메뉴 건너뛰기




Volumn 62, Issue 2, 2015, Pages 175-188

Profound blockade of T cell activation requires concomitant inhibition of different class I PI3K isoforms

Author keywords

p110 isoform; PI3K inhibitor; T lymphocyte

Indexed keywords

2 (6 AMINO 9 PURINYLMETHYL) 5 METHYL 3 (2 METHYLPHENYL) 3H QUINAZOLIN 4 ONE; 5 [5 (4 FLUORO 2 HYDROXYPHENYL)FURFURYLIDENE] 2,4 THIAZOLIDINEDIONE; AS 242525; BUPARLISIB; MONOCLONAL ANTIBODY CD28; MONOCLONAL ANTIBODY CD3; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; TGX 221; UNCLASSIFIED DRUG; ADENINE; CYTOKINE; ENZYME INHIBITOR; ISOENZYME; MORPHOLINE DERIVATIVE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE 3 KINASE; PROTEIN KINASE B; PYRIMIDINONE DERIVATIVE; QUINAZOLINE DERIVATIVE;

EID: 84930009783     PISSN: 0257277X     EISSN: 15590755     Source Type: Journal    
DOI: 10.1007/s12026-015-8648-y     Document Type: Article
Times cited : (11)

References (41)
  • 1
    • 0033604577 scopus 로고    scopus 로고
    • Signaling by distinct classes of phosphoinositide 3-kinases
    • COI: 1:CAS:528:DyaK1MXnsF2it7Y%3D, PID: 10579926
    • Vanhaesebroeck B, Waterfield MD. Signaling by distinct classes of phosphoinositide 3-kinases. Exp Cell Res. 1999;253:239–54.
    • (1999) Exp Cell Res , vol.253 , pp. 239-254
    • Vanhaesebroeck, B.1    Waterfield, M.D.2
  • 2
    • 0032497832 scopus 로고    scopus 로고
    • Structure and function of phosphoinositide 3-kinases
    • COI: 1:CAS:528:DyaK1cXns1Klur8%3D, PID: 9838078
    • Wymann MP, Pirola L. Structure and function of phosphoinositide 3-kinases. Biochim Biophys Acta. 1998;1436:127–50.
    • (1998) Biochim Biophys Acta , vol.1436 , pp. 127-150
    • Wymann, M.P.1    Pirola, L.2
  • 3
    • 38149120449 scopus 로고    scopus 로고
    • Targeting phosphoinositide 3-kinase: moving towards therapy
    • COI: 1:CAS:528:DC%2BD1cXptlerug%3D%3D, PID: 17997386
    • Marone R, Cmiljanovic V, Giese B, Wymann MP. Targeting phosphoinositide 3-kinase: moving towards therapy. Biochim Biophys Acta. 2008;1784:159–85.
    • (2008) Biochim Biophys Acta , vol.1784 , pp. 159-185
    • Marone, R.1    Cmiljanovic, V.2    Giese, B.3    Wymann, M.P.4
  • 5
    • 62849114529 scopus 로고    scopus 로고
    • Regulation of phosphoinositide 3-kinase expression in health and disease
    • COI: 1:CAS:528:DC%2BD1MXjvVOqu7g%3D, PID: 19299143
    • Kok K, Geering B, Vanhaesebroeck B. Regulation of phosphoinositide 3-kinase expression in health and disease. Trends Biochem Sci. 2009;34:115–27.
    • (2009) Trends Biochem Sci , vol.34 , pp. 115-127
    • Kok, K.1    Geering, B.2    Vanhaesebroeck, B.3
  • 8
    • 84859435368 scopus 로고    scopus 로고
    • PI3-kinase regulates eosinophil and neutrophil degranulation in patients with allergic rhinitis and allergic asthma irrespective of allergen challenge model
    • PID: 21384093
    • Kampe M, Lampinen M, Stolt I, Janson C, Stalenheim G, Carlson M. PI3-kinase regulates eosinophil and neutrophil degranulation in patients with allergic rhinitis and allergic asthma irrespective of allergen challenge model. Inflammation. 2012;35:230–9.
