Reversible anti-fertility effect of benzene extract of ocimum sanctum leaves on sperm parameters and fructose content in rats

Journal of Basic and Clinical Physiology and Pharmacology

Volumn 13, Issue 1, 2002, Pages 51-60

  Ahmed, Mukhtar ^a   Ahamed, R Nazeer ^a   Aladakatti, R H ^a   Ghosesawar, M G ^a  

^a KARNATAK UNIVERSITY   (India)

Author keywords

albino rat; epididymis; Ocimum sanctum; seminal vesicle; spermatozoa

Indexed keywords

ANTIANDROGEN; BENZENE DERIVATIVE; FRUCTOSE; OCIMUM SANCTUM EXTRACT;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG WITHDRAWAL; EPIDIDYMIS; MALE; NONHUMAN; PLANT LEAF; SEMEN ANALYSIS; SEMINAL VESICLE; SPERMATOZOON; SPERMATOZOON ABNORMALITY; SPERMATOZOON COUNT; SPERMATOZOON MOTILITY;

ANIMALS; BENZENE; EPIDIDYMIS; FEMALE; FRUCTOSE; INFERTILITY, MALE; MALE; OCIMUM; ORGAN SIZE; PLANT EXTRACTS; PLANT LEAVES; PLANTS, MEDICINAL; RATS; RATS, WISTAR; SEMEN; SPERM COUNT; SPERM MOTILITY; SPERMATOZOA; TESTIS;

EID: 0036399943     PISSN: 07926855     EISSN: 21910286     Source Type: Journal    
DOI: 10.1515/JBCPP.2002.13.1.51     Document Type: Article

References (46)

