메뉴 건너뛰기




Volumn 15, Issue 6, 2015, Pages 895-908

Blinatumomab: Enlisting serial killer T-cells in the war against hematologic malignancies

Author keywords

Acute lymphoblastic leukemia; AMG 103; Bi specific T cell engager; Blinatumomab; Non Hodgkin's lymphoma

Indexed keywords

BLINATUMOMAB; CHIMERIC ANTIGEN RECEPTOR; INOTUZUMAB OZOGAMICIN; ANTINEOPLASTIC AGENT; BISPECIFIC ANTIBODY;

EID: 84929863348     PISSN: 14712598     EISSN: 17447682     Source Type: Journal    
DOI: 10.1517/14712598.2015.1041912     Document Type: Article
Times cited : (25)

References (69)
  • 1
    • 33846869976 scopus 로고    scopus 로고
    • Outcome of 609 adults after relapse of acute lymphoblastic leukemia (ALL); An MRC UKALL12/ECOG 2993 study
    • Fielding AK, Richards SM, Chopra R, et al. Outcome of 609 adults after relapse of acute lymphoblastic leukemia (ALL); an MRC UKALL12/ECOG 2993 study. Blood (ASH Annual Meeting Abstracts) 2007;109:944-50
    • (2007) Blood (ASH Annual Meeting Abstracts , vol.109 , pp. 944-950
    • Fielding, A.K.1    Richards, S.M.2    Chopra, R.3
  • 2
    • 78650083131 scopus 로고    scopus 로고
    • Defining the course and prognosis of adults with acute lymphocytic leukemia in first salvage after induction failure or short first remission duration
    • Kantarjian HM, Thomas D, Ravandi F, et al. Defining the course and prognosis of adults with acute lymphocytic leukemia in first salvage after induction failure or short first remission duration. Cancer 2010;116:5568-74
    • (2010) Cancer , vol.116 , pp. 5568-5574
    • Kantarjian, H.M.1    Thomas, D.2    Ravandi, F.3
  • 3
    • 84866094086 scopus 로고    scopus 로고
    • Outcome of relapsed adult lymphoblastic leukemia depends on response to salvage chemotherapy, prognostic factors, and performance of stem cell transplantation
    • Gökbuget N, Stanze D, Beck J, et al. Outcome of relapsed adult lymphoblastic leukemia depends on response to salvage chemotherapy, prognostic factors, and performance of stem cell transplantation. Blood 2012;120:2032-41
    • (2012) Blood , vol.120 , pp. 2032-2041
    • Gökbuget, N.1    Stanze, D.2    Beck, J.3
  • 5
    • 0343415665 scopus 로고    scopus 로고
    • A recombinant bispecific single-chain antibody, CD19xCD3, induces rapid and high lymphoma-directed cytotoxicity by unstimulated T lymphocytes
    • Löffler A, Kufer P, Lutterbuse R, et al. A recombinant bispecific single-chain antibody, CD19xCD3, induces rapid and high lymphoma-directed cytotoxicity by unstimulated T lymphocytes. Blood (ASH Annual Meeting Abstracts) 2000;95(6):2098-103
    • (2000) Blood (ASH Annual Meeting Abstracts , vol.95 , Issue.6 , pp. 2098-2103
    • Löffler, A.1    Kufer, P.2    Lutterbuse, R.3
  • 6
    • 26244466523 scopus 로고    scopus 로고
    • BiTEs: Bispecific antibody constructs with unique anti-Tumor activity
    • Wolf E, Hofmeister R, Kufer P, et al. BiTEs: bispecific antibody constructs with unique anti-Tumor activity. Drug Discov Today 2005;10(18):1237-44
    • (2005) Drug Discov Today , vol.10 , Issue.18 , pp. 1237-1244
    • Wolf, E.1    Hofmeister, R.2    Kufer, P.3
  • 7
    • 28944434529 scopus 로고    scopus 로고
    • Induction of regular cytolytic T cell synapses by bispecific single-chain antibody constructs on MHC class I-negative tumor cells
    • Offner S, Hofmeister R, Romaniuk A, et al. Induction of regular cytolytic T cell synapses by bispecific single-chain antibody constructs on MHC class I-negative tumor cells. Mol Immunol 2006;43:763-71
    • (2006) Mol Immunol , vol.43 , pp. 763-771
    • Offner, S.1    Hofmeister, R.2    Romaniuk, A.3
  • 8
    • 0037851832 scopus 로고    scopus 로고
    • Efficient elimination of chronic lymphocytic leukemia B cells by autologous T cells with a bispecific anti-CD19/anti-CD3 single-chain antibody construct
