TMEM16A-mediated mucin secretion in IL-13-induced nasal epithelial cells from chronic rhinosinusitis patients

Allergy, Asthma and Immunology Research

Volumn 7, Issue 4, 2015, Pages 367-375

  Zhang, Yu ^a   Wang, Xiangdong ^a,b   Wang, Hong ^b   Jiao, Jian ^b   Li, Ying ^b   Fan, Erzhong ^b   Zhang, Luo ^a,b   Bachert, Claus ^c  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^c GHENT UNIVERSITY HOSPITAL   (Belgium)

Author keywords

Chronic rhinosinusitis with nasal polyps; MUC5AC; Mucin secretion; Nasal epithelial cells; TMEM16A

Indexed keywords

INTERLEUKIN 13; MEMBRANE PROTEIN; MUCIN; MUCIN 5AC; TRANSMEMBRANE PROTEIN 16A; UNCLASSIFIED DRUG;

ARTICLE; CELL LYSATE; CHRONIC RHINOSINUSITIS; CHRONIC RHINOSINUSITIS WITH NASAL POLYP; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOSCOPIC SINUS SURGERY; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIUM CELL; HUMAN; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; MUCUS SECRETION; NOSE POLYP; OUTCOME ASSESSMENT; PROTEIN EXPRESSION; WESTERN BLOTTING;

EID: 84929996502     PISSN: 20927355     EISSN: 20927363     Source Type: Journal    
DOI: 10.4168/aair.2015.7.4.367     Document Type: Article

References (34)

