-
1
-
-
84888205228
-
The role of estrogen and androgen receptors in bone health and disease
-
Manolagas SC, O'Brien CA, Almeida M., The role of estrogen and androgen receptors in bone health and disease. Nat Rev Endocrinol. 2013; 9: 699-712.
-
(2013)
Nat Rev Endocrinol.
, vol.9
, pp. 699-712
-
-
Manolagas, S.C.1
O'Brien, C.A.2
Almeida, M.3
-
2
-
-
84920100149
-
Sex steroid actions in male bone
-
Dec;.
-
Vanderschueren D, Laurent MR, Claessens F, et al., Sex steroid actions in male bone. Endocr Rev. 2014 Dec; 35 (6): 906-60.
-
(2014)
Endocr Rev.
, vol.35
, Issue.6
, pp. 906-960
-
-
Vanderschueren, D.1
Laurent, M.R.2
Claessens, F.3
-
3
-
-
77955374098
-
Update on estrogens and the skeleton
-
Khosla S., Update on estrogens and the skeleton. J Clin Endocrinol Metab. 2010; 95: 3569-77.
-
(2010)
J Clin Endocrinol Metab.
, vol.95
, pp. 3569-3577
-
-
Khosla, S.1
-
4
-
-
0034455103
-
Birth and death of bone cells: Basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis
-
Manolagas SC,. Birth and death of bone cells: Basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. Endocr Rev. 2000; 21: 115-37.
-
(2000)
Endocr Rev.
, vol.21
, pp. 115-137
-
-
Manolagas, S.C.1
-
5
-
-
0026777433
-
Increased osteoclast development after estrogen loss: Mediation by interleukin-6
-
Jilka RL, Hangoc G, Girasole G, et al., Increased osteoclast development after estrogen loss: mediation by interleukin-6. Science 1992; 257: 88-91.
-
(1992)
Science
, vol.257
, pp. 88-91
-
-
Jilka, R.L.1
Hangoc, G.2
Girasole, G.3
-
6
-
-
0035057030
-
Attenuation of the self-renewal of transit amplifying osteoblast progenitors in the murine bone marrow by 17b-estradiol
-
DiGregorio G, Yamamoto M, Ali A, et al., Attenuation of the self-renewal of transit amplifying osteoblast progenitors in the murine bone marrow by 17b-estradiol. J Clin Invest. 2001; 107: 803-12.
-
(2001)
J Clin Invest.
, vol.107
, pp. 803-812
-
-
Digregorio, G.1
Yamamoto, M.2
Ali, A.3
-
7
-
-
75149129597
-
From estrogen-centric to aging and oxidative stress: A revised perspective of the pathogenesis of osteoporosis
-
Manolagas SC,. From estrogen-centric to aging and oxidative stress: a revised perspective of the pathogenesis of osteoporosis. Endocr Rev. 2010; 31: 266-300.
-
(2010)
Endocr Rev.
, vol.31
, pp. 266-300
-
-
Manolagas, S.C.1
-
8
-
-
0029798819
-
Estrogen promotes apoptosis of murine osteoclasts mediated by TGF-b
-
Hughes DE, Dai A, Tiffee JC, Li HH, Mundy GR, Boyce BF,. Estrogen promotes apoptosis of murine osteoclasts mediated by TGF-b. Nat Med. 1996; 2: 1132-6.
-
(1996)
Nat Med.
, vol.2
, pp. 1132-1136
-
-
Hughes, D.E.1
Dai, A.2
Tiffee, J.C.3
Li, H.H.4
Mundy, G.R.5
Boyce, B.F.6
-
9
-
-
0035831020
-
Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: Dissociation from transcriptional activity
-
Kousteni S, Bellido T, Plotkin LI, et al., Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: dissociation from transcriptional activity. Cell 2001; 104: 719-30.
-
(2001)
Cell
, vol.104
, pp. 719-730
-
-
Kousteni, S.1
Bellido, T.2
Plotkin, L.I.3
-
10
-
-
0037174675
-
Reversal of bone loss in mice by nongenotropic signaling of sex steroids
-
Kousteni S, Chen J-R., Bellido T, et al., Reversal of bone loss in mice by nongenotropic signaling of sex steroids. Science 2002; 298: 843-6.
