Distributed abnormalities of brain white matter architecture in patients with dominant optic atrophy and OPA1 mutations

Journal of Neurology

Volumn 262, Issue 5, 2015, Pages 1216-1227

  Rocca, Maria A ^a   Bianchi Marzoli, Stefania ^b   Messina, Roberta ^a   Cascavilla, Maria Lucia ^a   Zeviani, Massimo ^c,d   Lamperti, Costanza ^c   Milesi, Jacopo ^a   Carta, Arturo ^e   Cammarata, Gabriella ^b   Leocani, Letizia ^a   Lamantea, Eleonora ^c   Bandello, Francesco ^a   Comi, Giancarlo ^a   Falini, Andrea ^a   Filippi, Massimo ^a  

^a VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

^b ISTITUTO AUXOLOGICO ITALIANO   (Italy)

^c DEPARTMENT OF NEUROSURGERY   (Italy)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^e UNIVERSITY OF PARMA   (Italy)

Author keywords

Diffusion tensor MRI; Dominant optic atrophy; Magnetic resonance imaging; Mitochondrial mutation; Optic coherence tomography; Regional atrophy; White matter

Indexed keywords

ADULT; ARTICLE; AUTOSOMAL DOMINANT OPTIC ATROPHY; BRAIN SIZE; CELL DEGENERATION; CINGULUM (BRAIN); CLINICAL ARTICLE; CONTROLLED STUDY; CORPUS CALLOSUM; DISEASE SEVERITY; EVOKED BRAIN STEM AUDITORY RESPONSE; FEMALE; FRACTIONAL ANISOTROPY; GENE; HAPLOINSUFFICIENCY; HUMAN; HUMAN TISSUE; INFERIOR LONGITUDINAL FASCICULUS; MALE; MISSENSE MUTATION; NUCLEAR MAGNETIC RESONANCE IMAGING; OCCIPITOFRONTAL FASCICULUS; OPA1 GENE; OPTIC NERVE; OPTIC TRACT; OPTICAL COHERENCE TOMOGRAPHY; PRIORITY JOURNAL; PYRAMIDAL TRACT; RETINA GANGLION CELL; TEMPORAL LOBE; VISUAL ACUITY; VISUAL SYSTEM; VOXEL BASED MORPHOMETRY; WHITE MATTER; ANISOTROPY; AUDITORY EVOKED POTENTIAL; DIFFUSION WEIGHTED IMAGING; ELECTROENCEPHALOGRAPHY; GENETICS; MIDDLE AGED; MUTATION; NEUROLOGIC EXAMINATION; NONPARAMETRIC TEST; PATHOLOGY; PHYSIOLOGY; VISUAL SYSTEM EXAMINATION; YOUNG ADULT;

GUANOSINE TRIPHOSPHATASE; OPA1 PROTEIN, HUMAN;

ADULT; ANISOTROPY; DIAGNOSTIC TECHNIQUES, OPHTHALMOLOGICAL; DIFFUSION MAGNETIC RESONANCE IMAGING; ELECTROENCEPHALOGRAPHY; EVOKED POTENTIALS, AUDITORY; FEMALE; GTP PHOSPHOHYDROLASES; HUMANS; MALE; MIDDLE AGED; MUTATION; NEUROLOGIC EXAMINATION; OPTIC ATROPHY, AUTOSOMAL DOMINANT; STATISTICS, NONPARAMETRIC; WHITE MATTER; YOUNG ADULT;

EID: 84929844846     PISSN: 03405354     EISSN: 14321459     Source Type: Journal    
DOI: 10.1007/s00415-015-7696-5     Document Type: Article

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