Upregulation of alveolar levels of activin B, but not activin A, in lungs of west highland white terriers with idiopathic pulmonary fibrosis and diffuse alveolar damage

Journal of Comparative Pathology

Volumn 152, Issue 2-3, 2015, Pages 192-200

  Lilja Maula, L ^a   Syrja P ^a   Laurila, H P ^a   Sutinen, E ^a   Palviainen, M ^a   Ritvos, O ^b   Koli, K ^b   Rajamaki M M ^a   Myllarniemi M ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Activins; Diffuse alveolar damage; Dog; Idiopathic pulmonary fibrosis

Indexed keywords

ACTIVIN A; MYELOPID; ACTIVIN;

ADULT RESPIRATORY DISTRESS SYNDROME; ANIMAL TISSUE; ARTICLE; FIBROSING ALVEOLITIS; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LUNG ALVEOLUS; LUNG ALVEOLUS EPITHELIUM; LUNG LAVAGE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TERRIER; UPREGULATION; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; BRONCHOALVEOLAR LAVAGE FLUID; CHEMISTRY; DOG; DOG DISEASE; METABOLISM; PATHOLOGY; VETERINARY;

CANIS FAMILIARIS;

ACTIVINS; ANIMALS; BLOTTING, WESTERN; BRONCHOALVEOLAR LAVAGE FLUID; DOG DISEASES; DOGS; IDIOPATHIC PULMONARY FIBROSIS; IMMUNOHISTOCHEMISTRY; PULMONARY ALVEOLI; UP-REGULATION;

EID: 84930004362     PISSN: 00219975     EISSN: 15323129     Source Type: Journal    
DOI: 10.1016/j.jcpa.2014.11.006     Document Type: Article

References (44)

