Mesenchymal stem cell therapy for knee osteoarthritis: 5 years follow-up of three patients

International Journal of Rheumatic Diseases

Volumn 19, Issue 3, 2016, Pages 219-225

  Davatchi, Fereydoun ^a   Sadeghi Abdollahi, Bahar ^a   Mohyeddin, Mandana ^a   Nikbin, Behrooz ^a  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Bone marrow; Intra articular injection; Knee osteoarthritis; Mesenchymal stem cell; Stem cell transplantation; Tissue culture

Indexed keywords

ADULT; AGED; ARTICLE; CASE REPORT; DETERIORATION; FEMALE; FLEXION CONTRACTURE; FOLLOW UP; HUMAN; JOINT LIMITATION; KNEE DISEASE; KNEE OSTEOARTHRITIS; KNEE PAIN; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MIDDLE AGED; MUSCULOSKELETAL DISEASE ASSESSMENT; OPEN STUDY; PATELLA CREPITUS; PATIENT GLOBAL ASSESSMENT; PILOT STUDY; PRIORITY JOURNAL; VISUAL ANALOG SCALE; CELL CULTURE; CLINICAL TRIAL; CONVALESCENCE; DISABILITY; INTRAARTICULAR DRUG ADMINISTRATION; KNEE; OSTEOARTHRITIS, KNEE; PAIN MEASUREMENT; PATHOLOGY; PATHOPHYSIOLOGY; SEVERITY OF ILLNESS INDEX; TIME FACTOR; TREATMENT OUTCOME;

AGED; CELLS, CULTURED; DISABILITY EVALUATION; FEMALE; HUMANS; INJECTIONS, INTRA-ARTICULAR; KNEE JOINT; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MIDDLE AGED; OSTEOARTHRITIS, KNEE; PAIN MEASUREMENT; PILOT PROJECTS; RECOVERY OF FUNCTION; SEVERITY OF ILLNESS INDEX; TIME FACTORS; TREATMENT OUTCOME;

EID: 84929850343     PISSN: 17561841     EISSN: 1756185X     Source Type: Journal    
DOI: 10.1111/1756-185X.12670     Document Type: Article

References (33)