-
(2002)
Science
, vol.298
, pp. 843-846
-
-
Kousteni, S.1
Chen, J.-R.2
Bellido, T.3
-
11
-
-
0030884639
-
The death of osteocytes via apoptosis accompanies estrogen withdrawal in human bone
-
Tomkinson A, Reeve J, Shaw RW, Noble BS,. The death of osteocytes via apoptosis accompanies estrogen withdrawal in human bone. J Clin Endocrinol Metab. 1997; 82: 3128-35.
-
(1997)
J Clin Endocrinol Metab.
, vol.82
, pp. 3128-3135
-
-
Tomkinson, A.1
Reeve, J.2
Shaw, R.W.3
Noble, B.S.4
-
12
-
-
0030750208
-
Estrogen inhibits bone resorption by directly inducing apoptosis of the bone-resorbing osteoclasts
-
Kameda T, Mano H, Yuasa T, et al., Estrogen inhibits bone resorption by directly inducing apoptosis of the bone-resorbing osteoclasts. J Exp Med. 1997; 186: 489-95.
-
(1997)
J Exp Med.
, vol.186
, pp. 489-495
-
-
Kameda, T.1
Mano, H.2
Yuasa, T.3
-
13
-
-
0041923632
-
Suppressive function of androgen receptor in bone resorption
-
Kawano H, Sato T, Yamada T, et al., Suppressive function of androgen receptor in bone resorption. Proc Natl Acad Sci USA 2003; 100: 9416-21.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 9416-9421
-
-
Kawano, H.1
Sato, T.2
Yamada, T.3
-
14
-
-
58249110407
-
Differential regulation of bone and body composition in male mice with combined inactivation of androgen and estrogen receptor-alpha
-
Callewaert F, Venken K, Ophoff J, et al., Differential regulation of bone and body composition in male mice with combined inactivation of androgen and estrogen receptor-alpha. FASEB. J. 2009; 23: 232-40.
-
(2009)
FASEB. J.
, vol.23
, pp. 232-240
-
-
Callewaert, F.1
Venken, K.2
Ophoff, J.3
-
15
-
-
65549171025
-
Mineralization and bone resorption are regulated by the androgen receptor in male mice
-
Chiang C, Chiu M, Moore AJ, et al., Mineralization and bone resorption are regulated by the androgen receptor in male mice. J Bone Miner Res. 2009; 24: 621-31.
-
(2009)
J Bone Miner Res.
, vol.24
, pp. 621-631
-
-
Chiang, C.1
Chiu, M.2
Moore, A.J.3
-
16
-
-
34247192540
-
Osteoblast deletion of exon 3 of the androgen receptor gene results in trabecular bone loss in adult male mice
-
Notini AJ, McManus JF, Moore A, et al., Osteoblast deletion of exon 3 of the androgen receptor gene results in trabecular bone loss in adult male mice. J Bone Miner Res. 2007; 22: 347-56.
-
(2007)
J Bone Miner Res.
, vol.22
, pp. 347-356
-
-
Notini, A.J.1
McManus, J.F.2
Moore, A.3
-
17
-
-
84869397973
-
Androgen receptor (AR) in osteocytes is important for the maintenance of male skeletal integrity: Evidence from targeted AR disruption in mouse osteocytes
-
Sinnesael M, Claessens F, Laurent M, et al., Androgen receptor (AR) in osteocytes is important for the maintenance of male skeletal integrity: evidence from targeted AR disruption in mouse osteocytes. J Bone Miner Res. 2012; 27: 2535-43.
-
(2012)
J Bone Miner Res.
, vol.27
, pp. 2535-2543
-
-
Sinnesael, M.1
Claessens, F.2
Laurent, M.3
-
18
-
-
84920090437
-
Inactivation of the androgen receptor in bone-forming cells leads to trabecular bone loss in adult female mice
-
Maatta JA, Buki KG, Ivaska KK, et al., Inactivation of the androgen receptor in bone-forming cells leads to trabecular bone loss in adult female mice. Bonekey Rep. 2013; 2: 440.
-
(2013)
Bonekey Rep.
