaka, K.; Nagai, T.; Muroi, K.; Ozawa, K. Nitric oxide plays a critical role in suppression of T-cell proliferation by mesenchymal stem cells. Blood 2007, 109, 228–234.
    • (2007) Blood , vol.109 , pp. 228-234
    • Sato, K.1    Ozaki, K.2    Oh, I.3    Meguro, A.4    Hatanaka, K.5    Nagai, T.6    Muroi, K.7    Ozawa, K.8
  • 82
    • 84866485020 scopus 로고    scopus 로고
    • Intercellular cytosolic transfer correlates with mesenchymal stromal cell rescue of umbilical cord blood cell viability during ex vivo expansion
    • Chu, P.P.; Bari, S.; Fan, X.; Gay, F.P.; Ang, J.M.; Chiu, G.N.; Lim, S.K.; Hwang, W.Y. Intercellular cytosolic transfer correlates with mesenchymal stromal cell rescue of umbilical cord blood cell viability during ex vivo expansion. Cytotherapy 2012, 14, 1064–1079.
    • (2012) Cytotherapy , vol.14 , pp. 1064-1079
    • Chu, P.P.1    Bari, S.2    Fan, X.3    Gay, F.P.4    Ang, J.M.5    Chiu, G.N.6    Lim, S.K.7    Hwang, W.Y.8
  • 83
    • 84889098431 scopus 로고    scopus 로고
    • Nanotubular crosstalk with distressed cardiomyocytes stimulates the paracrine repair function of mesenchymal stem cells
    • Figeac, F.; Lesault, P.F.; Le, C.O.; Damy, T.; Souktani, R.; Trebeau, C.; Schmitt, A.; Ribot, J.; Mounier, R.; Guguin, A.; et al. Nanotubular crosstalk with distressed cardiomyocytes stimulates the paracrine repair function of mesenchymal stem cells. Stem Cells 2014, 32, 216–230.
    • (2014) Stem Cells , vol.32 , pp. 216-230
    • Figeac, F.1    Lesault, P.F.2    Le, C.O.3    Damy, T.4    Souktani, R.5    Trebeau, C.6    Schmitt, A.7    Ribot, J.8    Mounier, R.9    Guguin, A.10
  • 84
    • 77951975599 scopus 로고    scopus 로고
    • Human umbilical cord mesenchymal stem cells hUC-MSCs exert immunosuppressive activities through a PGE2-dependent mechanism
    • Chen, K.; Wang, D.; Du, W.T.; Han, Z.B.; Ren, H.; Chi, Y.; Yang, S.G.; Zhu, D.; Bayard, F.; Han, Z.C. Human umbilical cord mesenchymal stem cells hUC-MSCs exert immunosuppressive activities through a PGE2-dependent mechanism. Clin. Immunol. 2010, 135, 448–458.
    • (2010) Clin. Immunol , vol.135 , pp. 448-458
    • Chen, K.1    Wang, D.2    Du, W.T.3    Han, Z.B.4    Ren, H.5    Chi, Y.6    Yang, S.G.7    Zhu, D.8    Bayard, F.9    Han, Z.C.10
  • 85
    • 77955093536 scopus 로고    scopus 로고
    • Mesenchymal stromal cells use PGE2 to modulate activation and proliferation of lymphocyte subsets: Combined comparison of adipose tissue, Wharton's Jelly and bone marrow sources
    • Najar, M.; Raicevic, G.; Boufker, H.I.; Fayyad, K.H.; De, B.C.; Meuleman, N.; Bron, D.; Toungouz, M.; Lagneaux, L. Mesenchymal stromal cells use PGE2 to modulate activation and proliferation of lymphocyte subsets: Combined comparison of adipose tissue, Wharton's Jelly and bone marrow sources. Cell Immunol. 2010, 264, 171–179.
