Vitamin D deficiency is common and associated with increased C-reactive protein in children and young adults with lupus: An Atherosclerosis Prevention in Pediatric Lupus Erythematosus substudy

Lupus Science and Medicine

Volumn 1, Issue 1, 2014, Pages

  Robinson, Angela Byun ^a   Tangpricha, Vin ^b   Yow, Eric ^c   Gurion, Reut ^a   McComsey, Grace A ^d   Schanberg, Laura E ^e  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c DUKE CLINICAL RESEARCH INSTITUTE   (United States)

^d UNIVERSITY HOSPITALS OF CLEVELAND   (United States)

^e DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

25 HYDROXYVITAMIN D; ACETYLSALICYLIC ACID; C REACTIVE PROTEIN; CALCIUM; CORTICOSTEROID; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; FOLIC ACID; HYDROXYCHLOROQUINE; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MULTIVITAMIN; PROTEIN; VITAMIN D;

ADULT; AGE; ARTERIAL WALL THICKNESS; ARTICLE; BODY MASS; CARDIOVASCULAR RISK; CHILD; DISEASE ACTIVITY; DISEASE ASSOCIATION; DISEASE DURATION; DISEASE SEVERITY ASSESSMENT; FEMALE; HUMAN; LATITUDE; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; MINORITY GROUP; PEDIATRIC CARDIOLOGY; PRIORITY JOURNAL; PROTEIN URINE LEVEL; PROTEINURIA; RACE; RANDOMIZED CONTROLLED TRIAL (TOPIC); SEASON; SECONDARY ANALYSIS; SLICC DAMAGE INDEX; SYSTEMIC LUPUS ERYTHEMATOSUS; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY; VITAMIN SUPPLEMENTATION; YOUNG ADULT;

EID: 84930195727     PISSN: None     EISSN: 20538790     Source Type: Journal    
DOI: 10.1136/lupus-2014-000011     Document Type: Article

References (28)

