Gliovascular disruption and cognitive deficits in a mouse model with features of small vessel disease

Journal of Cerebral Blood Flow and Metabolism

Volumn 35, Issue 6, 2015, Pages 1005-1014

  Holland, Philip R ^a,e   Searcy, James L ^a   Salvadores, Natalia ^a   Scullion, Gillian ^a   Chen, Guiquan ^a   Lawson, Greig ^a   Scott, Fiona ^a   Bastin, Mark E ^a   Ihara, Masafumi ^b   Kalaria, Rajesh ^c   Wood, Emma R ^a   Smith, Colin ^d   Wardlaw, Joanna M ^a   Horsburgh, Karen ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

^c NEWCASTLE UNIVERSITY   (United Kingdom)

^d UNIVERSITY OF EDINBURGH   (United Kingdom)

^e KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

cognition; diffusion tensor imaging; hypoperfusion; magnetic resonance imaging; small vessel disease

Indexed keywords

AQUAPORIN 4; CLAUDIN 5; MYELIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BASAL GANGLION; BLOOD BRAIN BARRIER; BLOOD VESSEL WALL; BRAIN ATROPHY; BRAIN HEMORRHAGE; BRAIN INFARCTION; BRAIN PERFUSION; BRAIN SIZE; CAPSULA INTERNA; CAROTID ARTERY OBSTRUCTION; CEREBROVASCULAR DISEASE; COGNITIVE DEFECT; CONTROLLED STUDY; CORPUS CALLOSUM; CORPUS STRIATUM; DIFFUSION TENSOR IMAGING; FIMBRIA; FRACTIONAL ANISOTROPY; GLIOVASCULAR DISRUPTION; HYPOTHALAMUS; MACROPHAGE; MALE; MEMORY DISORDER; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REFERENCE MEMORY; SUBCORTEX; THALAMUS; VASCULAR DISEASE; WHITE MATTER LESION; WORKING MEMORY; ANIMAL; ATROPHY; BRAIN; C57BL MOUSE; COGNITION; COMPLICATION; DISEASE MODEL; GLIA; MICROVASCULATURE; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOLOGY; WHITE MATTER;

ANIMALS; ATROPHY; BLOOD-BRAIN BARRIER; BRAIN; CEREBRAL SMALL VESSEL DISEASES; COGNITION; DIFFUSION TENSOR IMAGING; DISEASE MODELS, ANIMAL; MAGNETIC RESONANCE IMAGING; MALE; MICE, INBRED C57BL; MICROVESSELS; NEUROGLIA; WHITE MATTER;

EID: 84930179449     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2015.12     Document Type: Article

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