    • Löffler A, Gruen M, Wuchter C, et al. Efficient elimination of chronic lymphocytic leukemia B cells by autologous T cells with a bispecific anti-CD19/anti-CD3 single-chain antibody construct. Leukemia 2003;17:900-9
    • (2003) Leukemia , vol.17 , pp. 900-909
    • Löffler, A.1    Gruen, M.2    Wuchter, C.3
  • 9
    • 84863522243 scopus 로고    scopus 로고
    • Immunopharmacologic response of patients with B-lineage acute lymphoblastic leukemia to continuous infusion of T cell-engaging CD19/CD3-bispecific BiTE antibody blinatumomab
    • Klinger M, Brandl C, Zugmaier G, et al. Immunopharmacologic response of patients with B-lineage acute lymphoblastic leukemia to continuous infusion of T cell-engaging CD19/CD3-bispecific BiTE antibody blinatumomab. Blood (ASH Annual Meeting Abstracts) 2012;119(26):6226-33
    • (2012) Blood (ASH Annual Meeting Abstracts , vol.119 , Issue.26 , pp. 6226-6233
    • Klinger, M.1    Brandl, C.2    Zugmaier, G.3
  • 10
    • 0037143806 scopus 로고    scopus 로고
    • Extremely potent, rapid and costimulation-independent cytotoxic T-cell response against lymphoma cells catalyzed by a single-chain bispecific antibody
    • In vitro analysis of the pharmacokinetics and pharmacodynamics of blinatumomab
    • Dreier T, Lorenczerski G, Brandl C, et al. Extremely potent, rapid and costimulation-independent cytotoxic T-cell response against lymphoma cells catalyzed by a single-chain bispecific antibody. Int J Cancer 2002;100:690-7 . In vitro analysis of the pharmacokinetics and pharmacodynamics of blinatumomab.
    • (2002) Int J Cancer , vol.100 , pp. 690-697
    • Dreier, T.1    Lorenczerski, G.2    Brandl, C.3
  • 11
    • 17644385543 scopus 로고    scopus 로고
    • Serial killing of tumor cells by cytotoxic T cells redirected with a CD19-/CD3-bispecific single-chain antibody construct
    • Hoffman P, Hofmeister R, Brischwein K, et al. Serial killing of tumor cells by cytotoxic T cells redirected with a CD19-/CD3-bispecific single-chain antibody construct. Int J Cancer 2005;115:98-104
    • (2005) Int J Cancer , vol.115 , pp. 98-104
    • Hoffman, P.1    Hofmeister, R.2    Brischwein, K.3
  • 12
    • 3042802506 scopus 로고    scopus 로고
    • T-cell-mediated lysis of B cells induced by a CD19xCD3 bispecific single-chain antibody is perforin dependent and death receptor independent
    • Gruen M, Bommert K, Bargou RC. T-cell-mediated lysis of B cells induced by a CD19xCD3 bispecific single-chain antibody is perforin dependent and death receptor independent. Cancer Immunol Immunother 2004;53:625-32
    • (2004) Cancer Immunol Immunother , vol.53 , pp. 625-632
    • Gruen, M.1    Bommert, K.2    Bargou, R.C.3
  • 13
    • 58549109813 scopus 로고    scopus 로고
    • Combination of rituximab with blinatumomab (MT103/MEDI-538), a T cell-engaging CD19-/CD3-bispecific antibody, for highly efficient lysis of human B lymphoma cells
    • dArgouges S, Wissing S, Brandl C, et al. Combination of rituximab with blinatumomab (MT103/MEDI-538), a T cell-engaging CD19-/CD3-bispecific antibody, for highly efficient lysis of human B lymphoma cells. Leuk Res 2009;33(3):465-73
    • (2009) Leuk Res , vol.33 , Issue.3 , pp. 465-473
    • Dargouges, S.1    Wissing, S.2    Brandl, C.3
  • 14
    • 84877054341 scopus 로고    scopus 로고
    • CD19: A biomarker for B cell development, lymphoma diagnosis and therapy
    • Wang K, Wei G, Liu D. CD19: a biomarker for B cell development, lymphoma diagnosis and therapy. Exp Hematol Oncol 2012;1:36
    • (2012) Exp Hematol Oncol , vol.1 , pp. 36
    • Wang, K.1    Wei, G.2    Liu, D.3
  • 15
    • 79551641737 scopus 로고    scopus 로고
    • Surface antigens analysis reveals significant expression of candidate targets for immunotherapy in adult acute lymphoid leukemia
