Therapeutic potential of ocimum tenuiflorum as MPO inhibitor with implications for atherosclerosis prevention

Journal of Medicinal Food

Volumn 18, Issue 5, 2015, Pages 507-515

  Narasimhulu, Chandrakala Aluganti ^a   Vardhan, Sangamithra ^a  

^a UNIVERSITY OF CENTRAL FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

eugenol; inflammation; lipopolysaccharide; lipoproteins; oxidation; ursolic acid

Indexed keywords

ANTIINFLAMMATORY AGENT; ANTIOXIDANT; EUGENOL; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; MYELOPEROXIDASE; OCIMUM TENUIFLORUM EXTRACT; OXIDIZED LOW DENSITY LIPOPROTEIN; OXIDOREDUCTASE INHIBITOR; PLANT EXTRACT; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; URSOLIC ACID; ENZYME INHIBITOR; PEROXIDASE;

ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; AQUEOUS SOLUTION; ARTICLE; ATHEROSCLEROSIS; CELL VIABILITY; DOSE RESPONSE; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION; IN VITRO STUDY; LIPID OXIDATION; OCIMUM TENUIFLORUM; PLANT LEAF; PRIORITY JOURNAL; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE RAW 264.7; CHEMISTRY; ENZYMOLOGY; GENETICS; HUMAN; MEDICINAL PLANT; METABOLISM; MOUSE; OCIMUM;

OCIMUM; OCIMUM TENUIFLORUM;

ANIMALS; ATHEROSCLEROSIS; ENZYME INHIBITORS; HUMANS; MICE; OCIMUM; PEROXIDASE; PLANT EXTRACTS; PLANT LEAVES; PLANTS, MEDICINAL; RAW 264.7 CELLS;

EID: 84930001992     PISSN: 1096620X     EISSN: 15577600     Source Type: Journal    
DOI: 10.1089/jmf.2014.0125     Document Type: Article

References (42)

