메뉴 건너뛰기




Volumn 80, Issue 10, 2014, Pages 1123-1134

Pharmacological and clinical differences among transmucosal fentanyl formulations for the treatment of breakthrough cancer pain: A review article

Author keywords

Breakthrough pain; Fentanyl; Neoplasms; Pain

Indexed keywords

FENTANYL; PLACEBO; NARCOTIC ANALGESIC AGENT;

EID: 84930005359     PISSN: 03759393     EISSN: 18271596     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (16)

References (46)
  • 1
    • 84891832560 scopus 로고    scopus 로고
    • Prevalence of breakthrough cancer pain: A systematic review and a pooled analysis of published literature
    • Deandrea S, Corli O, Consonni D, Villani W, Greco MT, Apolone G. Prevalence of breakthrough cancer pain: a systematic review and a pooled analysis of published literature. J Pain Symptom Manage 2014;47:57-76.
    • (2014) J Pain Symptom Manage , vol.47 , pp. 57-76
    • Deandrea, S.1    Corli, O.2    Consonni, D.3    Villani, W.4    Greco, M.T.5    Apolone, G.6
  • 2
    • 61849093095 scopus 로고    scopus 로고
    • The management of cancer-related breakthrough pain: Recommendations of a task group of the Science Committee of the Association for Palliative Medicine of Great Britain and Ireland
    • Davies AN, Dickman A, Reid C, Stevens AM, Zeppetella G. The management of cancer-related breakthrough pain: recommendations of a task group of the Science Committee of the Association for Palliative Medicine of Great Britain and Ireland. Eur J Pain 2009;13:331-8.
    • (2009) Eur J Pain , vol.13 , pp. 331-338
    • Davies, A.N.1    Dickman, A.2    Reid, C.3    Stevens, A.M.4    Zeppetella, G.5
  • 4
    • 0032899247 scopus 로고    scopus 로고
    • Breakthrough pain: Characteristics and impact in patients with cancer pain
    • Portenoy RK, Payne D, Jacobsen P. Breakthrough pain: characteristics and impact in patients with cancer pain. Pain 1999;81:129-34.
    • (1999) Pain , vol.81 , pp. 129-134
    • Portenoy, R.K.1    Payne, D.2    Jacobsen, P.3
  • 5
    • 0033835177 scopus 로고    scopus 로고
    • Prevalence and characteristics of breakthrough pain in cancer patients admitted to a hospice
    • Zeppetella G, O'Doherty CA, Collins S. Prevalence and characteristics of breakthrough pain in cancer patients admitted to a hospice. J Pain Symptom Manage 2000;20:87-92.
    • (2000) J Pain Symptom Manage , vol.20 , pp. 87-92
    • Zeppetella, G.1    O'Doherty, C.A.2    Collins, S.3
  • 7
    • 0031759360 scopus 로고    scopus 로고
    • Dose-titration, multicenter study of oral transmucosal fentanyl citrate for the treatment of breakthrough pain in cancer patients using transdermal fentanyl for persistent pain
    • Christie JM, Simmonds M, Patt R, Coluzzi P, Busch MA, Nordbrock E et al. Dose-titration, multicenter study of oral transmucosal fentanyl citrate for the treatment of breakthrough pain in cancer patients using transdermal fentanyl for persistent pain. J Clin Oncol 1998;16:3238-45.
    • (1998) J Clin Oncol , vol.16 , pp. 3238-3245
    • Christie, J.M.1    Simmonds, M.2    Patt, R.3    Coluzzi, P.4    Busch, M.A.5    Nordbrock, E.6
  • 8
    • 77952336590 scopus 로고    scopus 로고
    • Breakthrough pain in community-dwelling patients with cancer pain and noncancer pain, part 1: Prevalence and characteristics
    • Portenoy RK, Bruns D, Shoemaker B, Shoemaker SA. Breakthrough pain in community-dwelling patients with cancer pain and noncancer pain, part 1: prevalence and characteristics. J Opioid Manag 2010;6:97-108.
    • (2010) J Opioid Manag , vol.6 , pp. 97-108
    • Portenoy, R.K.1    Bruns, D.2    Shoemaker, B.3    Shoemaker, S.A.4
  • 9
    • 79957773396 scopus 로고    scopus 로고
    • Assessing the impact of breakthrough cancer pain
    • Burton B, Zeppetella G. Assessing the impact of breakthrough cancer pain. Br J Nurs 2011;20:S14, S16-9.