    • (2010) Cell Immunol , vol.264 , pp. 171-179
    • Najar, M.1    Raicevic, G.2    Boufker, H.I.3    Fayyad, K.H.4    De, B.C.5    Meuleman, N.6    Bron, D.7    Toungouz, M.8    Lagneaux, L.9
  • 87
    • 77749298325 scopus 로고    scopus 로고
    • The immunosuppressive effect of Wharton’s jelly stromal cells depends on the timing of their licensing and on lymphocyte activation
    • Valencic, E.; Piscianz, E.; Andolina, M.; Ventura, A.; Tommasini, A. The immunosuppressive effect of Wharton’s jelly stromal cells depends on the timing of their licensing and on lymphocyte activation. Cytotherapy 2010, 12, 154–160.
    • (2010) Cytotherapy , vol.12 , pp. 154-160
    • Valencic, E.1    Piscianz, E.2    Andolina, M.3    Ventura, A.4    Tommasini, A.5
  • 88
    • 84883229944 scopus 로고    scopus 로고
    • Secreted galectin-3 as a possible biomarker for the immunomodulatory potential of human umbilical cord mesenchymal stromal cells
    • Liu, G.Y.; Xu, Y.; Li, Y.; Wang, L.H.; Liu, Y.J.; Zhu, D. Secreted galectin-3 as a possible biomarker for the immunomodulatory potential of human umbilical cord mesenchymal stromal cells. Cytotherapy 2013, 15, 1208–1217.
    • (2013) Cytotherapy , vol.15 , pp. 1208-1217
    • Liu, G.Y.1    Xu, Y.2    Li, Y.3    Wang, L.H.4    Liu, Y.J.5    Zhu, D.6
  • 89
    • 78149439868 scopus 로고    scopus 로고
    • Human multipotent mesenchymal stromal cells use galectin-1 to inhibit immune effector cells
    • Gieseke, F.; Bohringer, J.; Bussolari, R.; Dominici, M.; Handgretinger, R.; Muller, I. Human multipotent mesenchymal stromal cells use galectin-1 to inhibit immune effector cells. Blood 2010, 116, 3770–3779.
    • (2010) Blood , vol.116 , pp. 3770-3779
    • Gieseke, F.1    Bohringer, J.2    Bussolari, R.3    Dominici, M.4    Handgretinger, R.5    Muller, I.6
  • 90
    • 77949985881 scopus 로고    scopus 로고
    • Evidence for the involvement of galectin-3 in mesenchymal stem cell suppression of allogeneic T-cell proliferation. Scand
    • Sioud, M.; Mobergslien, A.; Boudabous, A.; Floisand, Y. Evidence for the involvement of galectin-3 in mesenchymal stem cell suppression of allogeneic T-cell proliferation. Scand. J. Immunol. 2010, 71, 267–274.
    • (2010) J. Immunol , vol.71 , pp. 267-274
    • Sioud, M.1    Mobergslien, A.2    Boudabous, A.3    Floisand, Y.4
  • 91
    • 84897428993 scopus 로고    scopus 로고
    • Galectin-9 is a suppressor of T and B cells and predicts the immune modulatory potential of mesenchymal stromal cell preparations
    • Ungerer, C.; Quade-Lyssy, P.; Radeke, H.H.; Henschler, R.; Konigs, C.; Kohl, U.; Seifried, E.; Schuttrumpf, J. Galectin-9 is a suppressor of T and B cells and predicts the immune modulatory potential of mesenchymal stromal cell preparations. Stem Cells Dev. 2014, 23, 755–766.
    • (2014) Stem Cells Dev , vol.23 , pp. 755-766
    • Ungerer, C.1    Quade-Lyssy, P.2    Radeke, H.H.3    Henschler, R.4    Konigs, C.5    Kohl, U.6    Seifried, E.7    Schuttrumpf, J.8
  • 93
    • 79960464308 scopus 로고    scopus 로고
    • Anti-inflammatory protein TSG-6 secreted by activated MSCs attenuates zymosan-induced mouse peritonitis by decreasing TLR2/NF-kappaB signaling in resident macrophages
    • Choi, H.; Lee, R.H.; Bazhanov, N.; Oh, J.Y.; Prockop, D.J. Anti-inflammatory protein TSG-6 secreted by activated MSCs attenuates zymosan-induced mouse peritonitis by decreasing TLR2/NF-kappaB signaling in resident macrophages. Blood 2011, 118, 330–338.
