Management of erectile dysfunction after radical prostatectomy

Pelvic Cancer Surgery: Modern Breakthroughs and Future Advances

Volumn , Issue , 2015, Pages 217-224

  Mulhall, John P ^a   Donatucci, Craig F ^b   Chiles, Kelly A ^c   Büttner, Hartwig ^d  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b ELI LILLY AND COMPANY   (United States)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

^d LILLY DEUTSCHLAND GMBH   (Germany)

Author keywords

Erectile dysfunction; Pathophysiology; Penile rehabilitation; Radical prostatectomy; Treatment

Indexed keywords

EID: 84930002238     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-4471-4258-4_22     Document Type: Chapter

References (37)

1. Tal R, Alphs HH, Krebs P, Nelson CJ, Mulhall JP. Erectile function recovery rate after radical prostatectomy: a meta-analysis. J Sex Med. 2009;6: 2538-46.
2. Walsh PC, Donker PJ. Impotence following radical prostatectomy: insight into etiology and prevention. J Urol. 1982;128:492-97.
3. Breza J, Aboseif SE, Orvis BR, Lue TF, Tanago EA. Detailed anatomy of penile neurovascular structures: surgical significance. J Urol. 1989;141:437-43.
4. Quinlan DM, Epstein JL, Carter BS, Walsh PC. Sexual function following radical prostatectomy: influence of preservation of neurovascular bundles. J Urol. 1991;145:998-1002.
5. Ficarra V, Novara G, Ahlering TE, Costello A, Eastham JA, Graefen M, Guazzoni G, Menon M, Mottrie A, Patel VR, Van der Poel H, Rosen RC, Tewari AK, Wilson TG, Zattoni F, Montorsi F. Systematic review and meta-analysis of studies reporting potency rates after robot-assisted radical prostatectomy. Eur Urol. 2012;62:418-30.
6. Hatzimouratidis K, Burnett AL, Hatzichristou D, McCullough AR, Montorsi F, Mullhall JP. Phosphodiesterase type 5 inhibitors in postprostatectomy erectile dysfunction: a critical analysis of the basic science rationale and clinical application. Eur Urol. 2009;55:334-47.
7. User HM, Zelner DJ, McKenna KE, McVary KT. J Urol. 2003;170:298-301.
8. Calenda G, Strong TD, Pavlovich CP, Schaeffer EM, Burnett AL, Yu W, Davies KP, Bivalacqua TJ. Whole genome microarray of the major pelvic ganglion after cavernous nerve injury: new insights. BJU Int. 2012;109:1552-64.
9. Schwartz EJ, Wong P, Graydon RJ. Sildenafil protects intracorporal smooth muscle after radical retropubic prostatectomy. J Urol. 2004;171:771-74.
10. Klein LT, Miller MI, Buttyan R, Raffo AJ, et al. Apoptosis in the rat penis after denervation. J Urol. 1997;158:626-30.
11. User HM, Hairston JH, Zelner DJ, McKenna KE, et al. Penile weight and cell subtype specific changes in a post-radical prostatectomy model of erectile dysfunction. J Urol. 2003;169:1175-9.
12. Iacono F, Gianella R, Somma P, Manno G, et al. Histologic alterations in cavernous tissue after radical prostatectomy. J Urol. 2005;173:1673-6.
13. Leungwattanakij S, Bivalacqua TJ, Usta MF, Yang DY, et al. Cavernous neurotomy causes hypoxia and fibrosisin rat corpus cavernosum. J Androl. 2003;24: 239-45.
14. Ozden E, Ozturk B, Kosan M, Tezel GG, et al. Effect of sildenafil citrate on penile weight and physiology of cavernous smooth muscle in a post-radical prostatectomy model of erectile dysfunction in rats. Urology. 2011;77:761.e1-761.e7
15. Aboseif S, Shinohara K, Breza J, Benard F, et al. Role of penile vascular injury in erectile dysfunction after radical prostatectomy. Br J Urol. 1994;73: 75-82.
16. Munding MD, Wessells HB, Dalkin BL. Pilot study of changes in stretched penile length 3 months after radical prostatectomy. Urology. 2001;58:567-9.
17. Savoie M, Kim SS, Soloway M. A prospective study measuring penile length in men treated by radical prostatectomy for prostate cancer. J Urol. 2003;169: 162-4.
