PHF2 histone demethylase acts as a tumor suppressor in association with p53 in cancer

Oncogene

Volumn 34, Issue 22, 2015, Pages 2897-2909

  Lee, K H ^a   Park, J W ^a   Sung, H S ^a   Choi, Y J ^a   Kim, W H ^a   Lee, H S ^a   Chung, H J ^a   Shin, H W ^a   Cho, C H ^a   Kim, T Y ^a   Li, S H ^a   Youn, H D ^a   Kim, S J ^a   Chun, Y S ^a  

^a Seoul National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

DOXORUBICIN; HISTONE DEMETHYLASE; OXALIPLATIN; PLANT HOMEODOMAIN FINGER 2; PROTEIN P21; PROTEIN P53; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; HOMEODOMAIN PROTEIN; PHF2 PROTEIN, HUMAN; SMALL INTERFERING RNA; TP53 PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL; CHROMATIN; COLON CANCER; COLON TUMOR; CONTROLLED STUDY; DOWN REGULATION; EPIGENETICS; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN TISSUE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STOMACH CANCER; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL DEATH; DRUG EFFECTS; DRUG SCREENING; GENE EXPRESSION REGULATION; GENETICS; HCT116 CELL LINE; HEK293 CELL LINE; HEPG2 CELL LINE; MCF 7 CELL LINE; NEOPLASMS; NUDE MOUSE; PATHOLOGY; PHYSIOLOGY; TUMOR CELL CULTURE; TUMOR SUPPRESSOR GENE;

ANIMALS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CELL DEATH; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, TUMOR SUPPRESSOR; HCT116 CELLS; HEK293 CELLS; HEP G2 CELLS; HOMEODOMAIN PROTEINS; HUMANS; MCF-7 CELLS; MICE; MICE, NUDE; NEOPLASMS; RNA, SMALL INTERFERING; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84930091205     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2014.219     Document Type: Article

References (34)