    • (2011) Blood , vol.118 , pp. 330-338
    • Choi, H.1    Lee, R.H.2    Bazhanov, N.3    Oh, J.Y.4    Prockop, D.J.5
  • 94
    • 84878221854 scopus 로고    scopus 로고
    • TSG-6 produced by hMSCs delays the onset of autoimmune diabetes by suppressing Th1 development and enhancing tolerogenicity
    • Kota, D.J.; Wiggins, L.L.; Yoon, N.; Lee, R.H. TSG-6 produced by hMSCs delays the onset of autoimmune diabetes by suppressing Th1 development and enhancing tolerogenicity. Diabetes 2013, 62, 2048–2058.
    • (2013) Diabetes , vol.62 , pp. 2048-2058
    • Kota, D.J.1    Wiggins, L.L.2    Yoon, N.3    Lee, R.H.4
  • 95
    • 67649171661 scopus 로고    scopus 로고
    • Intravenous hMSCs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG-6
    • Lee, R.H.; Pulin, A.A.; Seo, M.J.; Kota, D.J.; Ylostalo, J.; Larson, B.L.; Semprun-Prieto, L.; Delafontaine, P.; Prockop, D.J. Intravenous hMSCs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG-6. Cell Stem Cell 2009, 5, 54–63.
    • (2009) Cell Stem Cell , vol.5 , pp. 54-63
    • Lee, R.H.1    Pulin, A.A.2    Seo, M.J.3    Kota, D.J.4    Ylostalo, J.5    Larson, B.L.6    Semprun-Prieto, L.7    Delafontaine, P.8    Prockop, D.J.9
  • 96
    • 78049279294 scopus 로고    scopus 로고
    • Anti-inflammatory protein TSG-6 reduces inflammatory damage to the cornea following chemical and mechanical injury
    • Oh, J.Y.; Roddy, G.W.; Choi, H.; Lee, R.H.; Ylostalo, J.H.; Rosa, R.H., Jr.; Prockop, D.J. Anti-inflammatory protein TSG-6 reduces inflammatory damage to the cornea following chemical and mechanical injury. Proc. Natl. Acad. Sci. USA 2010, 107, 16875–16880.
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 16875-16880
    • Oh, J.Y.1    Roddy, G.W.2    Choi, H.3    Lee, R.H.4    Ylostalo, J.H.5    Rosa, R.H.6    Prockop, D.J.7
  • 97
    • 80053284296 scopus 로고    scopus 로고
    • Action at a distance: Systemically administered adult stem/progenitor cells (MSCs) reduce inflammatory damage to the cornea without engraftment and primarily by secretion of TNF-alpha stimulated gene/protein 6
    • Roddy, G.W.; Oh, J.Y.; Lee, R.H.; Bartosh, T.J.; Ylostalo, J.; Coble, K.; Rosa, R.H., Jr.; Prockop, D.J. Action at a distance: systemically administered adult stem/progenitor cells (MSCs) reduce inflammatory damage to the cornea without engraftment and primarily by secretion of TNF-alpha stimulated gene/protein 6. Stem Cells 2011, 29, 1572–1579.
    • (2011) Stem Cells , vol.29 , pp. 1572-1579
    • Roddy, G.W.1    Oh, J.Y.2    Lee, R.H.3    Bartosh, T.J.4    Ylostalo, J.5    Coble, K.6    Rosa, R.H.7    Prockop, D.J.8
  • 98
    • 84869080677 scopus 로고    scopus 로고
    • Intravenous mesenchymal stem cells prevented rejection of allogeneic corneal transplants by aborting the early inflammatory response
    • Oh, J.Y.; Lee, R.H.; Yu, J.M.; Ko, J.H.; Lee, H.J.; Ko, A.Y.; Roddy, G.W.; Prockop, D.J. Intravenous mesenchymal stem cells prevented rejection of allogeneic corneal transplants by aborting the early inflammatory response. Mol. Ther. 2012, 20, 2143–2152.
