Brain and testis accumulation of regorafenib is restricted by breast cancer resistance protein (BCRP/ABCG2) and P-glycoprotein (P-GP/ABCB1)

Pharmaceutical Research

Volumn 32, Issue 7, 2015, Pages 2205-2216

  Kort, Anita ^a,c   Durmus, Selvi ^a   Sparidans, Rolf W ^b   Wagenaar, Els ^a   Beijnen, Jos H ^a,b,c   Schinkel, Alfred H ^a  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

^c SLOTERVAART HOSPITAL   (Netherlands)

Author keywords

ABCB1; ABCG2; brain accumulation; regorafenib; testis accumulation

Indexed keywords

BREAST CANCER RESISTANCE PROTEIN; CYTOCHROME P450 3A; CYTOCHROME P450 3A4; DRUG METABOLITE; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 1A; MULTIDRUG RESISTANCE PROTEIN 1B; REGORAFENIB; UNCLASSIFIED DRUG; ABC TRANSPORTER; ABCB1 PROTEIN, HUMAN; ABCB1B PROTEIN, MOUSE; ABCG2 PROTEIN, HUMAN; ABCG2 PROTEIN, MOUSE; ANTINEOPLASTIC AGENT; CARBANILAMIDE DERIVATIVE; PYRIDINE DERIVATIVE; TUMOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG BIOAVAILABILITY; DRUG DISPOSITION; DRUG METABOLISM; DRUG PENETRATION; DRUG TRANSPORT; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TESTIS; ANIMAL; BLOOD; DOG; GENETIC TRANSFECTION; GENETICS; HUMAN; KNOCKOUT MOUSE; MDCK CELL LINE; METABOLISM; ORAL DRUG ADMINISTRATION; TISSUE DISTRIBUTION; TRANSPORT AT THE CELLULAR LEVEL;

ADMINISTRATION, ORAL; ANIMALS; ANTINEOPLASTIC AGENTS; ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL TRANSPORT; BRAIN; DOGS; HUMANS; MADIN DARBY CANINE KIDNEY CELLS; MALE; MICE; MICE, KNOCKOUT; NEOPLASM PROTEINS; P-GLYCOPROTEINS; PHENYLUREA COMPOUNDS; PYRIDINES; TESTIS; TISSUE DISTRIBUTION; TRANSFECTION;

EID: 84930177310     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-014-1609-7     Document Type: Article

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