    • (2011) Br J Nurs , vol.20 , Issue.S14 , pp. S16-S19
    • Burton, B.1    Zeppetella, G.2
  • 11
    • 79954546802 scopus 로고    scopus 로고
    • Integrated strategies for the successful management of breakthrough cancer pain
    • Dickman A. Integrated strategies for the successful management of breakthrough cancer pain. Curr Opin Support Palliat Care 2011;5:8-14.
    • (2011) Curr Opin Support Palliat Care , vol.5 , pp. 8-14
    • Dickman, A.1
  • 12
    • 78650908300 scopus 로고    scopus 로고
    • Epidemiology and pattern of care of breakthrough cancer pain in a longitudinal sample of cancer patients: Results from the Cancer Pain Outcome Research Study Group
    • Greco MT, Corli O, Montanari M, Deandrea S, Zagonel V, Apolone G. Epidemiology and pattern of care of breakthrough cancer pain in a longitudinal sample of cancer patients: results from the Cancer Pain Outcome Research Study Group. Clin J Pain 2011;27:9-18.
    • (2011) Clin J Pain , vol.27 , pp. 9-18
    • Greco, M.T.1    Corli, O.2    Montanari, M.3    Deandrea, S.4    Zagonel, V.5    Apolone, G.6
  • 13
    • 0037758126 scopus 로고    scopus 로고
    • Morphine and alternative opioids in cancer pain: The EAPC recommendations
    • Hanks GW, Conno F, Cherny N, Hanna M, Kalso E, McQuay HJ et al. Morphine and alternative opioids in cancer pain: the EAPC recommendations. Br J Cancer 2001;84:587-93.
    • (2001) Br J Cancer , vol.84 , pp. 587-593
    • Hanks, G.W.1    Conno, F.2    Cherny, N.3    Hanna, M.4    Kalso, E.5    McQuay, H.J.6
  • 14
    • 67650333512 scopus 로고    scopus 로고
    • Impact and management of breakthrough pain in cancer
    • Zeppetella G. Impact and management of breakthrough pain in cancer. Curr Opin Support Palliat Care 2009;3:1-6.
    • (2009) Curr Opin Support Palliat Care , vol.3 , pp. 1-6
    • Zeppetella, G.1
  • 15
    • 0021979044 scopus 로고
    • EEG quantitation of narcotic effect: The comparative pharmacodynamics of fentanyl and alfentanil
    • Scott JC, Ponganis KV, Stanski DR. EEG quantitation of narcotic effect: the comparative pharmacodynamics of fentanyl and alfentanil. Anesthesiology 1985;62:234-41.
    • (1985) Anesthesiology , vol.62 , pp. 234-241
    • Scott, J.C.1    Ponganis, K.V.2    Stanski, D.R.3
  • 16
    • 84874907441 scopus 로고    scopus 로고
    • Fentanyl for breakthrough cancer pain: Where are we?
    • Meriggi F, Zaniboni A. Fentanyl for breakthrough cancer pain: where are we? Rev Recent Clin Trials 2013;8:42-7.
    • (2013) Rev Recent Clin Trials , vol.8 , pp. 42-47
    • Meriggi, F.1    Zaniboni, A.2
  • 17
    • 84875322032 scopus 로고    scopus 로고
    • Considerations in selecting rapid-onset opioids for the management of breakthrough pain
    • Smith HS. Considerations in selecting rapid-onset opioids for the management of breakthrough pain. J Pain Res 2013;6:189-200.
    • (2013) J Pain Res , vol.6 , pp. 189-200
    • Smith, H.S.1
  • 18
    • 77951028134 scopus 로고    scopus 로고
    • Efficacy of intranasal fentanyl spray versus other opioids for breakthrough pain in cancer
    • Vissers D, Stam W, Nolte T, Lenre M, Jansen J. Efficacy of intranasal fentanyl spray versus other opioids for breakthrough pain in cancer. Curr Med Res Opin 2010;26:1037-45.