    • (2012) Mol. Ther , vol.20 , pp. 2143-2152
    • Oh, J.Y.1    Lee, R.H.2    Yu, J.M.3    Ko, J.H.4    Lee, H.J.5    Ko, A.Y.6    Roddy, G.W.7    Prockop, D.J.8
  • 99
    • 84905723566 scopus 로고    scopus 로고
    • Mesenchymal stem cells inhibit lipopolysaccharide-induced inflammatory responses of BV2 microglial cells through TSG-6
    • Liu, Y.; Zhang, R.; Yan, K.; Chen, F.; Huang, W.; Lv, B.; Sun, C.; Xu, L.; Li, F.; Jiang, X. Mesenchymal stem cells inhibit lipopolysaccharide-induced inflammatory responses of BV2 microglial cells through TSG-6. J. Neuroinflamm. 2014, 11, 135.
    • (2014) J. Neuroinflamm , vol.11 , pp. 135
    • Liu, Y.1    Zhang, R.2    Yan, K.3    Chen, F.4    Huang, W.5    Lv, B.6    Sun, C.7    Xu, L.8    Li, F.9    Jiang, X.10
  • 100
    • 84882521716 scopus 로고    scopus 로고
    • Anti-inflammatory and immunomodulatory mechanisms of mesenchymal stem cell transplantation in experimental traumatic brain injury
    • Zhang, R.; Liu, Y.; Yan, K.; Chen, L.; Chen, X.R.; Li, P.; Chen, F.F.; Jiang, X.D. Anti-inflammatory and immunomodulatory mechanisms of mesenchymal stem cell transplantation in experimental traumatic brain injury. J. Neuroinflamm. 2013, 10, 106.
    • (2013) J. Neuroinflamm , vol.10 , pp. 106
    • Zhang, R.1    Liu, Y.2    Yan, K.3    Chen, L.4    Chen, X.R.5    Li, P.6    Chen, F.F.7    Jiang, X.D.8
  • 101
    • 84902505700 scopus 로고    scopus 로고
    • Preparation of anti-inflammatory mesenchymal stem/precursor cells (MSCs) through sphere formation using hanging-drop culture technique
    • Bartosh, T.J.; Ylostalo, J.H. Preparation of anti-inflammatory mesenchymal stem/precursor cells (MSCs) through sphere formation using hanging-drop culture technique. Curr. Protoc. Stem Cell Biol. 2014, 28, 2B.6.1–2B.6.23.
    • (2014) Curr. Protoc. Stem Cell Biol , vol.28
    • Bartosh, T.J.1    Ylostalo, J.H.2
  • 102
    • 84939893615 scopus 로고    scopus 로고
    • Systematic Review of Preclinical Studies on the Therapeutic Potential of Mesenchymal Stromal Cell-Derived Microvesicles
    • Akyurekli, C.; Le, Y.; Richardson, R.B.; Fergusson, D.; Tay, J.; Allan, D.S. A Systematic Review of Preclinical Studies on the Therapeutic Potential of Mesenchymal Stromal Cell-Derived Microvesicles. Stem Cell. Rev. 2015, 11, 150–160.
    • (2015) Stem Cell. Rev , vol.11 , pp. 150-160
    • Akyurekli, C.1    Le, Y.2    Richardson, R.B.3    Fergusson, D.4    Tay, J.5    Allan, D.6
  • 103
    • 84887821866 scopus 로고    scopus 로고
    • Proteomic techniques for characterisation of mesenchymal stem cell secretome
    • Kupcova, S.H. Proteomic techniques for characterisation of mesenchymal stem cell secretome. Biochimie 2013, 95, 2196–2211.
    • (2013) Biochimie , vol.95 , pp. 2196-2211
    • Kupcova, S.H.1
  • 104
    • 84906964309 scopus 로고    scopus 로고
    • Paracrine mechanisms of Mesenchymal Stem cell-based therapy: Current status and perspectives
    • Liang, X.; Ding, Y.; Zhang, Y.; Tse, H.F.; Lian, Q. Paracrine mechanisms of Mesenchymal Stem cell-based therapy: Current status and perspectives. Cell Transplant. 2014, 23, 1045–1059.