    • Piccaluga PP, Arpinati M, Candoni A, et al. Surface antigens analysis reveals significant expression of candidate targets for immunotherapy in adult acute lymphoid leukemia. Leuk Lymphoma 2011;52(2):325-7
    • (2011) Leuk Lymphoma , vol.52 , Issue.2 , pp. 325-327
    • Piccaluga, P.P.1    Arpinati, M.2    Candoni, A.3
  • 16
    • 79957450612 scopus 로고    scopus 로고
    • Flow cytometric study of potential target antigens (CD19 CD20 CD22 CD33) for antibody-based immunotherapy in acute lymphoblastic leukemia: Analysis of 552 cases
    • Raponi S, De Propris MS, Intoppa S, et al. Flow cytometric study of potential target antigens (CD19, CD20, CD22, CD33) for antibody-based immunotherapy in acute lymphoblastic leukemia: analysis of 552 cases. Leuk Lymphoma 2011;52(6):1098-107
    • (2011) Leuk Lymphoma , vol.52 , Issue.6 , pp. 1098-1107
    • Raponi, S.1    De Propris, M.S.2    Intoppa, S.3
  • 17
    • 68449086890 scopus 로고    scopus 로고
    • Immunotherapy of lymphoma and leukemia with T-cell engaging BiTE antibody blinatumomab
    • Nagorsen D, Bargou R, Ruttinger D, et al. Immunotherapy of lymphoma and leukemia with T-cell engaging BiTE antibody blinatumomab. Leuk Lymphoma 2009;50(6):886-91
    • (2009) Leuk Lymphoma , vol.50 , Issue.6 , pp. 886-891
    • Nagorsen, D.1    Bargou, R.2    Ruttinger, D.3
  • 18
    • 84927667667 scopus 로고    scopus 로고
    • Blinatumomab exposure and pharmacodynamic response in patients with non-Hodgkin lymphoma (NHL)
    • abstract 3051
    • Hijazi Y, Klinger M, Schub A, et al. Blinatumomab exposure and pharmacodynamic response in patients with non-Hodgkin lymphoma (NHL). J Clin Oncol 31, 2013(Suppl):abstract 3051
    • (2013) J Clin Oncol , vol.31
    • Hijazi, Y.1    Klinger, M.2    Schub, A.3
  • 19
    • 34447643439 scopus 로고    scopus 로고
    • The effect of dexamethasone on polyclonal T cell activation and redirected target cell lysis as induced by a CD19/CD3-bispecific single-chain antibody construct
    • Brandl C, Haas C, dArgouges S, et al. The effect of dexamethasone on polyclonal T cell activation and redirected target cell lysis as induced by a CD19/CD3-bispecific single-chain antibody construct. Cancer Immunol Immunother 2007;56:1551-63
    • (2007) Cancer Immunol Immunother , vol.56 , pp. 1551-1563
    • Brandl, C.1    Haas, C.2    Dargouges, S.3
  • 21
    • 84922430955 scopus 로고    scopus 로고
    • Pharmacokinetics (PK) of blinatumomab and its clinical implications
    • abstract 3048
    • Wu B, Hijazi Y, Wolf A, et al. Pharmacokinetics (PK) of blinatumomab and its clinical implications. J Clin Oncol 31, 2013(Suppl):abstract 3048
    • (2013) J Clin Oncol , vol.31
    • Wu, B.1    Hijazi, Y.2    Wolf, A.3
  • 22
    • 49649120397 scopus 로고    scopus 로고
    • Tumor regression in cancer patients by very low doses of a T cell-engaging antibody
    • Bargou R, Leo E, Zugmaier G, et al. Tumor regression in cancer patients by very low doses of a T cell-engaging antibody. Science 2008;321:974-7
    • (2008) Science , vol.321 , pp. 974-977
    • Bargou, R.1    Leo, E.2    Zugmaier, G.3
  • 23
    • 84862634261 scopus 로고    scopus 로고
    • Blinatumomab (CD3/CD19 BiTE- Antibody) results in high response rate in patients with relapsed non-Hodgkins lymphoma (NHL) including MCL and DLBCL
    • abstract 068
    • Goebeler M, Viardot A, Noppeney R, et al. Blinatumomab (CD3/CD19 BiTE- Antibody) results in high response rate in patients with relapsed non-Hodgkins lymphoma (NHL) including MCL and DLBCL. Ann Oncol 2011;22(4):abstract 068
    • (2011) Ann Oncol , vol.22 , Issue.4
    • Goebeler, M.1    Viardot, A.2    Noppeney, R.3
  • 24
    • 84929875600 scopus 로고    scopus 로고
    • Final results from a phase 1 study of blinatumomab in patients with relapsed/refractory Non-Hodgkins lymphoma
    • abstract 302
