Normal peripheral prostate stromal cells stimulate prostate cancer development: Roles of c-kit signal

American Journal of Translational Research

Volumn 7, Issue 3, 2015, Pages 502-512

  Guo, Jian Hua ^a,b   Zhou, Juan ^a   Zhao, Yang ^a   Liu, Peng Yue ^a   Yao, Hai Jun ^a   Da, Jun ^a   Zhang, Ming ^a   Zhou, Zhe ^a   Chen, Qi ^a   Peng, Yu Bing ^a   Wang, Zhong ^a  

^a SHANGHAI SECOND MEDICAL UNIVERSITY   (China)

^b FUDAN UNIVERSITY PUDONG MEDICAL CENTER   (China)

Author keywords

c kit; Prostate cancer; Signaling transduction; Stromal epithelial interaction

Indexed keywords

C KIT PROTEIN; CHOLECYSTOKININ OCTAPEPTIDE; JANUS KINASE 2; PROTEIN; SHORT HAIRPIN RNA; STAT1 PROTEIN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CELL MIGRATION ASSAY; CELL VIABILITY; CLONOGENIC ASSAY; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LENTIVIRINAE; MAJOR CLINICAL STUDY; MALE; PERIPHERAL PROSTATE STROMAL CELL; PROSTATE CANCER; STROMA CELL; WESTERN BLOTTING;

LENTIVIRUS;

EID: 84930004438     PISSN: None     EISSN: 19438141     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Buijs JT and van der Pluijm G. Osteotropic cancers: from primary tumor to bone. Cancer Lett 2009; 273: 177-193.
2. Djakiew D, Pflug B and Onoda M. Stromal-epithelial paracrine interactions in the neoplastic rat and human prostate. Adv Exp Med Biol 1993; 330: 185-202.
3. Chung LW. Implications of stromal-epithelial interaction in human prostate cancer growth, progression and differentiation. Semin Cancer Biol 1993; 4: 183-192.
4. Sung SY and Chung LW. Prostate tumor-stroma interaction: molecular mechanisms and opportunities for therapeutic targeting. Diffe-rentiation 2002; 70: 506-521.
5. Lennartsson J and Ronnstrand L. Stem cell factor receptor/c-Kit: from basic science to clinical implications. Physiol Rev 2012; 92: 1619-1649.
6. Yarden Y, Kuang WJ, Yang-Feng T, Coussens L, Munemitsu S, Dull TJ, Chen E, Schlessinger J, Francke U and Ullrich A. Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand. EMBO J 1987; 6: 3341-3351.
7. Fletcher CD, Berman JJ, Corless C, Gorstein F, Lasota J, Longley BJ, Miettinen M, O’Leary TJ, Remotti H, Rubin BP, Shmookler B, Sobin LH and Weiss SW. Diagnosis of gastrointestinal stromal tumors: A consensus approach. Hum Pathol 2002; 33: 459-465.
8. Miettinen M and Lasota J. Gastrointestinal stromal tumors: review on morphology, molecular pathology, prognosis, and differential diagnosis. Arch Pathol Lab Med 2006; 130: 1466-1478.
9. Ali S and Ali S. Role of c-kit/SCF in cause and treatment of gastrointestinal stromal tumors (GIST). Gene 2007; 401: 38-45.
10. Demetri GD, von Mehren M, Blanke CD, Van den Abbeele AD, Eisenberg B, Roberts PJ, Heinrich MC, Tuveson DA, Singer S, Janicek M, Fletcher JA, Silverman SG, Silberman SL, Capdeville R, Kiese B, Peng B, Dimitrijevic S, Druker BJ, Corless C, Fletcher CD and Joensuu H. Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N Engl J Med 2002; 347: 472-480.
11. Simak R, Capodieci P, Cohen DW, Fair WR, Scher H, Melamed J, Drobnjak M, Heston WD, Stix U, Steiner G and Cordon-Cardo C. Exp-ression of c-kit and kit-ligand in benign and malignant prostatic tissues. Histol Histopathol 2000; 15: 365-374.
12. Van der Aa F, Roskams T, Blyweert W and De Ridder D. Interstitial cells in the human prostate: a new therapeutic target? Prostate 2003; 56: 250-255.
13. Shafik A, Shafik I and el-Sibai O. Identification of c-kit-positive cells in the human prostate: the interstitial cells of Cajal. Arch Androl 2005; 51: 345-351.
14. Peng YB, Zhou J, Gao Y, Li YH, Wang H, Zhang M, Ma LM, Chen Q, Da J, Wang Z and Li R. Normal prostate-derived stromal cells stimulate prostate cancer development. Cancer Sci 2011; 102: 1630-1635.
15. Imura M, Kojima Y, Kubota Y, Hamakawa T, Yasui T, Sasaki S, Hayashi Y and Kohri K. Regulation of cell proliferation through a KIT-mediated mechanism in benign prostatic hyperplasia. Prostate 2012; 72: 1506-1513.
16. Kitamura Y. Gastrointestinal stromal tumors: past, present, and future. J Gastroenterol 2008; 43: 499-508.
17. Chang YP, Tsai CC, Huang WC, Wang CY, Chen CL, Lin YS, Kai JI, Hsieh CY, Cheng YL, Choi PC, Chen SH, Chang SP, Liu HS and Lin CF. Autophagy facilitates IFN-gamma-induced Jak2-STAT1 activation and cellular inflammation. J Biol Chem 2010; 285: 28715-28722.
18. Deberry C, Mou S and Linnekin D. Stat1 associates with c-kit and is activated in response to stem cell factor. Biochem J 1997; 327: 73-80.
19. Di Lorenzo G, Autorino R, D’Armiento FP, Mignogna C, De Laurentiis M, De Sio M, D’Armiento M, Damiano R, Vecchio G and De Placido S. Expression of proto-oncogene c-kit in high risk prostate cancer. Eur J Surg Oncol 2004; 30: 987-992.
20. Wiesner C, Nabha SM, Dos Santos EB, Yamamoto H, Meng H, Melchior SW, Bittinger F, Thuroff JW, Vessella RL, Cher ML and Bonfil RD. C-kit and its ligand stem cell factor: potential contribution to prostate cancer bone metastasis. Neoplasia 2008; 10: 996-1003.