    • (2012) Inflammation , vol.35 , pp. 230-239
    • Kampe, M.1    Lampinen, M.2    Stolt, I.3    Janson, C.4    Stalenheim, G.5    Carlson, M.6
  • 9
    • 33746581368 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase-delta inhibitor reduces vascular permeability in a murine model of asthma
    • COI: 1:CAS:528:DC%2BD28Xot1Wrsbg%3D, PID: 16890765
    • Lee KS, Park SJ, Kim SR, Min KH, Jin SM, Puri KD, Lee YC. Phosphoinositide 3-kinase-delta inhibitor reduces vascular permeability in a murine model of asthma. J Allergy Clin Immunol. 2006;118:403–9.
    • (2006) J Allergy Clin Immunol , vol.118 , pp. 403-409
    • Lee, K.S.1    Park, S.J.2    Kim, S.R.3    Min, K.H.4    Jin, S.M.5    Puri, K.D.6    Lee, Y.C.7
  • 10
    • 15944425792 scopus 로고    scopus 로고
    • An anti-inflammatory role for a phosphoinositide 3-kinase inhibitor LY294002 in a mouse asthma model
    • COI: 1:CAS:528:DC%2BD2MXosFygsg%3D%3D, PID: 15683846
    • Duan W, Aguinaldo Datiles AM, Leung BP, Vlahos CJ, Wong WS. An anti-inflammatory role for a phosphoinositide 3-kinase inhibitor LY294002 in a mouse asthma model. Int Immunopharmacol. 2005;5:495–502.
    • (2005) Int Immunopharmacol , vol.5 , pp. 495-502
    • Duan, W.1    Aguinaldo Datiles, A.M.2    Leung, B.P.3    Vlahos, C.J.4    Wong, W.S.5
  • 11
    • 84865012034 scopus 로고    scopus 로고
    • Targeting PI3K isoforms and SHIP in the immune system: new therapeutics for inflammation and leukemia
    • COI: 1:CAS:528:DC%2BC38XltVyjtr0%3D, PID: 22483603
    • Blunt MD, Ward SG. Targeting PI3K isoforms and SHIP in the immune system: new therapeutics for inflammation and leukemia. Curr Opin Pharmacol. 2012;12:444–51.
    • (2012) Curr Opin Pharmacol , vol.12 , pp. 444-451
    • Blunt, M.D.1    Ward, S.G.2
  • 12
    • 84875141045 scopus 로고    scopus 로고
    • Therapeutic applications of PI3K inhibitors in cardiovascular diseases
    • COI: 1:CAS:528:DC%2BC3sXktVGqu7o%3D, PID: 23495693
    • Ghigo A, Morello F, Perino A, Hirsch E. Therapeutic applications of PI3K inhibitors in cardiovascular diseases. Future Med Chem. 2013;5:479–92.
    • (2013) Future Med Chem , vol.5 , pp. 479-492
    • Ghigo, A.1    Morello, F.2    Perino, A.3    Hirsch, E.4
  • 13
    • 84859057520 scopus 로고    scopus 로고
    • PI3K/AKT, MAPK and AMPK signalling: protein kinases in glucose homeostasis
    • PID: 22233681
    • Schultze SM, Hemmings BA, Niessen M, Tschopp O. PI3K/AKT, MAPK and AMPK signalling: protein kinases in glucose homeostasis. Expert Rev Mol Med. 2012;14:e1.
    • (2012) Expert Rev Mol Med , vol.14 , pp. 1
    • Schultze, S.M.1    Hemmings, B.A.2    Niessen, M.3    Tschopp, O.4
  • 14
    • 4043082729 scopus 로고    scopus 로고
    • Cutting edge: differential roles for phosphoinositide 3-kinases, p110gamma and p110delta, in lymphocyte chemotaxis and homing
    • COI: 1:CAS:528:DC%2BD2cXmt1OmurY%3D, PID: 15294934
    • Reif K, Okkenhaug K, Sasaki T, Penninger JM, Vanhaesebroeck B, Cyster JG. Cutting edge: differential roles for phosphoinositide 3-kinases, p110gamma and p110delta, in lymphocyte chemotaxis and homing. J Immunol. 2004;173:2236–40.