    • Goebeler ME, Viardot A, Kufer P, et al. Final results from a phase 1 study of blinatumomab in patients with relapsed/refractory Non-Hodgkins lymphoma. Hematol Oncol 2013;31(Suppl 1): abstract 302
    • (2013) Hematol Oncol , vol.31
    • Goebeler, M.E.1    Viardot, A.2    Kufer, P.3
  • 25
    • 84867857964 scopus 로고    scopus 로고
    • Blinatumomab monotherapy shows efficacy in patients with relapsed diffuse large b cell lymphoma
    • abstract 1637
    • Viardot A, Goebeler M, Nopponey R, et al. Blinatumomab monotherapy shows efficacy in patients with relapsed diffuse large B cell lymphoma. Blood (ASH Annual Meeting Abstracts) 2011;abstract 1637. Available from: https://ash.confex.com/ash/2011/webprogram/Paper36931.html
    • (2011) Blood (ASH Annual Meeting Abstracts)
    • Viardot, A.1    Goebeler, M.2    Nopponey, R.3
  • 26
    • 84873077857 scopus 로고    scopus 로고
    • Treatment of patients with non-Hodgkin lymphoma (NHL) with CD19/CD3 bispecific antibody blinatumomab (MT103): Double-step dose increase to continuous infusion of 60 μg/m2/d is tolerable and highly effective
    • abstract 2880
    • Viardot A, Goebeler M, Scheele J, et al. Treatment of patients with non-Hodgkin lymphoma (NHL) with CD19/CD3 bispecific antibody blinatumomab (MT103): double-step dose increase to continuous infusion of 60 μg/m2/d is tolerable and highly effective. Blood (ASH Annual Meeting Abstracts) 2010;116(21):abstract 2880
    • (2010) Blood (ASH Annual Meeting Abstracts , vol.116 , Issue.21
    • Viardot, A.1    Goebeler, M.2    Scheele, J.3
  • 28
    • 84916639631 scopus 로고    scopus 로고
    • Phase II Trial of the Anti-CD19 bispecific T cell-engager blinatumomab shows hematologic and molecular remissions in patients with relapsed or refractory B-precursor acute lymphoblastic leukemia
    • Topp MS, Gökbuget N, Zugmaier G, et al. Phase II Trial of the Anti-CD19 bispecific T cell-engager blinatumomab shows hematologic and molecular remissions in patients with relapsed or refractory B-precursor acute lymphoblastic leukemia. J Clin Oncol 2014;32(36):4134-40
    • (2014) J Clin Oncol , vol.32 , Issue.36 , pp. 4134-4140
    • Topp, M.S.1    Gökbuget, N.2    Zugmaier, G.3
  • 29
    • 84929877546 scopus 로고    scopus 로고
    • BLAST: A confirmatory, single-Arm, phase 2 study of blinatumomab, a bispecific T-cell engager (BiTE-) antibody construct, in patients with minimal residual disease B-precursor acute lymphoblastic leukemia (ALL)
    • abstract 379
    • Goekbuget N, Dombret H, Bonifacio M, et al. BLAST: a confirmatory, single-Arm, phase 2 study of blinatumomab, a bispecific T-cell engager (BiTE-) antibody construct, in patients with minimal residual disease B-precursor acute lymphoblastic leukemia (ALL). Blood (ASH Annual Meeting Abstracts) 2014;abstract 379. Available from: https://ash.confex.com/ash/2014/webprogram/Paper67851.html
    • (2014) Blood (ASH Annual Meeting Abstracts)
    • Goekbuget, N.1    Dombret, H.2    Bonifacio, M.3
  • 30
    • 79959312575 scopus 로고    scopus 로고
    • Targeted therapy with the T-cell-engaging antibody blinatumomab of chemotherapy-refractory minimal residual disease in B-lineage acute lymphoblastic leukemia patients results in high response rate and prolonged leukemia-free survival
    • First clinical trial to assess the efficacy of blinatumomab in ALL, specifically in elimination of MRD in patients in hematologic CR
    • Topp MS, Kufer P, Gökbuget N, et al. Targeted therapy with the T-cell-engaging antibody blinatumomab of chemotherapy-refractory minimal residual disease in B-lineage acute lymphoblastic leukemia patients results in high response rate and prolonged leukemia-free survival. J Clin Oncol 2011;29(18):2493-8 . First clinical trial to assess the efficacy of blinatumomab in ALL, specifically in elimination of MRD in patients in hematologic CR.
