Interleukin-8 is a key mediator of FKBP51-induced melanoma growth, angiogenesis and metastasis

British Journal of Cancer

Volumn 112, Issue 11, 2015, Pages 1772-1781

  Srivastava, S K ^a   Bhardwaj, A ^a   Arora, S ^a   Tyagi, N ^a   Singh, A P ^a   Carter, J E ^b   Scammell, J G ^a   Fodstad, O ^c   Singh, S ^a  

^a UNIVERSITY OF SOUTH ALABAMA   (United States)

^b UNIVERSITY OF SOUTH ALABAMA COLLEGE OF MEDICINE   (United States)

^c OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

angiogenesis; FKBP51; growth; IL 8; melanoma; metastasis; neutrophils; NF B

Indexed keywords

FKBP51 PROTEIN; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; NEUTRALIZING ANTIBODY; PROTEIN; UNCLASSIFIED DRUG; FK 506 BINDING PROTEIN; TACROLIMUS BINDING PROTEIN 5;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER GROWTH; CANCER INHIBITION; CELL INFILTRATION; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CHROMATIN IMMUNOPRECIPITATION; CLONOGENESIS; CYTOKINE PRODUCTION; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE OVEREXPRESSION; GENE SILENCING; HISTOLOGY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOCOMPETENT CELL; IMMUNOHISTOCHEMISTRY; LUNG METASTASIS; MELANOMA; MELANOMA CELL; MELANOMA CELL LINE; METASTASIS; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR XENOGRAFT; UMBILICAL VEIN ENDOTHELIAL CELL; ANIMAL; BIOSYNTHESIS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTERLEUKIN-8; MELANOMA; MICE; NEOPLASM METASTASIS; NEOVASCULARIZATION, PATHOLOGIC; NF-KAPPA B; PROMOTER REGIONS, GENETIC; TACROLIMUS BINDING PROTEINS;

EID: 84930045139     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.2015.154     Document Type: Article

References (47)

