Sexual dysfunction after pelvic surgery

International Journal of Impotence Research

Volumn 18, Issue 1, 2006, Pages 1-18

  Zippe, C ^a   Nandipati, K ^a   Agarwal, A ^a   Raina, R ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Penile rehabilitation; Radical pelvic surgery; Sexual dysfunction

Indexed keywords

ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; ANDROGEN; DOPAMINE RECEPTOR BLOCKING AGENT; ESTROGEN; GLYCERYL TRINITRATE; PAPAVERINE; PHENTOLAMINE; PHOSPHODIESTERASE INHIBITOR; PHOSPHODIESTERASE V INHIBITOR; PROSTAGLANDIN E1; SILDENAFIL; TADALAFIL; VARDENAFIL; VASOACTIVE AGENT;

BLADDER CANCER; CANCER SURGERY; CLINICAL TRIAL; CYSTECTOMY; DRUG EFFICACY; DRUG SAFETY; DYSPEPSIA; ERECTILE DYSFUNCTION; FEMALE SEXUAL DYSFUNCTION; FLUSHING; HEADACHE; HUMAN; HYPOTENSION; LAPAROSCOPY; MEDICAL PRACTICE; MYALGIA; PELVIS SURGERY; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; PROSTATE CANCER; PROSTATECTOMY; QUESTIONNAIRE; RECTUM CANCER; REVIEW; RHINITIS; SEXUAL DYSFUNCTION; SURGICAL TECHNIQUE; URINE INCONTINENCE;

ANIMALS; CYSTECTOMY; HUMANS; INTESTINES; PELVIS; QUALITY OF LIFE; SEXUAL DYSFUNCTION, PHYSIOLOGICAL;

EID: 30044448076     PISSN: 09559930     EISSN: 14765489     Source Type: Journal    
DOI: 10.1038/sj.ijir.3901353     Document Type: Review

References (120)

1. NIH Consensus Conference. Impotence. NIH Consensus Development Panel on Impotence. JAMA 1993; 270: 83-90.
2. Landis SH, Murray T, Bolden S, Wingo PA. Cancer statistics, 1999. CA Cancer J Clin 1999; 49: 8-31.
3. Walsh PC, Partin AW, Epstein JI. Cancer control and quality of life following anatomical radical retropubic prostatectomy: results at 10 years. J Urol 1994; 152: 1831-1836.
4. Shrader-Bogen CL, Kjellberg JL, McPherson CP, Murray CL. Quality of life and treatment outcomes: prostate carcinoma patients' perspectives after prostatectomy or radiation therapy. Cancer 1997; 79: 1977-1986.
5. Walsh PC, Marschke P, Ricker D, Burnett AL. Patient-reported urinary continence and sexual function after anatomic radical prostatectomy. Urology 2000; 55: 58-61.
6. Mulcahy JJ. Erectile function after radical prostatectomy. Semin Urol Oncol 2000; 18: 71-75.
7. Quinlan DM, Epstein JI, Carter BS, Walsh PC. Sexual function following radical prostatectomy: influence of preservation of neurovascular bundles. J Urol 1991; 145: 998-1002.
8. Sexton WJ, Benedict JF, Jarow JP. Comparison of long-term outcomes of penile prostheses and intracavernosal injection therapy. J Urol 1998; 159: 811-815.
9. Walsh PC, Donker PJ. Impotence following radical prostatectomy: insight into etiology and prevention. J Urol 1982; 128: 492-497.
10. Kundu SD et al. Potency, continence and complications in 3,477 consecutive radical retropubic prostatectomies. J Urol 2004; 172: 2227-2231.
11. Catalona WJ, Basler JW. Return of erections and urinary continence following nerve sparing radical retropubic prostatectomy. J Urol 1993; 150: 905-907.
12. Catalona WJ, Carvalhal GF, Mager DE, Smith DS. Potency, continence and complication rates in 1,870 consecutive radical retropubic prostatectomies. J Urol 1999; 162: 433-438.