    • (2010) Curr Med Res Opin , vol.26 , pp. 1037-1045
    • Vissers, D.1    Stam, W.2    Nolte, T.3    Lenre, M.4    Jansen, J.5
  • 19
    • 0032522607 scopus 로고    scopus 로고
    • Oral transmucosal fentanyl citrate: Randomized, double-blinded, placebo-controlled trial for treatment of breakthrough pain in cancer patients
    • Farrar JT, Cleary J, Rauck R, Busch M, Nordbrock E. Oral transmucosal fentanyl citrate: randomized, double-blinded, placebo-controlled trial for treatment of breakthrough pain in cancer patients. J Natl Cancer Inst 1998;90:611-6.
    • (1998) J Natl Cancer Inst , vol.90 , pp. 611-616
    • Farrar, J.T.1    Cleary, J.2    Rauck, R.3    Busch, M.4    Nordbrock, E.5
  • 20
    • 0035059131 scopus 로고    scopus 로고
    • Breakthrough cancer pain: A ran-domized trial comparing oral transmucosal fentanyl citrate (OTFC) and morphine sulfate immediate release (MSIR)
    • Coluzzi PH, Schwartzberg L, Conroy JD, Charapata S, Gay M, Busch MA et al. Breakthrough cancer pain: a ran-domized trial comparing oral transmucosal fentanyl citrate (OTFC) and morphine sulfate immediate release (MSIR). Pain 2001;91:123-30.
    • (2001) Pain , vol.91 , pp. 123-130
    • Coluzzi, P.H.1    Schwartzberg, L.2    Conroy, J.D.3    Charapata, S.4    Gay, M.5    Busch, M.A.6
  • 21
    • 72549097280 scopus 로고    scopus 로고
    • A comparison of intranasal fentanyl spray with oral transmucosal fentanyl citrate for the treatment of breakthrough cancer pain: An open-label, randomised, crossover trial
    • Mercadante S, Radbruch L, Davies A, Poulain P, Sitte T, Perkins P et al. A comparison of intranasal fentanyl spray with oral transmucosal fentanyl citrate for the treatment of breakthrough cancer pain: an open-label, randomised, crossover trial. Curr Med Res Opin 2009;25:2805-15.
    • (2009) Curr Med Res Opin , vol.25 , pp. 2805-2815
    • Mercadante, S.1    Radbruch, L.2    Davies, A.3    Poulain, P.4    Sitte, T.5    Perkins, P.6
  • 22
    • 33750322229 scopus 로고    scopus 로고
    • A randomized, placebo-controlled study of fentanyl buccal tablet for breakthrough pain in opioid-treated patients with cancer
    • Portenoy RK, Taylor D, Messina J, Tremmel L. A randomized, placebo-controlled study of fentanyl buccal tablet for breakthrough pain in opioid-treated patients with cancer. Clin J Pain 2006;22:805-11.
    • (2006) Clin J Pain , vol.22 , pp. 805-811
    • Portenoy, R.K.1    Taylor, D.2    Messina, J.3    Tremmel, L.4
  • 23
    • 34948821962 scopus 로고    scopus 로고
    • Fentanyl buccal tablet for relief of breakthrough pain in opioid-tolerant patients with cancer-related chronic pain
    • Slatkin NE, Xie F, Messina J, Segal TJ. Fentanyl buccal tablet for relief of breakthrough pain in opioid-tolerant patients with cancer-related chronic pain. J Support Oncol 2007;5:327-34.
    • (2007) J Support Oncol , vol.5 , pp. 327-334
    • Slatkin, N.E.1    Xie, F.2    Messina, J.3    Segal, T.J.4
  • 24
    • 78049374058 scopus 로고    scopus 로고
    • Consistent and clinically relevant effects with fentanyl buccal tablet in the treatment of patients receiving maintenance opioid therapy and experiencing cancer-related breakthrough pain
    • Zeppetella G, Messina J, Xie F, Slatkin NE. Consistent and clinically relevant effects with fentanyl buccal tablet in the treatment of patients receiving maintenance opioid therapy and experiencing cancer-related breakthrough pain. Pain Pract 2010;10:287-93.
    • (2010) Pain Pract , vol.10 , pp. 287-293
    • Zeppetella, G.1    Messina, J.2    Xie, F.3    Slatkin, N.E.4
  • 25
    • 79951877274 scopus 로고    scopus 로고
    • Consistency of efficacy, patient acceptability, and nasal tolerability of fentanyl pectin nasal spray compared with immediate-release morphine sulfate in breakthrough cancer pain
    • Davies A, Sitte T, Elsner F, Reale C, Espinosa J, Brooks D et al. Consistency of efficacy, patient acceptability, and nasal tolerability of fentanyl pectin nasal spray compared with immediate-release morphine sulfate in breakthrough cancer pain. J Pain Symptom Manage 2011;41:358-66.