    • (2014) Cell Transplant , vol.23 , pp. 1045-1059
    • Liang, X.1    Ding, Y.2    Zhang, Y.3    Tse, H.F.4    Lian, Q.5
  • 105
    • 84887825747 scopus 로고    scopus 로고
    • Mesenchymal stem cells in regenerative medicine applied to rheumatic diseases: Role of secretome and exosomes
    • Maumus, M.; Jorgensen, C.; Noel, D. Mesenchymal stem cells in regenerative medicine applied to rheumatic diseases: role of secretome and exosomes. Biochimie 2013, 95, 2229–2234.
    • (2013) Biochimie , vol.95 , pp. 2229-2234
    • Maumus, M.1    Jorgensen, C.2    Noel, D.3
  • 106
    • 84874988827 scopus 로고    scopus 로고
    • Mesenchymal stem cell: An efficient mass producer of exosomes for drug delivery
    • Yeo, R.W.; Lai, R.C.; Zhang, B.; Tan, S.S.; Yin, Y.; Teh, B.J.; Lim, S.K. Mesenchymal stem cell: An efficient mass producer of exosomes for drug delivery. Adv. Drug Deliv. Rev. 2013, 65, 336–341.
    • (2013) Adv. Drug Deliv. Rev , vol.65 , pp. 336-341
    • Yeo, R.W.1    Lai, R.C.2    Zhang, B.3    Tan, S.S.4    Yin, Y.5    Teh, B.J.6    Lim, S.K.7
  • 107
    • 84896475773 scopus 로고    scopus 로고
    • Exosomes derived from mesenchymal stem cells
    • Yu, B.; Zhang, X.; Li, X. Exosomes derived from mesenchymal stem cells. Int. J. Mol. Sci. 2014, 15, 4142–4157.
    • (2014) Int. J. Mol. Sci , vol.15 , pp. 4142-4157
    • Yu, B.1    Zhang, X.2    Li, X.3
  • 108
    • 84896453064 scopus 로고    scopus 로고
    • Mesenchymal stem cells secrete immunologically active exosomes
    • Zhang, B.; Yin, Y.; Lai, R.C.; Tan, S.S.; Choo, A.B.; Lim, S.K. Mesenchymal stem cells secrete immunologically active exosomes. Stem Cells Dev. 2014, 23, 1233–1244.
    • (2014) Stem Cells Dev , vol.23 , pp. 1233-1244
    • Zhang, B.1    Yin, Y.2    Lai, R.C.3    Tan, S.S.4    Choo, A.B.5    Lim, S.K.6
  • 109
    • 84913605925 scopus 로고    scopus 로고
    • Microvescicles Derived from Mesenchymal Stromal Cells Are Not as Effective as Their Cellular Counterpart in the Ability to Modulate Immune Responses In Vitro
    • Conforti, A.; Scarsella, M.; Starc, N.; Giorda, E.; Biagini, S.; Proia, A.; Carsetti, R.; Locatelli, F.; Bernardo, M.E. Microvescicles Derived from Mesenchymal Stromal Cells Are Not as Effective as Their Cellular Counterpart in the Ability to Modulate Immune Responses In Vitro. Stem Cells Dev. 2014, 23, 2591–2599.
    • (2014) Stem Cells Dev , vol.23 , pp. 2591-2599
    • Conforti, A.1    Scarsella, M.2    Starc, N.3    Giorda, E.4    Biagini, S.5    Proia, A.6    Carsetti, R.7    Locatelli, F.8    Bernardo, M.E.9
  • 111
  • 112
    • 80052461617 scopus 로고    scopus 로고
    • Promising cellular therapeutics for prevention or management of graft-versus-host disease (A review)
    • McGuirk, J.P.; Weiss, M.L. Promising cellular therapeutics for prevention or management of graft-versus-host disease (a review). Placenta 2011, 32 (Suppl. 4), S304–S310.