13. Litwin MS et al. Quality of life before death for men with prostate cancer: results from the CaPSURE database. J Urol 2001; 165: 871-875.
14. Rabbani F et al. Factors predicting recovery of erections after radical prostatectomy. J Urol 2000; 164: 1929-1934.
15. Stanford JL et al. Urinary and sexual function after radical prostatectomy for clinically localized prostate cancer: the Prostate Cancer Outcomes Study. JAMA 2000; 283: 354-360.
16. Geary ES, Dendinger TE, Freiha FS, Stamey TA. Incontinence and vesical neck strictures following radical retropubic prostatectomy. Urology 1995; 45: 1000-1006.
17. Nandipati KC, Raina R, Agarwal A, Zippe CD. Five year potency status after radical prostatectomy: role of oral therapy in erectaids. American Urological Association Annual Meeting 2005 (abstract # 05-AB-5086).
18. Weldon VE, Tavel FR. Potency-sparing radical perineal prostatectomy: anatomy, surgical technique and initial results. J Urol 1988; 140: 559-562.
19. Harris MJ. Radical perineal prostatectomy: cost efficient, outcome effective, minimally invasive prostate cancer management. Eur Urol 2003; 44: 303-308.
20. Frazier HA, Robertson JE, Paulson DF. Radical prostatectomy: the pros and cons of the perineal versus retropubic approach. J Urol 1992; 147: 888-890.
21. Weldon VE, Tavel FR, Neuwirth H. Continence, potency and morbidity after radical perineal prostatectomy. J Urol 1997; 158: 1470-1475.
22. Guillonneau B et al. Laparoscopic radical prostatectomy: assessment after 550 procedures. Crit Rev Oncol Hematol 2002; 43: 123-133.
23. Rassweiler J et al. Laparoscopic versus open radical prostatectomy: a comparative study at a single institution. J Urol 2003; 169: 1689-1693.
24. Katz R et al. Patient reported sexual function following laparoscopic radical prostatectomy. J Urol 2002; 168: 2078-2082.
25. Stein JP, Skinner DG. Results with radical cystectomy for treating bladder cancer: a 'reference standard' for high-grade, invasive bladder cancer. BJU Int 2003; 92: 12-17.
26. Schlegel PN, Walsh PC. Neuroanatomical approach to radical cystoprostatectomy with preservation of sexual function. J Urol 1987; 138: 1402-1406.
27. Walsh PC, Mostwin JL. Radical prostatectomy and cystoprostatectomy with preservation of potency. Results using a new nerve-sparing technique. Br J Urol 1984; 56: 694-697.
28. Brendler CB et al. Local recurrence and survival following nerve-sparing radical cystoprostatectomy. J Urol 1990; 144: 1137-1140, discussion 1140-1141.
29. Schoenberg MP et al. Local recurrence and survival following nerve sparing radical cystoprostatectomy for bladder cancer: 10-year followup. J Urol 1996; 155: 490-494.
30. Koraitim M, Khalil R. Preservation of urosexual functions after radical cystectomy. Urology 1992; 39: 117-121.
31. Marshall FF et al. Ileocolic neobladder post-cystectomy: continence and potency. J Urol 1991; 145: 502-504.
32. Spitz A, Stein JP, Lieskovsky G, Skinner DG. Orthotopic urinary diversion with preservation of erectile and ejaculatory function in men requiring radical cystectomy for nonurothelial malignancy: a new technique. J Urol 1999; 161: 1761-1764.
33. Ramon J, Leandri P, Rossignol G, Gautier JR. Preservation of urinary continence and potency after cystoprostatectomy. Prog Clin Biol Res 1992; 378: 125-132.
34. Horenblas S, Meinhardt W, Ijzerman W, Moonen LF. Sexuality preserving cystectomy and neobladder: initial results. J Urol 2001; 166: 837-840.
