DNA replication fidelity in Mycobacterium tuberculosis is mediated by an ancestral prokaryotic proofreader

Nature Genetics

Volumn 47, Issue 6, 2015, Pages 677-681

  Rock, Jeremy M ^a   Lang, Ulla F ^b   Chase, Michael R ^a   Ford, Christopher B ^a,c   Gerrick, Elias R ^a   Gawande, Richa ^a   Coscolla, Mireia ^d,e   Gagneux, Sebastien ^d,e   Fortune, Sarah M ^a,c,f   Lamers, Meindert H ^b  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^c BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^d SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^e UNIVERSITY OF BASEL   (Switzerland)

^f MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNAE1 PROTEIN; EXONUCLEASE; UNCLASSIFIED DRUG; BACTERIAL DNA; BACTERIAL PROTEIN; DNA DIRECTED DNA POLYMERASE GAMMA; DNA POLYMERASE III, ALPHA SUBUNIT; TUBERCULOSTATIC AGENT;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL MUTATION; CELL DEATH; DNA REPLICATION; ENZYME ACTIVITY; ESCHERICHIA COLI; GENE INACTIVATION; MUTATION RATE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PHENOTYPE; PHYLOGENY; PRIORITY JOURNAL; PROKARYOTE; REPLISOME; AMINO ACID SEQUENCE; DRUG EFFECTS; ENZYMOLOGY; GENETICS; MICROBIAL SENSITIVITY TEST; MOLECULAR GENETICS; SINGLE NUCLEOTIDE POLYMORPHISM;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; MYCOBACTERIUM TUBERCULOSIS; PROKARYOTA;

AMINO ACID SEQUENCE; ANTITUBERCULAR AGENTS; BACTERIAL PROTEINS; DNA POLYMERASE III; DNA REPLICATION; DNA, BACTERIAL; DRUG RESISTANCE, BACTERIAL; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; MYCOBACTERIUM TUBERCULOSIS; PHENOTYPE; PHYLOGENY; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84930090059     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.3269     Document Type: Article

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