1. Slavin RG. Nasal polyps and sinusitis. JAMA 1997;278:1849-54.
2. Drake-Lee AB, Lowe D, Swanston A, Grace A. Clinical profile and recurrence of nasal polyps. J Laryngol Otol 1984;98:783-93.
3. Settipane GA, Klein DE, Settipane RJ. Nasal polyps. State of the art. Rhinol Suppl 1991;11:33-6.
4. Ramanathan M Jr, Lee WK, Spannhake EW, Lane AP. Th2 cytokines associated with chronic rhinosinusitis with polyps down-regulate the antimicrobial immune function of human sinonasal epithelial cells. Am J Rhinol 2008;22:115-21.
5. Park SJ, Kim TH, Jun YJ, Lee SH, Ryu HY, Jung KJ, et al. Chronic rhinosinusitis with polyps and without polyps is associated with increased expression of suppressors of cytokine signaling 1 and 3. J Allergy Clin Immunol 2013;131:772-80.
6. Van Zele T, Claeys S, Gevaert P, Van Maele G, Holtappels G, Van Cauwenberge P, et al. Differentiation of chronic sinus diseases by measurement of inflammatory mediators. Allergy 2006;61:1280-9.
7. Van Bruaene N, Pérez-Novo CA, Basinski TM, Van Zele T, Holtappels G, De Ruyck N, et al. T-cell regulation in chronic paranasal sinus disease. J Allergy Clin Immunol 2008;121:1435-41, 1441.e1-3.
8. Lu X, Wang N, Long XB, You XJ, Cui YH, Liu Z. The cytokine-driven regulation of secretoglobins in normal human upper airway and their expression, particularly that of uteroglobin-related protein 1, in chronic rhinosinusitis. Respir Res 2011;12:28.
9. Ocampo C, Suh L, Kern R, Kato A, Conley D, Chandra R, et al. Levels of the cytokines IL-5, IL-13 and Rantes in nasal lavage fluids parallel the cytokine content of nasal polyps in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). J Allergy Clin Immunol 2013;131:AB237.
10. Nabavi M, Arshi S, Bahrami A, Aryan Z, Bemanian MH, Esmaeilzadeh H, et al. Increased level of interleukin-13, but not interleukin-4 and interferon-γ in chronic rhinosinusitis with nasal polyps. Allergol Immunopathol (Madr) 2014;42:465-71.
11. Bachert C, Zhang N, Holtappels G, De Lobel L, van Cauwenberge P, Liu S, et al. Presence of IL-5 protein and IgE antibodies to staphylococcal enterotoxins in nasal polyps is associated with comorbid asthma. J Allergy Clin Immunol 2010;126:962-8, 968.e1-6.
12. Iwashita H, Fujimoto K, Morita S, Nakanishi A, Kubo K. Increased human Ca2+-activated Cl-channel 1 expression and mucus overproduction in airway epithelia of smokers and chronic obstructive pulmonary disease patients. Respir Res 2012;13:55.
13. Huang F, Wong X, Jan LY. International Union of Basic and Clinical Pharmacology. LXXXV: calcium-activated chloride channels. Pharmacol Rev 2012;64:1-15.
14. Cunningham SA, Awayda MS, Bubien JK, Ismailov II, Arrate MP, Berdiev BK, et al. Cloning of an epithelial chloride channel from bovine trachea. J Biol Chem 1995;270:31016-26.
15. Sun H, Tsunenari T, Yau KW, Nathans J. The vitelliform macular dystrophy protein defines a new family of chloride channels. Proc Natl Acad Sci U S A 2002;99:4008-13.
16. Qu Z, Wei RW, Mann W, Hartzell HC. Two bestrophins cloned from Xenopus laevis oocytes express Ca2+-activated Cl-currents. J Biol Chem 2003;278:49563-72.
17. Suzuki M, Mizuno A. A novel human Cl(-) channel family related to Drosophila flightless locus. J Biol Chem 2004;279:22461-8.
18. Galietta LJ. The TMEM16 protein family: a new class of chloride channels? Biophys J 2009;97:3047-53.
19. Schroeder BC, Cheng T, Jan YN, Jan LY. Expression cloning of TMEM16A as a calcium-activated chloride channel subunit. Cell 2008; 134:1019-29.
20. Yang YD, Cho H, Koo JY, Tak MH, Cho Y, Shim WS, et al. TMEM16A confers receptor-activated calcium-dependent chloride conductance. Nature 2008;455:1210-5.
21. Caputo A, Caci E, Ferrera L, Pedemonte N, Barsanti C, Sondo E, et al. TMEM16A, a membrane protein associated with calcium-dependent chloride channel activity. Science 2008;322:590-4.
22. Tian Y, Kongsuphol P, Hug M, Ousingsawat J, Witzgall R, Schreiber R, et al. Calmodulin-dependent activation of the epithelial calcium-dependent chloride channel TMEM16A. FASEB J 2011;25: 1058-68.
23. Rock JR, O'Neal WK, Gabriel SE, Randell SH, Harfe BD, Boucher RC, et al. Transmembrane protein 16A (TMEM16A) is a Ca2+-regulated Cl-secretory channel in mouse airways. J Biol Chem 2009; 284:14875-80.
24. Huang F, Zhang H, Wu M, Yang H, Kudo M, Peters CJ, et al. Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction. Proc Natl Acad Sci U S A 2012;109:16354-9.
25. Namkung W, Phuan PW, Verkman AS. TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells. J Biol Chem 2011;286:2365-74.
26. Fokkens WJ, Lund VJ, Mullol J, Bachert C, Alobid I, Baroody F, et al. EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists. Rhinology 2012;50:1-12.
27. Kondo M, Tamaoki J, Takeyama K, Nakata J, Nagai A. Interleukin-13 induces goblet cell differentiation in primary cell culture from Guinea pig tracheal epithelium. Am J Respir Cell Mol Biol 2002;27:536-41.
28. Kanoh S, Tanabe T, Rubin BK. IL-13-induced MUC5AC production and goblet cell differentiation is steroid resistant in human airway cells. Clin Exp Allergy 2011;41:1747-56.
29. Patou J, Gevaert P, Van Zele T, Holtappels G, van Cauwenberge P, Bachert C. Staphylococcus aureus enterotoxin B, protein A, and lipoteichoic acid stimulations in nasal polyps. J Allergy Clin Immunol 2008;121:110-5.
30. Scudieri P, Caci E, Bruno S, Ferrera L, Schiavon M, Sondo E, et al. Association of TMEM16A chloride channel overexpression with airway goblet cell metaplasia. J Physiol 2012;590:6141-55.
31. Ousingsawat J, Martins JR, Schreiber R, Rock JR, Harfe BD, Kunzelmann K. Loss of TMEM16A causes a defect in epithelial Ca2+-dependent chloride transport. J Biol Chem 2009;284:28698-703.
32. Kondo M, Tamaoki J, Takeyama K, Isono K, Kawatani K, Izumo T, et al. Elimination of IL-13 reverses established goblet cell metaplasia into ciliated epithelia in airway epithelial cell culture. Allergol Int 2006;55:329-36.
33. Nakano T, Inoue H, Fukuyama S, Matsumoto K, Matsumura M, Tsuda M, et al. Niflumic acid suppresses interleukin-13-induced asthma phenotypes. Am J Respir Crit Care Med 2006;173:1216-21.
34. Rogers DF. The airway goblet cell. Int J Biochem Cell Biol 2003;35:1-6.