35. Meinhardt W, Horenblas S. Sexuality preserving cystectomy and neobladder (SPCN): functional results of a neobladder anastomosed to the prostate. Eur Urol 2003; 43: 646-650.
36. Vallancien G et al. Cystectomy with prostate sparing for bladder cancer in 100 patients: 10-year experience. J Urol 2002; 168: 2413-2417.
37. Zippe CD et al. Sexual function after male radical cystectomy in a sexually active population. Urology 2004; 64: 682-685, discussion 685-686.
38. Nordstrom GM, Nyman CR. Male and female sexual function and activity following ileal conduit urinary diversion. Br J Urol 1992; 70: 33-39.
39. Berman L et al. Seeking help for sexual function complaints: what gynecologists need to know about the female patient's experience. Fertil Steril 2003; 79: 572-576.
40. Stenzl A et al. Rationale and technique of nerve sparing radical cystectomy before an orthotopic neobladder procedure in women. J Urol 1995; 154: 2044-2049.
41. Stenzl A et al. Anterior exenteration with subsequent ureteroileal urethrostomy in females. Anatomy, risk of urethral recurrence, surgical technique, and results. Eur Urol 1998; 33(Suppl 4): 18-20.
42. Bjerre BD, Johansen C, Steven K. A questionnaire study of sexological problems following urinary diversion in the female patient. Scand J Urol Nephrol 1997; 31: 155-160.
43. Zippe CD et al. Female sexual dysfunction after radical cystectomy: a new outcome measure. Urology 2004; 63: 1153-1157.
44. Walsh PC, Lepor H, Eggleston JC. Radical prostatectomy with preservation of sexual function: anatomical and pathological considerations. Prostate 1983; 4: 473-485.
45. Burkhard FC, Studer UE. Orthotopic bladder substitution. Curr Opin Urol 2000; 10: 343-349.
46. Kessler TM et al. Attempted nerve sparing surgery and age have a significant effect on urinary continence and erectile function after radical cystoprostatectomy and ileal orthotopic bladder substitution. J Urol 2004; 172: 1323-1327.
47. Nandipati KC et al. Impact of neurovascular preservation on female sexual dysfunction following orthoptic radical cystectomy. Thirteeth Annual Meeting with the American Society of Andrology (abstract # 139).
48. Mazer NA, Leiblum SR, Rosen RC. The brief index of sexual functioning for women (BISF-W): a new scoring algorithm and comparison of normative and surgically menopausal populations. Menopause 2000; 7: 350-363.
49. Nappi RE et al. Serum allopregnanolone levels relate to FSFI score during the menstrual cycle. J Sex Marital Ther 2003; 29(Suppl 1): 95-102.
50. Lepine LA et al. Hysterectomy surveillance - United States, 1980-1993. MMWR CDC Surveill Summ 1997; 46: 1-15.
51. Dennerstein L, Wood C, Burrows GD. Sexual response following hysterectomy and oophorectomy. Obstet Gynecol 1977; 49: 92-96.
52. Dennerstein L, Wood G, Burrows GD. Sexual dysfunction following hysterectomy. Aust Fam Physician 1977; 6: 535-543.
53. Bergmark K et al. Patient-rating of distressful symptoms after treatment for early cervical cancer. Acta Obstet Gynecol Scand 2002; 81: 443-450.
54. Jensen PT et al. Early-stage cervical carcinoma, radical hysterectomy, and sexual function. A longitudinal study. Cancer 2004; 100: 97-106.
55. Carmack Taylor CL, Basen-Engquist K, Shinn EH, Bodurka DC. Predictors of sexual functioning in ovarian cancer patients. J Clin Oncol 2004; 22: 881-889.
56. Helstrom L. Sexuality after hysterectomy: a model based on quantitative and qualitative analysis of 104 women before and after subtotal hysterectomy. J Psychosom Obstet Gynaecol 1994; 15: 219-229.