1. Autiero M, De SF, Claes F, Carmeliet P. (2005). Role of neural guidance signals in blood vessel navigation. Cardiovasc Res 65(3): 629-638
2. Bhardwaj A, Srivastava SK, Singh S, Arora S, Tyagi N, Andrews J, McClellan S, Carter JE, Singh AP. (2014). CXCL12/CXCR4 signaling counteracts docetaxel-induced microtubule stabilization via p21-Activated kinase 4-dependent activation of LIM domain kinase 1. Oncotarget 5(22): 11490-11500
3. Bist P, Leow SC, Phua QH, Shu S, Zhuang Q, Loh WT, Nguyen TH, Zhou JB, Hooi SC, Lim LH. (2011). Annexin-1 interacts with NEMO and RIP1 to constitutively activate IKK complex and NF-kappaB: implication in breast cancer metastasis. Oncogene 30(28): 3174-3185
4. Bracher A, Kozany C, Hahle A, Wild P, Zacharias M, Hausch F. (2013). Crystal structures of the free and ligand-bound FK1-FK2 domain segment of FKBP52 reveal a flexible inter-domain hinge. J Mol Biol 425(22): 4134-4144
5. De Larco JE, Wuertz BR, Furcht LT. (2004). The potential role of neutrophils in promoting the metastatic phenotype of tumors releasing interleukin-8. Clin Cancer Res 10(15): 4895-4900
6. Fossati G, Ricevuti G, Edwards SW, Walker C, Dalton A, Rossi ML. (1999). Neutrophil infiltration into human gliomas. Acta Neuropathol 98(4): 349-354
7. Gabellini C, Trisciuoglio D, Desideri M, Candiloro A, Ragazzoni Y, Orlandi A, Zupi G, Del BD. (2009). Functional activity of CXCL8 receptors, CXCR1 and CXCR2, on human malignant melanoma progression. Eur J Cancer 45(14): 2618-2627
8. Galat A. (1993). Peptidylproline cis-Trans-isomerases: immunophilins. Eur J Biochem 216(3): 689-707
9. Huang S, Mills L, Mian B, Tellez C, McCarty M, Yang XD, Gudas JM, Bar-Eli M. (2002). Fully humanized neutralizing antibodies to interleukin-8 (ABXIL8) inhibit angiogenesis, tumor growth, and metastasis of human melanoma. Am J Pathol 161(1): 125-134
10. Huber AR, Kunkel SL, Todd III RF, Weiss SJ. (1991). Regulation of transendothelial neutrophil migration by endogenous interleukin-8. Science 254(5028): 99-102
11. Huh SJ, Liang S, Sharma A, Dong C, Robertson GP. (2010). Transiently entrapped circulating tumor cells interact with neutrophils to facilitate lung metastasis development. Cancer Res 70(14): 6071-6082
12. Jiang W, Cazacu S, Xiang C, Zenklusen JC, Fine HA, Berens M, Armstrong B, Brodie C, Mikkelsen T. (2008). FK506 binding protein mediates glioma cell growth and sensitivity to rapamycin treatment by regulating NF-kappaB signaling pathway. Neoplasia 10(3): 235-243
13. Kukreja P, Abdel-Mageed AB, Mondal D, Liu K, Agrawal KC. (2005). Upregulation of CXCR4 expression in PC-3 cells by stromal-derived factor-1alpha (CXCL12) increases endothelial adhesion and transendothelial migration: role of MEK/ERK signaling pathway-dependent NF-kappaB activation. Cancer Res 65(21): 9891-9898
14. Kunsch C, Rosen CA. (1993). NF-kappa B subunit-specific regulation of the interleukin-8 promoter. Mol Cell Biol 13(10): 6137-6146
15. Li A, Dubey S, Varney ML, Dave BJ, Singh RK. (2003). IL-8 directly enhanced endothelial cell survival, proliferation, and matrix metalloproteinases production and regulated angiogenesis. J Immunol 170(6): 3369-3376
16. Lin Y, Bai L, Chen W, Xu S. (2010). The NF-kappaB activation pathways, emerging molecular targets for cancer prevention and therapy. Expert Opin Ther Targets 14(1): 45-55
17. Ma J, Ren Z, Ma Y, Xu L, Zhao Y, Zheng C, Fang Y, Xue T, Sun B, Xiao W. (2009). Targeted knockdown of EGR-1 inhibits IL-8 production and IL-8-mediated invasion of prostate cancer cells through suppressing EGR-1/NF-kappaB synergy. J Biol Chem 284(50): 34600-34606
18. Manna SK, Ramesh GT. (2005). Interleukin-8 induces nuclear transcription factor-kappaB through a TRAF6-dependent pathway. J Biol Chem 280(8): 7010-7021
19. Mollinedo F, Borregaard N, Boxer LA. (1999). Novel trends in neutrophil structure, function and development. Immunol Today 20(12): 535-537
20. Reid MD, Basturk O, Thirabanjasak D, Hruban RH, Klimstra DS, Bagci P, Altinel D, Adsay V. (2011). Tumor-infiltrating neutrophils in pancreatic neoplasia. Mod Pathol 24(12): 1612-1619
21. Rodic S, Mihalcioiu C, Saleh RR. (2014). Detection methods of circulating tumor cells in cutaneous melanoma: a systematic review. Crit Rev Oncol Hematol 91(1): 74-92
22. Roebuck KA. (1999). Regulation of interleukin-8 gene expression. J Interferon Cytokine Res 19(5): 429-438
23. Romano MF, Avellino R, Petrella A, Bisogni R, Romano S, Venuta S. (2004). Rapamycin inhibits doxorubicin-induced NF-kappaB/Rel nuclear activity and enhances the apoptosis of melanoma cells. Eur J Cancer 40(18): 2829-2836
24. Romano S, D'Angelillo A, D'Arrigo P, Staibano S, Greco A, Brunetti A, Scalvenzi M, Bisogni R, Scala I, Romano MF. (2014). FKBP51 increases the tumour-promoter potential of TGF-beta. Clin Transl Med 3(1): 1-3