18. Montorsi F, Guazzoni G, Strambi LF, Da Pozzo LF, et al. Recovery of spontaneous erectile function after nerve-sparing radical reteropubic prostatectomy with and without early intracavernous injections of alprostadil: results of a prospective randomized trial. J Urol. 1997;158:1408-10.
19. Mulhall JP, Bivalacqua TJ, Becher EF. Standard operating procedure for the preservation of erectile function outcomes after radical prostatectomy. J Sex Med. 2013;10:195-203.
20. Padma-Nathan H, McCullough AR, Levine LA, Lipshultz LI, et al. Randomized, double-blind, placebo-controlled study of postoperative nightly sildenafil citrate for the prevention of erectile dysfunction after bilateral nerve-sparing radical prostatectomy. Int J Impot Res. 2008;20:479-86.
21. Montorsi F, Brock G, Lee J, Shapiro J, et al. Effect of nightly versus on-demand vardenafil on recovery of erectile function in men following bilateral nervesparing radical prostatectomy. Eur Urol. 2008;54: 924-31.
22. Wrishko R, Sorsaburo S, Wong D, Strawbridge A, et al. Safety, efficacy and pharmacokinetic overview of low-dose daily administration of tadalafil. J Sex Med. 2009;6:2039-48.
23. Montorsi F, Brock G, Stolzenburg JU, Mulhall J, et al. Effects of tadalafil treatment on erectile function recovery following bilateral nerve-sparing radical prostatectomy: a randomised placebo-controlled study (REACTT). Eur Urol. 2014;65:587-96.
24. Castiglione F, Nini A, Briganti A. Penile rehabilitation with phosphodiesterase type 5 inhibitors after nerve-sparing radical prostatectomy: are we targeting the right patients? Eur Urol. 2014;65:663-4.
25. Kilminster S, Müller S, Menon M, Joseph JV, et al. Predicting erectile function outcome in men after radical prostatectomy for prostate cancer. BJU Int. 2011;110:422-6.
26. Berookhim BM, Nelson CJ, Kunzel B, Mulhall JP, et al. A Prospective analysis of penile length changes following radical prostatectomy. BJU Int. 2013. doi: 10.1111/bju. 12443 BJU Int. 2014;113:E131-6.
27. Rabbani F, Schiff J, Piecuch M, et al. Time course of recovery of erectile function after radical retropubic prostatectomy: does anyone recover after 2 years? J Sex Med. 2010;7:3984-90.
28. Smith 2nd WB, McCaslin IR, Gokce A, Mandava SH, et al. PDE5 inhibitors: considerations for preference and long-term adherence. Int J Clin Pract. 2013;67: 768-80.
29. Katz D, Bennett NE, Stasi J, Eastham JA, et al. Chronology of erectile function in patients with early functional erections following radical prostatectomy. J Sex Med. 2010;7:803-9.
30. Raina R, Lakin MM, Agarwal A, Sharma A, et al. Long-term effect of sildenafil citrate on erectile dysfunction after radical prostatectomy: 3-year follow-up. Urology. 2003;62:110-5.
31. Montorsi F, McCullough A. Efficacy of sildenafil citrate in men with erectile dysfunction following radical prostatectomy: a systematic review of clinical data. J Sex Med. 2005;2:658-67.
32. Coombs PG, Heck M, Guhring P, Narus J, et al. A review of outcomes of an intracavernosal injection therapy programme. BJU Int. 2012;110:1787-91.
33. Baniel J, Israilov S, Segenreich E, Livne PM. Comparative evaluation of treatments for erectile dysfunction in patients with prostate cancer after radical retropubic prostatectomy. BJU Int. 2001;88:58-62.
34. Zippe C, Nandipati K, Agarwal A, Raina R. Sexual dysfunction after pelvic surgery. Int J Impot Res. 2006;18:1-18.
35. Köhler TS, Pedro R, Hendlin K, Utz W, et al. A pilot study on the early use of the vacuum erection device after radical retropubic prostatectomy. BJU Int. 2007;100:858-62.
36. Costabile RA, Spevak M, Fishman IJ, Govier FE, et al. Efficacy and safety of transurethral alprostadil in patients with erectile dysfunction following radical prostatectomy. J Urol. 1998;160:1325-8.
37. Ramsawh HJ, Morgentaler A, Covino N, Barlow DH, et al. Quality of life following simultaneous placement of penile prosthesis with radical prostatectomy. J Urol. 2005;174:1395-8.