    • (2004) J Immunol , vol.173 , pp. 2236-2240
    • Reif, K.1    Okkenhaug, K.2    Sasaki, T.3    Penninger, J.M.4    Vanhaesebroeck, B.5    Cyster, J.G.6
  • 15
    • 79952750885 scopus 로고    scopus 로고
    • Class IA phosphoinositide 3-kinase beta and delta regulate neutrophil oxidase activation in response to Aspergillus fumigatus hyphae
    • COI: 1:CAS:528:DC%2BC3MXhvFCjs74%3D, PID: 21257963
    • Boyle KB, Gyori D, Sindrilaru A, Scharffetter-Kochanek K, Taylor PR, Mocsai A, Stephens LR, Hawkins PT. Class IA phosphoinositide 3-kinase beta and delta regulate neutrophil oxidase activation in response to Aspergillus fumigatus hyphae. J Immunol. 2011;186:2978–89.
    • (2011) J Immunol , vol.186 , pp. 2978-2989
    • Boyle, K.B.1    Gyori, D.2    Sindrilaru, A.3    Scharffetter-Kochanek, K.4    Taylor, P.R.5    Mocsai, A.6    Stephens, L.R.7    Hawkins, P.T.8
  • 19
    • 2342483743 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase in T cell activation and survival
    • COI: 1:CAS:528:DC%2BD2cXjtVSgu70%3D, PID: 15046602
    • Okkenhaug K, Bilancio A, Emery JL, Vanhaesebroeck B. Phosphoinositide 3-kinase in T cell activation and survival. Biochem Soc Trans. 2004;32:332–5.
    • (2004) Biochem Soc Trans , vol.32 , pp. 332-335
    • Okkenhaug, K.1    Bilancio, A.2    Emery, J.L.3    Vanhaesebroeck, B.4
  • 20
    • 33749515632 scopus 로고    scopus 로고
    • The p110delta isoform of phosphoinositide 3-kinase controls clonal expansion and differentiation of Th cells
    • COI: 1:CAS:528:DC%2BD28XhtVansrvP, PID: 17015696
    • Okkenhaug K, Patton DT, Bilancio A, Garcon F, Rowan WC, Vanhaesebroeck B. The p110delta isoform of phosphoinositide 3-kinase controls clonal expansion and differentiation of Th cells. J Immunol. 2006;177:5122–8.
    • (2006) J Immunol , vol.177 , pp. 5122-5128
    • Okkenhaug, K.1    Patton, D.T.2    Bilancio, A.3    Garcon, F.4    Rowan, W.C.5    Vanhaesebroeck, B.6
  • 24
    • 58149295945 scopus 로고    scopus 로고
    • Inhibition of PI3K by ZSTK474 suppressed tumor growth not via apoptosis but G0/G1 arrest
    • COI: 1:CAS:528:DC%2BD1MXosVSjug%3D%3D, PID: 19094964
    • Dan S, Yoshimi H, Okamura M, Mukai Y, Yamori T. Inhibition of PI3K by ZSTK474 suppressed tumor growth not via apoptosis but G0/G1 arrest. Biochem Biophys Res Commun. 2009;379:104–9.
    • (2009) Biochem Biophys Res Commun , vol.379 , pp. 104-109
    • Dan, S.1    Yoshimi, H.2    Okamura, M.3    Mukai, Y.4    Yamori, T.5
  • 25
    • 34548596728 scopus 로고    scopus 로고
    • A dual phosphoinositide-3-kinase alpha/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant glioma
    • COI: 1:CAS:528:DC%2BD2sXpvFKjtrg%3D, PID: 17804702
    • Fan QW, Cheng CK, Nicolaides TP, Hackett CS, Knight ZA, Shokat KM, Weiss WA. A dual phosphoinositide-3-kinase alpha/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant glioma. Cancer Res. 2007;67:7960–5.
    • (2007) Cancer Res , vol.67 , pp. 7960-7965
    • Fan, Q.W.1    Cheng, C.K.2    Nicolaides, T.P.3    Hackett, C.S.4    Knight, Z.A.5    Shokat, K.M.6    Weiss, W.A.7
  • 26
    • 17644365138 scopus 로고    scopus 로고
    • Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs
    • COI: 1:CAS:528:DC%2BD2MXktFOjtbg%3D, PID: 15771568
    • Cyster JG. Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs. Annu Rev Immunol. 2005;23:127–59.
    • (2005) Annu Rev Immunol , vol.23 , pp. 127-159
    • Cyster, J.G.1
  • 27
    • 33748160137 scopus 로고    scopus 로고
    • T-cell homing specificity and plasticity: new concepts and future challenges
    • COI: 1:CAS:528:DC%2BD28XktVyit7w%3D, PID: 16580261
    • Mora JR, von Andrian UH. T-cell homing specificity and plasticity: new concepts and future challenges. Trends Immunol. 2006;27:235–43.