, vol.2
, pp. 440
-
-
Maatta, J.A.1
Buki, K.G.2
Ivaska, K.K.3
-
19
-
-
10744226931
-
A Sertoli cell-selective knockout of the androgen receptor causes spermatogenic arrest in meiosis
-
De Gendt K, Swinnen JV, Saunders PT, et al., A Sertoli cell-selective knockout of the androgen receptor causes spermatogenic arrest in meiosis. Proc Natl Acad Sci USA 2004; 101: 1327-32.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 1327-1332
-
-
De Gendt, K.1
Swinnen, J.V.2
Saunders, P.T.3
-
20
-
-
0036076389
-
Expression of Cre recombinase in the developing mouse limb bud driven by a Prxl enhancer
-
Logan M, Martin JF, Nagy A, Lobe C, Olson EN, Tabin CJ,. Expression of Cre recombinase in the developing mouse limb bud driven by a Prxl enhancer. Genesis 2002; 33: 77-80.
-
(2002)
Genesis
, vol.33
, pp. 77-80
-
-
Logan, M.1
Martin, J.F.2
Nagy, A.3
Lobe, C.4
Olson, E.N.5
Tabin, C.J.6
-
21
-
-
0033177995
-
Conditional gene targeting in macrophages and granulocytes using LysMcre mice
-
Clausen BE, Burkhardt C, Reith W, Renkawitz R, Forster I, Conditional gene targeting in macrophages and granulocytes using LysMcre mice. Transgenic Res. 1999; 8: 265-77.
-
(1999)
Transgenic Res.
, vol.8
, pp. 265-277
-
-
Clausen, B.E.1
Burkhardt, C.2
Reith, W.3
Renkawitz, R.4
Forster, I.5
-
22
-
-
75149165271
-
The estrogen receptor alpha in osteoclasts mediates the protective effects of estrogens on cancellous but not cortical bone
-
Martin-Millan M, Almeida M, Ambrogini E, et al., The estrogen receptor alpha in osteoclasts mediates the protective effects of estrogens on cancellous but not cortical bone. Mol Endocrinol. 2010; 24: 323-34.
-
(2010)
Mol Endocrinol.
, vol.24
, pp. 323-334
-
-
Martin-Millan, M.1
Almeida, M.2
Ambrogini, E.3
-
23
-
-
84873824098
-
Estrogen receptor-alpha signaling in osteoblast progenitors stimulates cortical bone accrual
-
Almeida M, Iyer S, Martin-Millan M, et al., Estrogen receptor-alpha signaling in osteoblast progenitors stimulates cortical bone accrual. J Clin Invest. 2013; 123: 394-404.
-
(2013)
J Clin Invest.
, vol.123
, pp. 394-404
-
-
Almeida, M.1
Iyer, S.2
Martin-Millan, M.3
-
24
-
-
84864029795
-
Decreased body weight in young Osterix-Cre transgenic mice results in delayed cortical bone expansion and accrual
-
Davey RA, Clarke MV, Sastra S, et al., Decreased body weight in young Osterix-Cre transgenic mice results in delayed cortical bone expansion and accrual. Transgenic Res. 2011; 21: 885-93.
-
(2011)
Transgenic Res.
, vol.21
, pp. 885-893
-
-
Davey, R.A.1
Clarke, M.V.2
Sastra, S.3
-
25
-
-
26844486477
-
IL-6 is not required for parathyroid hormone stimulation of RANKL expression, osteoclast formation, and bone loss in mice
-
O'Brien CA, Jilka RL, Fu Q, Stewart S, Weinstein RS, Manolagas SC,. IL-6 is not required for parathyroid hormone stimulation of RANKL expression, osteoclast formation, and bone loss in mice. Am J Physiol Endocrinol Metab. 2005; 289: E784-93.
-
(2005)
Am J Physiol Endocrinol Metab.
, vol.289
, pp. E784-E793
-
-
O'Brien, C.A.1
Jilka, R.L.2
Fu, Q.3
Stewart, S.4
Weinstein, R.S.5
Manolagas, S.C.6
-
26
-
-
77954756294
-
Guidelines for assessment of bone microstructure in rodents using micro-computed tomography
-
Bouxsein ML, Boyd SK, Christiansen BA, Guldberg RE, Jepsen KJ, Muller R., Guidelines for assessment of bone microstructure in rodents using micro-computed tomography. J Bone Miner Res. 2010; 25: 1468-86.
-
(2010)
J Bone Miner Res.