    • (2011) J Clin Oncol , vol.29 , Issue.18 , pp. 2493-2498
    • Topp, M.S.1    Kufer, P.2    Gökbuget, N.3
  • 31
    • 31544467825 scopus 로고    scopus 로고
    • Clinical significance of minimal residual disease quantification in adult patients with standard-risk acute lymphoblastic leukemia
    • Bruggemann M, Raff T, Flohr T, et al. Clinical significance of minimal residual disease quantification in adult patients with standard-risk acute lymphoblastic leukemia. Blood 2006;107(3):1116-23
    • (2006) Blood , vol.107 , Issue.3 , pp. 1116-1123
    • Bruggemann, M.1    Raff, T.2    Flohr, T.3
  • 32
    • 66149141393 scopus 로고    scopus 로고
    • Improved risk classification for riskspecific therapy based on the molecular study of minimal residual disease (MRD)in adult acute lymphoblastic leukemia (ALL)
    • Bassan R, Spinelli O, Oldani E, et al. Improved risk classification for riskspecific therapy based on the molecular study of minimal residual disease (MRD) in adult acute lymphoblastic leukemia (ALL). Blood 2009;113(18):4153-62
    • (2009) Blood , vol.113 , Issue.18 , pp. 4153-4162
    • Bassan, R.1    Spinelli, O.2    Oldani, E.3
  • 33
    • 33846882622 scopus 로고    scopus 로고
    • Molecular relapse in adult standard-risk ALL patients detected by prospective MRD monitoring during and after maintenance treatment: Data from the GMALL 06/99 and 07/03 trials
    • Raff T, Gökbuget N, Luschen S, et al. Molecular relapse in adult standard-risk ALL patients detected by prospective MRD monitoring during and after maintenance treatment: data from the GMALL 06/99 and 07/03 trials. Blood 2007;109(3):910-15
    • (2007) Blood , vol.109 , Issue.3 , pp. 910-915
    • Raff, T.1    Gökbuget, N.2    Luschen, S.3
  • 34
    • 84865709936 scopus 로고    scopus 로고
    • Adult patients with acute lymphoblastic leukemia and molecular failure display a poor prognosis and are candidates for stem cell transplantation and targeted therapies
    • Gökbuget N, Kneba M, Raff T, et al. Adult patients with acute lymphoblastic leukemia and molecular failure display a poor prognosis and are candidates for stem cell transplantation and targeted therapies. Blood 2012;120(9):1868-76
    • (2012) Blood , vol.120 , Issue.9 , pp. 1868-1876
    • Gökbuget, N.1    Kneba, M.2    Raff, T.3
  • 35
    • 84871491706 scopus 로고    scopus 로고
    • Long-Term follow-up of hematologic relapse-free survival in a phase 2 study of blinatumomab in patients with MRD in B-lineage ALL
    • Topp MS, Gökbuget N, Zugmaier et al. Long-Term follow-up of hematologic relapse-free survival in a phase 2 study of blinatumomab in patients with MRD in B-lineage ALL. Blood 2012;120(26): 5185-7
    • (2012) Blood , vol.120 , Issue.26 , pp. 5185-5187
    • Topp, M.S.1    Gökbuget, N.Z.2
  • 36
    • 84929929949 scopus 로고    scopus 로고
    • Long-Term survival in adult patients with relapsed/refractory B-precursor acute lymphoblastic leukemia (ALL) who achieved minimal residual disease (MRD) response following anti-CD19 BiTE-blinatumomab
    • 2014;abstract 2287
    • Zugmaier G, Gökbuget N, Viardot A, et al. Long-Term survival in adult patients with relapsed/refractory B-precursor acute lymphoblastic leukemia (ALL) who achieved minimal residual disease (MRD) response following anti-CD19 BiTE- blinatumomab. Blood (ASH Annual Meeting Abstracts) 2014;abstract 2287. Available from: https://ash.confex.com/ash/2014/webprogram/Paper69269.html
    • Blood (ASH Annual Meeting Abstracts)
    • Zugmaier, G.1    Gökbuget, N.2    Viardot, A.3
  • 37
    • 84926099033 scopus 로고    scopus 로고
    • Safety and activity of blinatumomab for adult patients with relapsed or refractory B-precursor acute lymphoblastic leukaemia: A multicentre, single-Arm, phase 2 study
    • Topp MS, Gökbuget N, Stein AS, et al. Safety and activity of blinatumomab for adult patients with relapsed or refractory B-precursor acute lymphoblastic leukaemia: a multicentre, single-Arm, phase 2 study. Lancet Oncol 2015;16:57-66
    • (2015) Lancet Oncol , vol.16 , pp. 57-66
    • Topp, M.S.1    Gökbuget, N.2    Stein, A.S.3
  • 39
    • 78651290248 scopus 로고    scopus 로고
    • Complete remission after blinatumomab-induced donor T-cell activation in three pediatric patients with post-Transplant relapsed acute lymphoblastic leukemia