    • (2011) Placenta , vol.32
    • McGuirk, J.P.1    Weiss, M.L.2
  • 114
    • 84886871106 scopus 로고    scopus 로고
    • Assessment of immunosuppressive activity of human mesenchymal stem cells using murine antigen specific CD4 and CD8 T cells in vitro
    • Nazarov, C.; Lo, S.J.; Bauer, S.R.; Wei, C.H. Assessment of immunosuppressive activity of human mesenchymal stem cells using murine antigen specific CD4 and CD8 T cells in vitro. Stem Cell Res. Ther. 2013, 4, 128.
    • (2013) Stem Cell Res. Ther , vol.4 , pp. 128
    • Nazarov, C.1    Lo, S.J.2    Bauer, S.R.3    Wei, C.H.4
  • 115
    • 84866099775 scopus 로고    scopus 로고
    • Human umbilical cord mesenchymal stem cells reduce systemic inflammation and attenuate LPS-induced acute lung injury in rats
    • Li, J.; Li, D.; Liu, X.; Tang, S.; Wei, F. Human umbilical cord mesenchymal stem cells reduce systemic inflammation and attenuate LPS-induced acute lung injury in rats. J. Inflamm. (Lond.) 2012, 9, 33.
    • (2012) J. Inflamm. (Lond.) , vol.9 , pp. 33
    • Li, J.1    Li, D.2    Liu, X.3    Tang, S.4    Wei, F.5
  • 116
    • 84902574385 scopus 로고    scopus 로고
    • CCR7 guides migration of mesenchymal stem cell to secondary lymphoid organs: A novel approach to separate GvHD from GvL effect
    • Li, H.; Jiang, Y.; Jiang, X.; Guo, X.; Ning, H.; Li, Y.; Liao, L.; Yao, H.; Wang, X.; Liu, Y.; et al. CCR7 guides migration of mesenchymal stem cell to secondary lymphoid organs: A novel approach to separate GvHD from GvL effect. Stem Cells 2014, 32, 1890–1903.
    • (2014) Stem Cells , vol.32 , pp. 1890-1903
    • Li, H.1    Jiang, Y.2    Jiang, X.3    Guo, X.4    Ning, H.5    Li, Y.6    Liao, L.7    Yao, H.8    Wang, X.9    Liu, Y.10
  • 118
    • 84922568930 scopus 로고    scopus 로고
    • Standardization of Good Manufacturing Practice-compliant production of bone marrow-derived human mesenchymal stromal cells for immunotherapeutic applications
    • Wuchter, P.; Bieback, K.; Schrezenmeier, H.; Bornhauser, M.; Muller, L.P.; Bonig, H.; Wagner, W.; Meisel, R.; Pavel, P.; Tonn, T.; et al. Standardization of Good Manufacturing Practice-compliant production of bone marrow-derived human mesenchymal stromal cells for immunotherapeutic applications. Cytotherapy 2015, 17, 128–139.
    • (2015) Cytotherapy , vol.17 , pp. 128-139
    • Wuchter, P.1    Bieback, K.2    Schrezenmeier, H.3    Bornhauser, M.4    Muller, L.P.5    Bonig, H.6    Wagner, W.7    Meisel, R.8    Pavel, P.9    Tonn, T.10
  • 119
    • 84901368359 scopus 로고    scopus 로고
    • Soliciting strategies for developing cell-based reference materials to advance mesenchymal stromal cell research and clinical translation
    • Viswanathan, S.; Keating, A.; Deans, R.; Hematti, P.; Prockop, D.; Stroncek, D.F.; Stacey, G.; Weiss, D.J.; Mason, C.; Rao, M.S. Soliciting strategies for developing cell-based reference materials to advance mesenchymal stromal cell research and clinical translation. Stem Cells Dev. 2014, 23, 1157–1167.
    • (2014) Stem Cells Dev , vol.23 , pp. 1157-1167
    • Viswanathan, S.1    Keating, A.2    Deans, R.3    Hematti, P.4    Prockop, D.5    Stroncek, D.F.6    Stacey, G.7    Weiss, D.J.8    Mason, C.9    Rao, M.S.10
  • 120
    • 84893725179 scopus 로고    scopus 로고
    • MSC-based product characterization for clinical trials: An FDA perspective
    • Mendicino, M.; Bailey, A.M.; Wonnacott, K.; Puri, R.K.; Bauer, S.R. MSC-based product characterization for clinical trials: An FDA perspective. Cell Stem Cell 2014, 14, 141–145.