    • (2006) Trends Immunol , vol.27 , pp. 235-243
    • Mora, J.R.1    von Andrian, U.H.2
  • 28
    • 2142730100 scopus 로고    scopus 로고
    • Central memory and effector memory T cell subsets: function, generation, and maintenance
    • COI: 1:CAS:528:DC%2BD2cXktlOgsb8%3D, PID: 15032595
    • Sallusto F, Geginat J, Lanzavecchia A. Central memory and effector memory T cell subsets: function, generation, and maintenance. Annu Rev Immunol. 2004;22:745–63.
    • (2004) Annu Rev Immunol , vol.22 , pp. 745-763
    • Sallusto, F.1    Geginat, J.2    Lanzavecchia, A.3
  • 29
    • 0031571264 scopus 로고    scopus 로고
    • Mechanisms of L-selectin regulation by activated T cells
    • COI: 1:CAS:528:DyaK2sXltlCmur4%3D, PID: 9257829
    • Chao CC, Jensen R, Dailey MO. Mechanisms of L-selectin regulation by activated T cells. J Immunol. 1997;159:1686–94.
    • (1997) J Immunol , vol.159 , pp. 1686-1694
    • Chao, C.C.1    Jensen, R.2    Dailey, M.O.3
  • 30
    • 42649086026 scopus 로고    scopus 로고
    • CCR7 and its ligands: balancing immunity and tolerance
    • PID: 18379575
    • Forster R, Davalos-Misslitz AC, Rot A. CCR7 and its ligands: balancing immunity and tolerance. Nat Rev Immunol. 2008;8:362–71.
    • (2008) Nat Rev Immunol , vol.8 , pp. 362-371
    • Forster, R.1    Davalos-Misslitz, A.C.2    Rot, A.3
  • 31
    • 33749169817 scopus 로고    scopus 로고
    • Specificity and plasticity of memory lymphocyte migration
    • COI: 1:CAS:528:DC%2BD28XpvFeltrY%3D, PID: 16922087
    • Mora JR, von Andrian UH. Specificity and plasticity of memory lymphocyte migration. Curr Top Microbiol Immunol. 2006;308:83–116.
    • (2006) Curr Top Microbiol Immunol , vol.308 , pp. 83-116
    • Mora, J.R.1    von Andrian, U.H.2
  • 33
    • 35148819807 scopus 로고    scopus 로고
    • PI3Kgamma is the dominant isoform involved in migratory responses of human T lymphocytes: effects of ex vivo maintenance and limitations of non-viral delivery of siRNA
    • COI: 1:CAS:528:DC%2BD2sXhtFKitrrL, PID: 17900864
    • Smith LD, Hickman ES, Parry RV, Westwick J, Ward SG. PI3Kgamma is the dominant isoform involved in migratory responses of human T lymphocytes: effects of ex vivo maintenance and limitations of non-viral delivery of siRNA. Cell Signal. 2007;19:2528–39.
    • (2007) Cell Signal , vol.19 , pp. 2528-2539
    • Smith, L.D.1    Hickman, E.S.2    Parry, R.V.3    Westwick, J.4    Ward, S.G.5
  • 34
    • 77951678634 scopus 로고    scopus 로고
    • The role of mTOR in memory CD8 T-cell differentiation
    • COI: 1:CAS:528:DC%2BC3cXnt1Kjtrc%3D, PID: 20536567
    • Araki K, Youngblood B, Ahmed R. The role of mTOR in memory CD8 T-cell differentiation. Immunol Rev. 2010;235:234–43.
    • (2010) Immunol Rev , vol.235 , pp. 234-243
    • Araki, K.1    Youngblood, B.2    Ahmed, R.3
  • 35
    • 79151486083 scopus 로고    scopus 로고
    • Metabolism, migration and memory in cytotoxic T cells
    • COI: 1:CAS:528:DC%2BC3MXlsFegtA%3D%3D, PID: 21233853
    • Finlay D, Cantrell DA. Metabolism, migration and memory in cytotoxic T cells. Nat Rev Immunol. 2011;11:109–17.