    • (2011) J Pain Symptom Manage , vol.41 , pp. 358-366
    • Davies, A.1    Sitte, T.2    Elsner, F.3    Reale, C.4    Espinosa, J.5    Brooks, D.6
  • 26
    • 82955196255 scopus 로고    scopus 로고
    • Efficacy and safety of fentanyl pectin nasal spray compared with immediate-release morphine sulfate tablets in the treatment of breakthrough cancer pain: A multicenter, randomized, controlled, double-blind, double-dummy multiple-crossover study
    • Fallon M, Reale C, Davies A, Lux AE, Kumar K, Stachowiak A et al. Efficacy and safety of fentanyl pectin nasal spray compared with immediate-release morphine sulfate tablets in the treatment of breakthrough cancer pain: a multicenter, randomized, controlled, double-blind, double-dummy multiple-crossover study. J Support Oncol 2011;9:224-31.
    • (2011) J Support Oncol , vol.9 , pp. 224-231
    • Fallon, M.1    Reale, C.2    Davies, A.3    Lux, A.E.4    Kumar, K.5    Stachowiak, A.6
  • 27
    • 68949120909 scopus 로고    scopus 로고
    • Efficacy and tolerability of intranasal fentanyl spray 50 to 200 microg for breakthrough pain in patients with cancer: A phase III, multinational, randomized, double-blind, placebo-controlled, crossover trial with a 10-month, open-label extension treatment period
    • Kress HG, Oronska A, Kaczmarek Z, Kaasa S, Colberg T, Nolte T. Efficacy and tolerability of intranasal fentanyl spray 50 to 200 microg for breakthrough pain in patients with cancer: a phase III, multinational, randomized, double-blind, placebo-controlled, crossover trial with a 10-month, open-label extension treatment period. Clin Ther 2009;31:1177-91.
    • (2009) Clin Ther , vol.31 , pp. 1177-1191
    • Kress, H.G.1    Oronska, A.2    Kaczmarek, Z.3    Kaasa, S.4    Colberg, T.5    Nolte, T.6
  • 28
    • 78049464453 scopus 로고    scopus 로고
    • A multicenter, placebo-controlled, double-blind, multiple-crossover study of Fentanyl Pectin Nasal Spray (FPNS) in the treatment of breakthrough cancer pain
    • Portenoy RK, Burton AW, Gabrail N, Taylor D. A multicenter, placebo-controlled, double-blind, multiple-crossover study of Fentanyl Pectin Nasal Spray (FPNS) in the treatment of breakthrough cancer pain. Pain 2010;151:617-24.
    • (2010) Pain , vol.151 , pp. 617-624
    • Portenoy, R.K.1    Burton, A.W.2    Gabrail, N.3    Taylor, D.4
  • 29
    • 77951618928 scopus 로고    scopus 로고
    • Fentanyl buccal soluble film (FBSF) for breakthrough pain in patients with cancer: A randomized, double-blind, placebocontrolled study
    • Rauck R, North J, Gever LN, Tagarro I, Finn AL. Fentanyl buccal soluble film (FBSF) for breakthrough pain in patients with cancer: a randomized, double-blind, placebocontrolled study. Ann Oncol 2010;21:1308-14.
    • (2010) Ann Oncol , vol.21 , pp. 1308-1314
    • Rauck, R.1    North, J.2    Gever, L.N.3    Tagarro, I.4    Finn, A.L.5
  • 30
    • 72549117859 scopus 로고    scopus 로고
    • Efficacy and long-term tolerability of sublingual fentanyl orally disintegrating tablet in the treatment of breakthrough cancer pain
    • Rauck RL, Tark M, Reyes E, Hayes TG, Bartkowiak AJ, Hassman D et al. Efficacy and long-term tolerability of sublingual fentanyl orally disintegrating tablet in the treatment of breakthrough cancer pain. Curr Med Res Opin 2009;25:2877-85.