57. Helstrom L, Lundberg PO, Sorbom D, Backstrom T. Sexuality after hysterectomy: a factor analysis of women's sexual lives before and after subtotal hysterectomy. Obstet Gynecol 1993; 81: 357-362.
58. Dodds DT, Potgieter CR, Turner PJ, Scheepers GP. The physical and emotional results of hysterectomy; a review of 162 cases. S Afr Med J 1961; 35: 53-54.
59. Rhodes JC, Kjerulff KH, Langenberg PW, Guzinski GM. Hysterectomy and sexual functioning. JAMA 1999; 282: 1934-1941.
60. Dragisic KG, Milad MP. Sexual functioning and patient expectations of sexual functioning after hysterectomy. Am J Obstet Gynecol 2004; 190: 1416-1418.
61. El-Toukhy TA, Hefni M, Davies A, Mahadevan S. The effect of different types of hysterectomy on urinary and sexual functions: a prospective study. J Obstet Gynaecol 2004; 24: 420-125.
62. Lindsey I, George BD, Kettlewell MG, Mortensen NJ. Impotence after mesorectal and close rectal dissection for inflammatory bowel disease. Dis Colon Rectum 2001; 44: 831-835.
63. Watts JM, de Dombal FT, Goligher JC. Long-term complications and prognosis following major surgery for ulcerative colitis. Br J Surg 1966; 53: 1014-1023.
64. Keating JP. Sexual function after rectal excision. ANZ J Surg 2004; 74: 248-259.
65. Banerjee AK. Sexual dysfunction after surgery for rectal cancer. Lancet 1999; 353: 1900-1902.
66. Mannaerts GH et al. Urologic and sexual morbidity following multimodality treatment for locally advanced primary and locally recurrent rectal cancer. Eur J Surg Oncol 2001; 27: 265-272.
67. Williams JT, Slack WW. A prospective study of sexual function after major colorectal surgery. Br J Surg 1980; 67: 772-774.
68. Danzi M, Ferulano GP, Abate S, Califano G. Male sexual function after abdominoperineal resection for rectal cancer. Dis Colon Rectum 1983; 26: 665-668.
69. Havenga K et al. Male and female sexual and urinary function after total mesorectal excision with autonomic nerve preservation for carcinoma of the rectum. J Am Coll Surg 1996; 182: 495-502.
70. Fazio VW, Fletcher J, Montague D. Prospective study of the effect of resection of the rectum on male sexual function. World J Surg 1980; 4: 149-152.
71. Enker WE. Total mesorectal excision - the new golden standard of surgery for rectal cancer. Ann Med 1997; 29: 127-133.
72. Enker WE et al. Abdominoperineal resection via total mesorectal excision and autonomic nerve preservation for low rectal cancer. World J Surg 1997; 21: 715-720.
73. Pocard M et al. A prospective study of sexual and urinary function before and after total mesorectal excision with autonomic nerve preservation for rectal cancer. Surgery 2002; 131: 368-372.
74. Quah HM, Jayne DG, Eu KW, Seow-Choen F. Bladder and sexual dysfunction following laparoscopically assisted and conventional open mesorectal resection for cancer. Br J Surg 2002; 89: 1551-1556.
75. Sidi AA, Becher EF, Zhang G, Lewis JH. Patient acceptance of and satisfaction with an external negative pressure device for impotence. J Urol 1990; 144: 1154-1156.
76. Soderdahl DW, Thrasher JB, Hansberry KL. Intracavernosal drug-induced erection therapy versus external vacuum devices in the treatment of erectile dysfunction. Br J Urol 1997; 79: 952-957.
77. Blackard CE, Borkon WD, Lima JS, Nelson J. Use of vacuum tumescence device for impotence secondary to venous leakage. Urology 1993; 41: 225-230.
78. Jeremy JY et al. Effects of sildenafil, a type-5 cGMP phosphodiesterase inhibitor, and papaverine on cyclic GMP and cyclic AMP levels in the rabbit corpus cavernosum in vitro. Br J Urol 1997; 79: 958-963.