    • Handgretinger R, Zugmaier G, Henze G, et al. Complete remission after blinatumomab-induced donor T-cell activation in three pediatric patients with post-Transplant relapsed acute lymphoblastic leukemia. Leukemia 2011;25:181-4
    • (2011) Leukemia , vol.25 , pp. 181-184
    • Handgretinger, R.1    Zugmaier, G.2    Henze, G.3
  • 40
    • 84903632926 scopus 로고    scopus 로고
    • Pediatric posttransplant relapsed/refractory B-precursor acute lymphoblastic leukemia shows durable remission by therapy with the T-cell engaging bispecific antibody blinatumomab
    • Schlegel P, Lang P, Zugmaier G, et al. Pediatric posttransplant relapsed/refractory B-precursor acute lymphoblastic leukemia shows durable remission by therapy with the T-cell engaging bispecific antibody blinatumomab. Haematologica 2014;99(7):1212-19
    • (2014) Haematologica , vol.99 , Issue.7 , pp. 1212-1219
    • Schlegel, P.1    Lang, P.2    Zugmaier, G.3
  • 43
    • 84889849596 scopus 로고    scopus 로고
    • Blinatumomab induces autologous T-cell killing of chronic lymphocytic leukemia cells
    • Wong R, Pepper C, Brennan P, et al. Blinatumomab induces autologous T-cell killing of chronic lymphocytic leukemia cells. Haematologica 2013;98(12):1930-8
    • (2013) Haematologica , vol.98 , Issue.12 , pp. 1930-8
    • Wong, R.1    Pepper, C.2    Brennan, P.3
  • 44
    • 84908144124 scopus 로고    scopus 로고
    • A novel method using blinatumomab for efficient, clinical-grade expansion of polyclonal T cells for adoptive immunotherapy
    • Golay J, DAmico A, Borleri G, et al. A novel method using blinatumomab for efficient, clinical-grade expansion of polyclonal T cells for adoptive immunotherapy. J Immunol 2014;193:4739-47
    • (2014) J Immunol , vol.193 , pp. 4739-4747
    • Golay, J.1    Damico, A.2    Borleri, G.3
  • 45
    • 84873133651 scopus 로고    scopus 로고
    • Increased frequency of CD8+ and CD4+ regulatory T cells in chronic lymphocytic leukemia: Association with disease progression
    • Jadidi-Niaragh F, Yousefi M, Memarian A, et al. Increased frequency of CD8+ and CD4+ regulatory T cells in chronic lymphocytic leukemia: association with disease progression. Cancer Invest 2013;31:121-31
    • (2013) Cancer Invest , vol.31 , pp. 121-131
    • Jadidi-Niaragh, F.1    Yousefi, M.2    Memarian, A.3
  • 46
    • 0026638734 scopus 로고
    • Phenotypical characteristics of acute myelocytic leukemia associated with the t(8;21)(q22;q22) chromosomal abnormality: Frequent expression of immature B-cell antigen CD19 together with stem cell antigen CD34
    • Kita K, Nakase K, Miwa H, et al. Phenotypical characteristics of acute myelocytic leukemia associated with the t(8;21)(q22;q22) chromosomal abnormality: frequent expression of immature B-cell antigen CD19 together with stem cell antigen CD34. Blood 1992;80(2):470-7
    • (1992) Blood , vol.80 , Issue.2 , pp. 470-477
    • Kita, K.1    Nakase, K.2    Miwa, H.3
  • 47
    • 0031040109 scopus 로고    scopus 로고
    • Aberrant expression of CD19 as a marker of monocytic lineage in acute myelogenous leukemia
    • Brandt JT, Tisone JA, Bohman JE, Theil KS. Aberrant expression of CD19 as a marker of monocytic lineage in acute myelogenous leukemia. Am J Clin Pathol 1997;107(3):283-91
    • (1997) Am J Clin Pathol , vol.107 , Issue.3 , pp. 283-291
    • Brandt, J.T.1    Tisone, J.A.2    Bohman, J.E.3    Theil, K.S.4
  • 48
    • 0025912609 scopus 로고
    • Prognostic value of lymphocyte surface markers in acute myeloid leukemia
    • Ball ED, Davis RB, Griffin JD, et al. Prognostic value of lymphocyte surface markers in acute myeloid leukemia. Blood 1991;77(10):2242-50
    • (1991) Blood , vol.77 , Issue.10 , pp. 2242-2250
    • Ball, E.D.1    Davis, R.B.2    Griffin, J.D.3
  • 49
    • 0026762750 scopus 로고
    • Surface markers in adult acute myeloblastic leukemia: Correlation of CD19+, CD34+ and CD14+/DR-phenotypes with shorter survival
    • Solary E, Casasnovas RO, Campos L, et al. Surface markers in adult acute myeloblastic leukemia: correlation of CD19+, CD34+ and CD14+/DR-phenotypes with shorter survival. Leukemia 1992;6(5):393-9
    • (1992) Leukemia , vol.6 , Issue.5 , pp. 393-399
    • Solary, E.1    Casasnovas, R.O.2    Campos, L.3
  • 50
    • 84897018823 scopus 로고    scopus 로고
    • Cellular determinants for preclinical activity of a novel CD33/CD3 bispecific T-cell engager (BiTE) antibody AMG 330 against human AML