    • (2014) Cell Stem Cell , vol.14 , pp. 141-145
    • Mendicino, M.1    Bailey, A.M.2    Wonnacott, K.3    Puri, R.K.4    Bauer, S.R.5
  • 121
    • 84887116253 scopus 로고    scopus 로고
    • Automated microscopy as a quantitative method to measure differences in adipogenic differentiation in preparations of human mesenchymal stromal cells
    • Lo Surdo, J.L.; Millis, B.A.; Bauer, S.R. Automated microscopy as a quantitative method to measure differences in adipogenic differentiation in preparations of human mesenchymal stromal cells. Cytotherapy 2013, 15, 1527–1540.
    • (2013) Cytotherapy , vol.15 , pp. 1527-1540
    • Lo Surdo, J.L.1    Millis, B.A.2    Bauer, S.R.3
  • 122
    • 84868010082 scopus 로고    scopus 로고
    • Quantitative approaches to detect donor and passage differences in adipogenic potential and clonogenicity in human bone marrow-derived mesenchymal stem cells
    • Lo Surdo, J.; Bauer, S.R. Quantitative approaches to detect donor and passage differences in adipogenic potential and clonogenicity in human bone marrow-derived mesenchymal stem cells. Tissue Eng. Part C Methods 2012, 18, 877–889.
    • (2012) Tissue Eng. Part C Methods , vol.18 , pp. 877-889
    • Lo Surdo, J.1    Bauer, S.R.2
  • 124
    • 84875539909 scopus 로고    scopus 로고
    • Mesenchymal stem cell: Keystone of the hematopoietic stem cell niche and a stepping-stone for regenerative medicine
    • Frenette, P.S.; Pinho, S.; Lucas, D.; Scheiermann, C. Mesenchymal stem cell: keystone of the hematopoietic stem cell niche and a stepping-stone for regenerative medicine. Annu. Rev. Immunol. 2013, 31, 285–316.
    • (2013) Annu. Rev. Immunol , vol.31 , pp. 285-316
    • Frenette, P.S.1    Pinho, S.2    Lucas, D.3    Scheiermann, C.4
  • 125
    • 84880652108 scopus 로고    scopus 로고
    • PDGFRalpha and CD51 mark human nestin+ sphere-forming mesenchymal stem cells capable of hematopoietic progenitor cell expansion
    • Pinho, S.; Lacombe, J.; Hanoun, M.; Mizoguchi, T.; Bruns, I.; Kunisaki, Y.; Frenette, P.S. PDGFRalpha and CD51 mark human nestin+ sphere-forming mesenchymal stem cells capable of hematopoietic progenitor cell expansion. J. Exp. Med. 2013, 210, 1351–1367.
    • (2013) J. Exp. Med , vol.210 , pp. 1351-1367
    • Pinho, S.1    Lacombe, J.2    Hanoun, M.3    Mizoguchi, T.4    Bruns, I.5    Kunisaki, Y.6    Frenette, P.S.7
  • 126
    • 84884936600 scopus 로고    scopus 로고
    • Clonal analysis of multipotent stromal cells derived from CD271+ bone marrow mononuclear cells: Functional heterogeneity and different mechanisms of allosuppression
    • Kuci, Z.; Seiberth, J.; Latifi-Pupovci, H.; Wehner, S.; Stein, S.; Grez, M.; Bonig, H.; Kohl, U.; Klingebiel, T.; Bader, P.; Kuci, S. Clonal analysis of multipotent stromal cells derived from CD271+ bone marrow mononuclear cells: functional heterogeneity and different mechanisms of allosuppression. Haematologica 2013, 98, 1609–1616.