79. Stief CG, Wetterauer U. Erectile responses to intracavernous papaverine and phentolamine: comparison of single and combined delivery. J Urol 1988; 140: 1415-1416.
80. Lee LM, Stevenson RW, Szasz G. Prostaglandin E1 versus phentolamine/papaverine for the treatment of erectile impotence: a double-blind comparison. J Urol 1989; 141: 549-550.
81. Raina R et al. Long-term efficacy and compliance of intracorporeal (IC) injection for erectile dysfunction following radical prostatectomy: SHIM (IIEF-5) analysis. Int J Impot Res 2003; 15: 318-322.
82. Lakin MM et al. Intracavernous injection therapy: analysis of results and complications. J Urol 1990; 143: 1138-1141.
83. Mulhall JP et al. The causes of patient dropout from penile self-injection therapy for impotence. J Urol 1999; 162: 1214-1291.
84. Padma-Nathan H et al. Treatment of men with erectile dysfunction with transurethral alprostadil. Medicated Urethral System for Erection (MUSE) Study Group. N Engl J Med 1997; 336: 1-7.
85. Costabile RA et al. Efficacy and safety of transurethral alprostadil in patients with erectile dysfunction following radical prostatectomy. J Urol 1998; 160: 1325-1328.
86. Porst H. Transurethral alprostadil with MUSE (medicated urethral system for erection) vs intracavernous alprostadil - a comparative study in 103 patients with erectile dysfunction. Int J Impot Res 1997; 9: 187-192.
87. Raina R et al. Long-term efficacy and compliance of MUSE for erectile dysfunction following radical prostatectomy: SHIM (IIEF-5) analysis. Int J Impot Res 2004; 17: 86-90.
88. Zippe CD et al. Role of Viagra after radical prostatectomy. Urology 2000; 55: 241-245.
89. Raina R et al. Long-term effect of sildenafil citrate on erectile dysfunction after radical prostatectomy: 3-year follow-up. Urology 2003; 62: 110-115.
90. Raina R et al. Efficacy and factors associated with successful outcome of sildenafil citrate use for erectile dysfunction after radical prostatectomy. Urology 2004; 63: 960-966.
91. Padma-Nathan H et al. On-demand IC351 (Cialis) enhances erectile function in patients with erectile dysfunction. Int J Impot Res 2001; 13: 2-9.
92. Montorsi F et al. Tadalafil in the treatment of erectile dysfunction following bilateral nerve sparing radical retropubic prostatectomy: a randomized, double-blind, placebo controlled trial. J Urol 2004; 172: 1036-1041.
93. Brock G et al. Safety and efficacy of vardenafil for the treatment of men with erectile dysfunction after radical retropubic prostatectomy. J Urol 2003; 170: 1278-1283.
94. Nandipati KC, Raina R, Agarwal A, Zippe CD. Efficacy and treatment satisfaction of PDE-5 inhibitors in management of erectile dysfunction following radical prostatectomy: SHIM analysis. 30th Annual Meeting with the American Society of Andrology 2005 (abstract # 99).
95. Padma-Nathan H et al. Postoperative nightly administration of sildenafil citrate significantly improves the return of normal spontaneous erectile function after bilateral nerve-sparing radical prostatectomy. J Urol 2003; 169(Suppl): 375, abstract 1402.
96. Raina R, Klepacz H, Agarwal A, Zippe CD. Early use of vacuum constriction device (VCD) following radical prostatectomy (RP) facilitates early sexual activity and potential return of erection. J Urol 2002; 167(Suppl): 279, abstract 1099.
97. Montorsi F et al. Recovery of spontaneous erectile function after nerve-sparing radical retropubic prostatectomy with and without early intracavernous injections of alprostadil: results of a prospective, randomized trial. J Urol 1997; 158: 1408-1410.