, vol.25
, pp. 1468-1486
-
-
Bouxsein, M.L.1
Boyd, S.K.2
Christiansen, B.A.3
Guldberg, R.E.4
Jepsen, K.J.5
Muller, R.6
-
27
-
-
29244446792
-
Wnt proteins prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by beta-catenin-dependent and -independent signaling cascades involving Src/ERK and phosphatidylinositol 3-kinase/AKT
-
Almeida M, Han L, Bellido T, Manolagas SC, Kousteni S., Wnt proteins prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by beta-catenin-dependent and -independent signaling cascades involving Src/ERK and phosphatidylinositol 3-kinase/AKT. J Biol Chem. 2005; 280: 41342-51.
-
(2005)
J Biol Chem.
, vol.280
, pp. 41342-41351
-
-
Almeida, M.1
Han, L.2
Bellido, T.3
Manolagas, S.C.4
Kousteni, S.5
-
28
-
-
0035710746
-
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method
-
Livak KJ, Schmittgen TD,. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001; 25: 402-8.
-
(2001)
Methods
, vol.25
, pp. 402-408
-
-
Livak, K.J.1
Schmittgen, T.D.2
-
29
-
-
64749088085
-
Susceptibility to autoimmunity and B cell resistance to apoptosis in mice lacking androgen receptor in B cells
-
Altuwaijri S, Chuang KH, Lai KP, et al., Susceptibility to autoimmunity and B cell resistance to apoptosis in mice lacking androgen receptor in B cells. Mol Endocrinol. 2009; 23: 444-53.
-
(2009)
Mol Endocrinol.
, vol.23
, pp. 444-453
-
-
Altuwaijri, S.1
Chuang, K.H.2
Lai, K.P.3
-
30
-
-
33846914931
-
Height and bone mineral density in androgen insensitivity syndrome with mutations in the androgen receptor gene
-
Danilovic DL, Correa PH, Costa EM, Melo KF, Mendonca BB, Arnhold IJ,. Height and bone mineral density in androgen insensitivity syndrome with mutations in the androgen receptor gene. Osteoporos Int. 2007; 18: 369-74.
-
(2007)
Osteoporos Int.
, vol.18
, pp. 369-374
-
-
Danilovic, D.L.1
Correa, P.H.2
Costa, E.M.3
Melo, K.F.4
Mendonca, B.B.5
Arnhold, I.J.6
-
31
-
-
0033766292
-
Skeletal effects of estrogen deficiency as induced by an aromatase inhibitor in an aged male rat model
-
Vanderschueren D, Boonen S, Ederveen AG, et al., Skeletal effects of estrogen deficiency as induced by an aromatase inhibitor in an aged male rat model. Bone 2000; 27: 611-7.
-
(2000)
Bone
, vol.27
, pp. 611-617
-
-
Vanderschueren, D.1
Boonen, S.2
Ederveen, A.G.3
-
32
-
-
34548274444
-
Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts
-
Nakamura T, Imai Y, Matsumoto T, et al., Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts. Cell 2007; 130: 811-23.
-
(2007)
Cell
, vol.130
, pp. 811-823
-
-
Nakamura, T.1
Imai, Y.2
Matsumoto, T.3
-
33
-
-
84873452045
-
Estrogen receptor-alpha in osteocytes is important for trabecular bone formation in male mice
-
Windahl SH, Borjesson AE, Farman HH, et al., Estrogen receptor-alpha in osteocytes is important for trabecular bone formation in male mice. Proc Natl Acad Sci USA 2013; 110: 2294-9.
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, pp. 2294-2299
-
-
Windahl, S.H.1
Borjesson, A.E.2
Farman, H.H.3
-
34
-
-
84873459994
-
Inactivation of estrogen receptor alpha in bone-forming cells induces bone loss in female mice
-
Maatta JA, Buki KG, Gu G, et al., Inactivation of estrogen receptor alpha in bone-forming cells induces bone loss in female mice. FASEB. J. 2013; 27: 478-88.
-
(2013)
FASEB. J.
, vol.27
, pp. 478-488
-
-
Maatta, J.A.1
Buki, K.G.2
Gu, G.3
-
35
-
-
84892733720
-
Female mice lacking estrogen receptor-alpha in osteoblasts have compromised bone mass and strength
-
Feb;.
-
Melville KM, Kelly NH, Khan SA, et al., Female mice lacking estrogen receptor-alpha in osteoblasts have compromised bone mass and strength. J Bone Miner Res. 2014 Feb; 29 (2): 370-9.
-
(2014)
J Bone Miner Res.