    • (2013) Haematologica , vol.98 , pp. 1609-1616
    • Kuci, Z.1    Seiberth, J.2    Latifi-Pupovci, H.3    Wehner, S.4    Stein, S.5    Grez, M.6    Bonig, H.7    Kohl, U.8    Klingebiel, T.9    Bader, P.10    Kuci, S.11
  • 127
    • 34249662219 scopus 로고    scopus 로고
    • IFN-gamma and TNF-alpha differentially regulate immunomodulation by murine mesenchymal stem cells
    • English, K.; Barry, F.P.; Field-Corbett, C.P.; Mahon, B.P. IFN-gamma and TNF-alpha differentially regulate immunomodulation by murine mesenchymal stem cells. Immunol. Lett. 2007, 110, 91–100.
    • (2007) Immunol. Lett , vol.110 , pp. 91-100
    • English, K.1    Barry, F.P.2    Field-Corbett, C.P.3    Mahon, B.P.4
  • 128
    • 80052360805 scopus 로고    scopus 로고
    • Ligation of TLR2 and TLR4 on murine bone marrow-derived mesenchymal stem cells triggers differential effects on their immunosuppressive activity
    • Lei, J.; Wang, Z.; Hui, D.; Yu, W.; Zhou, D.; Xia, W.; Chen, C.; Zhang, Q.; Wang, Z.; Zhang, Q.; Xiang, A.P. Ligation of TLR2 and TLR4 on murine bone marrow-derived mesenchymal stem cells triggers differential effects on their immunosuppressive activity. Cell Immunol. 2011, 271, 147–156.
    • (2011) Cell Immunol , vol.271 , pp. 147-156
    • Lei, J.1    Wang, Z.2    Hui, D.3    Yu, W.4    Zhou, D.5    Xia, W.6    Chen, C.7    Zhang, Q.8    Wang, Z.9    Zhang, Q.10    Xiang, A.P.11
  • 129
    • 38349060182 scopus 로고    scopus 로고
    • Toll-like receptors 3 and 4 are expressed by human bone marrow-derived mesenchymal stem cells and can inhibit their T-cell modulatory activity by impairing Notch signaling
    • Liotta, F.; Angeli, R.; Cosmi, L.; Fili, L.; Manuelli, C.; Frosali, F.; Mazzinghi, B.; Maggi, L.; Pasini, A.; Lisi, V.; et al. Toll-like receptors 3 and 4 are expressed by human bone marrow-derived mesenchymal stem cells and can inhibit their T-cell modulatory activity by impairing Notch signaling. Stem Cells 2008, 26, 279–289.
    • (2008) Stem Cells , vol.26 , pp. 279-289
    • Liotta, F.1    Angeli, R.2    Cosmi, L.3    Fili, L.4    Manuelli, C.5    Frosali, F.6    Mazzinghi, B.7    Maggi, L.8    Pasini, A.9    Lisi, V.10
  • 130
    • 77956420421 scopus 로고    scopus 로고
    • A new mesenchymal stem cell (MSC) paradigm: Polarization into a pro-inflammatory MSC1 or an Immunosuppressive MSC2 phenotype
    • Waterman, R.S.; Tomchuck, S.L.; Henkle, S.L.; Betancourt, A.M. A new mesenchymal stem cell (MSC) paradigm: polarization into a pro-inflammatory MSC1 or an Immunosuppressive MSC2 phenotype. PLoS One 2010, 5, e10088.
    • (2010) Plos One , vol.5
    • Waterman, R.S.1    Tomchuck, S.L.2    Henkle, S.L.3    Betancourt, A.M.4
  • 131
    • 84869204405 scopus 로고    scopus 로고
    • Activation of Toll-like receptor 3 amplifies mesenchymal stem cell trophic factors and enhances therapeutic potency
    • Mastri, M.; Shah, Z.; McLaughlin, T.; Greene, C.J.; Baum, L.; Suzuki, G.; Lee, T. Activation of Toll-like receptor 3 amplifies mesenchymal stem cell trophic factors and enhances therapeutic potency. Am. J. Physiol. Cell. Physiol. 2012, 303, C1021–C1033.
    • (2012) Am. J. Physiol. Cell. Physiol , vol.303
    • Mastri, M.1    Shah, Z.2    McLaughlin, T.3    Greene, C.J.4    Baum, L.5    Suzuki, G.6    Lee, T.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.