Combining varenicline and nicotine patches: A randomized controlled trial study in smoking cessation

BMC Medicine

Volumn 12, Issue 1, 2014, Pages

  Ramon, Josep M ^a,b   Morchon, Sergio ^a,b   Baena, Antoni ^a   Masuet Aumatell, Cristina ^a,b  

^a HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

^b UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Combination therapy; Nicotine patches; Randomized trial; Smoking cessation; Varenicline

Indexed keywords

CARBON MONOXIDE; NICOTINE PATCH; PLACEBO; VARENICLINE; BENZAZEPINE DERIVATIVE; NICOTINE; NICOTINE GUM; NICOTINIC AGENT; QUINOXALINE DERIVATIVE;

ABNORMAL DREAMING; ADULT; ARTICLE; BEHAVIOR THERAPY; BREATH ANALYSIS; COMBINATION DRUG THERAPY; CONSTIPATION; CONTROLLED STUDY; DEPRESSION; DRUG EFFICACY; DYSPEPSIA; FATIGUE; FEMALE; HEADACHE; HUMAN; HYPOTENSION; INSOMNIA; IRRITABILITY; MAJOR CLINICAL STUDY; MALE; MONOTHERAPY; NAUSEA; OUTCOME ASSESSMENT; POST HOC ANALYSIS; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; SMOKING CESSATION; TOBACCO DEPENDENCE; TREATMENT DURATION; ADOLESCENT; DRUG COMBINATION; INTRADERMAL DRUG ADMINISTRATION; MIDDLE AGED; TOBACCO USE DISORDER; TREATMENT OUTCOME;

ADMINISTRATION, CUTANEOUS; ADOLESCENT; ADULT; BENZAZEPINES; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; MALE; MIDDLE AGED; NICOTINE; NICOTINIC AGONISTS; QUINOXALINES; SMOKING CESSATION; TOBACCO USE CESSATION PRODUCTS; TOBACCO USE DISORDER; TREATMENT OUTCOME;

EID: 84929939139     PISSN: None     EISSN: 17417015     Source Type: Journal    
DOI: 10.1186/s12916-014-0172-8     Document Type: Article

References (19)

1. Fiore MC, Jaen CR, Baker TB, Bailey WC, Benowitz NL, Curry SJ, Dorfman SF, Froelicher ES, Goldstein MG, Healton CG, Henderson PN, Heyman RB, Koh HK, Kottke TE, Lando HA, Mecklenburg RE, Mermelstein RJ, Mullen PD, Orleans CT, Robinson L, Stitzer ML, Tommasello AC, Villejo L, Wewers ME: Treating tobacco use and dependence: 2008 update-clinical pbiractice guideline. Rockville, MD: US Department of Health and Human Services, Public Health Service; 2008.
2. Mills EJ, Wu P, Lockhart I, Thorlund K, Puhan M, Ebbert JO: Comparisons of high-dose and combination nicotine replacement therapy, varenicline, and bupropion for smoking cessation: a systematic review and multiple treatment meta-analysis. Ann Med 2012, 44:588-597.
3. Cahill K, Stevens S, Perera R, Lancaster T: Pharmacological interventions for smoking cessation: an overview and network meta-analysis. Cochrane Database Syst Rev 2013, 5, CD009329.
4. Shah SD, Wilken LA, Winkler SR, Lin SJ: Systematic review and meta-analysis of combination therapy for smoking cessation. J Am Pharm Assoc 2008, 48:659-665.
5. Williams KE, Reeves KR, Billing CB Jr, Pennington AM, Gong J: A double-blind study evaluating the long-term safety of varenicline for smoking cessation. Curr Med Res Opin 2007, 23:793-801.
6. Oncken C, Gonzales D, Nides M, Rennard S, Watsky E, Billing CB, Anziano R, Reeves K: Efficacy and safety of the novel selective nicotinic acetylcholine receptor partial agonist, varenicline, for smoking cessation. Arch Intern Med 2006, 166:1571-1577.
7. Ebbert JO, BurkeMV, Hays JT, Hurt RD: Combination treatment with varenicline and nicotine replacement therapy. Nicotine Tob Res 2009, 11:572-576.
8. Hajek P, Smith KM, Dhanji AR, McRobbie H: Is a combination of varenicline and nicotine patch more effective in helping smokers quit than varenicline alone? A randomised controlled trial. BMC Med 2013, 11:140.
9. Koegelenberg CF, Noor F, Bateman ED, Van Zyl-Smit RN, Bruning A, O'Brien JA, Smith C, Abdool-Gaffar MS, Emanuel S, Esterhuizen TM, Irusen EM: Efficacy of varenicline combined with nicotine replacement therapy vs varenicline alone for smoking cessation: a randomized clinical trial. JAMA 2014, 312:155-161.
10. Beck AT, Steer RA, Brown GK: Depression Inventory Manual. 2nd edition. San Antonio, TX: Psychological Corp; 1996.
11. Hamilton M: The assessment of anxiety states by rating. Br J Med Psychol 1959, 32:50-55.
12. Hughes JR: Minnesota nicotine Withdrawal Scale-Revised. http://www.uvm.edu/~hbpl/?Page=minnesota/default.html Accessed December 11,2013.
13. Beck AT, Kovacs M, Weissman A: Assessment of suicidal intention: the scale for suicide ideation. J Consult Clin Psychol 1979, 47:343-352.
14. Hughes JR, Keely JP, Niaura RS, Ossip-Klein DJ, Richmond RL, Swan GE: Measures of abstinence in clinical trials: issues and recommendations. Nicotine Tob Res 2003, 5:13-25.
15. West R, Hajek P, Stead L, Stapleton J: Outcome criteria in smoking cessation trials: proposal for common standard. Addiction 2005, 100:299-303.
16. Hajek P, West R: Commentary on Smolkowski, et al (2010): Why is it important to assume that non-responders in tobacco cessation trials have relapsed?. Addiction 2010, 105:1016-1017.
17. Japuntich SJ, Leventhal AM, Piper ME, Bolt DM, Roberts LJ, Fiore MC, Baker TB: Smoker characteristics and smoking-cessation milestones. Am J Prev Med 2011, 40:286-294.
18. Ebbert JO, Hatsukami DK, Croghan IT, Schroeder DR, Allen SS, Hays JT, Hurt RD: Combination varenicline and bupropion SR for tobacco-dependence treatment in cigarette smokers. A randomized trial. JAMA 2014, 311:155-163.
19. Miller WR, Rollnick S: Motivational interviewing: preparing people for change. 2nd edition. New York: Guildford Press; 2002.