    • Laszlo GS, Gudgeon CJ, Harrington KH, et al. Cellular determinants for preclinical activity of a novel CD33/CD3 bispecific T-cell engager (BiTE) antibody, AMG 330, against human AML. Blood 2014;123(4):554-61
    • (2014) Blood , vol.123 , Issue.4 , pp. 554-561
    • Laszlo, G.S.1    Gudgeon, C.J.2    Harrington, K.H.3
  • 51
    • 84897019168 scopus 로고    scopus 로고
    • CD33 target validation and sustained depletion of AML blasts in long-Term cultures by the bispecific T-cell-engaging antibody AMG 330
    • Krupka C, Kufer P, Kischel R, et al. CD33 target validation and sustained depletion of AML blasts in long-Term cultures by the bispecific T-cell-engaging antibody AMG 330. Blood 2014;123(3):356-65
    • (2014) Blood , vol.123 , Issue.3 , pp. 356-365
    • Krupka, C.1    Kufer, P.2    Kischel, R.3
  • 52
    • 84876116790 scopus 로고    scopus 로고
    • T lymphocytes can be effectively recruited for ex vivo and in vivo lysis of AML blasts by a novel CD33/CD3-bispecific BiTE antibody construct
    • Aigner M, Feulner J, Schaffer S, et al. T lymphocytes can be effectively recruited for ex vivo and in vivo lysis of AML blasts by a novel CD33/CD3-bispecific BiTE antibody construct. Leukemia 2013;27(5):1107-15
    • (2013) Leukemia , vol.27 , Issue.5 , pp. 1107-1115
    • Aigner, M.1    Feulner, J.2    Schaffer, S.3
  • 55
    • 84882782587 scopus 로고    scopus 로고
    • Cytokine release syndrome after blinatumomab treatment related to abnormal macrophage activation and ameliorated with cytokine-directed therapy
    • Teachey DT, Rheingold SR, Maude SL, et al. Cytokine release syndrome after blinatumomab treatment related to abnormal macrophage activation and ameliorated with cytokine-directed therapy. Blood 2013;121(26):5154-7
    • (2013) Blood , vol.121 , Issue.26 , pp. 5154-5157
    • Teachey, D.T.1    Rheingold, S.R.2    Maude, S.L.3
  • 56
    • 84904097189 scopus 로고    scopus 로고
    • Current concepts in diagnosis and management of cytokine release syndrome
    • Lee DW, Gardner R, Porter DL, et al. Current concepts in diagnosis and management of cytokine release syndrome. Blood 2014;124(2):188-95
    • (2014) Blood , vol.124 , Issue.2 , pp. 188-195
    • Lee, D.W.1    Gardner, R.2    Porter, D.L.3
  • 57
    • 84925461494 scopus 로고    scopus 로고
    • Long-Term follow-up of serum immunoglobulin levels in blinatumomabtreated patients with minimal residual disease-positive B-precursor acute lymphoblastic leukemia
    • Zugmaier G, Topp MS, Alekar S, et al. Long-Term follow-up of serum immunoglobulin levels in blinatumomabtreated patients with minimal residual disease-positive B-precursor acute lymphoblastic leukemia. Blood Cancer J 2014;4:244
    • (2014) Blood Cancer J , vol.4 , pp. 244
    • Zugmaier, G.1    Topp, M.S.2    Alekar, S.3
  • 58
    • 84929877146 scopus 로고    scopus 로고
    • National Comprehensive Cancer Network. Acute Lymphoblastic Leukemia [Version 2.2014]. [Accessed 8 Febuary 2015]
    • National Comprehensive Cancer Network. Acute Lymphoblastic Leukemia [Version 2.2014]. [Accessed 8 Febuary 2015]
  • 59
    • 84929868959 scopus 로고    scopus 로고
    • Crucial role of regulatory T cells in predicting the outcome of the T cell engaging antibody blinatumomab in relapsed and refractory B precursor ALL patients
    • abstract 2291
    • Duell J, Dittrich M, Bedke T, et al. Crucial role of regulatory T cells in predicting the outcome of the T cell engaging antibody blinatumomab in relapsed and refractory B precursor ALL patients. Blood (ASH Annual Meeting Abstracts) 2014;abstract 2291. Available from: https://ash.confex.com/ash/2014/webprogram/Paper69981.html
    • (2014) Blood (ASH Annual Meeting Abstracts)
    • Duell, J.1    Dittrich, M.2    Bedke, T.3
  • 60
    • 84875716409 scopus 로고    scopus 로고
    • High-dose vincristine sulfate liposome injection for advanced, relapsed, and refractory adult Philadelphia chromosomenegative acute lymphoblastic leukemia
    • OBrien S, Schiller G, Lister J, et al. High-dose vincristine sulfate liposome injection for advanced, relapsed, and refractory adult Philadelphia chromosomenegative acute lymphoblastic leukemia. J Clin Oncol 2013;31(6):676-83
    • (2013) J Clin Oncol , vol.31 , Issue.6 , pp. 676-683
    • Obrien, S.1    Schiller, G.2    Lister, J.3
  • 61
    • 84939943612 scopus 로고    scopus 로고