1. Aoki F, Kurabayashi M, Hasegawa Y, Kojima I (2005) Attenuation of bleomycin-induced pulmonary fibrosis by follistatin. American Journal of Respiratory and Critical Care Medicine, 172, 713-720.
2. Apostolou E, Stavropoulos A, Sountoulidis A, Xirakia C, Giaglis S et al. (2012) Activin-A overexpression in the murine lung causes pathology that simulates acute respiratory distress syndrome. American Journal of Respiratory and Critical Care Medicine, 185, 382-391.
3. Bernard DJ, Lee KB, Santos MM (2006) Activin B can signal through both ALK4 and ALK7 in gonadotrope cells. Reproductive Biology and Endocrinology, 4, 52-59.
4. Besson-Fournier C, Latour C, Kautz L, Bertrand J, Ganz T et al. (2012) Induction of activin B by inflammatory stimuli up-regulates expression of the iron-regulatory peptide hepcidin through Smad1/5/8 signaling. Blood, 120, 431-439.
5. Böttinger EP, Letterio JJ, Roberts AB (1997) Biology of TGF-beta in knockout and transgenic mouse models. Kidney International, 51, 1355-1360.
6. Castro CY (2006) ARDS and diffuse alveolar damage: a pathologist's perspective. Seminars in Thoracic and Cardiovascular Surgery, 18, 13-19.
7. Cho SH, Yao Z, Wang S-W, Alban RF, Barbers RG et al. (2003) Regulation of activin A expression in mast cells and asthma: its effect on the proliferation of human airway smooth muscle cells. Journal of Immunology, 170, 4045-4052.
8. Collard HR, Moore BB, Flaherty KR, Brown KK, Kaner RJ et al. (2007) Acute exacerbations of idiopathic pulmonary fibrosis. American Journal of Respiratory and Critical Care Medicine, 176, 636-643.
9. Corcoran BM, Cobb M, Martin MWS, Dukes-McEwan J, French A et al. (1999) Chronic pulmonary disease in West Highland white terriers. Veterinary Record, 144, 611-616.
10. Coward WR, Saini G, Jenkins G (2010) The pathogenesis of idiopathic pulmonary fibrosis. Therapeutic Advances in Respiratory Diseases, 4, 367-388.
11. DeClue AE, Cohn LA (2007) Acute respiratory distress syndrome in dogs and cats: a review of clinical findings and pathophysiology. Journal of Veterinary Emergency and Critical Care, 17, 340-347.
12. de Kretser DM, O'Hehir RE, Hardy CL, Hedger MP (2012) The roles of activin A and its binding protein, follistatin, in inflammation and tissue repair. Molecular and Cellular Endocrinology, 359, 101-106.
13. de Kretser DM, Bensley JG, Pettilä V, Linko R, Hedger MP (2013) Serum activin A and B levels predict outcome in patients with acute respiratory failure: a prospective cohort study. Critical Care, 17, R263.
14. Hedger MP, de Kretser DM (2013) The activins and their binding protein, follistatin e diagnostic and therapeutic targets in inflammatory disease and fibrosis. Cytokine and Growth Factor Reviews, 24, 285-295.
15. Hedger MP, Winnall WR, Phillips DJ, de Kretser DM (2011) The regulation and functions of activin and follistatin in inflammation and immunity. Vitamins and Hormones, 85, 255-297.
16. Heikkilä HP, Lappalainen AK, Day MJ, Clercx C, Rajamäki MM (2011) Clinical, bronchoscopic, histopathologic, diagnostic imaging and arterial oxygenation findings in West Highland white terriers with idiopathic pulmonary fibrosis. Journal of Veterinary Internal Medicine, 25, 433-439.
17. Itoh S, Itoh F, Goumans MJ, Ten Dijke P (2003) Signaling of transforming growth factor-b family members through Smad proteins. European Journal of Biochemistry, 267, 6954-6967.
18. Karagiannidis C, Hense G, Martin C, Epstein M, Rückert B et al. (2006) Activin A is an acute allergenresponsive cytokine and provides a link to TGF-b-mediated airway remodeling in asthma. Journal of Allergy and Clinical Immunology, 117, 111-118.
19. Khalil N, O'Connor RN, Flanders KC, Unruh HW (1996) TGF-b1, but not TGF-b2 or TGF-b3, is differentially present in epithelial cells of advanced pulmonary fibrosis: an immunohistochemical study. American Journal of Respiratory Cell and Molecular Biology, 14, 131-138.
20. Khalil N, O'Connor RN, Unruh HW, Warren PW, Flanders KC et al. (1991) Increased production and immunohistochemical localization of transforming growth factor-b in idiopathic pulmonary fibrosis. American Journal of Respiratory Cell and Molecular Biology, 5, 155-162.
21. Kim DS, Collard HR, King TE Jr. (2006) Classification and natural history of the idiopathic interstitial pneumonias. Proceedings of the American Thoracic Society, 3, 285-292.
22. Koli K, Myllärniemi M, Keski-Oja J, Kinnula VL (2008) Forum review: transforming growth factor-b activation in the lung: focus on fibrosis and reactive oxygen species. Antioxidants and Redox Signaling, 10, 333-342.
