A mechanistic model for drug release in PLGA biodegradable stent coatings coupled with polymer degradation and erosion

Journal of Biomedical Materials Research - Part A

Volumn 103, Issue 7, 2015, Pages 2269-2279

  Zhu, Xiaoxiang ^a   Braatz, Richard D ^a  

^a Massachusetts Institute of Technology   (United States)

Author keywords

drug release; drug eluting stents; effective diffusivity; mathematical modeling; PLGA degradation and erosion

Indexed keywords

ARTIFICIAL ORGANS; BIODEGRADABLE POLYMERS; COATINGS; COPOLYMERS; DIFFUSION COATINGS; EROSION; FILLED POLYMERS; MATHEMATICAL MODELS; PLASTIC COATINGS; POLYMERS;

ANALYTICAL EXPRESSIONS; BIODEGRADABLE STENTS; DRUG RELEASE; DRUG-ELUTING STENTS; EFFECTIVE DIFFUSIVITIES; MECHANISTIC MODELING; POLY(D ,L LACTIC CO GLYCOLIC ACID) (PLGA); POLYMER DEGRADATION;

STENTS;

POLYGLACTIN; POLYMER; RAPAMYCIN; BIOCOMPATIBLE COATED MATERIAL; LACTIC ACID; POLYGLYCOLIC ACID; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER;

ANALYTIC METHOD; ANALYTICAL PARAMETERS; AQUEOUS SOLUTION; ARTICLE; CHEMICAL COMPOSITION; CHEMICAL REACTION; CONTROLLED CLINICAL TRIAL (TOPIC); DEGRADATION KINETICS; DRUG DELIVERY SYSTEM; DRUG DIFFUSION; DRUG ELUTING STENT; DRUG RELEASE; DRUG TRANSPORT; EXPERIMENTAL STUDY; HYDROPHOBICITY; IN VITRO STUDY; MATERIAL COATING; MATHEMATICAL MODEL; MOLECULAR WEIGHT; PHYSICAL PARAMETERS; POLYMERIZATION; POROSITY; BIOLOGICAL MODEL; CHEMISTRY; STENT;

COATED MATERIALS, BIOCOMPATIBLE; LACTIC ACID; MODELS, BIOLOGICAL; POLYGLYCOLIC ACID; POLYMERS; STENTS;

EID: 84930150753     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.35357     Document Type: Article

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