Increased human Ca 2+-activated Cl - channel 1 expression and mucus overproduction in airway epithelia of smokers and chronic obstructive pulmonary disease patients

Respiratory Research

Volumn 13, Issue , 2012, Pages

  Iwashita, Hiroki ^a   Fujimoto, Keisaku ^b   Morita, Shigeru ^a   Nakanishi, Atsushi ^a   Kubo, Keishi ^b  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

^b SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Airway epithelia; Ca 2+ activated Cl channel 1 (CLCA1); Chronic obstructive pulmonary disease (COPD); Mucus production; Smoking

Indexed keywords

CALCIUM RELEASE ACTIVATED CALCIUM CHANNEL 1; MESSENGER RNA; CHLORIDE CHANNEL; CLCA1 PROTEIN, HUMAN; INTERLEUKIN 13 RECEPTOR; INTERLEUKIN 13 RECEPTOR, HUMAN; INTERLEUKIN-13 RECEPTOR, HUMAN; MUC5AC PROTEIN, HUMAN; MUCIN 5AC;

AGED; ARTICLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MALE; MUCUS SECRETION; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RESPIRATORY EPITHELIUM; SMOKING; SPUTUM; UPREGULATION; ADULT; CASE CONTROL STUDY; CYTOLOGY; EPITHELIUM CELL; FEMALE; FORCED EXPIRATORY VOLUME; GENETICS; LUNG; METABOLISM; MIDDLE AGED; MUCUS; PATHOPHYSIOLOGY; RESPIRATORY TRACT MUCOSA; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VITAL CAPACITY;

ADULT; AGED; CASE-CONTROL STUDIES; CHLORIDE CHANNELS; EPITHELIAL CELLS; FEMALE; FORCED EXPIRATORY VOLUME; HUMANS; IMMUNOHISTOCHEMISTRY; LUNG; MALE; MIDDLE AGED; MUCIN 5AC; MUCUS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, INTERLEUKIN-13; RESPIRATORY MUCOSA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SMOKING; SPUTUM; UP-REGULATION; VITAL CAPACITY;

EID: 84862631447     PISSN: 14659921     EISSN: 1465993X     Source Type: Journal    
DOI: 10.1186/1465-9921-13-55     Document Type: Article

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