, vol.29
, Issue.2
, pp. 370-379
-
-
Melville, K.M.1
Kelly, N.H.2
Khan, S.A.3
-
36
-
-
84891126649
-
Estrogen receptor alpha in osteocytes regulates trabecular bone formation in female mice
-
Kondoh S, Inoue K, Igarashi K, et al., Estrogen receptor alpha in osteocytes regulates trabecular bone formation in female mice. Bone 2014; 60: 68-77.
-
(2014)
Bone
, vol.60
, pp. 68-77
-
-
Kondoh, S.1
Inoue, K.2
Igarashi, K.3
-
37
-
-
84907611779
-
Reproducibility of results in pre-clinical studies: A perspective from the bone field
-
Manolagas SC, Kronenberg HM,. Reproducibility of results in pre-clinical studies: a perspective from the bone field. J Bone Miner Res. 2014; 29: 2131-40.
-
(2014)
J Bone Miner Res.
, vol.29
, pp. 2131-2140
-
-
Manolagas, S.C.1
Kronenberg, H.M.2
-
39
-
-
84865446399
-
Receptor activator of nuclear factor kappaB ligand (RANKL) protein expression by B lymphocytes contributes to ovariectomy-induced bone loss
-
Onal M, Xiong J, Chen X, et al., Receptor activator of nuclear factor kappaB ligand (RANKL) protein expression by B lymphocytes contributes to ovariectomy-induced bone loss. J Biol Chem. 2012; 287: 29851-60.
-
(2012)
J Biol Chem.
, vol.287
, pp. 29851-29860
-
-
Onal, M.1
Xiong, J.2
Chen, X.3
-
40
-
-
34848878406
-
Skeletal involution by age-associated oxidative stress and its acceleration by loss of sex steroids
-
Almeida M, Han L, Martin-Millan M, et al., Skeletal involution by age-associated oxidative stress and its acceleration by loss of sex steroids. J Biol Chem. 2007; 282: 27285-97.
-
(2007)
J Biol Chem.
, vol.282
, pp. 27285-27297
-
-
Almeida, M.1
Han, L.2
Martin-Millan, M.3
-
41
-
-
84867742991
-
Androgen insensitivity syndrome
-
Hughes IA, Davies JD, Bunch TI, Pasterski V, Mastroyannopoulou K, MacDougall J., Androgen insensitivity syndrome. Lancet 2012; 380: 1419-28.
-
(2012)
Lancet
, vol.380
, pp. 1419-1428
-
-
Hughes, I.A.1
Davies, J.D.2
Bunch, T.I.3
Pasterski, V.4
Mastroyannopoulou, K.5
Macdougall, J.6
-
42
-
-
0034454501
-
The contribution of testosterone to skeletal development and maintenance: Lessons from the androgen insensitivity syndrome
-
Marcus R, Leary D, Schneider DL, Shane E, Favus M, Quigley CA,. The contribution of testosterone to skeletal development and maintenance: lessons from the androgen insensitivity syndrome. J Clin Endocrinol Metab. 2000; 85: 1032-7.
-
(2000)
J Clin Endocrinol Metab.
, vol.85
, pp. 1032-1037
-
-
Marcus, R.1
Leary, D.2
Schneider, D.L.3
Shane, E.4
Favus, M.5
Quigley, C.A.6
-
43
-
-
79953852887
-
Higher serum free testosterone concentration in older women is associated with greater bone mineral density, lean body mass, and total fat mass: The cardiovascular health study
-
Rariy CM, Ratcliffe SJ, Weinstein R, et al., Higher serum free testosterone concentration in older women is associated with greater bone mineral density, lean body mass, and total fat mass: the cardiovascular health study. J Clin Endocrinol Metab. 2011; 96: 989-96.
-
(2011)
J Clin Endocrinol Metab.
, vol.96
, pp. 989-996
-
-
Rariy, C.M.1
Ratcliffe, S.J.2
Weinstein, R.3
-
44
-
-
0030900409
-
Androgen-receptor blockade does not impair bone mineral density in adolescent females
-
Bertelloni S, Baroncelli GI, Sorrentino MC, Costa S, Battini R, S aggese G. Androgen-receptor blockade does not impair bone mineral density in adolescent females. Calcif Tissue Int. 1997;61:1-5.
-
(1997)
Calcif Tissue Int.
, vol.61
, pp. 1-5
-
-
Bertelloni, S.1
Baroncelli, G.I.2
Sorrentino, M.C.3
Costa, S.4
Battini, R.5
Aggese G, S.6
|