    • (2009) Curr Med Res Opin , vol.25 , pp. 2877-2885
    • Rauck, R.L.1    Tark, M.2    Reyes, E.3    Hayes, T.G.4    Bartkowiak, A.J.5    Hassman, D.6
  • 32
    • 33847772352 scopus 로고    scopus 로고
    • Oral transmucosal fentanyl citrate for the treatment of breakthrough pain in cancer patients: An overview of its pharmacological and clinical characteristics
    • Mystakidou K, Katsouda E, Parpa E, Tsiatas ML, Vlahos L. Oral transmucosal fentanyl citrate for the treatment of breakthrough pain in cancer patients: an overview of its pharmacological and clinical characteristics. J Opioid Manag 2005;1:36-40.
    • (2005) J Opioid Manag , vol.1 , pp. 36-40
    • Mystakidou, K.1    Katsouda, E.2    Parpa, E.3    Tsiatas, M.L.4    Vlahos, L.5
  • 33
    • 34548605294 scopus 로고    scopus 로고
    • Effect of buccal dwell time on the pharmacokinetic profile of fentanyl buccal tablet
    • Darwish M, Kirby M, Jiang JG. Effect of buccal dwell time on the pharmacokinetic profile of fentanyl buccal tablet. Expert Opin Pharmacother 2007;8:2011-6.
    • (2007) Expert Opin Pharmacother , vol.8 , pp. 2011-2016
    • Darwish, M.1    Kirby, M.2    Jiang, J.G.3
  • 34
    • 84859803851 scopus 로고    scopus 로고
    • Intranasal drug delivery: An efficient and non-invasive route for systemic administration: Focus on opioids
    • Grassin-Delyle S, Buenestado A, Naline E, Faisy C, Blouquit-Laye S, Couderc LJ et al. Intranasal drug delivery: an efficient and non-invasive route for systemic administration: focus on opioids. Pharmacol Ther 2012;134:366-79.
    • (2012) Pharmacol Ther , vol.134 , pp. 366-379
    • Grassin-Delyle, S.1    Buenestado, A.2    Naline, E.3    Faisy, C.4    Blouquit-Laye, S.5    Couderc, L.J.6
  • 35
    • 76749095006 scopus 로고    scopus 로고
    • Pharmacokinetic comparisons of three nasal fentanyl formulations; pectin, chitosan and chitosan-poloxamer 188
    • Fisher A, Watling M, Smith A, Knight A. Pharmacokinetic comparisons of three nasal fentanyl formulations; pectin, chitosan and chitosan-poloxamer 188. Int J Clin Pharmacol Ther 2010;48:138-45.
    • (2010) Int J Clin Pharmacol Ther , vol.48 , pp. 138-145
    • Fisher, A.1    Watling, M.2    Smith, A.3    Knight, A.4
  • 36
    • 67649229310 scopus 로고    scopus 로고
    • PecSys: In situ gelling system for optimised nasal drug delivery
    • Watts P, Smith A. PecSys: in situ gelling system for optimised nasal drug delivery. Expert Opin Drug Deliv 2009;6:543-52.
    • (2009) Expert Opin Drug Deliv , vol.6 , pp. 543-552
    • Watts, P.1    Smith, A.2
  • 37
    • 33746799704 scopus 로고    scopus 로고
    • Comparison of equivalent doses of fentanyl buccal tablets and arteriovenous differences in fentanyl pharmacokinetics
    • Darwish M, Kirby M, Robertson P, Jr., Hellriegel E, Jiang JG. Comparison of equivalent doses of fentanyl buccal tablets and arteriovenous differences in fentanyl pharmacokinetics. Clin Pharmacokinet 2006;45:843-50.
    • (2006) Clin Pharmacokinet , vol.45 , pp. 843-850
    • Darwish, M.1    Kirby, M.2    Robertson, P.3    Hellriegel, E.4    Jiang, J.G.5
  • 38
    • 80051511227 scopus 로고    scopus 로고
    • Newer generation fentanyl transmucosal products for breakthrough pain in opioid-tolerant cancer patients
    • Elsner F, Zeppetella G, Porta-Sales J, Tagarro I. Newer generation fentanyl transmucosal products for breakthrough pain in opioid-tolerant cancer patients. Clin Drug Investig 2011;31:605-18.
    • (2011) Clin Drug Investig , vol.31 , pp. 605-618
    • Elsner, F.1    Zeppetella, G.2    Porta-Sales, J.3    Tagarro, I.4
  • 39
    • 79958192467 scopus 로고    scopus 로고
    • Fentanyl pectin nasal spray: In breakthrough pain in opioid-tolerant adults with cancer
    • Lyseng-Williamson KA. Fentanyl pectin nasal spray: in breakthrough pain in opioid-tolerant adults with cancer. CNS Drugs 2011;25:511-22.