1. Davatchi F (2006) Rheumatic diseases in the APLAR region. APLAR J Rheumatol 9, 5-10.
2. Haq SA, Davatchi F (2011) Osteoarthritis of the knees in the COPCORD world. Int J Rheum Dis 14, 122-9.
3. Davatchi F, Jamshidi F, Tehrani Banihashemi A et al. (2008) WHO-ILAR COPCORD Study (Stage 1, urban study) in Iran. J Rheumatol 35, 1384-90.
4. Davatchi F, Tehrani Banihashemi A, Gholami J et al. (2009) The prevalence of musculoskeletal complaints in a rural area in Iran: a WHO-ILAR COPCORD study (stage 1, rural study) in Iran. Clin Rheumatol 28, 1267-74.
5. Sandoughi M, Zakeri Z, Tehrani Banihashemi A et al. (2013) Prevalence of musculoskeletal disorders in southeastern Iran: a WHO-ILAR COPCORD study (stage 1, urban study). Int J Rheum Dis 16, 509-17.
6. Moghimi N, Davatchi F, Rahimi E et al. (2013) WHO-ILAR COPCORD study (stage 1, urban study) in Sanandaj, Iran. Clin Rheumatol 34, 535-543, doi:10.1007/s10067-013-2430-0.
7. Barry F, Murphy M (2013) Mesenchymal stem cells in joint disease and repair. Nat Rev Rheumatol 9, 584-94.
8. Mastbergen S, Saris D, Lafeber F (2013) Functional articular cartilage repair: here, near, or is the best approach not yet clear? Nat Rev Rheumatol 9, 277-90.
9. Dahaghin S, Tehrani-Banihashemi A, Faezi ST et al. (2009) Squatting, sitting on the floor, or cycling: are life-long daily activities risk factors for clinical knee osteoarthritis? Stage III results of a community-based study. Arthritis Rheum 61, 1337-42.
10. Guilak F (2011) Biomechanical factors in osteoarthritis. Best Pract Res Clin Rheumatol 25, 815-23.
11. Davatchi F, Jamshidi AR, Tehran Banihashemi A et al. (2009) Effect of ethnic origin (Caucasians versus Turks) on the prevalence of rheumatic diseases: a WHO-ILAR COPCORD urban study in Iran. Clin Rheumatol 28, 1275-82.
12. Haq SA, Davatchi F, Dahaghin S et al. (2010) Development of a questionnaire for identification of the risk factors for osteoarthritis of the knees in developing countries. A pilot study in Iran and Bangladesh. An ILAR-COPCORD phase III study. Int J Rheum Dis (in press) 13, 203-214.
13. Findlay DM (2010) If good things come from above, do bad things come from below? Arthritis Res Ther 12, 119-20.
14. Tanamas SK, Wluka AE, Pelletier JP et al. (2010) The association between subchondral bone cysts and tibial cartilage volume and risk of joint replacement in people with knee osteoarthritis: a longitudinal study. Arthritis Res Ther 12, R58.
15. Goldring MB, Goldring SR (2010) Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis. Ann NY Acad Sci 1192, 230-7.
16. Blom AB, van Lent PL, Holthuysen AE et al. (2004) Synovial lining macrophages mediate osteophyte formation during experimental osteoarthritis. Osteoarthritis Cartilage 12, 627-35.
17. Kapoor M, Martel-Pelletier J, Lajeunesse D, Pelletier JP, Fahmi H (2011) Role of proinflammatory cytokines in the pathophysiology of osteoarthritis. Nat Rev Rheumatol 7, 33-42.
18. De Lange-Brokaar BJ et al. (2012) Synovial inflammation, immune cells and their cytokines in osteoarthritis: a review. Osteoarthritis Cartilage 20, 1484-99.
19. Benito MJ, Veale DJ, FitzGerald O, van den Berg WB, Bresnihan B (2005) Synovial tissue inflammation in early and late osteoarthritis. Ann Rheum Dis 64, 1263-7.
20. Murphy JM, Fink DJ, Hunziker EB, Barry FP (2003) Stem cell therapy in a caprine model of osteoarthritis. Arthritis Rheum 48, 3464-74.
21. Lee KB, Hui JH, Song IC, Ardany L, Lee EH (2007) Injectable mesenchymal stem cell therapy for large cartilage defects-a porcine model. Stem Cell 25, 2964-71.
22. ter Huurne M, Schelbergen R, Blattes R et al. (2012) Antiinflammatory and chondroprotective effects of intraarticular injection of adipose-derived stem cells in experimental osteoarthritis. Arthritis Rheum 64, 3604-13.
23. Desando G, Cavallo C, Sartoni F et al. (2013) Intra-articular delivery of adipose derived stromal cells attenuates osteoarthritis progression in an experimental rabbit model. Arthritis Res Ther 15, R22.
24. van Lent PL, van den Berg WB (2013) Mesenchymal stem cell therapy in osteoarthritis: advanced tissue repair or intervention with smouldering synovial activation? Arthritis Res Ther 15, 112.
25. Roelofs AJ, Rocke JP, De Bari C (2013) Cell-based approaches to joint surface repair: a research perspective. Osteoarthritis Cartilage 21, 892-900.
26. Centeno CJ, Busse D, Kisiday J, Keohan C, Freeman M, Karli D (2008) Increased knee cartilage volume in degenerative joint disease using percutaneously implanted, autologous mesenchymal stem cells. Pain Phys 11, 343-53.
27. Centeno CJ, Busse D, Kisiday J, Keohan C, Freeman M, Karli D (2008) Regeneration of meniscus cartilage in a knee treated with percutaneously implanted autologous mesenchymal stem cells. Med Hypotheses 71, 900-8.
28. Davatchi F, Abdollahi BS, Mohyeddin M, Shahram F, Nikbin B (2011) Mesenchymal stem cell therapy for knee osteoarthritis. Preliminary report of four patients. Int J Rheum Dis 14, 211-5.
29. Emadedin M, Aghdami N, Taghiyar L et al. (2012) Intra-articular injection of autologous mesenchymal stem cells in six patients with knee osteoarthritis. Arch Iran Med 15, 422-8.
30. Glasson SS, Askew R, Sheppard B et al. (2005) Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis. Nature 434, 644-8.
31. Li J, Anemaet W, Diaz MA et al. (2011) Knockout of ADAMTS5 does not eliminate cartilage aggrecanase activity but abrogates joint fibrosis and promotes cartilage aggrecan deposition in murine osteoarthritis models. J Orthop Res 29, 516-22.
32. van der Kraan PM, Goumans ML (2012) Age-dependent alteration of TGF-β signalling in osteoarthritis. Cell Tissue Res 347, 257-65.
33. Centeno CJ, Freeman MD (2014) Percutaneous injection of autologous, culture-expanded mesenchymal stem cells into carpometacarpal hand joints: a case series with an untreated comparison group. Wien Med Wochenschr 164, 83-7.