23. Krafft E, Heikkilä HP, Day MJ, Peters IR, Mc Entee K et al. (2012) Transforming growth factor beta-1 and its activating pathways in canine idiopathic pulmonary fibrosis. Proceedings of the 22nd Congress of the European College of Veterinary Internal Medicine, Maastricht, pp. 236-237.
24. Krafft E, Heikkilä HP, Jespers J, Mc Entee K, Lequarre AS et al. (2011) High serum transforming growth factor beta-1 concentration in West Highland white terriers:a key to the breed predisposition in canine idiopathic pulmonary fibrosis. Proceedings of the 21st Congress of the European College of Veterinary Internal Medicine, Seville, p. 1501.
25. Leask A, Abraham DJ (2004) TGF-b signaling and the fibrotic response. FASEB Journal, 18, 816-827.
26. Liang N, Ying S-H, Ueno N, Shimasaki S, Esch F et al. (1986) Pituitary FSH is released by a heterodimer of b-subunits from two forms of inhibin. Nature, 132, 779-782.
27. Lilja-Maula LIO, Laurila HP, Syrjä P, Lappalainen AK, Krafft E et al. (2014a) Long-term outcome and use of 6-minute walk test in West Highland white terriers with idiopathic pulmonary fibrosis. Journal of Veterinary Internal Medicine, 28, 379-385.
28. Lilja-Maula L, Syrjä P, Laurila HP, Sutinen E, Rönty M et al. (2014b) Comparative study of transforming growth factor-b signalling and regulatory molecules in human and canine idiopathic pulmonary fibrosis. Journal of Comparative Pathology, 150, 399-407.
29. Lobetti RG, Milner R, Lane E (2001) Chronic idiopathic pulmonary fibrosis in five dogs. Journal of the American Animal Hospital Association, 37, 119-127.
30. Marino G, Zanghì A (2013) Activins and inhibins: expression and role in normal and pathological canine reproductive organs. Anatomia, Histologia, Embryologia, 42, 1-8.
31. Marino G, Zanghì A, Catone G, Bontempo RA, Nicòtina PA (2003) Expression of inhibin/activin a, bA and bB subunits in the ovary of the bitch. Veterinary Research Communications, 27(Suppl. 1), 611-614.
32. Matsuse T, Fukuchi Y, Eto Y, Matsui H, Hosoi T et al. (1995) Expression of immunoreactive and bioactive activin A protein in adult murine lung after bleomycin treatment. American Journal of Respiratory Cell and Molecular Biology, 13, 17-24.
33. Matsuse T, Ikegami A, Ohga E, Hosoi T, Oka T et al. (1996) Expression of immunoreactive activin A protein in remodeling lesions associated with interstitial pulmonary fibrosis. American Journal of Pathology, 148, 707-713.
34. Mayer K, Buchbinder A, Morty RE (2012) Activin A: a mediator governing inflammation, immunity, and repair. American Journal of Respiratory and Critical Care Medicine, 185, 350-352.
35. Meltzer EB, Noble PW (2008) Review: idiopathic pulmonary fibrosis. Orphanet Journal of Rare Diseases, 3, 8.
36. Ohga E, Matsuse T, Teramoto S, Katayama H, Nagase T et al. (1996) Effects of activin A on proliferation and differentiation of human lung fibroblasts. Biochemical and Biophysical Research Communications, 228, 391-396.
37. Patella S, Phillips DJ, Tchongue J, de Kretser DM, Sievert W (2006) Follistatin attenuates early liver fibrosis: effects on hepatic stellate cell activation and hepatocyte apoptosis. American Journal of Physiology; Gastrointestinal and Liver Physiology, 290, 137-144.
38. Raghu G, Collard HR, Egan JJ, Martinez FJ, Behr J et al., ATS/ERS/JRS/ALAT Committee on Idiopathic Pulmonary Fibrosis (2011) An official ATS/ERS/JRS/ALAT statement: idiopathic pulmonary fibrosis:evidence-based guidelines for diagnosis and management. American Journal of Respiratory and Critical Care Medicine, 183, 788-824.
39. Rosendahl A, Checchin D, Fehniger TE, ten Dijke P, Heldin C-H et al. (2001) Activation of the TGF-b/activin-Smad2 pathway during allergic airway inflammation. American Journal of Respiratory Cell and Molecular Biology, 25, 60-68.
40. Syrjä P, Heikkilä HP, Lilja-Maula L, Krafft E, Clercx C et al. (2013) The histopathology of idiopathic pulmonary fibrosis in West Highland white terriers shares features of both non-specific interstitial pneumonia and usual interstitial pneumonia in man. Journal of Comparative Pathology, 149, 303-313.
41. Syrjä P, Saari S, Rajamäki M, Saario E, Järvinen AK (2009) Pulmonary histopathology in Dalmatians with familial acute respiratory distress syndrome (ARDS). Journal of Comparative Pathology, 141, 254-259.
42. Vale W, Rivier J, Vaughan J, McClintock R, Corrigan A et al. (1986) Purification and characterization of an FSH releasing protein from porcine ovarian follicular fluid. Nature, 321, 776-779.
43. van den Blink B, Wijsenbeek MS, Hoogsteden HC (2010) Serum biomarkers in idiopathic pulmonary fibrosis. Pulmonary Pharmacology and Therapeutics, 23, 515-520.
44. Zhao Y, Silbajoris R, Young SL (1996) Identification and developmental expression of two activin receptors in baboon lung. Biochemical and Biophysical Research Communications, 229, 50-57.