    • T cells engineered with a chimeric antigen receptor (CAR) targeting CD19 (CTL019) have long term persistence and induce durable remissions in children with relapsed, refractory all
    • Abstract 380
    • Grupp S, Maude SL, Shaw P, et al. T cells engineered with a chimeric antigen receptor (CAR) targeting CD19 (CTL019) have long term persistence and induce durable remissions in children with relapsed, refractory all. Blood (ASH Annual Meeting Abstracts) 2014;abstract 380. Available from: https://ash.confex.com/ash/2014/webprogram/Paper69932.html
    • (2014) Blood (ASH Annual Meeting Abstracts)
    • Grupp, S.1    Maude, S.L.2    Shaw, P.3
  • 62
    • 84908073316 scopus 로고    scopus 로고
    • Chimeric antigen receptor T cells for sustained remissions in leukemia
    • Maude SL, Frey N, Shaw PA, et al. Chimeric antigen receptor T cells for sustained remissions in leukemia. N Engl J Med 2014;371:1507-17
    • (2014) N Engl J Med , vol.371 , pp. 1507-1517
    • Maude, S.L.1    Frey, N.2    Shaw, P.A.3
  • 63
    • 84929915562 scopus 로고    scopus 로고
    • Refractory cytokine release syndrome in recipients of chimeric antigen receptor (CAR) T cells
    • abstract 2296
    • Frey NV, Levine BL, Lacey SF, et al. Refractory cytokine release syndrome in recipients of chimeric antigen receptor (CAR) T cells. Blood (ASH Annual Meeting Abstracts) 2014;abstract 2296. Available from: https://ash.confex.com/ash/2014/webprogram/Paper76315.html
    • (2014) Blood (ASH Annual Meeting Abstracts)
    • Frey, N.V.1    Levine, B.L.2    Lacey, S.F.3
  • 64
    • 84876005284 scopus 로고    scopus 로고
    • CD19-Targeted T cells rapidly induce molecular remissions in adults with chemotherapy-refractory acute lymphoblastic leukemia
    • Brentjens R, Davila M, Riviere I, et al. CD19-Targeted T cells rapidly induce molecular remissions in adults with chemotherapy-refractory acute lymphoblastic leukemia. Sci Transl Med 2013;5(177):177ra38
    • (2013) Sci Transl Med , vol.5 , Issue.177 , pp. 177ra38
    • Brentjens, R.1    Davila, M.2    Riviere, I.3
  • 66
    • 84929877664 scopus 로고    scopus 로고
    • Intent-To-Treat results of a phase i trial of CD19 chimeric antigen receptor T cells using a consistent treatment regimen reveals a 67% complete response rate in relapsed, refractory acute lymphoblastic leukemia
    • abstract 381
    • Lee DW, Stetler-Stevenson M, Sabatino M, et al. Intent-To-Treat results of a phase I trial of CD19 chimeric antigen receptor T cells using a consistent treatment regimen reveals a 67% complete response rate in relapsed, refractory acute lymphoblastic leukemia. Blood (ASH Annual Meeting Abstracts) 2014;124(21):abstract 381. Available from: https://ash.confex.com/ash/2014/webprogram/Paper75723.html
    • (2014) Blood (ASH Annual Meeting Abstracts , vol.124 , Issue.21
    • Lee, D.W.1    Stetler-Stevenson, M.2    Sabatino, M.3
  • 67
    • 84879387212 scopus 로고    scopus 로고
    • CD19 expression in acute leukemia is not restricted to the cytogenetically aberrant populations
    • Francis J, Dharmadhikari AV, Sait SN, et al. CD19 expression in acute leukemia is not restricted to the cytogenetically aberrant populations. Leuk Lymphoma 2013;57(7):1517-20
    • (2013) Leuk Lymphoma , vol.57 , Issue.7 , pp. 1517-1520
    • Francis, J.1    Dharmadhikari, A.V.2    Sait, S.N.3
  • 68
    • 84862786326 scopus 로고    scopus 로고
    • Inotuzumab ozogamicin an anti-CD22-calecheamicin conjugate for refractory and relapsed acute lymphocytic leukaemia: A phase 2 study
    • Kantarjian H, Thomas D, Jorgensen J, et al. Inotuzumab ozogamicin, an anti-CD22-calecheamicin conjugate, for refractory and relapsed acute lymphocytic leukaemia: a phase 2 study. Lancet Oncol 2012;13(4):403-11
    • (2012) Lancet Oncol , vol.13 , Issue.4 , pp. 403-411
    • Kantarjian, H.1    Thomas, D.2    Jorgensen, J.3
  • 69
    • 84880574025 scopus 로고    scopus 로고
    • Results of inotuzumab ozogamicin, a CD22 monoclonal antibody, in refractory and relapsed acute lymphocytic leukemia
    • Kantarjian H, Thomas D, Jorgensen J, et al. Results of inotuzumab ozogamicin, a CD22 monoclonal antibody, in refractory and relapsed acute lymphocytic leukemia. Cancer 2013;119:2728-36
    • (2013) Cancer , vol.119 , pp. 2728-2736
    • Kantarjian, H.1    Thomas, D.2    Jorgensen, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.