1. Nadkarni, AK. Nadkarni&s Indian Materia Medica, vols. 1 and II, 3rd ed. Bombay, India: Popular Book Depot, 1954.
2. Gupta, V. Antibiot Chemother 1955; 5: 22.
3. Bhat, Broker, J. Sci Indust Res 1954; 13B: 305.
4. Kirtikar, KR, Basu, BD. Indian medicinal plants. Lalit Mohan Basu Allahabad 1935; 351.
5. Seth, SD, Johri, N, Sundaram, KR. Antispermatogenic effect of Ocimum sanctum. Indian J Exp Biol 1981; 19: 975–976.
6. Kasinathan, S, Ramakrishnan, S, Basu, SL. Antifertility effect of Ocimum sanctum L. Indian J Exp Biol 1972; 10: 23–25.
7. Khanna, S, Gupta, SR, Grover, JK. Effect of long term feeding of tulsi (Ocimum sanctum Linn) on reproductive performance of adult albino rats. Indian J Exp Biol. 1986 May;24(5):302-4.
8. Kantak, NM, Gogate, MG. Effect of long term feeding of tulsi(Ocimum sanctum Linn) on reproductive performance of adult albino rats. Indian J Exp Biol. 1986 May;24(5):302-4.
9. Sardessai, SR, Borker, AS, Abraham, ME. Effect of long term feeding of tulsi (Ocimum sanctum Linn) on reproductive performance of adult albino rats. Indian J Exp Biol 1986; 24: 302–304.
10. Vreeburg, JTM. Distribution of testosterone and 5 a-dihydrotestosterone in rat epididymis and their concentrations in efferent duct. Endocrinology 1975; 67 203–210.
11. World Health Organization. Protocol Lg-06. Extraction and fractionation for biological and phytochemical studies. APJF/IP A 1983: 1001–1083.
12. Besley, MA, Eliarson, R, Gallegos, AJ, Moghissi, KS, Paulsen, CA, Prasad, MRN. Laboratory Manual for the Examination of Human Semen and Semen Cervical Mucus Interaction. Singapore: WHO Press concern, 1980.
13. Ratnasoorya, WD. Effect of atropine on fertility of female rat and sperm motility. Indian J Exp Biol 1984; 22: 463–466.
14. Bauer, JD, Ackerman, PG, Toro, G. Clinical Laboratory Methods. St. Louis, Missouri, USA: Mosby Co., 1974.
15. Chinoy, NJ, GeetaRanga. Antiandrogenic and antifertility effects of Vinca rosea leaf extract in male albino rats. Comp Physiol Ecol 1983; 8: 41–51.
16. Murugavel, T, Ruknudin, A, Thangavelu, S, Akbarsha, MA. Antifertility effect of Vinca rosea (Linn) leaf extract in male mice—A sperm parametric study. Curr Sci 1989; 58: 1102–1103.
17. Rao, MV. Effect of alcoholic extract of Solanum xanthocarpum seeds in adult male rats. Indian J Exp Biol 1988; 26: 95–98.
18. Vanithakumari, G, Manonayaki, S, Padma, S, Malini, T. Antifertility effect of Bambusa arundinacen shoot extracts in male rats. J Ethnopharmacol 1989; 25: 173–180.
19. Murugan, K, Vanithakumari, G, Sampathraj, R. Effect of combined extracts of Dolichos biflorus seeds and Amaranthus spinosus roots on the accessory sex organs of male rats. Ancient Sci Life 1993; 12: 351–357.
20. Lohia, NK, Goyal, RB. Antifertility investigations on the crude chloroform extract of Carica papaya Linn seeds in albino male rats. Indian J Pharmacognosy 1992; 30: 308–320.
21. Chinoy, NJ, D&souza, TM, Padman, P. Contraceptive efficacy of Carica papaya seed extract in male mice (Mus musculus). Physiotherapy 1995; 9: 30–36.
22. Sharma, A, Mathur, A, Mathur, R, Sharma, S, Dixit, VP. A novel male antifertility agent: Spirulina plantensis (Blue green algae). Natl Symp Reprod Health Care and V Ann Meet Indian Soc for the Study of Reprod Fertil Abs. 68, 1994.
23. ndInt Neem Cont Raviachhol hauson 1983; 473–482.
24. Brooks, DE. Metabolic activity in the epididymis and its regulation by andorgens. Physiol Rev 1981; 61: 515–518.
25. Dyson, ALMB, Orgebein-Crist, MC. Effect of hypophysectomy, castration and androgen replacement upon the fertilizing ability of rat epididymal spermatozoa. Endocrinology 1973; 93: 391–402.
26. Setty, BS, Rair, SS, Kar, AB. Androgenic control of epididymal function in rhesus monkey and rabbit. Fertil Steril 1977; 28: 674–681.
27. Amann, RP. A critical review of methods for evaluation of spermatogenesis from seminal characteristics. J Androl 1981; 2: 37.
28. Freund, M. Interrelationships among the characteristics of human semen and factors affecting semen specimen quality. J Reprod Fertil 1962; 4: 143.
29. Smith, KD, Rodriguez-Rigeu, LJ, Steinberger, E. Relation between indices of semen analysis and pregnancy rate in infertile couples. Fertil Steril 1977; 28: 1314.
30. Macleod, J. The significance of deviations in human sperm. In: Rosenberg E, Palusen CA, eds, Human Testis. New York, NY, USA: Plenum, 1973.
31. Sherins, RJ, Brightwell, D, Sternthal, PM. The testis in normal and infertile men. In: Toren P, Nankin HR, eds, New York, NY, USA: Raven Press, 1971; 473–478.
32. Gopal Krishman, K, Hinduja, IN, Anandkumar, TC. Volume of semen as a parameter of its quality. India J Med Res 1992; B96: 215–218.
33. Katz, DF, Diel, L, Overstreet, JW. Differences in the moment of morphologically normal and abnormal human seminal spermatozoa. Biol Reprod 1982; 26: 566–570.
34. Rogers, BJ, Bentwood, BJ, Van Campen, H, Helmbrecht, G, Sonderdahl, Hale RW. Sperm morphology assessment as an indicator of human fertilizing capacity. J Androl 1983; 4: 119.
35. Gopal Krishman, K, Hinduja, IN, Anandkumar, TC. Pinheads (headless) spermatozoa as markers in fertile and infertile men. Adv Cont Deliv Syst 1989; 5: 361.
36. Chinoy, NJ. Structure and function of epididymis in relation to vulnerable points of intervention for male fertility regulation. Indian Rev Life Sci 1984; 4: 37–68.
37. Prasad, MR. Comparative physiology of the mammalian epididymis. Gen Comp Endocrinol 1976; 28: 530–537.
38. Prasad, MR, Rajalakshmi, M. Recent advances in the control of male reproductive functions. Int Rev Physiol 1977; 13: 153–199.
39. Blaquier, JAT. The intracellular binding of androgens in rat epididymis. Acta Physiol Latinoam 1971; 21: 101.
40. Qaiser, J, Setty, BS, Kar, AB. Studies on physiology and biochemistry of mammalian epididymis: Effect of castration and steroid hormone replacement on sperm survival in rat epididymis. Indian J Exp Biol 1973; 11:270–273.
41. Setty, BS, Kar, AB. Nature and site of action of 3-chloro-1,2-propanediol—An oral antifertility agent for the male. Indian J Exp Biol 1970; 8: 49.
42. Lubiz-Nawrocki, C, Glover, TD. Effects of gonadectomy and testosterone replacement on the viability of epididymal spermatozoa in the golden hamster (Mesocricetus auratus). J Endocrinol 1970; 48: xxii-xxiii.
43. Joel, CA. Fertility disturbances in men and women, a text book with special reference to etiology, diagnosis and treatment. New York NY, USA: S. Karger Basel, 1971.
44. Cooper, TG, Yeung, CH, Nashan, D, Jockenhovel, F, Neischlag, E. Improvement in the assessment of human epididymal function by the use of inhibitors in the assay of a-glucosidase in seminal plasma. Int J Androl 1990; 13: 297–305.
45. Turner, CD, Bagnara, JT. General Endocrinology. Philadelphia-London: WB Saunders, 1976.
46. Mann, T. The Biochemistry of Semen and of the Male Reproductive Tract. London, UK: Metheum & Co, Ltd., 1964; 239.