MRI is a sensitive marker of subtle white matter pathology in hypoperfused mice

Neurobiology of Aging

Volumn 32, Issue 12, 2011, Pages 2325.e1-2325.e6

  Holland, Philip R ^a   Bastin, Mark E ^a   Jansen, Maurits A ^a   Merrifield, Gavin D ^a   Coltman, Robin B ^a   Scott, Fiona ^a   Nowers, Hanna ^a   Khallout, Karim ^a   Marshall, Ian ^a   Wardlaw, Joanna M ^a   Deary, Ian J ^a   McCulloch, James ^a   Horsburgh, Karen ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Chronic cerebral hypoperfusion; Diffusion tensor imaging; Magnetization transfer imaging and white matter

Indexed keywords

AMYLOID PRECURSOR PROTEIN; MYELIN; MYELIN ASSOCIATED GLYCOPROTEIN;

AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AXONAL INJURY; BRAIN DISEASE; BRAIN ISCHEMIA; BRAIN PERFUSION; CAPSULA INTERNA; CONTROLLED STUDY; CORPUS CALLOSUM; DIFFUSION TENSOR IMAGING; FRACTIONAL ANISOTROPY; GRAY MATTER DISEASE; IMAGE ANALYSIS; IN VIVO STUDY; MALE; MOUSE; NEUROPATHOLOGY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OPTIC TRACT; PRIORITY JOURNAL; PROTEIN DEGRADATION; SENSITIVITY ANALYSIS; WHITE MATTER DISEASE;

EID: 79960836094     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2010.11.009     Document Type: Article

References (18)

1. Adachi T., Takagi M., Hoshino H., Inafuku T. Effect of extracranial carotid artery stenosis and other risk factors for stroke on periventricular hyperintensity. Stroke 1997, 28:2174-2179.
2. Bastin M.E., Clayden J.D., Pattie A., Gerrish I.F., Wardlaw J.M., Deary I.J. Diffusion tensor and magnetization transfer MRI measurements of periventricular white matter hyperintensities in old age. Neurobiol. Aging 2009, 30:125-136.
3. Beaulieu C. The basis of anisotropic water diffusion in the nervous system-a technical review. NMR Biomed 2002, 15:435-455.
4. Coltman R., Spain A., Tsenkina Y., Fowler J.H., Smith J., Scullion G., Allerhand M., Scott F., Kalaria R.N., Ihara M., Daumas S., Deary I.J., Wood E., McCulloch J., Horsburgh K. Selective white matter pathology induces specific impairment in spatial working memory. Neurobiol. Aging 2010, in press. 10.1016/j.neurobiolaging.2010.09.005.
5. Deary I.J., Bastin M.E., Pattie A., Clayden J.D., Whalley L.J., Starr J.M., Wardlaw J.M. White matter integrity and cognition in childhood and old age. Neurology 2006, 66:505-512.
6. Harsan L.A., Poulet P., Guignard B., Parizel N., Skoff R.P., Ghandour M.S. Astrocytic hypertrophy in dysmyelination influences the diffusion anisotropy of white matter. J. Neurosci. Res 2007, 85:935-944.
7. Harsan L.A., Steibel J., Zaremba A., Agin A., Sapin R., Poulet P., Guignard B., Parizel N., Grucker D., Boehm N., Miller R.H., Ghandour M.S. Recovery from chronic demyelination by thyroid hormone therapy: myelinogenesis induction and assessment by diffusion tensor magnetic resonance imaging. J. Neurosci 2008, 28:14189-14201.
8. Jones D.K., Horsfield M.A., Simmons A. Optimal strategies for measuring diffusion in anisotropic systems by magnetic resonance imaging. Magn. Reson. Med 1999, 42:515-525.
9. Kado H., Kimura H., Tsuchida T., Yonekura Y., Tokime T., Tokuriki Y., Itoh H. Abnormal magnetization transfer ratios in normal-appearing white matter on conventional MR images of patients with occlusive cerebrovascular disease. AJNR Am. J. Neuroradiol 2001, 22:922-927.
10. Murray A.D., Staff R.T., Shenkin S.D., Deary I.J., Starr J.M., Whalley L.J. Brain white matter hyperintensities: relative importance of vascular risk factors in nondemented elderly people. Radiology 2005, 237. 251-25.
11. Maclullich A.M., Ferguson K.J., Reid L.M., Deary I.J., Starr J.M., Seckl J.R., Bastin M.E., Wardlaw J.M. Higher systolic blood pressure is associated with increased water diffusivity in normal-appearing white matter. Stroke 2009, 40(12):3869-3871.
12. Penke L., Maniega S.M., Houlihan L.M., Murray C., Gow A.J., Clayden J.D., Bastin M.E., Wardlaw J.M., Deary I.J. White matter integrity in the splenium of the corpus callosum is related to successful cognitive aging and partly mediates the protective effect of an ancestral polymorphism in ADRB2. Behav. Genet 2010, 40:146-156.
13. Pfefferbaum A., Sullivan E.V., Hedehus M., Lim K.O., Adalsteinsson E., Moseley M. Age-related decline in brain white matter anisotropy measured with spatially corrected echo-planar diffusion tensor imaging. Magn. Reson. Med 2000, 44:259-268.
14. Shibata M., Ohtani R., Ihara M., Tomimoto H. White matter lesions and glial activation in a novel mouse model of chronic cerebral hypoperfusion. Stroke 2004, 35:2598-2603.
15. Silver N.C., Barker G.J., MacManus D.G., Tofts P.S., Miller D.H. Magnetisation transfer ratio of normal brain white matter: a normative database spanning four decades of life. J. Neurol. Neurosurg. Psychiatry 1997, 62:223-228.
16. Song S.K., Kim J.H., Lin S.J., Brendza R.P., Holtzman D.M. Diffusion tensor imaging detects age-dependent white matter changes in a transgenic mouse model with amyloid deposition. Neurobiol. Dis 2004, 15:640-647.
17. Sun S.W., Neil J.J., Liang H.F., He Y.Y., Schmidt R.E., Hsu C.Y., Song S.K. Formalin fixation alters water diffusion coefficient magnitude but not anisotropy in infarcted brain. Magn. Reson. Med 2005, 53:1447-1451.
18. Zaaraoui W., Deloire M., Merle M., Girard C., Raffard G., Biran M., Inglese M., Petry K.G., Gonen O., Brochet B., Franconi J.M., Dousset V. Monitoring demyelination and remyelination by magnetization transfer imaging in the mouse brain at 9.4 T. Magma 2008, 21:357-362.