1. Nossent J, Cikes N, Kiss E, et al. Current causes of death in systemic lupus erythematosus in Europe, 2000-2004: relation to disease activity and damage accrual. Lupus 2007;16:309-17.
2. Manzi S, Meilahn EN, Rairie JE, et al. Age-specific incidence rates of myocardial infarction and angina in women with systemic lupus erythematosus: comparison with the Framingham Study. Am J Epidemiol 1997;145:408-15.
3. Esdaile JM, Abrahamowicz M, Grodzicky T, et al. Traditional Framingham risk factors fail to fully account for accelerated atherosclerosis in systemic lupus erythematosus. Arthritis Rheum 2001;44:2331-7.
4. Westerweel PE, Luyten RK, Hoomans HA, et al. Premature atherosclerotic cardiovascular disease in systemic lupus erythemarosus. Arthritis Rheum 2007;56:1384-96.
5. Kienrich K, Tomaschitz A, Verheyen N, et al. Vitamin D and cardiovascular disease. Nutrients 2013;5:3005-21.
6. DiRosa M, Malaguarnera G, DeGregorio C, et al. Immuno-modulatory effects of vitamin D3 in human monocyte and macrophages. Cell Immunol 2012;280:36-43.
7. Ruiz-Irastorza G, Egurbide MV, Olivares N, et al. Vitamin D deficiency in systemic lupus erythematosus: prevalence, predictors and clinical consequences. Rheumatology 2008;47:920-3.
8. Kamen DL, Cooper GS, Bouali H, et al. Vitamin D deficiency in systemic lupus erythematosus. Autoimmunity Rev 2006;5:114-17.
9. Wright TB, Shults J, Leonard MB, et al. Hypovitaminosis D is associated with greater body mass index and disease activity in pediatric systemic lupus erythematosus. J Pediatr 2009;155:260-5.
10. Borba VZC, Vieira JGH, Kasamatsu T, et al. Vitamin D deficiency in patients with active systemic lupus erythematosus. Osteoporosis Int 2009;20:427-33.
11. Robinson AB, Thierry-Palmer M, Gibson KL, et al. Disease activity, proteinuria, and vitamin D status in children with systemic lupus erythematosus and juvenile dermatomyositis. J Pediatr 2012;160:297-302.
12. Adams JS, Hewison M. Unexpected actions of vitamin D: new perspectives on the regulation of innate and adaptive immunity. Nat Clin Pract Endocrinol Metab 2008;4:80-90.
13. Piemonti L, Monti P, Sironi M, et al. Vitamin D3 affects differentiation, maturation, and function of human monocyte-derived dendritic cells. J Immunol 2000;164:4443-51.
14. D'Ambrosio D, Cippitelli M, Cocciolo MG, et al. Inhibition of IL-12 production by 1,25-dihydroxyvitamin D3. Involvement of NF-kappaB downregulation in transcriptional repression of the p40 gene. J Clin Invest 1998;101:252-62.
15. Chen S, Sims GP, Chen XX, et al. Modulatory effects of 1,25-dihydroxyvitamin D3 on human B cell differentiation. J Immunol 2007;179:1634-47.
16. Ronnblom L, Pascual V. The innate immune system in SLE: Type I interferons and dendritic cells. Lupus 2008;17:394-9.
17. Wang TJ, Pencina MJ, Booth SL, et al. Vitamin D deficiency and risk of cardiovascular disease. Circulation 2008;117:503-11.
18. Schwartz JB. Effects of vitamin D supplementation in atorvastatin-treated patients: A new drug interaction with an unexpected consequence. Clin Pharmacol Ther 2009;85:198-203.
19. Schanberg LE, Sandborg C, Barnhart HX, et al. Use of atorvastatin in systemic lupus erythematosus in children and adolescents. Arthritis Rheum 2012;64:285-96.
20. Schanberg LE, Sandborg C, Barnhart HX, et al. Premature atherosclerosis in pediatric systemic lupus erythematosus: risk factors for increased carotid intima-media thickness in the atherosclerosis prevention in pediatric lupus erythematosus cohort. Arthritis Rheum 2009;60:1496-507.
21. Petri M, Bello KJ, Fang H, et al. Vitamin D in systemic lupus erythematosus: modest association with disease activity and the urine protein-to-creatinine ratio. Arthritis Rheum 2013;65:1865-71.
22. Kiani AN, Fang H, Magder LS, et al. Vitamin D deficiency does not predict progression of coronary artery calcium, carotid intima-media thickness or high-sensitivity C-reactive protein in systemic lupus erythematosus. Rheumatology 2013;52:2071-6.
23. Lee SS, Singh S, Magder LS, et al. Predictors of high sensitivity C-reactive protein levels in patients with systemic lupus erythematosus. Lupus 2008;17:114-23.
24. Mochizuki T, Aotsuka S, Satoh T. Clinical and laboratory features of lupus patients with complicating pulmonary disease. Respir Med 1999;93:95-101.
25. Moutsopoulos HM, Mavridis AK, Acritidis NC, et al. High C-reactive protein response in lupus polyarthritis. Clin Exp Rheumatol 1983;1:53-5.
26. Liou LB. Serum and in vitro production of IL-1 receptor antagonist correlate with C-reactive protein levels in newly diagnosed, untreated lupus patients. Clin Exp Rheumatol 2001;19:515-23.
27. Robinson AB, Tangpricha V, Yow E, et al. for the APPLE Investigators. Vitamin D status is a determinant of the effect of atorvastatin on carotid intima medial thickening progression rate in children with lupus: An APPLE substudy. Pediatric Rheumatology Symposium of the American College of Rheumatology; 3-6 April 2014, Orlando, FL, USA, 31.
28. Ross AC, Judd S, Kumari M, et al. Vitamin D is linked to carotid intima-media thickness and immune reconstitution in HIV-positive individuals. Antivir Ther 2011;16:555-63.