1. Levine AJ, Oren M. The first 30 years of p53: growing ever more complex. Nat Rev Cancer 2009; 9: 749-758.
2. Riley T, Sontag E, Chen P, Levine A. Transcriptional control of human p53-regulated genes. Nat Rev Mol Cell Biol 2008; 9: 402-412.
3. Murray-Zmijewski F, Slee EA, Lu X. A complex barcode underlies the heterogeneous response of p53 to stress. Nat Rev Mol Cell Biol 2008; 9: 702-712.
4. Gu W, Shi X-L, Roeder RG. Synergistic activation of transcription by CBP and p53. Nature 1997; 387: 819-823.
5. Gu W, Roeder RG. Activation of p53 sequence-specific dna binding by acetylation of the p53 C-terminal domain. Cell 1997; 90: 595-606.
6. Sakaguchi K, Herrera JE, Si Saito, Miki T, Bustin M, Vassilev A et al. DNA damage activates p53 through a phosphorylation-acetylation cascade. Genes Dev 1998; 12: 2831-2841.
7. Legube G, Linares LK, Tyteca S, Caron C, Scheffner M, Chevillard-Briet M et al. Role of the Histone Acetyl Transferase Tip60 in the p53 Pathway. J Biol Chem 2004; 279: 44825-44833.
8. Jin L, Hanigan CL, Wu Y, Wang W, Park BH, Woster PM et al. Loss of LSD1 (lysinespecific demethylase 1) suppresses growth and alters gene expression of human colon cancer cells in a p53-and DNMT1(DNA methyltransferase 1)-independent manner. Biochem J 2013; 449: 459-468.
9. Wiesner GL, Daley D, Lewis S, Ticknor C, Platzer P, Lutterbaugh J et al. A subset of familial colorectal neoplasia kindreds linked to chromosome 9q22.2-31.2. Proc Natl Acad Sci 2003; 100: 12961-12965.
10. Sinha S, Singh R, Alam N, Roy A, Roychoudhury S, Panda C. Alterations in candidate genes PHF2, FANCC, PTCH1 and XPA at chromosomal 9q22.3 region: Pathological significance in early-and late-onset breast carcinoma. Mol Cancer 2008; 7: 84.
11. Ghosh A, Ghosh S, Maiti GP, Mukherjee S, Mukherjee N, Chakraborty J et al. Association of FANCC and PTCH1 with the development of early dysplastic lesions of the head and neck. Ann Surg Oncol 2012; 19: 528-538.
12. Hasenpusch-Theil K, Chadwick BP, Theil T, Heath SK, Wilkinson DG, Frischauf A-M. PHF2 a novel PHD finger gene located on human Chromosome 9q22. Mamm Genome 1999; 10: 294-298.
13. Wen H, Li J, Song T, Lu M, Kan P-Y, Lee MG et al. Recognition of histone H3K4 trimethylation by the plant homeodomain of PHF2 modulates histone demethylation. J Biol Chem 2010; 285: 9322-9326.
14. Baba A, Ohtake F, Okuno Y, Yokota K, Okada M, Imai Y et al. PKA-dependent regulation of the histone lysine demethylase complex PHF2-ARID5B. Nat Cell Biol 2011; 13: 668-675.
15. Okuno Y, Ohtake F, Igarashi K, Kanno J, Matsumoto T, Takada I et al. Epigenetic regulation of adipogenesis by PHF2 histone demethylase. Diabetes 2012; 33: 1426-1434.
16. Stender Joshua D, Pascual G, Liu W, Kaikkonen Minna U, Do K, Spann Nathanael J et al. Control of proinflammatory gene programs by regulated trimethylation and demethylation of histone H4K20. Mol Cell 2012; 48: 28-38.
17. Kurdistani SK, Grunstein M. Histone acetylation and deacetylation in yeast. Nat Rev Mol Cell Biol 2003; 4: 276-284.
18. Jaskelioff M, Peterson CL. Chromatin and transcription: histones continue to make their marks. Nat Cell Biol 2003; 5: 395-399.
19. Schneider R, Grosschedl R. Dynamics and interplay of nuclear architecture, genome organization, and gene expression. Genes Dev 2007; 21: 3027-3043.
20. Mungamuri SK, Benson EK, Wang S, Gu W, Lee SW, Aaronson SA. p53-mediated heterochromatin reorganization regulates its cell fate decisions. Nat Struct Mol Biol 2012; 19: 478-484.
21. Fortschegger K, Shiekhattar R. Plant homeodomain fingers form a helping hand for transcription. Epigenetics 2011; 6: 4-8.
22. Feng W, Yonezawa M, Ye J, Jenuwein T, Grummt I. PHF8 activates transcription of rRNA genes through H3K4me3 binding and H3K9me1/2 demethylation. Nat Struct Mol Biol 2010; 17: 445-450.
23. Kleine-Kohlbrecher D, Christensen J, Vandamme J, Abarrategui I, Bak M, Tommerup N et al. A functional link between the histone demethylase PHF8 and the transcription factor ZNF711 in X-linked mental retardation. Mol Cell 2010; 38: 165-178.
24. Qiu J, Shi G, Jia Y, Li J, Wu M, Dong S et al. The X-linked mental retardation gene PHF8 is a histone demethylase involved in neuronal differentiation. Cell Res 2010; 20: 908-918.
25. Liu W, Tanasa B, Tyurina OV, Zhou TY, Gassmann R, Liu WT et al. PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression. Nature 2010; 466: 508-512.
26. Chuikov S, Kurash JK, Wilson JR, Xiao B, Justin N, Ivanov GS et al. Regulation of p53 activity through lysine methylation. Nature 2004; 432: 353-360.
27. Huang J, Perez-Burgos L, Placek BJ, Sengupta R, Richter M, Dorsey JA et al. Repression of p53 activity by Smyd2-mediated methylation. Nature 2006; 444: 629-632.
28. Shi X, Kachirskaia I, Yamaguchi H, West LE, Wen H, Wang EW et al. Modulation of p53 Function by SET8-Mediated Methylation at Lysine 382. Mol Cell 2007; 27: 636-646.
29. Munro AJ, Lain S, Lane DP. P53 abnormalities and outcomes in colorectal cancer: a systematic review. Br J Cancer 2005; 92: 434-444.
30. Brosh R, Rotter V. When mutants gain new powers: news from the mutant p53 field. Nat Rev Cancer 2009; 9: 701-713.
31. Zirbes TK, Baldus SE, Moenig SP, Nolden S, Kunze D, Shafizadeh ST et al. Prognostic impact of p21/waf1/cip1 in colorectal cancer. Int J Cancer 2000; 89: 14-18.
32. Ogino S, Nosho K, Shima K, Baba Y, Irahara N, Kirkner GJ et al. p21 Expression in Colon Cancer and Modifying Effects of Patient Age and Body Mass Index on Prognosis. Cancer Epidemiol Biomarkers Prev 2009; 18: 2513-2521.
33. Yeo E-J, Chun Y-S, Cho Y-S, Kim J, Lee J-C, Kim M-S et al. YC-1: A Potential Anticancer Drug Targeting Hypoxia-Inducible Factor 1. J Natl Cancer Ins 2003; 95: 516-525.
34. Skrzypczak M, Goryca K, Rubel T, Paziewska A, Mikula M, Jarosz D et al. Modeling Oncogenic Signaling in Colon Tumors by Multidirectional Analyses of Microarray Data Directed for Maximization of Analytical Reliability. PLoS ONE 2010; 5: e13091.