    • (2011) Nat Rev Immunol , vol.11 , pp. 109-117
    • Finlay, D.1    Cantrell, D.A.2
  • 36
    • 0030019716 scopus 로고    scopus 로고
    • Beta chemokines costimulate lymphocyte cytolysis, proliferation, and lymphokine production
    • COI: 1:CAS:528:DyaK28XnslCisQ%3D%3D, PID: 8558072
    • Taub DD, Ortaldo JR, Turcovski-Corrales SM, Key ML, Longo DL, Murphy WJ. Beta chemokines costimulate lymphocyte cytolysis, proliferation, and lymphokine production. J Leukoc Biol. 1996;59:81–9.
    • (1996) J Leukoc Biol , vol.59 , pp. 81-89
    • Taub, D.D.1    Ortaldo, J.R.2    Turcovski-Corrales, S.M.3    Key, M.L.4    Longo, D.L.5    Murphy, W.J.6
  • 37
    • 84868103203 scopus 로고    scopus 로고
    • Poly(I:C) costimulation induces a stronger antiviral chemokine and granzyme B release in human CD4 T cells than CD28 costimulation
    • COI: 1:CAS:528:DC%2BC38XhsFSmtrvP, PID: 22750548
    • Meyer T, Oberg HH, Peters C, Martens I, Adam-Klages S, Kabelitz D, Wesch D. Poly(I:C) costimulation induces a stronger antiviral chemokine and granzyme B release in human CD4 T cells than CD28 costimulation. J Leukoc Biol. 2012;92:765–74.
    • (2012) J Leukoc Biol , vol.92 , pp. 765-774
    • Meyer, T.1    Oberg, H.H.2    Peters, C.3    Martens, I.4    Adam-Klages, S.5    Kabelitz, D.6    Wesch, D.7
  • 38
    • 0032829555 scopus 로고    scopus 로고
    • The mode and duration of anti-CD28 costimulation determine resistance to infection by macrophage-tropic strains of human immunodeficiency virus type 1 in vitro
    • COI: 1:CAS:528:DyaK1MXmslGruro%3D, PID: 10516042
    • Creson JR, Lin AA, Li Q, Broad DF, Roberts MR, Anderson SJ. The mode and duration of anti-CD28 costimulation determine resistance to infection by macrophage-tropic strains of human immunodeficiency virus type 1 in vitro. J Virol. 1999;73:9337–47.
    • (1999) J Virol , vol.73 , pp. 9337-9347
    • Creson, J.R.1    Lin, A.A.2    Li, Q.3    Broad, D.F.4    Roberts, M.R.5    Anderson, S.J.6
  • 40
    • 33845379986 scopus 로고    scopus 로고
    • Rapamycin promotes expansion of functional CD4+CD25+FOXP3+regulatory T cells of both healthy subjects and type 1 diabetic patients
    • COI: 1:CAS:528:DC%2BD28Xht1KisbbJ, PID: 17142730
    • Battaglia M, Stabilini A, Migliavacca B, Horejs-Hoeck J, Kaupper T, Roncarolo MG. Rapamycin promotes expansion of functional CD4+CD25+FOXP3+regulatory T cells of both healthy subjects and type 1 diabetic patients. J Immunol. 2006;177:8338–47.
    • (2006) J Immunol , vol.177 , pp. 8338-8347
    • Battaglia, M.1    Stabilini, A.2    Migliavacca, B.3    Horejs-Hoeck, J.4    Kaupper, T.5    Roncarolo, M.G.6
  • 41
    • 84856558003 scopus 로고    scopus 로고
    • Immunotherapy with PI3K inhibitor and Toll-like receptor agonist induces IFN-gamma+IL-17+polyfunctional T cells that mediate rejection of murine tumors
    • COI: 1:CAS:528:DC%2BC38XhslCjsb8%3D, PID: 22158905
    • Marshall NA, Galvin KC, Corcoran AM, Boon L, Higgs R, Mills KH. Immunotherapy with PI3K inhibitor and Toll-like receptor agonist induces IFN-gamma+IL-17+polyfunctional T cells that mediate rejection of murine tumors. Cancer Res. 2012;72:581–91.
    • (2012) Cancer Res , vol.72 , pp. 581-591
    • Marshall, N.A.1    Galvin, K.C.2    Corcoran, A.M.3    Boon, L.4    Higgs, R.5    Mills, K.H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.