    • (2011) CNS Drugs , vol.25 , pp. 511-522
    • Lyseng-Williamson, K.A.1
  • 40
    • 41649083735 scopus 로고    scopus 로고
    • Pharmacokinetics, efficacy, and tolerability of fentanyl following intranasal versus intravenous administration in adults undergoing third-molar extraction: A randomized, double-blind, double-dummy, two-way, crossover study
    • Christrup LL, Foster D, Popper LD, Troen T, Upton R. Pharmacokinetics, efficacy, and tolerability of fentanyl following intranasal versus intravenous administration in adults undergoing third-molar extraction: a randomized, double-blind, double-dummy, two-way, crossover study. Clin Ther 2008;30:469-81.
    • (2008) Clin Ther , vol.30 , pp. 469-481
    • Christrup, L.L.1    Foster, D.2    Popper, L.D.3    Troen, T.4    Upton, R.5
  • 41
    • 13444274550 scopus 로고    scopus 로고
    • Pharmacokinetics and tolerability of different doses of fentanyl following sublingual administration of a rapidly dissolving tablet to cancer patients: A new approach to treatment of incident pain
    • Lennernas B, Hedner T, Holmberg M, Bredenberg S, Nys-trom C, Lennernas H. Pharmacokinetics and tolerability of different doses of fentanyl following sublingual administration of a rapidly dissolving tablet to cancer patients: a new approach to treatment of incident pain. Br J Clin Pharmacol 2005;59:249-53.
    • (2005) Br J Clin Pharmacol , vol.59 , pp. 249-253
    • Lennernas, B.1    Hedner, T.2    Holmberg, M.3    Bredenberg, S.4    Nys-trom, C.5    Lennernas, H.6
  • 42
    • 0034578738 scopus 로고    scopus 로고
    • Defining the clinically important difference in pain outcome measures
    • Farrar JT, Portenoy RK, Berlin JA, Kinman JL, Strom BL. Defining the clinically important difference in pain outcome measures. Pain 2000;88:287-94.
    • (2000) Pain , vol.88 , pp. 287-294
    • Farrar, J.T.1    Portenoy, R.K.2    Berlin, J.A.3    Kinman, J.L.4    Strom, B.L.5
  • 43
    • 2442712489 scopus 로고    scopus 로고
    • Tolerability and effects of two formulations of oral transmucosal fentanyl citrate (OTFC; ACTIQ) in patients with radiation-induced oral mucositis
    • Shaiova L, Lapin J, Manco LS, Shasha D, Hu K, Harrison L et al. Tolerability and effects of two formulations of oral transmucosal fentanyl citrate (OTFC; ACTIQ) in patients with radiation-induced oral mucositis. Support Care Cancer 2004;12:268-73.
    • (2004) Support Care Cancer , vol.12 , pp. 268-273
    • Shaiova, L.1    Lapin, J.2    Manco, L.S.3    Shasha, D.4    Hu, K.5    Harrison, L.6
  • 44
    • 84856176066 scopus 로고    scopus 로고
    • Absorption and tolerability of fentanyl buccal soluble film (FBSF) in patients with cancer in the presence of oral mucositis
    • Finn AL, Hill WC, Tagarro I, Gever LN. Absorption and tolerability of fentanyl buccal soluble film (FBSF) in patients with cancer in the presence of oral mucositis. J Pain Res 2011;4:245-51.
    • (2011) J Pain Res , vol.4 , pp. 245-251
    • Finn, A.L.1    Hill, W.C.2    Tagarro, I.3    Gever, L.N.4
  • 45
    • 34548077818 scopus 로고    scopus 로고
    • Absorption of fentanyl from fentanyl buccal tablet in cancer patients with or without oral mucositis: A pilot study
    • Darwish M, Kirby M, Robertson P, Tracewell W, Jiang JG. Absorption of fentanyl from fentanyl buccal tablet in cancer patients with or without oral mucositis: a pilot study. Clin Drug Investig 2007;27:605-11.
    • (2007) Clin Drug Investig , vol.27 , pp. 605-611
    • Darwish, M.1    Kirby, M.2    Robertson, P.3    Tracewell, W.4    Jiang, J.G.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.