Sustained functional improvement by hepatocyte growth factor-like small molecule BB3 after focal cerebral ischemia in rats and mice

Journal of Cerebral Blood Flow and Metabolism

Volumn 35, Issue 6, 2015, Pages 1044-1053

  Chaparro, Rafael E ^a   Izutsu, Miwa ^a   Sasaki, Toshihiro ^a   Sheng, Huaxin ^a   Zheng, Yi ^b   Sadeghian, Homa ^b   Qin, Tao ^b   Von Bornstadt, Daniel ^b   Herisson, Fanny ^b   Duan, Bin ^c   Li, Jing Song ^c   Jiang, Kai ^c   Pearlstein, Molly ^a   Pearlstein, Robert D ^a   Smith, David E ^c   Goldberg, Itzhak D ^c   Ayata, Cenk ^a,b   Warner, David S ^a,b  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c ANGION BIOMEDICA CORP   (United States)

Author keywords

brain; hepatocyte growth factor; ischemia; preclinical; stroke

Indexed keywords

BB 3; RECOMBINANT SCATTER FACTOR; SCATTER FACTOR RECEPTOR; SYNAPTOPHYSIN; UNCLASSIFIED DRUG; SCATTER FACTOR;

AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BLOOD PRESSURE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; COMORBIDITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG EFFECT; DRUG EFFICACY; DRUG PENETRATION; DRUG SCREENING; FEMALE; LONG TERM CARE; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NEUROLOGIC EXAMINATION; NONHUMAN; PRACTICE GUIDELINE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; REPERFUSION; THERAPY DELAY; ANIMAL; BRAIN; C57BL MOUSE; CHEMISTRY; DRUG EFFECTS; INFARCTION, MIDDLE CEREBRAL ARTERY; LONG EVANS RAT; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; TREATMENT OUTCOME; VASCULARIZATION; WISTAR RAT;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; FEMALE; HEPATOCYTE GROWTH FACTOR; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; MICE; MICE, INBRED C57BL; RATS; RATS, LONG-EVANS; RATS, WISTAR; TREATMENT OUTCOME;

EID: 84930181994     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2015.23     Document Type: Article

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