25. Romano S, D'Angelillo A, Pacelli R, Staibano S, De LE, Bisogni R, Eskelinen EL, Mascolo M, Cali G, Arra C, Romano MF. (2010). Role of FK506-binding protein 51 in the control of apoptosis of irradiated melanoma cells. Cell Death Differ 17(1): 145-157
26. Romano S, Mallardo M, Romano MF. (2011). FKBP51 and the NF-kappaB regulatory pathway in cancer. Curr Opin Pharmacol 11(4): 288-293
27. Romano S, Staibano S, Greco A, Brunetti A, Nappo G, Ilardi G, Martinelli R, Sorrentino A, Di PA, Mascolo M, Bisogni R, Scalvenzi M, Alfano B, Romano MF. (2013). FK506 binding protein 51 positively regulates melanoma stemness and metastatic potential. Cell Death Dis 4: e578
28. Sadanandam A, Rosenbaugh EG, Singh S, Varney M, Singh RK. (2010). Semaphorin 5A promotes angiogenesis by increasing endothelial cell proliferation, migration, and decreasing apoptosis. Microvasc Res 79(1): 1-9
29. Sakamoto Y, Harada T, Horie S, Iba Y, Taniguchi F, Yoshida S, Iwabe T, Terakawa N. (2003). Tumor necrosis factor-Alpha-induced interleukin-8 (IL-8) expression in endometriotic stromal cells, probably through nuclear factorkappa B activation: gonadotropin-releasing hormone agonist treatment reduced IL-8 expression. J Clin Endocrinol Metab 88(2): 730-735
30. Siegel RL, Miller KD, Jemal A. (2015). Cancer statistics, 2015. CA Cancer J Clin 65(1): 5-29
31. Sinars CR, Cheung-Flynn J, Rimerman RA, Scammell JG, Smith DF, Clardy J. (2003). Structure of the large FK506-binding protein FKBP51, an Hsp90-binding protein and a component of steroid receptor complexes. Proc Natl Acad Sci U S A 100(3): 868-873
32. Singh AP, Arora S, Bhardwaj A, Srivastava SK, Kadakia MP, Wang B, Grizzle WE, Owen LB, Singh S. (2012). CXCL12/CXCR4 protein signaling axis induces sonic hedgehog expression in pancreatic cancer cells via extracellular regulated kinase-And Akt kinase-mediated activation of nuclear factor kappaB: implications for bidirectional tumor-stromal interactions. J Biol Chem 287(46): 39115-39124
33. Singh S, Nannuru KC, Sadanandam A, Varney ML, Singh RK. (2009). CXCR1 and CXCR2 enhances human melanoma tumourigenesis, growth and invasion. Br J Cancer 19(10): 1638-1646
34. Singh S, Singh AP, Sharma B, Owen LB, Singh RK. (2010). CXCL8 and its cognate receptors in melanoma progression and metastasis. Future Oncol 6(1): 111-116
35. Singh S, Varney M, Singh RK. (2009). Host CXCR2-dependent regulation of melanoma growth, angiogenesis, and experimental lung metastasis. Cancer Res 69(2): 411-415
36. Singh S, Wu S, Varney M, Singh AP, Singh RK. (2011). CXCR1 and CXCR2 silencing modulates CXCL8-dependent endothelial cell proliferation, migration and capillary-like structure formation. Microvasc Res 82(3): 318-325
37. Spicer JD, McDonald B, Cools-Lartigue JJ, Chow SC, Giannias B, Kubes P, Ferri LE. (2012). Neutrophils promote liver metastasis via Mac-1-mediated interactions with circulating tumor cells. Cancer Res 72(16): 3919-3927
38. Storer CL, Dickey CA, Galigniana MD, Rein T, Cox MB. (2011). FKBP51 and FKBP52 in signaling and disease. Trends Endocrinol Metab 22(12): 481-490
39. Sun V, Zhou WB, Nosrati M, Majid S, Thummala S, de SD, Bezrookove V, de FS, Chun L, Schadendorf D, Debs R, Kashani-Sabet M, Dar AA. (2015). Antitumor activity of miR-1280 in melanoma by regulation of Src. Mol Ther 23(1): 71-78
40. Tazzyman S, Lewis CE, Murdoch C. (2009). Neutrophils: key mediators of tumour angiogenesis. Int J Exp Pathol 90(3): 222-231
41. Tyagi N, Bhardwaj A, Singh AP, McClellan S, Carter JE, Singh S. (2014). p-21 activated kinase 4 promotes proliferation and survival of pancreatic cancer cells through AKT-And ERK-dependent activation of NF-kappaB pathway. Oncotarget 5(18): 8778-8789
42. Varney ML, Johansson SL, Singh RK. (2006). Distinct expression of CXCL8 and its receptors CXCR1 and CXCR2 and their association with vessel density and aggressiveness in malignant melanoma. Am J Clin Pathol 125(2): 209-216
43. Wang JM, Taraboletti G, Matsushima K, Van DJ, Mantovani A. (1990). Induction of haptotactic migration of melanoma cells by neutrophil activating protein/interleukin-8. Biochem Biophys Res Commun 169(1): 165-170
44. Waugh DJ, Wilson C. (2008). The interleukin-8 pathway in cancer. Clin Cancer Res 14(21): 6735-6741
45. Wu S, Singh S, Varney ML, Kindle S, Singh RK. (2012). Modulation of CXCL-8 expression in human melanoma cells regulates tumor growth, angiogenesis, invasion, and metastasis. Cancer Med 1(3): 306-317
46. Xie K. (2001). Interleukin-8 and human cancer biology. Cytokine Growth Factor Rev 12(4): 375-391
47. Yao C, Lin Y, Chua MS, Ye CS, Bi J, Li W, Zhu YF, Wang SM. (2007). Interleukin-8 modulates growth and invasiveness of estrogen receptor-negative breast cancer cells. Int J Cancer 121(9): 1949-1957