1. Mabberley DJ. The plant book: A portable dictionary of the higher plants of genera and families of angiosperms. J California Native Plant Soc 1997; 30: 1-36
2. Chattopadhyay RR. A comparative evaluation of some blood sugar lowering agents of plant origin. J Ethnopharmacol 1999; 67: 367-372
3. Prakash J, Gupta SK. Chemopreventive activity of Ocimum sanctum seed oil. J Ethanopharmacol 2000; 72: 29-34
4. Umadevi P. Radioprotective, anticarcinogenic and antioxidant properties of the Indian holy basil, Ocimum Sanctum (Tulasi). Indian J Exp Biol 2001; 39: 185-190
5. Dev S. Ocimum sanctum Linn. In. Prime Ayurvedic Plant Drugs. Anamaya Publishers, New Delhi, 2006, pp. 326-332
6. Ahmed M, Ahamed RN, Aladakatti RH, Ghosesawar MG. Reversible anti-fertility effect of benzene extract of Ocimum sanctum leaves on sperm parameters and fructose content in rats. J Basic Clin Physiol Pharmacol 2002; 13: 51-59
7. Banerjee S, Parashar R, Kumar A, Rao AR. Modulatory influence of alcoholic extract of Ocimum leaves on carcinogenmetabolizing enzyme activities and reduced glutathione levels in mouse. Nutr Cancer 1996; 25: 205-217
8. Bansod S and Rai M. Antifungal activity of essential oils from indian medicinal plants against human pathogenic Aspergillus fumigatus and A. niger. World J Med Sci 2008; 3: 81-88
9. Chattopadhyay RR. Hypoglycemic effect of O. sanctum leaf extract in normal and streptozotocin diabetic rats. Indian J Exp Biol 1993; 31: 891-893
10. Chiang LC, Ng LT, Cheng PW, Chiang W, Lin C. Antiviral activities of extracts and selected pure constituents of Ocimum basilicum. Clin Exp Pharmacol Physiol 2005; 32: 811-816
11. Farid O, Amraoui EL, Zeggwagh NA, Eddouks M. Effect of Ocimum basilicum on glucose and lipids metabolism. In. Advances in Phytotherapy Research (Eddouks M, ed). Research Signpost, India, 2009, pp. 187-200
12. Gupta SK, Prakash J, Srivastava SV. Validation of claim of Tulsi, Ocimum sanctum Linn as a medicinal plant. Indian J Exp Biol 2002; 40: 765-773
13. Markowitz K, Moynihan M, Liv M, Kim S. Biologic properties of eugenol and zinc oxide-eugenol. Oral Surg Oral Med Oral Pathol 1992; 73: 729-737
14. IARC Monographs Evaluation of Carcinogenic Risk of Chemicals to Humans. Vol. 36, Lyon, France, 1985, pp. 75-97
15. Wagner H, Jurcic K, Deininger R. Antispasmodic activity of eugenol-esters and-ethers. Planta Med 1979; 37: 9-14
16. Feng J, Lipton JM. Eugenol: Antipyretic activity in rabbits. Neuropharmacology 1987; 26: 1775-1778
17. Hume WR. Effect of eugenol on constrictor responses in blood vessels of the rabbit ear. J Dent Res 1983; 62: 1013-1015
18. Moleyar V, Narasimham P. Antibacterial activity of essential oil components. Int J Food Microbiol 1992; 16: 337-342
19. Raghavenra H, Diwakr BT, Lokesh BR, Naidu KA. Eugenol-The active principle from cloves inhibits 5-lipoxygenase activity and leukotriene-C4 in human PMNL cells. Prostaglandins Leukot Essent Fatty Acids 2006; 74: 23-27
20. Goretti M, Silva V, Vieira IGP, Mendes FNP, Albuquerque IL, Santos RN, Silva FO, Morais SM. Variation of ursolic acid content in eight Ocimum species from northeastern Brazil. Molecules 2008; 13: 2482-2487
21. Nataraju A, Gowda CDR, Rajesh R, Vishwanath BS. Group IIA secretory PLA2 inhibition by ursolic acid: A potent antiinflammatory molecule. Curr Top Med. Chem 2007; 7: 801-809
22. Shin KM, Kim RK, Azefack TL, David L, Luc SB, Choudhary MI, Park HJ, Choi JW, Lee KT. In vitro anti-inflammatory activity of 23-hydroxyursolic acid isolated from Cussonia bancoensis in murine macrophage RAW 264.7 cells. Planta Med 2004; 70: 803-807
23. Souza CE, Maitra D, Saed GM, Diamond MP, Moura AA, Pennathur S, Abu-Soud HM. Hypochlorous acid-induced heme degradation from lactoperoxidase as a novel mechanism of free iron release and tissue injury in inflammatory diseases. PLoS One 2011; 6: e27641
24. Gumiero A, Metcalfe CL, Pearson AR, Raven EL, Moody PC. Nature of the ferryl heme in compounds i and ii. J Biol Chem 2011; 286: 1260-1268
25. Undurti A, Huang Y, Lupica JA, Smith JD, DiDonato JA, Hazen SL. Modification of high density lipoprotein by myeloperoxidase generates a pro-inflammatory particle. J Biol Chem 2009; 284: 30825-30835
26. Shao B, Pennathur S, Pagani I, Oda MN, Witztum JL, Oram JF, Heinecke JW. Modifying apolipoprotein a-i by malondialdehyde, but not by an array of other reactive carbonyls, blocks cholesterol efflux by the abca1 pathway. J Biol Chem 2010; 285: 18473-18484
27. Shao B, Oda MN, Bergt C, Fu X, Green PS, Brot N, Oram JF, Heinecke JW. Myeloperoxidase impairs abca1-dependent cholesterol efflux through methionine oxidation and site-specific tyrosine chlorination of apolipoprotein a-i. J Biol Chem 2006; 281: 9001-9004
28. Santanam N, Parthasarathy S. Paradoxical actions of antioxidants in the oxidation of low density lipoprotein by peroxidases. J Clin Invest 1995; 95: 2594-2600
29. Chandrakala AN, Sukul D, Selvarajan K, Sai-Sudhakar C, Sun B, Parthasarathy S. Induction of brain natriuretic peptide and monocyte chemotactic protein-1 gene expression by oxidized low-density lipoprotein: Relevance to ischemic heart failure. Am J Physiol Cell Physiol 2012; 302: C165-C177
30. Auerbach BJ, Kiely JS, Cornicelli JA.: A spectrophotometric microtiter-based assay for the detection of hydroperoxy derivatives of linoleic acid. Anal Biochem 1992; 201: 375-380
31. Steinbrecher UP, Parthasarathy S, Leake DS, Witztum JL, Steinberg D. Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids. Proc Natl Acad Sci USA 1984; 81: 3883-3887
32. Khan-Merchant N, Penumetcha M, Meilhac O, Parthasarathy S. Oxidized fatty acids promote atherosclerosis only in the presence of dietarycholesterol in low-density lipoprotein receptor knockout mice. J Nutr 2002; 132: 3256-3262
33. Desser RK, Himmelhoch SR, Evans WH, Januska M, Mage M, Shelton E. Guinea pig heterophil and eosinophil peroxidase. Arch Biochem Biophys 1972; 148: 452-465
34. Suzuki K, Ota H, Sasagawa S, Sakatani T, Fujikura T. Assay method for myeloperoxidase in human polymorphonuclear leukocytes. Anal Biochem 1983; 132: 345-352
35. Stocker R, Keaney JF Jr.: Role of oxidative modification in atherosclerosis. Physiol Rev 2004; 84: 138-478
36. Kamiya K, Tanaka Y, Endang H. Chemical constituents of Morinda citrifolia fruits inhibit copper induced low-density lipoprotein oxidation. J Agric Food Chem 2004; 52: 5843-5848
37. Navab M, Hama SY, Anantharamaiah GM, Hassan K, Hough GP, Watson AD, Reddy ST, Sevanian A, Fonarow GC, Fogelman AM. Normal high density lipoprotein inhibits three steps in the formation of mildly oxidized low density lipoprotein: Steps 2 and 3. J Lipid Res 2000; 41: 1495-1508
38. Navab M, Hama SY, Cooke CJ, Anantharamaiah GM, Chaddha M, Jin L, Subbanagounder G, Faull KF, Reddy ST, Miller NE, Fogelman AM. Normal high density lipoprotein inhibits three steps in the formation of mildly oxidized low density lipoprotein: Step 1. J Lipid Res 2000; 41: 1481-1494
39. Aviram M, Rosenblat M, Bisgaier CL, Newton RS, Primo-Parmo SL, La Du BN. Paraoxonase inhibits high-density lipoprotein oxidation and preserves its functions a possible peroxidative role for paraoxonase. J Clin Invest 1998; 101: 1581-1590
40. Hancock RE, Scott MG. The role of antimicrobial peptides in animal defense Proc Natl Acad Sci USA 2000; 97: 8856-8861
41. Cohen J. The immunopathogenesis of sepsis. Nature 2002; 420: 885-891
42. Bachiega TF, de Sousa JP, Bastos JK, Sforcin JM. Clove and eugenol in noncytotoxic concentrations exert immunomodulatory/anti-inflammatory action on cytokine production by murine macrophages. J Pharm Pharmacol 2012; 64: 610-616