98. Quinlan DM, Nelson RJ, Walsh PC. Cavernous nerve grafts restore erectile function in denervated rats. J Urol 1991; 145: 380-383.
99. Walsh PC. Nerve grafts are rarely necessary and are unlikely to improve sexual function in men undergoing anatomic radical prostatectomy. Urology 2001; 57: 1020-1024.
100. Kim ED et al. Bilateral nerve grafting during radical retropubic prostatectomy: extended follow-up. Urology 2001; 58: 983-987.
101. Anastasiadis AG et al. Cavernous nerve graft reconstruction during radical prostatectomy or radical cystectomy: safe and technically feasible. Prostate Cancer Prostatic Dis 2003; 6: 56-60.
102. Lee M, Doolabh VB, Mackinnon SE, Jost S. FK506 promotes functional recovery in crushed rat sciatic nerve. Muscle Nerve 2000; 23: 633-640.
103. Sezen SF, Blackshaw S, Steiner JP, Burnett AL. FK506 binding protein 12 is expressed in rat penile innervation and upregulated after cavernous nerve injury. Int J Impot Res 2002; 14: 506-512.
104. Lin CS et al. Intracavernosal injection of vascular endothelial growth factor induces nitric oxide synthase isoforms. BJU Int 2002; 89: 955-960.
105. Lee MC et al. The effect of vascular endothelial growth factor on a rat model of traumatic arteriogenic erectile dysfunction. J Urol 2002; 167: 761-767.
106. Burnett AL. Gene transfer of endothelial nitric oxide synthase to the penis augments erectile responses in the aged rat. Int J Impot Res 2000; 12: 340.
107. Filippi S et al. Effects of NCX 4050, a new NO donor, in rabbit and human corpus cavernosum. Int J Androl 2003; 26: 101-108.
108. Kalsi JS, Kell PD, Cellek S, Ralph DJ. NCX-911, a novel nitric oxide-releasing PDE5 inhibitor relaxes rabbit corpus cavernosum in the absence of endogenous nitric oxide. Int J Impot Res 2004; 16: 195-200.
109. Fourcroy JL. Female sexual dysfunction: potential for pharmacotherapy. Drugs 2003; 63: 1445-1457.
110. Collins A, Landgren BM. Reproductive health, use of estrogen and experience of symptoms in perimenopausal women: a population-based study. Maturitas 1994; 20: 101-111.
111. Basson R. Female sexual response: the role of drugs in the management of sexual dysfunction. Obstet Gynecol 2001; 98: 350-353.
112. Kaplan SA et al. Safety and efficacy of sildenafil in postmenopausal women with sexual dysfunction. Urology 1999; 53: 481-486.
113. Geary ES, Dendinger TE, Freiha FS, Stamey TA. Nerve sparing radical prostatectomy: a different view. J Urol 1995; 154: 145-149.
114. Salomon L et al. Outcome and complications of radical prostatectomy in patients with PSA <10 ng/ml: comparison between the retropubic, perineal and laparoscopic approach. Prostate Cancer Prostatic Dis 2002; 5: 285-290.
115. Varkarakis J, Bartsch G, Horninger W. Long-term morbidity and mortality of transurethral prostatectomy: a 10-year follow-up. Prostate 2004; 58: 248-251.
116. Turk I et al. Laparoscopic radical prostatectomy. Technical aspects and experience with 125 cases. Eur Urol 2001; 40: 46-52.
117. Hoznek A et al. Laparoscopic radical prostatectomy. The Creteil experience. Eur Urol 2001; 40: 38-45.
118. Eden CG et al. Laparoscopic radical prostatectomy: the initial UK series. BJU Int 2002; 90: 876-882.
119. Rassweiler J et al. Laparoscopic radical prostatectomy: functional and oncological outcomes. Curr Opin Urol 2004; 14: 75-82.
120. Tomic R, Sjodin JG. Sexual function in men after radical cystectomy with or without urethrectomy. Scand J Urol Nephrol 1992; 26: 127-129.